[Retracted] Sevoflurane attenuates brain damage through inhibiting autophagy and apoptosis in cerebral ischemia‑reperfusion rats.

Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that, regarding the immunohistochemistry experiments shown in Fig. 4A, the 'Tak‑242' and the 'Se+Tak‑242' panels appeared to show an overlapping section of data, and for the western blot data shown in Figs. 6 and 7, the β‑actin data in Fig.

Multidisciplinary early activity team collaboration practice in ICUs: A qualitative study.

Purpose: To understand the collaborative practice experience of ICU patients' multidisciplinary early activity team members to provide a reference for formulating a scientific multidisciplinary team collaboration model.

Methods: Based on the phenomenological research methodology of qualitative research, in-depth interviews were conducted with 22 multidisciplinary early mobilization teams of ICU patients in nine general tertiary hospitals in China, using a purposive sampling method, Themes were then distilled.

Results: Three themes and six subthemes emerged from the analysis.

Informed consent competency assessment for brain-computer interface clinical research and application in psychiatric disorders: A systematic review.

Background: Brain-computer interface (BCI) technology is rapidly advancing in psychiatry. Informed consent competency (ICC) assessment among psychiatric patients is a pivotal concern in clinical research.

Aim: To analyze the assessment of ICC and form a framework with multi-dimensional elements involved in ICC of BCI clinical research among psychiatric disorders.

Plant-based traditional remedies and their role in public health: ethnomedicinal perspectives for a growing population.

Background: Traditional plant-based remedies remain essential to public health, especially in regions where formal healthcare access is limited. This study documents ethnomedicinal practices in Tehsil Hasilpur, Punjab, Pakistan, highlighting how growing and diverse populations utilize local flora for therapeutic purposes.

Methods: A total of 421 informants (247 males, 174 females) across 39 villages contributed to the documentation of 39 medicinal plant species from 19 botanical families.

Computationally Guided Design of a Soluble, Abundant and Functional AnfH Variant for the Expression of Fe-Only Nitrogenase in Plant Mitochondria.

Engineering nitrogenase directly into crops is a long-held aspiration in plant biotechnology. Of the three types, the Fe-only nitrogenase is a promising engineering target, as it has a simpler maturation pathway than the MoFe- and VFe-nitrogenases and does not require any heterometals for its cofactor. However, previously, we have reported that the obligate electron donor of the Fe-only nitrogenase from A.

Large language model powered knowledge graph construction for mental health exploration.

Mental health is a major global concern, yet findings remain fragmented across studies and databases, hindering integrative understanding and clinical translation. To address this gap, we present the Mental Disorders Knowledge Graph (MDKG)-a large-scale, contextualized knowledge graph built using large language models to unify evidence from biomedical literature and curated databases. MDKG comprises over 10 million relations, including nearly 1 million novel associations absent from existing resources.

Integrated untargeted and targeted metabolomics to reveal the mechanisms of herbal medicine HLXLD on Alzheimer's disease.

Huo-Luo-Xiao-Ling-Dan (HLXLD), a Chinese herbal medicine consisting of 11 herbs, has been shown to be effective in alleviating cognitive and memory impairment in Alzheimer's disease (AD). However, the underlying mechanisms require further investigation. This study aimed to clarify potential therapeutic mechanisms of HLXLD in the treatment of AD from a metabolic perspective.

AFF4 promotes tumor progression and cisplatin resistance by modulating the PTEN/PI3K/AKT/mTOR axis to accelerate glycolysis in lung adenocarcinoma.

Background: Although aerobic glycolysis contributes to malignancy and drug resistance in human cancers, the vital regulators of glycolysis in lung adenocarcinoma (LUAD) remain largely unknown. Transcription factor AF4/FMR2 family member 4 (AFF4) is the scaffolding protein of the super elongation complex (SEC) and regulates the transcription of cancer-related genes. However, the role of AFF4 in glycolysis and LUAD development remains unidentified.

Artificial Intelligence-Enabled Facial Privacy Protection for Ocular Diagnosis: Development and Validation Study.

Background: Facial biometric data, while valuable for clinical applications, poses substantial privacy and security risks.

Objective: This paper aims to address the privacy and security concerns related to facial biometric data and support auxiliary diagnoses, in pursuit of which we developed Digital FaceDefender, an artificial intelligence-driven privacy safeguard solution.

Methods: We constructed a diverse set of digitally synthesized Asian face avatars representing both sexes, spanning ages 5 to 85 years in 10-year increments, using 70,000 facial images and 13,061 Asian face images.

N-acetyltransferase 10 in the nucleus accumbens participates in methamphetamine-induced conditioned place preference and hyperlocomotion in mice.

Drug addiction is characterized by compulsive drug use despite significant negative consequences. N-acetyltransferase 10 (NAT10), a member of the Gcn5-related N-acetyltransferases (GNAT) family, has been associated with depression, anxiety-like behaviors, and cognitive dysfunction. However, its role in addiction remains largely unknown.

Sustainably Polyanionic Hyaluronic Acid-Based Hydrogel for Efficient Removal of Fe, Cd, and Pb Ions in Soil with Enhanced Sorghum Growth.

Toxic metals damage soil quality and harm human health via bioaccumulation, necessitating eco-friendly removal techniques. Hydrogel-based adsorption offers a promising approach for heavy metal extraction. Nevertheless, the potential of innovative hyaluronic acid (HA)-based hydrogels has not been fully investigated.

Manipulating interfacial built-in electric field of heterostructure catalysts to promote overall water splitting in alkaline.

The strategic construction of built-in electric fields (BIEF) through heterostructure engineering has emerged as a promising avenue for enhancing the intrinsic catalytic activity in dual-functional water electrolysis. In this work, we develop an innovative in-situ topological reconstruction strategy to fabricate phosphorus-defect-enriched NiCoP@NiFe LDH p-n heterojunction architectures on nickel foam (denoted as NiCoP@NiFe LDH/NF), establishing a quantitative structure-activity relationship between BIEF intensity modulation and catalytic performance enhancement. The introduced phosphorus vacancies at the heterointerface synergistically amplify the BIEF strength compared to defect-free counterparts, as evidenced by advanced characterizations, which orchestrates three critical catalytic enhancements: (i) accelerated interfacial charge transfer kinetics (charge transfer resistance reduced by 48 %), (ii) optimized adsorption/desorption energetics for reactive intermediates (ΔG = -0.

Engineering Electronic Structure of Sulfur-Bridged Atomically Dispersed Asymmetric Dual-site Catalysts for Enhancing Oxygen Bifunctional Activity.

The top-level design of oxygen reduction and evolution reaction (ORR/OER) bifunctional electrocatalyst materials with intrinsic activity and high site exposure is considered to be the most promising strategy to solve the problems of sluggish kinetics and unsatisfactory cycling durability faced by clean and renewable energy conversion systems. Herein, a directional strategy of bonding-strengthening to obtain a flexurally stable Fe-S-Ni bridge bond with high intrinsic activity by axial bonding of sulfur atoms introducing into hexa-coordinating FeNi dual sites (Fe-S-Ni-NC) at the atom design level to further enhance the asymmetry of the site and boost reversible ORR/OER bifunctional activity in pH-universal electrolytes with a lower potential gap of 0.66 V and higher turnover frequency, which is superior to the benchmark catalyst (Pt/C for ORR and RuO for OER).

Platelets in preeclampsia: an observational study of indices associated with aspirin nonresponsiveness, activation and transcriptional landscape.

Background: Platelets play critical roles in the pathogenesis of preeclampsia, including thrombosis, endothelial dysfunction and inflammation. However, preeclampsia-associated changes in platelet gene expression and activation at the maternal-foetal interface remain unknown. Moreover, aspirin nonresponsiveness in high-risk pregnancies underscores the need for low-cost biomarkers to identify nonresponders.

Volatile compounds evaluation and characteristic aroma compounds screening in representative germplasm of mei (Prunus mume) based on metabolomics and sensomics.

Mei (Prunus mume), the only floral-scented species within the Prunus genus, holds exceptional ornamental, edible, and medicinal value. By synergizing headspace solid-phase microextraction (HS-SPME) and organic solvent extraction (OSE) coupled with gas chromatography-mass spectrometry (GC-MS), we systematically detected 103 emitted and 83 endogenous volatiles from 67 mei cultivars and 3 congeneric species, constructing a comprehensive volatile metabolite library to date. Crucially, 17 emitted and 23 endogenous volatiles were identified as main volatiles, dominated by aldehydes, alcohols, esters, and phenols.

Feasibility study of fracturing flowback fluid degradation by dielectric barrier discharge plasma.

Fracturing flowback fluid, which is the waste fluid generated following the hydraulic fracturing of oil wells, has garnered significant attention in recent years regarding its safe treatment technologies. Low-temperature plasma water treatment technology is particularly notable for its high degradation efficiency and the environmentally benign by-products it produces. This study represents the inaugural application of dielectric barrier discharge (DBD) plasma for the degradation of fracturing flowback fluid.

Development and Initial Validation of the Multi-dimensional Attention Rating Scale in Highly Educated Adults.

Objectives: To report the development, validation, and findings of the Multi-dimensional Attention Rating Scale (MARS), a self-report tool crafted to evaluate six-dimension attention levels.

Methods: The MARS was developed based on Classical Test Theory (CTT) , with initial item selection and content validation conducted by six experts in psychiatry and psychology using the Delphi method. Healthy adult participants were recruited to complete the MARS and related scales, along with on-site measures.

Thyroid hormone ameliorates ursodeoxycholic acid-induced heart damage in zebrafish embryos.

Ursodeoxycholic acid (UDCA) is the most commonly prescribed treatment for intrahepatic cholestasis of pregnancy (ICP) worldwide. Clinical studies show that UDCA helps alleviate maternal pruritus and lowers serum bile acid levels. However, despite treatment, women with ICP still experience unpredictable fetal deaths and other serious pregnancy complications.

CATI: A medical context-enhanced framework for diagnosis code assignment in the UK Biobank study.

Diagnosis codes are standard code format of diseases or medical conditions. This study is aimed at assigning diagnosis codes to patients in large-scale biobanks, particularly addressing the issue of missing codes for some patients. This is crucial for downstream disease-related tasks.

Pharmacogenomics and Pharmacokinetics of Aspirin in Preeclampsia Prevention.

Background: It has become evident that some women develop preeclampsia despite aspirin. This study aimed to examine how such aspirin nonresponsiveness develops in high-risk preeclampsia pregnancies by exploring the role of genetic polymorphisms and aspirin metabolism.

Methods: The study involved pregnant women who developed preeclampsia despite low-dose aspirin and those who did not.

Fabrication, characterization, stability and re-dispersity of H-aggregates fucoxanthin/whey protein/chitosan nanoparticles.

This study aimed to establish a unique and controlled protocol of H-aggregates fucoxanthin and improve the water dispersibility and stability of H-aggregates fucoxanthin. H-aggregates fucoxanthin has been controllably prepared by regulating the key factor of the molecular self-aggregation of fucoxanthin in hydrated-organic systems. The H-aggregates fucoxanthin/BSA/chitosan nanoparticles (H-FBC-NPs), with a hydrated size around 171 ± 4 nm, were prepared by adjusting the three types of whey protein and initial concentration of fucoxanthin, which was constructed by a layer-by-layer self-assembly method.

Association between glucose time-in-range and the severity of metabolic dysfunction-associated steatotic liver disease in Chinese adults with type 2 diabetes mellitus.

Background: This study investigated the correlation between glucose time-in-range (TIR) and hepatic steatosis severity or liver fibrosis risk in Chinese adults with type 2 diabetes mellitus (T2DM) comorbid with metabolic dysfunction-associated steatotic liver disease (MASLD).

Methods: Participants with T2DM were evaluated for hepatic steatosis and fibrosis using vibration-controlled transient elastography. TIR was calculated based on data from a retrospective continuous glucose monitoring system.

UKB-MDRMF: a multi-disease risk and multimorbidity framework based on UK biobank data.

The rapid accumulation of biomedical cohort data presents opportunities to explore disease mechanisms, risk factors, and prognostic markers. However, current research often has a narrow focus, limiting the exploration of risk factors and inter-disease correlations. Additionally, fragmented processes and time constraints can hinder comprehensive analysis of the disease landscape.

Community modularity structure promotes the evolution of phase clusters and chimeralike states.

Community modularity structure is widely observed across various brain scales, reflecting a balance between information processing efficiency and neural wiring metabolic efficiency. Revealing the relationship between community structure and brain function facilitates our further understanding of the brain. Here, we construct an adaptive neural network (ANN) consisting of leaky integrate-and-fire neurons with adaptivity governed by spike-time-dependent plasticity rules.

Increased blood urea nitrogen levels and compromised peripheral nerve function in patients with type 2 diabetes.

Background: Increased blood urea nitrogen (BUN) levels have been demonstrated to be associated with broader metabolic disturbances and the incidence of type 2 diabetes (T2D), potentially playing a role in the development of diabetic complications, including diabetic peripheral neuropathy.

Aim: To examine the relationship between BUN levels and peripheral nerve function in patients with T2D.

Methods: This observational study involved the systematic recruitment of 585 patients with T2D for whom BUN levels and estimated glomerular filtration rate were measured.