CAN: Cascade Augmentations Against Noise for Image Restoration.

Image restoration aims to recover the latent clean image from a degraded counterpart. In general, the prevailing state-of-the-art image restoration methods concentrate on solving only a specific degradation type according to the task, e.g.

Changes in antibiotic use associated with the National Centralized Drug Procurement policy in China from 2019 to 2023.

This study used prescription data from four medical institutions in representative cities in Central, Western and Eastern China, focusing on changes in antibiotic use under the National Centralized Drug Procurement Policy (NCDP) and calculating the contribution of NCDP and non-NCDP varieties to the changes. In outpatient settings, NCDP policy had little impact on the antibiotic prescription rate. Changes in antibiotic utilization rates were predominantly driven by non-NCDP varieties, particularly newer-generation antibiotics with enhanced therapeutic profiles.

Power spectrum curve compensation method for image quality enhancement in high-throughput gene sequencing.

In high-throughput gene sequencing, the quality of sequencing images is critical for the accuracy of subsequent base calling. However, during practical sequencing processes, the time delay integration (TDI) camera's push-scan imaging often leads to significant degradation of image quality along the push-scan direction. Addressing the current limitations in TDI image restoration research for gene sequencing, this study establishes an imaging spectrum model of sequencing images based on MGI's ultra-high-throughput sequencer.

Selective splenectomy centered on graft-to-spleen volume ratio is a practical option in living donor liver transplantation to prevent early allograft dysfunction: A Prospective validation study.

Background: While simultaneous splenectomy (SPX) is an option in selected cases of living donor liver transplantation (LDLT) to protect graft function, graft-to-spleen volume ratio (GSVR) may serve as a new determinant of SPX. A prospective validation study was conducted to test our institutional strategy of SPX based mainly on GSVR, which has been employed since 2019.

Methods: This prospective study enrolled 141 LDLT recipients from 2019 to 2024.

The IL-1β/NETs/AIM2 axis participates in the formation of trauma-induced heterotopic ossification by orchestrating crosstalk between neutrophils and macrophages.

Introduction: The limitations of clinical treatment for trauma-induced heterotopic ossification (tHO) make it of great significance to fully study its pathogenesis for the treatment of this disease. The infiltration of inflammatory cells, as an important indicator of disease progression, should be further studied.

Objectives: In our study, we found that in the early stages of acute tendon injury, increased IL-1β can induce NETosis in neutrophils.

Transmembrane uptake of polystyrene nanoplastics mediated by aquaporin in tartary buckwheat: Physiological consequence and genomic mechanism.

It is still unclear how polystyrene nanoplastics (Ps-NPs) go through plant cell, and its physiological consequence and molecular mechanisms. To address this issue, the seedlings of tartary buckwheat (Fagopyrum tataricum) were exposed to hydroponic solution with 100 mg/L fluorescent-labeled Ps-NPs (100-nm diameter) across 0-2-4-6-8 days. Laser confocal microscopy, scanning electron microscopy and transmission electron microscope illuminated that Ps-NPs can go through root cells and cause significant physiological responses with time.

Data driven assessment of built environment impacts on urban health across United States cities.

The built environment plays a crucial role in urban health through its constant interaction with residents. Yet, a comprehensive analysis across multiple U.S.

iVR-GS: Inverse Volume Rendering for Explorable Visualization via Editable 3D Gaussian Splatting.

In volume visualization, users can interactively explore the three-dimensional data by specifying color and opacity mappings in the transfer function (TF) or adjusting lighting parameters, facilitating meaningful interpretation of the underlying structure. However, rendering large-scale volumes demands powerful GPUs and high-speed memory access for real-time performance. While existing novel view synthesis (NVS) methods offer faster rendering speeds with lower hardware requirements, the visible parts of a reconstructed scene are fixed and constrained by preset TF settings, significantly limiting user exploration.

UncTrack: Reliable Visual Object Tracking With Uncertainty-Aware Prototype Memory Network.

Transformer-based trackers have achieved promising success and become the dominant tracking paradigm because of their accuracy and efficiency. Despite the substantial progress, most of the existing approaches handle object tracking as a deterministic coordinate regression problem, while the target localization uncertainty has been largely overlooked, which hampers trackers' ability to maintain reliable target state prediction in challenging scenarios. To address this issue, we propose UncTrack, a novel uncertainty-aware transformer-based tracker that predicts the target localization uncertainty and incorporates this uncertainty information for accurate target state inference.

Risk stratification of residual abscess after surgical treatment for gastroduodenal perforation.

Aims: Residual abscess is a major complication after emergency surgery for gastroduodenal (GD) perforation. However, there is little evidence regarding potential risk factors contributing to its development. Establishing a risk stratification strategy would be valuable for the entire management process.

Intersecting Paths to Health: A Factor Analysis Approach to Socioeconomic and Environmental Determinants in Indiana.

Public health is the basis of society's well-being and the nation's development. Despite the importance of this factor and huge investments in the health sector in the United States, public health is facing enormous challenges due to the unknown nature of the influential variables in this sector. This research aims to investigate the influential variables on public health from different sources including the demographic features, built environment, socioeconomic variables, and environmental factors impact on 30 major health issues.

Group 1 innate lymphoid cells protect liver transplants from ischemia-reperfusion injury via an interferon gamma-mediated pathway.

As important immune regulatory cells, whether innate lymphoid cells (ILCs) are involved in liver transplantation (LT) remains unclear. In a murine orthotopic LT model, we dissected roles of ILCs in liver ischemia-reperfusion injury (IRI). Wild-type (WT) grafts suffered significantly higher IRI in Rag2-γc double knockout (DKO) than Rag2 knockout (KO) recipients, in association with downregulation of group 1 ILCs genes, including interferon gamma.

Hierarchical Graph Interaction Transformer With Dynamic Token Clustering for Camouflaged Object Detection.

Camouflaged object detection (COD) aims to identify the objects that seamlessly blend into the surrounding backgrounds. Due to the intrinsic similarity between the camouflaged objects and the background region, it is extremely challenging to precisely distinguish the camouflaged objects by existing approaches. In this paper, we propose a hierarchical graph interaction network termed HGINet for camouflaged object detection, which is capable of discovering imperceptible objects via effective graph interaction among the hierarchical tokenized features.

Examining the Role of Passive Design Indicators in Energy Burden Reduction: Insights from a Machine Learning and Deep Learning Approach.

Passive design characteristics (PDC) play a pivotal role in reducing the energy burden on households without imposing additional financial constraints on project stakeholders. However, the scarcity of PDC data has posed a challenge in previous studies when assessing their energy-saving impact. To tackle this issue, this research introduces an innovative approach that combines deep learning-powered computer vision with machine learning techniques to examine the relationship between PDC and energy burden in residential buildings.

The Coming Age of Antisense Oligos for the Treatment of Hepatic Ischemia/Reperfusion (IRI) and Other Liver Disorders: Role of Oxidative Stress and Potential Antioxidant Effect.

Imbalances in the redox state of the liver arise during metabolic processes, inflammatory injuries, and proliferative liver disorders. Acute exposure to intracellular reactive oxygen species (ROS) results from high levels of oxidative stress (OxS) that occur in response to hepatic ischemia/reperfusion injury (IRI) and metabolic diseases of the liver. Antisense oligonucleotides (ASOs) are an emerging class of gene expression modulators that target RNA molecules by Watson-Crick binding specificity, leading to RNA degradation, splicing modulation, and/or translation interference.

Cold stress-induced ferroptosis in liver sinusoidal endothelial cells determines liver transplant injury and outcomes.

Although cold preservation remains the gold standard in organ transplantation, cold stress-induced cellular injury is a significant problem in clinical orthotopic liver transplantation (OLT). Because a recent study showed that cold stress activates ferroptosis, a form of regulated cell death, we investigated whether and how ferroptosis determines OLT outcomes in mice and humans. Treatment with ferroptosis inhibitor (ferrostatin-1) during cold preservation reduced lipid peroxidation (malondialdehyde; MDA), primarily in liver sinusoidal endothelial cells (LSECs), and alleviated ischemia/reperfusion injury in mouse OLT.

SIRT1 regulates hepatocyte programmed cell death via GSDME - IL18 axis in human and mouse liver transplantation.

Sirtuin 1 (SIRT1) is a histone/protein deacetylase in the cellular response to inflammatory, metabolic, and oxidative stressors. We previously reported that myeloid SIRT1 regulates the inflamed liver's canonical pyroptosis cell death pathway. However, whether/how hepatocyte SIRT1 is engaged in programmed cell death in the cold-stressed liver remains uncertain.

Simplified risk stratification in early cholecystectomy for acute cholecystitis based on age: A report from an institution with zero mortality.

Background/purpose: The existing risk stratification for early cholecystectomy in patients with acute cholecystitis (AC) is complex. This study aims to establish a simpler risk assessment for surgical complications after cholecystectomy based on age group.

Methods: This single-center retrospective observational study enrolled 350 patients diagnosed with AC who underwent early cholecystectomy within 72 h of diagnosis from 2013 to 2021.

New therapeutic concepts against ischemia-reperfusion injury in organ transplantation.

Introduction: Ischemia-reperfusion injury (IRI) involves a positive amplification feedback loop that stimulates innate immune-driven tissue damage associated with organ procurement from deceased donors and during transplantation surgery. As our appreciation of its basic immune mechanisms has improved in recent years, translating putative biomarkers into therapeutic interventions in clinical transplantation remains challenging.

Areas Covered: This review presents advances in translational/clinical studies targeting immune responses to reactive oxygen species in IRI-stressed solid organ transplants, especially livers.

T Cell CEACAM1-TIM-3 Crosstalk Alleviates Liver Transplant Injury in Mice and Humans.

Background & Aims: Carcinoembryonic antigen-related cell adhesion molecule 1 (CC1) acts through homophilic and heterophilic interactions with T cell immunoglobulin domain and mucin domain-containing protein 3 (TIM-3), which regulates innate immune activation in orthotopic liver transplantation (OLT). We investigated whether cluster of differentiation (CD) 4 T cell-dependent CC1-TIM-3 crosstalk may affect OLT outcomes in mice and humans.

Methods: Wild-type (WT) and CC1-deficient (CC1 knock-out [KO]) mouse livers were transplanted into WT, CC1KO, or T-cell TIM-3 transgenic (TIM-3Tg)/CC1KO double-mutant recipients.

SIRT1 Regulates Hepatocyte Programmed Cell Death via GSDME - IL18 Axis in Human and Mouse Liver Transplantation.

Sirtuin 1 (SIRT1) is a histone/protein deacetylase involved in cellular senescence, inflammation, and stress resistance. We previously reported that myeloid SIRT1 signaling regulates the inflamed liver's canonical pyroptosis cell death pathway. However, whether/how hepatocyte SIRT1 is engaged in programmed cell death in the cold-stressed liver remains uncertain.

Recipient signaling regulates ischemia reperfusion-induced ER stress and metabolic responses in liver transplantation: from mouse-to-human.

T-cell immunoglobulin and mucin ()4 is expressed on APCs, including macrophages, as one of the main amplifiers in the mechanism of liver ischemia-reperfusion injury (IRI) following orthotopic liver transplantation (OLT). Though donor selectively expressed on Kupffer cells serves as a checkpoint regulator of innate immune-driven IRI cascades, its role on cells outside the OLT remains unclear. To dissect the role of donor vs.

Association Between Constipation and a Reduction in Lower Limb Muscle Strength in Preoperative Patients with Thoracic Spinal Tumors.

Objective To investigate the clinical symptoms experienced by patients with thoracic spinal tumors and verify the associated symptoms that are predictive of a decline in muscle strength in the lower limbs. Methods A single-center, retrospective cross-sectional study was conducted on in-patients diagnosed with epidural thoracic spinal tumors between January 2011 and May 2021. The study involved a review of electronic medical records and radiographs and the collection of clinical data.