The effect of melatonin supplementation on glycemic control in patients with type 2 diabetes.

Background And Purpose: Melatonin supplementation has shown potential benefits in the management of diabetes in clinical trials; however, prior meta-analyses have not specifically focused on individuals with type 2 diabetes mellitus (T2DM). This study investigates the efficacy of melatonin supplementation in improving glycemic control among patients with T2DM by systematically reviewing and analyzing data from randomized controlled trials (RCTs).

Methods: A comprehensive literature search was conducted in PubMed, Cochrane Library, Scopus, Web of Science, and Embase from their inception to September 2024.

Coupling Mechanism of Methane Production and Carbon Fixation Regulated by Artificial Humic Acid in Paddy Soils: Insights into Microbial Communities and Metabolic Pathways.

The impact of artificial humic acid (HA) under varying water management conditions on the interactions between carbon metabolic pathways in rice soils remains unclear. Therefore, this study employed incubation experiments using HA-treated soil columns under continuous flooding (CF) and alternating wet-dry (AWD) to explore the relationship between CH production and CO fixation. The results demonstrate that HA significantly increased CH emissions, with a 102.

Comprehensive Review on Personalized Pain Assessment and Multimodal Interventions for Postoperative Recovery Optimization.

Postoperative pain management is an important determinant of patient recovery, as it directly influences rehabilitation efficiency, hospitalization duration, and the risk of postoperative complications. Despite its significance, traditional pain management strategies often fail to adequately address individual variability and the multidimensional nature of pain, thereby limiting their effectiveness. To address these limitations, we designed this comprehensive narrative review to systematically summarize relevant literature published between 2000 and 2024, from databases such as PubMed and Web of Science, with a particular focus on personalized pain assessment and multimodal interventions to optimize postoperative recovery.

miR-126-5p protects from URSA via inhibiting Caspase-1-dependent pyroptosis of trophoblast cells.

Unexplained recurrent spontaneous abortion (URSA) is a distressing pregnancy complication that seriously threat to women's reproductive health. Trophoblast pyroptosis was involved in the occurrence of URSA, but the potential mechanism remains unclear. In this work, we found CASP1 transcription and the level of pyroptosis were significantly elevated in the villous tissues of URSA patients.

Microbial community assemblage altered by coprecipitation of artificial humic substances and ferrihydrite: Implications for carbon fixation pathway transformation.

The suppression of soil carbon mineralization has been demonstrated to be effectively facilitated by carbon‑iron interactions, yet the specific mechanisms by which artificial humic substances (A-HS) coupled with ferrihydrite influence this process remain insufficiently explored. This study is to investigate how the A-HS, specifically artificial fulvic acid (A-FA) and artificial humic acid (A-HA), coupled with ferrihydrite, affect carbon mineralization under anaerobic system that simulates paddy flooding conditions. The object is to investigate trends in carbon emissions and to delineate microbial community structure and functional pathways.

Synergistic enhancement of cadmium immobilization and soil fertility through biochar and artificial humic acid-assisted microbial-induced calcium carbonate precipitation.

Microbially induced carbonate precipitation (MICP) is emerging as a favorable alternative to traditional soil remediation techniques for heavy metals, primarily due to its environmental friendliness. However, a significant challenge in using MICP for farmland is not only to immobilize heavy metals but also to concurrently enhance soil fertility. This study explores the innovative combination of artificial humic acid (A-HA), biochar (BC), and Sporosarcina pasteurii (S.

Artificial humic acid regulates the impact of fungal community on soil macroaggregates formation.

Artificial humic acid (A-HA), which is synthesized from agricultural wastes and has high similarity to a natural humic substance (HS) extracted from soil, has been proven by our group to have potential for biological carbon sequestration in black soils. However, the mechanism involves in the application of A-HA on soil aggregation processes resulting from microbial activity stimulation and modifications to microbial communities remains unclear. This study investigates the correlation between the formation and stability of soil aggregates and fungal communities with various amounts of A-HA added to the rhizosphere and non-rhizosphere soil.