Fully Erasable Amphibious Adhesives Derived from Soybean Oil with Record-High Underwater Adhesion Strength.

Developing amphibious adhesives that combine high adhesion strength with on-demand erasability in both dry and wet environments remains a significant challenge. In this study, biomass-derived, amphibious, and erasable adhesives are fabricated by grafting 3-aminobenzoic acid and 3-aminobenzeneboronic acid onto epoxidized soybean oil (ESO), yielding ESO-Am adhesives. These adhesives are dynamically cross-linked with boroxines, hydrogen bonds, and hydrogen-bonded hydrophobic nanodomains.

Prevalence and correlated factors of REM sleep behavior disorder in patients with progressive supranuclear palsy.

Background: Progressive supranuclear palsy (PSP) is a rapidly advancing tauopathy, and amongst rapid eye movement (REM) sleep behavior disorder (RBD) has been observed. Prior studies were limited by small samples and inconsistent results; meanwhile, research is lacking since the updated criteria for PSP. This cross-sectional study aimed to assess RBD in a sizable PSP cohort.

Calcium Oscillations Within Juxtaglomerular Cell Clusters Control Renin Release.

Background: Juxtaglomerular cells are sensors that control blood pressure and fluid-electrolyte homeostasis. They are arranged as clusters at the tip of each afferent arteriole. In response to decreased blood pressure or extracellular fluid volume, juxtaglomerular cells secrete renin, initiating an enzymatic cascade that culminates in the production of Ang II (angiotensin II), a potent vasoconstrictor that restores blood pressure and fluid-electrolyte homeostasis.

Remaining useful life prediction of lithium-ion batteries via spatial attention TLSTM and dilated CNN with evolutionary optimization.

The precise estimation of the Remaining Useful Life (RUL) of lithium-ion batteries is essential for averting unforeseen failures and enhancing operational efficiency and maintenance planning. This paper presents an advanced deep learning framework that couples a spatial-attention mechanism with a Transductive Long Short-Term Memory (TLSTM) model, augmented by one-dimensional dilated convolutional layers to capture long-range temporal dependencies. In contrast to traditional LSTM or GRU models, our methodology utilizes one-dimensional dilated convolutional layers to effectively capture long-range temporal relationships and implements a clustering-based Differential Evolution (DE) strategy for resilient weight initialization and optimization.

Reaction of an osmium(VI) nitrido complex with enamines generated from ketones and anilines.

The reaction of [Os(N)(L)(CN)] (OsN, HL = 2-(2-hydroxy-5-nitrophenyl)-benzoxazole) with a mixture of acetone and 2,4,6-trimethylaniline (MesNH) affords [Os(L)(CN)(L)] (L = -mesityl-2-(mesitylimino)propanimidamide), where L is derived from the combination of an acetone molecule, a nitrido ligand, and two MesNH units. The reaction of OsN with acetone and the less bulky aniline gives [Os(L)(CN)(L)] (L = 1,3-diphenylguanidine) and phenylacetamide, where L is derived from the combination of three anilines, one acetone, and the nitrido ligand; this reaction results in C-C bond cleavage of acetone. C-C bond cleavage of ketone also occurs in the reaction of OsN with 2-butanone and aniline.

Elevated serum IL-10/IL-6 ratio as a novel biomarker for secondary central nervous system lymphoma and poor prognosis in DLBCL.

Introduction: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma and carries a poor prognosis when it involves the central nervous system (CNS), a condition known as secondary CNS lymphoma (SCNSL). Although the CNS International Prognostic Index (CNS-IPI) is used to estimate SCNSL risk, its limited sensitivity highlights the need for more reliable biomarkers to improve risk stratification and enable earlier intervention.

Methods: We evaluated pretreatment levels of interleukin-10 (IL-10) and interleukin-6 (IL-6) in both peripheral blood (PB) and cerebrospinal fluid (CSF), and compared clinical characteristics between DLBCL patients with and without SCNSL.

Application of an innovative isoniazid-loaded biomimetic mineralized bone collagen scaffold in bone defect treatment.

Bone defects, arising from various causes such as trauma, infection, tumor, surgical debridement, and congenital diseases, pose challenges to the natural self-healing process of bone tissue. Large-scale bone defects may lead to non-healing of the bone, and they need to be repaired through surgery using transplant materials. While graft materials serve as scaffolds for cell attachment and growth, infectious bone defects, like tuberculosis of the bone and joint, require anti-infective therapy concurrent with defect repair.

Immunotherapy and senolytics in head and neck squamous cell carcinoma: phase 2 trial results.

Recent advancements in cancer immunotherapy have improved patient outcomes, yet responses to immunotherapy remain moderate. Immunosenescence has been shown to contribute to the development and progression of various diseases; however, its specific role in solid tumors has not been fully delineated. Here we conducted a phase 2 clinical trial involving 51 patients with cancer undergoing neoadjuvant chemoimmunotherapy and applied single-cell RNA as well as TCR and BCR sequencing on tumor and blood samples to elucidate the immune cell perturbations.

Cobalt-based catalyst for ammonia synthesis under ambient conditions via transient confinement.

The Haber-Bosch process is used for industrial ammonia production worldwide, and it accounts for ~2% of the global energy consumption and 1.3% anthropogenic carbon footprint. Ammonia synthesis under ambient conditions with minimum carbon emission is highly desired, but it is still in the initial stage.

A maize Ni/Co transporter ZL1 maintains cobalt and nickel homeostasis and contributes to photosynthesis.

Transition metals play essential roles as coenzymes and catalysts in plants and are vital for chloroplast function and photosynthetic efficiency. Nickel (Ni) and cobalt (Co) are two important trace transition metals that are present in chloroplasts. However, the functions of Ni and Co in maize and the mechanisms regulating their homeostasis in chloroplasts remain poorly understood.

Incidence and risk factors of acute kidney injury after abdominal surgery: a systematic review and meta-analysis.

Objective: To determine the incidence of acute kidney injury (AKI) following abdominal surgery, assess its outcome associations, and identify factors associated with postoperative AKI development.

Methods: We performed a systematic search of PubMed, Embase, and Cochrane Database of Systematic Reviews, from January 2004, to December 2024. We included studies reporting AKI based on consensus criteria (RIFLE, AKIN, or KDIGO) in adult abdominal surgery patients.

Left atrial reverse remodeling in patients with persistent atrial fibrillation and HFpEF following radiofrequency ablation: prospective evaluation with echocardiographic atrial analysis.

Objective: This study aimed to assess the extent of Left Atrial (LA) structural and functional reverse remodeling following Radiofrequency Catheter Ablation (RFCA) for Atrial Fibrillation (AF) in patients with persistent AF and Heart Failure with preserved Ejection Fraction (HFpEF).

Methods: A cohort study was performed following the STROBE Statement. Thirty consecutive HFpEF patients with persistent AF were prospectively enrolled and planned for RFCA.

Epidemiology, Clinical Features, and Molecular Basis of TTMV::RARA-driven Acute Promyelocytic Leukemia.

Integration of torque teno mini virus (TTMV) generating the TTMV::RARA fusion represents a newly recognized subtype of acute promyelocytic leukemia (APL) that merits detailed investigation. We present the first comprehensive characterization of its epidemiologic profile, clinical presentation, virologic characteristics, and underlying molecular mechanisms. Our findings indicate that TTMV::RARA is more prevalent in pediatric patients and represents the second most common retinoic acid receptor fusion after PML::RARA.

Integrating flavonoid metabolome and RNA-seq data unveil flower color variation in Bombax ceiba.

Floral pigmentation is essential for ornamental species. This investigation utilized flower tissues from five distinct color phenotypes (dark red, red, orange-red, orange-yellow, yellow) of Bombax ceiba to conduct targeted flavonoid metabolomics and RNA sequencing analyses, resulting in the identification of 137 metabolites and 44,725 genes. The results indicated that the expression levels of BcCHSs, BcCHIs, BcF3'5'Hs, BcDFRs, and BcLDOXs were significantly lower in yellow flowers compared to their counterparts of other colors.

Association of US Nativity and Length of US Residence With Cardiometabolic Risk Factors, by Disaggregated Race and Ethnicity.

Background: The prevalence of cardiometabolic risk factors may vary by disaggregated race and ethnicity categories, and by acculturation-related factors. We evaluated the association between nativity and length of US residence, and prevalence of diabetes, hypertension, and hypercholesterolemia by select disaggregated race and ethnicity groups.

Methods: We conducted a pooled cross-sectional study of 218 158 US adults from the Medical Expenditure Panel Survey (2013-2022).

An Ultra-Selective and Humidity-Resistant Room-Temperature-Operated NO Sensor Based on Black TiO.

As a common gas-sensing material, TiO is limited by poor gas selectivity and humidity immunity like many other metal oxides. Here, an ultra-selective and humidity-resistant room temperature-operated NO sensor is developed using black TiO for the first time. Compared with conventional white TiO, black TiO significantly enhances NO selectivity and humidity resistance by enhancing the NO response for ≥10 times while simultaneously suppressing responses to 7 common interfering gases and HO adsorption.

HFPO-TA induces liver damage and ferroptosis in zebrafish by disrupting iron metabolism homeostasis.

Hexafluoropropylene oxide trimeric acid (HFPO-TA) is a novel alternative to perfluorooctanoic acid (PFOA) with similar toxicity to PFOA. However, whether HFPO-TA causes ferroptosis is currently unknown. In this experiment, we systematically investigated the induction of zebrafish embryonic liver ferroptosis by HFPO-TA to cause liver injury.

3-O-Acetyl-11-Keto--Boswellic Acid Suppresses Colitis-Associated Colorectal Cancer by Inhibiting the NF-Kb Signaling Pathway and Remodeling Gut Microbiota.

Objectives: Colorectal cancer (CRC) is one of the most common cancers all over the world. The progression of CRC is associated with inflammation and disruptions in intestinal flora. 3-O-Acetyl-11-keto-β-boswellic acid (AKBA) has been noted for its potent anti-inflammatory properties.

THE EFFICACY OF RANIBIZUMAB COMBINED WITH SUBSCLERAL TRABECULAR SURGERY IN THE TREATMENT OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.

Objective: To investigate the clinical effect of subscleral trabecular surgery combined with intravitreal injection of ranibizumab in the treatment of neovascular age-related macular degeneration (NVG).

Methods: 132 patients (132 eyes) with NVG admitted to Jiaozhou Center Hospital of Qingdao from November 2018 to June 2021 were selected. All patients were diagnosed by laboratory examination.

Inhibition of UBE2C Promotes Parkin-Mediated K63-Linked Ubiquitination of TOP2A to Induce Senescence and Increase Sensitivity of Doxorubicin in Breast Cancer.

Breast cancer is now the second most commonly diagnosed cancer and the most common female malignancy. Chemotherapy-based adjuvant therapy after surgery and neoadjuvant therapy before surgery are cornerstones of breast cancer treatment. Doxorubicin is one of the most commonly used anthracycline chemotherapy treatments for breast cancer; however, doxorubicin resistance is a major barrier to its clinical use.

A randomized, phase Ib trial of recombinant human serum albumin in cirrhotic patients with ascites.

Background: Recombinant human serum albumin (rHA) is a promising alternative to human serum albumin (HSA) for managing ascites in cirrhotic patients. This phase Ib study aims to assess the safety, tolerability, and pharmacokinetics/pharmacodynamics (PK/PD) profiles of rHA in this population.

Methods: This randomized, open-label, phase Ib trial was conducted between December 2019 and September 2020 at 3 medical centers in China.

SHAP combined with machine learning to predict mortality risk in maintenance hemodialysis patients: a retrospective study.

Background: Patients undergoing maintenance hemodialysis face a high mortality rate, yet effective tools for predicting mortality risk in this population are lacking. This study aims to develop an interpretable machine learning model to predict mortality risk among maintenance hemodialysis patients.

Methods: A retrospective analysis was conducted on clinical data from 512 maintenance hemodialysis patients treated at The Central Hospital of Wuhan between January 2021 and October 2024.

Detailed three-dimensional fault model of the 2022 M 6.6 Luding earthquake reveals seismic hazard potential in the southeastern Tibetan plateau.

The detailed 3D fault model and further seismic rupture behavior analysis and fault mechanics simulation based on it are important and meaningful. A strong Mw 6.6 earthquake occurred in Luding, Sichuan, on 5 September 2022, the epicenter was located near the Y-shaped junction of the Xianshuihe Fault Zone (XSHF), the Longmen Shan Fault Zone (LMSF), and the Anninghe Fault Zone (ANHF).

Distribution, chemical speciation, and potential ecological risks of hazardous trace elements in solid wastes: a case study of an ultra-low emission coal-fired power plant in Tongling, Anhui Province.

The application of ultra-low emission (ULE) technology in Chinese coal-fired power plants (CFPPs) had reduced the emissions of particulate matter but increased the kind of solid wastes, which raising public and scientific concerns over potential risks of hazardous trace elements (HTEs) in solid wastes. This study investigated the concentration, chemical speciation, and potential ecological risk of As, Cd, Cr, Hg, and Pb in bottom ash, fly ash, desulfurization gypsum, and wet sludge from a typical ULE-CFPPs. The results showed that the highest concentrations of As, Cr, Hg, and Pb were found in wet sludge, while Cd had the highest concentration in fly ash.