Association between burnout and physiological-psychological-social health domains among Chinese resident physicians: a network analysis approach.

Background: Burnout affects the physical and mental health of residents. This study aims to investigate the association between burnout and health across biological, psychological, and social domains among Chinese residents.

Method: A cross-sectional study was conducted from July 2022 to June 2024 at Peking Union Medical College Hospital in China.

Development and psychometric evaluation of the hospitalized patients' expectations for treatment scale-patient version-satisfaction scale.

Background: This study aimed to develop and initially assess the reliability and psychometric properties of the Hospitalized Patients' Expectations for Treatment Scale - Patient Version - Satisfaction Scale (HOPE-PS), a structured assessment tool that measures patient satisfaction based on expectations.

Methods: Medical experts and patients were consulted, and their opinions were gathered and consolidated using the Delphi method. A total of 1,000 inpatients from various wards of a general hospital in China were recruited for the study.

Acupoint Injection Combined with BCG-PSN and Thymosin Enteric-Coated Tablets Improve China Han Psoriasis Vulgaris by Regulating T Cell Subsets.

Purpose: Psoriasis is a common chronic inflammatory skin disease. Acupoint injection is reported to be used for the treatment of psoriasis, however its mechanism is not yet clear. The study aimed to investigate the efficiency of combined treatment including acupoint injection in the treatment of psoriasis.

Feasibility and effects of high-intensity interval training in older adults with mild to moderate depressive symptoms: A pilot cluster-randomized controlled trial.

Background: Older adults with mild-to-moderate depressive symptoms (MMDS) are at high risk of developing severe depression along with mortality and disability. The aim of this study was to investigate the feasibility and preliminary effects of high-intensity interval training (HIIT) in older adults with MMDS in a small sample size.

Methods: Three elderly centers involving 24 older adults with MMDS were randomized into: 1) HIIT (n = 8); 2) moderate-intensity continuous training (Baduanjin Qigong) (MICT-BDJ) (n = 8); or 3) recreation workshop (RW) control (n = 8) for 16-week (32 session) intervention.

Effects of a blended face-to-face and eHealth lifestyle intervention on physical activity, diet, and health outcomes in Hong Kong community-dwelling older adults: a randomized controlled trial.

Background: The effectiveness of a blended approach integrating face-to-face and eHealth interventions for promoting positive lifestyle behaviours in older adults has not been systematically tested. This study aimed to assess the feasibility and effectiveness of such interventions in improving health behaviours and outcomes among older adults in Hong Kong.

Methods: A 10-week, single-blind, randomized controlled trial recruited 132 eligible older adults.

Effectiveness of a WeChat Mini Program-Based Intervention on Promoting Multiple Health Behavior Changes Among Chinese Patients With Cardiovascular Diseases in Home-Based Rehabilitation: Randomized Controlled Trial.

Background: WeChat mini program-based interventions grounded in behavior change theories show promise in promoting and maintaining healthy lifestyles among patients with cardiovascular diseases (CVDs) after hospital discharge. However, limited randomized controlled trials have evaluated the effectiveness of such interventions among Chinese patients with CVDs in a home-based rehabilitation context.

Objective: This study aimed to assess the effectiveness of a 10-week WeChat mini program-based intervention on multiple health behaviors, including moderate to vigorous physical activity (MVPA), fruit and vegetable consumption (FVC), integrated lifestyle indicator (ie, meeting both MVPA and FVC recommendations), psychosocial resources (intrinsic and extrinsic) of behavior change, and health-related outcomes (ie, depressive symptoms and perceived quality of life) among Chinese patients with CVDs.

Understanding parental support for children's 24-hour movement behaviors based on an adapted HAPA framework: A three-wave prospective study.

Parental supportive behavior (PSB) plays a pivotal role in shaping children's 24-hour movement behaviors (24-HMB), including light physical activity (LPA), moderate-to-vigorous physical activity (MVPA), sedentary screen time (SST), and sleep. However, the psychosocial determinants and the changing process of PSB remain understudied. Using a three-wave prospective design over four months, this study examined the psychosocial mechanisms of PSB towards children's 24-HMB based on an adapted health action process approach (HAPA) framework among 812 parents (36.

Zwitterionic-based hybrid monoliths for capillary microextraction of polypeptides in dairy products.

The pretreatment of complex food matrices is challenging due to matrix interferences and non-specific adsorption of macromolecules. This study proposes a biocompatible solid-phase microextraction method to effectively enrich polypeptide antibiotics in dairy products using various zwitterionic-based capillary microextraction (CME) techniques. The proposed method demonstrated a broad linear range of 20-800 μg L, with a detection limit (LOD) of 10 μg L when employing the phosphorylcholine-based column for polypeptide antibiotics extraction.

Use of multicomponent structured exercise to improve depression in older adults: A systematic review and meta-analysis.

Objective: To summarize the characteristics, estimate the efficacy of multicomponent structured exercise (MSE) intervention on older adults' depression, and investigate its potential moderators.

Methods: MEDLINE, PubMed, PsycINFO, SPORTDiscus, Web of Science and Embase databases were searched from January 1, 2000 to June 1, 2024. Randomized controlled trials (RCTs) that included MSE intervention with aerobic, resistance and balance components targeting older adults, and reported depression as an outcome were selected.

Hollow mesoporous silica nanoparticles for drug formulation and delivery: Opportunities for cancer therapy.

The advantages of large surface area, high volume ratio, good biocompatibility, and controllable surface functionalization make hollow mesoporous silica nanoparticles (HMSNs) an ideal drug carrier. HMSNs can achieve high efficiency, targeting, and controlled release by adjusting the microstructure and surface modification of its particles, which makes it broad application prospects in the field of medical therapy, especially in cancer therapy. Numerous studies have shown that preparation method, shape, particle size, hollow inner diameter, aperture and wall thickness of the HMSNs, the characteristics of the drugs, the interaction between the drugs and the carriers, and the external environment all closely affect the drug delivery, release, and efficacy.

Anisotropic Microparticles with a Controllable Structure via Soap-Free Seeded Emulsion Polymerization.

Anisotropic particles have a wide range of applications in materials science such as emulsion stabilization, oil-water separation, and catalysis due to their asymmetric structure and properties. Nevertheless, designing and synthesizing large quantities of anisotropic particles with controlled morphologies continue to present considerable challenges. In this study, we successfully synthesized anisotropic microspheres using a soap-free seed emulsion polymerization method.

Modelling the compensatory and carry-over effects between physical activity and fruit-vegetable consumption in young adults.

Physical activity (PA) and fruit and vegetable consumption (FVC) are crucial factors jointly affecting young adults' physical and mental health. However, the psychosocial interactive mechanisms of these behaviors remain understudied. Using a two-wave prospective design over two months, this study investigated the psychological mechanisms underlying multiple health behavior change (MHBC) through a novel two-layer social-cognitive framework, the Compensatory Carry-Over Action Model (CCAM), among 322 Chinese college students (19.

Ecologically friendly remediation of groundwater sulfamethoxazole contamination: Biologically synergistic degradation by thermally modified activated carbon-activated peracetic acid in porous media.

This study examines the efficacy and environmental impact of peracetic acid (PAA) activated by thermally modified activated carbon (AC600) for degrading antibiotics in actual groundwater. Laboratory-scale experiments evaluated the system's effects on contaminant degradation, ecological balance, and substance cycling in the hyporheic zone. Our findings demonstrated the effectiveness of the AC600/PAA system in removing sulfamethoxazole (SMX) from groundwater porous media.

Psychometric properties of the Sinhala perceived stress questionnaire (PSQ8-11) in Sri Lankan primary school children.

Background: Stress influences examination performance among Sri Lankan students. Validated tests are required to evaluate stress levels among elementary students in Sri Lanka. Therefore, the Perceived Stress Questionnaire 8-11 (PSQ8-11) was translated into a Sinhala version.

A supervised consultation-Liaison psychiatry training model in a general hospital in China.

Consultation-liaison (CL) psychiatry is becoming a recognized subspecialty in medical settings; it is a branch of psychiatry that addresses the treatment of the medically ill. Training for CL psychiatry is still insufficient in China. We introduce our training model, supervised CL based on the Union Psychosomatic Clinical Approach with Learning Exchange (UPSCALE) model, to improve consultation-liaison skills among psychiatrists.

Effects of High-Intensity Interval Training on the Parameters Related to Physical Fitness and Health of Older Adults: A Systematic Review and Meta-Analysis.

Background: As a novel and time-efficient exercise form, high-intensity interval training (HIIT) has shown great potential in improving health-related physical fitness among diverse populations. However, empirical evidence on its efficacy among the elderly has not been well summarized. This systematic review and meta-analysis aimed to determine the effect of HIIT interventions on the parameters related to physical fitness and health of older adults, including resting heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), cardiorespiratory fitness (CRF), body mass index (BMI), body fat percent (BF%), waist circumference (WC), muscular endurance (ME), muscular strength (MS), muscular power (MP), balance and flexibility, compared to non-exercise and other-exercise (e.

Assessment of psychometric properties of the union physio-psycho-social assessment questionnaire (UPPSAQ-70) in a large sample of general hospital psychiatric outpatients.

Objective: To evaluate the psychometric properties of the Union Physio-Psycho-Social Assessment Questionnaire (UPPSAQ-70) among general hospital psychiatric outpatients.

Methods: A total of 2000 participants responded to the survey. Factor analyses were used to test the construct validity of the scale.

Treatment expectations of patients and clinicians: a cross-sectional study.

Importance: Understanding treatment expectations of patients and their clinicians is of great importance in improving personalized medical services and enhancing patient safety systems.

Objective: To investigate treatment expectations of patients and their clinicians and compare differences between both, by using a pair of validated structured assessment tools covering three key aspects/dimensions of clinical interests.

Design Setting And Participants: This single-center cross-sectional study was conducted at Peking Union Medical College Hospital in China.

The Asymmetric Total Synthesis of the Female-Produced Sex Pheromone of the Tea Tussock Moth.

The tea tussock moth is a pest that damages tea leaves, affecting the quality and yield of tea and causing huge economic losses. The efficient asymmetric total synthesis of the sex pheromone of the tea tussock moth was achieved using commercially available starting materials with a 25% overall yield in 11 steps. Moreover, the chiral moiety was introduced by Evans' template and the key C-C bond construction was accomplished through Julia-Kocienski olefination coupling.

Source apportionment of organic carbon and nitrogen in sediments from river and lake in the highly urbanized Changjiang Delta.

While the impact of human activities on organic matter pollution is recognized, how these impacts vary seasonally in the Changjiang Delta needs further investigation. This study addresses this gap by investigating seasonal variations in organic matter sources and ecological responses to human activities in Changjiang Delta sediments. Total organic carbon (TOC), total nitrogen (TN), and carbon (δC) and nitrogen (δN) isotopic compositions of surface sediments collected from the Taipu River and Dalian Lake wetland were analyzed.

Causal role of immune cells in uveitis: a Mendelian randomization study.

Background: Uveitis refers to a group inflammation affecting the uvea, retina, retinal blood vessels as well as vitreous body, which is one of the common causes of blindness. There is growing evidence linking different types of immune cells to uveitis, although it remains uncertain if these associations imply causal relationships. Recent advancements in high-density genetic markers like SNPs or CNVs for genotyping, along with the progress in genome-wide association studies (GWAS) technologies, have improved our understanding of the immunological mechanisms involved in ocular diseases.

FDA-approved small molecule kinase inhibitors for cancer treatment (2001-2015): Medical indication, structural optimization, and binding mode Part I.

The dysregulation of kinases has emerged as a major class of targets for anticancer drug discovery given its node roles in the etiology of tumorigenesis, progression, invasion, and metastasis of malignancies, which is validated by the FDA approval of 28 small molecule kinase inhibitor (SMKI) drugs for cancer treatment at the end of 2015. While the preclinical and clinical data of these drugs are widely presented, it is highly essential to give an updated review on the medical indications, design principles and binding modes of these anti-tumor SMKIs approved by the FDA to offer insights for the future development of SMKIs with specific efficacy and safety.

Associations of Reallocating Sedentary Time to Physical Activity and Sleep with Physical and Mental Health of Older Adults.

Introduction: Twenty-four-hour movement behaviors: moderate-to-vigorous physical activity (MVPA), light physical activity (LPA), sedentary behavior (SB), and sleep are crucial factors affecting older adults' health. Using a compositional data analysis approach, this study examined the associations of time spent in these four movement behaviors with cardiometabolic health, physical fitness, and mental health among older adults. Furthermore, this study identified the estimated changes in aforementioned health outcomes by reallocating SB time to other movement behaviors.