Nursing support for testicular sperm aspiration and intracytoplasmic sperm injection in patients with high paraplegia: a retrospective case series.

Background: High paraplegia, primarily affecting young men during their reproductive years, often results in ejaculatory dysfunction and infertility. Testicular sperm aspiration (TESA) combined with intracytoplasmic sperm injection (ICSI) offers a viable path to biological parenthood for this population. However, evidence on nursing strategies supporting such procedures is limited.

Association between burnout and physiological-psychological-social health domains among Chinese resident physicians: a network analysis approach.

Background: Burnout affects the physical and mental health of residents. This study aims to investigate the association between burnout and health across biological, psychological, and social domains among Chinese residents.

Method: A cross-sectional study was conducted from July 2022 to June 2024 at Peking Union Medical College Hospital in China.

Ultrafast dynamics of ferroelectric polarization of NbOI captured with femtosecond electron diffraction.

Two-dimensional ferroelectric materials like NbOI have garnered significant interest, yet their temporal response and synergetic interaction with light remain underexplored. Previous studies on the polarization of oxide ferroelectrics have relied on time-resolved optical second harmonic generation or ultrafast X-ray scattering. Here, we probe the laser-induced polarization dynamics of NbOI nanocrystals using ultrafast transmission electron diffraction and deflectometry.

Development and psychometric evaluation of the hospitalized patients' expectations for treatment scale-patient version-satisfaction scale.

Background: This study aimed to develop and initially assess the reliability and psychometric properties of the Hospitalized Patients' Expectations for Treatment Scale - Patient Version - Satisfaction Scale (HOPE-PS), a structured assessment tool that measures patient satisfaction based on expectations.

Methods: Medical experts and patients were consulted, and their opinions were gathered and consolidated using the Delphi method. A total of 1,000 inpatients from various wards of a general hospital in China were recruited for the study.

Causal relationship between multiple types of food intake and myopia: a Mendelian randomization study.

Aim: To investigate the causal relationship between dietary intake and myopia using Mendelian randomization (MR) analysis.

Methods: Genome-wide association study (GWAS) data from the IEU Open GWAS database were utilized to examine associations between myopia and various dietary factors. MR analysis, incorporating both univariable and multivariable approaches, assessed the impact of food intake on myopia risk through five analytical methods, with inverse variance weighted (IVW) serving as the primary reference.

Asymmetric Fe-Ov-Co Synergizing Free Nitrogen Sites in Carbon-Support Spinel Nanodots: Dual-Engineered Electronic States for High-Efficiency Peroxymonosulfate Activation.

Oxygen vacancies (O) play an important role in promoting peroxymonosulfate (PMS) activation. However, conventional symmetric O exhibits low electron transfer efficiency due to symmetric adjacent cations, constraining their catalytic performance. Asymmetric vacancies (M-O-M) offer enhanced catalytic potential, yet developing catalysts featuring uniformly distributed asymmetric O remains challenging.

CCL4L2 is a potential biomarker for differentiating central and peripheral vertigo.

Background: Central vertigo and peripheral vertigo are common clinical conditions with different underlying pathophysiologies. The identification of reliable biomarkers for differential diagnosis remains a challenge.

Objectives: This study aimed to explore the differential expression of CCL4L2 in the serum of patients with central and peripheral vertigo and assess its diagnostic potential.

Clinical Efficacy of Gauze Tamponade in Preventing Vaginal Bleeding After Transvaginal Oocyte Retrieval: A Retrospective Analysis.

Objective: To evaluate the clinical value of routinely using sterile gauze strips to occlude the vagina after transvaginal ultrasound-guided oocyte retrieval (TVOR) in preventing postoperative vaginal bleeding.

Methods: The medical records of 1194 patients who underwent transvaginal oocyte retrieval between March and April 2024 were retrospectively analyzed. Patients with no obvious bleeding at the vaginal puncture site were divided into group A (without gauze packing, 586 cases) and group B (with conventional gauze packing, 608 cases) according to whether gauze was used to control bleeding.

A Qualitative Study of the Emotional and Decision-Making Experiences of Mothers Whose Daughter Undergoes Assisted Reproductive Technology with Donor Sperm.

Objective: To explore the emotional experiences, decision-making dilemmas, and social support needs of mothers whose daughter has used donor sperm in assisted reproduction treatment due to azoospermia in the daughter's partner. The findings will provide a basis for developing clinical education programs and optimising family decision support systems.

Methods: Mothers of 12 female patients undergoing donor sperm assisted reproduction at a A-grade tertiary care reproductive center were selected for semi-structured interviews from January 2025 to March 2025, and Colaizzi's phenomenological analysis was used to distil themes and report them according to COREQ guidelines.

Longitudinal patterns of attention-deficit/hyperactivity disorder children in Shanghai, China.

This study aimed to assess dynamic changes in emotional and behavioral problems among children with Attention-Deficit/Hyperactivity Disorder (ADHD) in Shanghai, China. Using a longitudinal design, school-aged children with ADHD were enrolled and followed, with emotional and behavioral measures repeatedly assessed. Due to varying COVID-19 measures and changing epidemics, and no intervention was admitted, an event-based longitudinal design was adopted, using calendar time from the enrollment of the first participant.

Fabricating mixed-halide perovskite nanowire photodetectors for polarized light detection and encrypted optical communication via nanoimprinting and anion exchange.

Mixed-halide perovskite nanowires have broad applications in optoelectronics due to their excellent charge transport properties and high mobility. However, traditional preparation methods face challenges in achieving compositional uniformity and structural stability. In this study, we employ a two-step method combining nanoimprinting and liquid-phase anion exchange to fabricate mixed-halide nanowires.

UPLC-Q-TOF-MS-Based Serum Metabolomics Explores the Mechanism of Pingwei Powder in Treating the Damp Retention in the Middle-Jiao Syndrome.

Pingwei powder (PWP) was a classic prescription to treat damp retention in the middle-jiao syndrome (DRMS) in clinic. This study aimed to investigate the therapeutic effects and functional mechanisms of PWP in treating DRMS by analyzing the general characteristics, fecal morphology, clinical chemistry, histopathology, and ultra-performance liquid chromatography-electrospray ionization-quadrupole-time of flight-mass spectrometry (UPLC-Q-TOF-MS)-based serum metabolomics. The results indicated that PWP significantly improved the general morphological characteristics, fecal humidity, body weight, and gastrointestinal peristalsis function, as well as inflammation damage and edema in the small intestine, stomach, and kidney tissues of model rats.

Differential susceptibility and role for senescence in CART cells based on costimulatory domains.

Despite the success of chimeric antigen receptor T (CART) cell therapy in hematological malignancies, durable remissions remain low. Here, we report CART senescence as a potential resistance mechanism in 41BB-costimulated CART cell therapy. To mimic cancer relapse, we utilized an in vitro model with repeated CART cell activation cycles followed by rest periods.

Ratiometric fluorescence sensing of sialic acid based on dual-emission carbon dots.

Biomolecular detection based on a single fluorescence signal response is often difficult to completely eliminate the influence from interfering factors on the assay results. In this work, a ratiometric fluorescence probe was designed based on a dual emission carbon dot (CD). It produces dual-color emission (400 nm blue emission band and 560 nm green emission band) under 360 nm excitation.

Intrinsic immunosuppressive features of monocytes suppress CAR-T19 through IL-1 pathway modulation in mantle cell lymphoma.

CD19-targeted chimeric antigen receptor T cells (CAR-T19) have shown remarkable success in B cell malignancies, but most patients relapse within 1-2 years. Here, we identified interleukin-1 (IL-1) receptor antagonist (IL-1ra) as a mediator of M2-like macrophage-derived inhibition of CAR-T19 in mantle cell lymphoma (MCL), as well as a potential target to enhance CAR-T19 efficacy. In preclinical models that recapitulated interactions between tumor, macrophages, and T cells, we demonstrated that M2-derived IL-1ra impairs IL-1 signaling and functions of CAR-T19.

Successful Treatment of Critically Severe Empyema With Bronchopleural Fistula via ECMO: A Case Report.

Empyema is one of the most dangerous complications in thoracic surgery. It can easily progress to severe empyema with life-threatening conditions that are extremely challenging to treat. We successfully treated a patient with critically severe empyema via extracorporeal membrane oxygenation (ECMO), and the patient eventually recovered and was discharged.

A Qualitative Study of Fertility Preservation Experience in Women with Breast Cancer.

Objective: To explore the experiences of women with breast cancer who have undergone fertility preservation and to explore the psychological needs of patients.

Methods: Using descriptive phenomenological research methods, 11 patients who underwent oocyte or embryo cryopreservation after diagnosis of breast cancer were selected for semi-structured interviews in a tertiary care hospital. Themes were distilled using Colaizzi's 7-step analysis and reported according to COREQ guidelines.

Self-assembled TMB-CuO nanosheets for dual-mode colorimetric and NIR-II photothermal detection of uranyl ion.

Background: The development of highly sensitive and selective point-of-care testing (POCT) techniques using optical methods for uranyl ion (UO) is essential for the effective monitoring of acidic uranium contamination. colorimetric methods have gained significant attention for their rapid response times, ease of use, and cost-effectiveness in the quantitative analysis of uranyl ions.

Results: Herein, this study presents a self-assembled nanosheet composed of 3,3,5,5-tetramethylbenzidine (TMB) and CuO, designed for the dual-mode colorimetric and photothermal detection of UO.

Prussian Blue Nanosphere/Fe-Metal Organic Frameworks/Ce Nanocomposite as a Colorimetric Sensing Platform for Direct Detection in Organophosphorus Pesticides in Fetal Bovine Serum.

Acute pesticide poisoning has resulted in several symptoms that threaten life safety. Thus, developing a rapid detection method would facilitate the identification of toxicants as soon as possible. This study presented an affordable and straightforward detection platform based on a core-shell structure nanocomposite of Prussian blue/Fe-metal-organic frameworks/Ce nanocomposite material, which exhibited peroxidase-like activity and multiple capture sites [marked as phosphate buffer (PB)/Fe-MOF/Ce NPs].

Nanoimprint crystalithography for organic semiconductors.

Organic semiconductor crystals (OSCs) offer mechanical flexibility, high carrier mobility, and tunable electronic structures, making them promising for optoelectronic and photonic applications. However, traditional lithographic techniques damage OSCs due to high-energy beams or solvents, leading to high defect densities, poor uniformity, and significant device-to-device variation. Existing methods also struggle to eliminate residual layers while forming independent, complex two-dimensional patterns.

Benzotrifuran-Based Covalent Organic Frameworks for Artificial Photosynthesis of HO from HO, O, and Sunlight.

Hydrogen peroxide (HO) is an important green chemical and a potential energy carrier. Artificial photosynthesis of HO from only HO and O under sunlight is a fascinating and sustainable tactic. However, deficient proton sources come from the kinetically sluggish HO oxidation process (∼s) seriously impede half-reaction of O reduction (µs∼ms), leading to inferior photocatalytic efficiency.

Ultrasensitive and smart trace detection via interface-enhanced multi-phonon resonance Raman scattering.

Trace detection technology has important applications in fields such as biomedicine, food safety, and environmental monitoring. However, it currently faces challenges including insufficient sensitivity, low efficiency, and a need for improved personalized services, which seriously hinder the in-depth development and widespread application of trace detection technology. Herein, a metal/semiconductor heterojunction was designed and constructed.

Phages-bacteria interactions underlying the dynamics of polyhydroxyalkanoate-producing mixed microbial cultures via meta-omics study.

The dynamics of the structure of polyhydroxyalkanoate-producing mixed microbial cultures (PHA-MMCs) during enrichment and maintenance is an unsolved problem. The effect of phages has been proposed as a cause of dynamic changes in community structure, but evidence is lacking. To address this question, five PHA-MMCs were enriched, and biological samples were sampled temporally to study the interactions between phage and bacterial members by combining metagenomics and metatranscriptomics.

Inhibition of LINC00707/miR-223-3p/FKBP5 axis has a protective effect on diabetic kidney disease.

Objective: Research indicates that LINC00707 is abnormally expressed in patients suffering from diabetic kidney disease (DKD). Nevertheless, the precise role of LINC00707 in the context of DKD remains enigmatic and warrants further investigation.

Methods: Initially, RT-qPCR was employed to assess the expression levels of LINC00707 in patients with DKD.