A magnetic porous carbon material achieving rapid and convenient separation of volatile cinnamaldehyde in cinnamon.

Rapid and convenient enrichment and detection of volatile cinnamaldehyde (Cin) from a common herbal medicine, cinnamon, was achieved through a reliable MSPE-HPLC-DAD approach. The magnetic porous carbon material (Carbon-FeC/lignin) used for MSPE was prepared as follows. First, the metal organic framework (MIL-101-NH (Fe)) was synthesized using the solvothermal method.

Stable SIFSIX-3-Ni NanoMOF Enabled Green Capture and Circular Utilization of CO/CF/CF: A Carbon-Neutral Strategy for Aluminum Electrolysis Emission Control.

The aluminum electrolysis industry generates massive greenhouse gas emissions dominated by CO and perfluorocarbons (PFCs, CF/CF), presenting dual challenges of climate impact and resource waste. Here, we report a robust nickel-based metal-organic framework (SIFSIX-3-Ni) featuring confined square channels (3.55 Å) that achieves the molecular-sieving separation of CO from CF/CF mixtures.

Prospective associations of dynapenic abdominal obesity status with distinct trajectories of depressive symptoms: A national cohort study.

Background And Aims: Dynapenic abdominal obesity has been shown as a risk factor for adverse outcomes. There is no evidence on the longitudinal association of this condition with different courses of depressive symptoms. This study aimed to investigate the association of dynapenic abdominal obesity status with the risk of distinct trajectories of depressive symptoms.

Branched DNA for disease diagnosis and therapy.

DNA exhibits remarkable versatility, which is attributed to its inherent molecular recognition capabilities, programmable sequences, and excellent biocompatibility. Among its various topological forms, branched DNA (bDNA), including Y-shaped DNA (Y-DNA), X-shaped DNA (X-DNA), etc., stands out as a fundamental building block for fabricating functional DNA-based materials and has demonstrated great promise across diverse applications in recent years.

Reconstruction of three-dimensional fractures in coal based on multidirection slicing and U-Net segmentation.

Introduction: Accurate characterization of multi-size fractures in coal is crucial for estimating its transport properties. However, the extraction of narrow microfractures in 3D voxel-type CT images is difficult, which causes the loss of connectivity in the extracted fracture network and reduces the accuracy of the predicted transport properties.

Objectives: Improving the image quality and optimizing the segmentation process to deal with the inaccuracy of fracture extraction from coal CT images.

Chitosan films incorporating bacterial cellulose-stabilized oregano oil emulsions: A functional approach for fresh walnut shelf-life extension.

Fresh walnuts are prone to moisture loss and spoilage after harvest, leading to reduced appearance and sensory quality. In this study, a multifunctional chitosan (CS)-based film was fabricated by incorporating a bacterial cellulose/oregano essential oil (BC/OEO) Pickering emulsion, with hydrogen bonding promoting cohesive matrix integration. The film's physicochemical properties, along with its antimicrobial and antioxidant activities, were systematically evaluated.

Integration of transcriptomics and metabolomics to reveal crizotinib-induced liver injury in mice.

Drug-induced liver injury is a major cause of acute liver failure. Crizotinib is a first-line treatment for patients with cellular-mesenchymal epithelial transition factor (c-MET), anaplastic lymphoma kinase (ALK), and ROS proto-oncogene 1 (ROS1)-positive non-small cell lung cancer. Although some patients treated with crizotinib experience hepatic adverse effects, the underlying mechanisms remain unclear.

Optimal stimulation site and fiber tracts in subthalamic deep brain stimulation for Meige syndrome.

Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has emerged as an effective therapy for Meige syndrome (MS). However, the optimal stimulation site within STN and the most effective stimulation fiber tracts have not been investigated.

Methods: Based on the discovery cohort (n = 65), we first identified the optimal stimulation site within the STN using the sweet spot mapping method.

Endogenous YAP/TAZ partitioning in TEAD condensates orchestrates the Hippo response.

YAP/TAZ are transcriptional co-activators that pair with transcription factor TEA/ATTS domains (TEADs) for modulating the Hippo pathway. Previous works propose the potential role of YAP/TAZ phase separation for transcriptional activation, yet the biomolecular basis of endogenous YAP/TAZ-TEAD condensates remains unclear. Here, we dissect their endogenous morphology, revealing that YAP/TAZ are client proteins recruited to TEAD condensates in various human cell lines.

Discovery of novel xanthotoxin-pyridine quaternary ammonium derivatives with membrane-targeting mode of action as potential antimicrobials against methicillin-resistant Staphylococcus aureus.

Methicillin-resistant Staphylococcus aureus (MRSA) is a major global health threat owing to its multi-drug resistance, creating an urgent need for novel antibiotics. This study focused on developing anti-MRSA agents by designing and synthesizing 30 xanthotoxin-pyridine quaternary ammonium derivatives, followed by evaluating their antibacterial activity and dissecting their mechanism of action against MRSA. Among all derivatives, III13 demonstrated as the most promising candidate: it exhibited potent anti-MRSA activity (MIC = 1 μg/mL), low cytotoxicity, minimal hemolysis, rapid bactericidal effects, and the ability to disrupt biofilms.

Insights into gut microbiota and metabolite profiles during in vitro fermentation of Volvaria volvacea polysaccharides: unraveling the central role of Bacteroides thetaiotaomicron.

Volvaria volvacea polysaccharides (VVP) possess diverse bioactivities with promising applications in biomedicine and functional foods. This study investigated the metabolic fate of VVP in human gut microbiota and uncovered the pivotal role of Bacteroides thetaiotaomicron using in vitro fecal fermentation models. VVP selectively promoted B.

Crocin facilitates peripheral nerve regeneration through modulation of the STAT3/Bcl-2/Beclin-1 signaling axis-mediated autophagic pathway.

Peripheral nerve injury (PNI) is notoriously difficult to repair due to impaired axonal regeneration and dysregulated inflammatory microenvironments. This study demonstrates that crocin facilitates peripheral nerve regeneration by modulating the STAT3/Bcl-2/Beclin-1 signaling axis, enhancing autophagy while suppressing NLRP3 inflammasome-mediated pyroptosis. In a rat model of sciatic nerve crush injury, crocin treatment improved axonal regrowth and ultrastructural remyelination, as evidenced by upregulated expression of β3-Tubulin, neurofilament-200 (NF200), and myelin basic protein (MBP), alongside significantly elevated sciatic functional index (SFI) scores, reduced muscle atrophy, and diminished collagen deposition.

Incidence, risk factors, and machine learning prediction models of rib fractures in patients with traumatic thoracic vertebral fractures.

Objective: This study aimed to comprehensively describe the clinical characteristics of rib fractures in patients with traumatic thoracic vertebral fractures (TVFs), and to develop machine learning (ML) models for predicting the risk of rib fractures.

Methods: We retrospectively reviewed patients diagnosed with TVFs at a single hospital between January 2007 and November 2024, enrolling 1420 patients and 20 variables. Chest CT scans were used to confirm the presence of rib fractures and to examine their distribution characteristics.

Metal-Free, Regiodivergent -Alkylation of 1-Indazoles Enabled by Brønsted Acid Catalysis.

The catalytic -selective functionalization of indazoles is pivotal in medicinal chemistry; however, achieving regiodivergent -alkylation remains challenging due to the aromatic stabilization and tautomeric equilibrium of indazoles. Herein, we report a metal-free, Brønsted acid-catalyzed alkylation of 1-indazoles using sulfoxonium ylides, which affords excellent -selectivity and good yields. Modulation of the catalyst enables switchable /-alkylation.

Multiomics analysis of gibberellin involved in far-red light-regulated internode elongation in cucumber seedlings.

GA participates in FR light-induced internode elongation of cucumber by regulating the expression of genes/proteins related to aquaporins, expansins, cell wall biosynthesis, hormone metabolism, and signal transduction. This study investigated the effects of the interaction between far-red (FR) light and gibberellin (GA) on the internode elongation of cucumber (Cucumis sativus L. 'Zhongnong No.

Fully Erasable Amphibious Adhesives Derived from Soybean Oil with Record-High Underwater Adhesion Strength.

Developing amphibious adhesives that combine high adhesion strength with on-demand erasability in both dry and wet environments remains a significant challenge. In this study, biomass-derived, amphibious, and erasable adhesives are fabricated by grafting 3-aminobenzoic acid and 3-aminobenzeneboronic acid onto epoxidized soybean oil (ESO), yielding ESO-Am adhesives. These adhesives are dynamically cross-linked with boroxines, hydrogen bonds, and hydrogen-bonded hydrophobic nanodomains.

Inhibition of Macrophage ARID3A Alleviates Myocardial Ischemia-Reperfusion Injury After Heart Transplantation by Reducing THBS1/CD47 Signaling-Mediated Neutrophil Extracellular Traps Formation.

Mitigating myocardial ischemia-reperfusion (IR) injury is essential for enhancing the success of heart transplantation (HT) and improving patient outcomes. During HT, infiltrating neutrophils are influenced and regulated by various other cell types, contributing to myocardial IR injury through the excessive release of neutrophil extracellular traps (NETs). Nonetheless, the precise mechanisms underlying the interactions between neutrophils and other non-cardiomyocytes remain largely unexplored.

Amorphous Silica Induced Loose CeO Clusters with Isolated Pt Atoms for Efficient Reverse-Water Gas Shift Reaction.

Pt-based catalysts exhibit extraordinary potential in reverse-water gas shift (RWGS) reactions, but often fail to possess a high reaction rate and high durability at the same time under high temperature. Herein, we designed a SiO-induced loose CeO as an effective capture for Pt atoms. The abundant surface O vacancies in the loose CeO can trigger significant electron transfer from Pt to CeO and play a crucial role in stabilizing Pt atoms, therefore, largely improving its thermal stability.

Effects of immune checkpoint inhibitors on the pulmonary circulation in lung cancer patients.

Immune checkpoint inhibitors (ICIs) are effective anti-tumor agents, but new immune-related side effects (irAEs) are emerging. This retrospective cohort study investigated 461 lung cancer patients treated with ICIs over 2 years, analyzing changes in pulmonary artery diameter (PAD), aortic diameter (AoD), and the pulmonary artery/aortic diameter (PAD/AoD) ratio through chest computed tomography (CT) at baseline, 3 months, 6 months, 1 year, and 2 years post-treatment. The PAD increased from 25.

Connexin43 and Its Regulation of Astrocyte Gap Junction Function: Influencing Depression Progression by Mediating Electrical and Chemical Signals.

Background: Depression is a common mental illness with a high relapse rate, which has a serious negative impact on national economic development and happiness. At present, the pathogenesis of depression is still unclear, and there are inevitable limitations in first-line clinical treatment. Therefore, it is very important to clarify the pathological mechanism of depression for the development of safe and effective antidepressants.

Duration of Supervised Exercise Necessary for Meaningful Improvement in Peripheral Artery Disease.

Background: Supervised treadmill exercise improves walking performance in people with lower extremity peripheral artery disease, but benefits are not immediate. This study identified the time course of attaining meaningful improvement in 6-minute walk distance and patient-reported outcome measures during a 6-month supervised exercise intervention in people with peripheral artery disease.

Methods: Participants with peripheral artery disease were randomized to supervised treadmill exercise 3 time weekly or a nonexercise control group for 6 months.

Single-Cell RNA Sequencing Reveals Granzyme K CD8 T Cells as a Target for Mitigating Plaque Instability Following Radiation.

Background: Cardiac issues following radiotherapy are increasingly prevalent among patients with thoracic cancer and coronary disease. However, the mechanisms underlying radiotherapy-induced plaque instability and changes in plaque characteristics on imaging remain unclear. This study used single-cell RNA sequencing to identify key features of vulnerable plaques following radiotherapy.

The association between the uric acid to high-density lipoprotein cholesterol ratio (UHR) index and obesity in postmenopausal women: a cross-sectional analysis based on the NHANES.

Background: Obesity has emerged as a critical global public health challenge. Postmenopausal women experience significantly elevated risks of metabolic disorders and a marked increase in obesity prevalence due to declining estrogen levels. The uric acid to high-density lipoprotein cholesterol ratio (UHR), an emerging biomarker for metabolic syndrome, is gaining clinical recognition.