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Article Abstract
Scallops (Mizuhopecten yessoensis) accumulate abnormal levels of cadmium (Cd) in their bodies; however, the chemical form of Cd in vivo remains unclear. In this study, Cd concentrations in various scallop tissues were measured, revealing that Cd predominantly accumulated as a water-soluble component within the midgut gland. High-performance liquid chromatography combined with the post-column tetraphenylporphyrin tetrasulfonic acid (TPPS) experiment revealed that the molecular weight of the Cd-binding substances was approximately 44 kDa. Moreover, Cd-immobilized affinity chromatography and CdS precipitation identified M. yessoensis meprin A subunit alpha-like (myMEP1A) as a Cd-binding protein. The myMEP1A gene was specifically expressed in the midgut gland. TPPS measurements indicated that myMEP1A exhibited strong Cd-binding activity. These results suggested that myMEP1A is a protein responsible for Cd accumulation in the midgut gland.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357810 | PMC |
| http://dx.doi.org/10.1007/s11356-025-36799-1 | DOI Listing |
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