Single-Cell RNA Sequencing Reveals Granzyme K CD8 T Cells as a Target for Mitigating Plaque Instability Following Radiation.

Background: Cardiac issues following radiotherapy are increasingly prevalent among patients with thoracic cancer and coronary disease. However, the mechanisms underlying radiotherapy-induced plaque instability and changes in plaque characteristics on imaging remain unclear. This study used single-cell RNA sequencing to identify key features of vulnerable plaques following radiotherapy.

Applying timing theory to nursing case management of type 2 diabetes mellitus: A clinical retrospective study.

This study investigates the impact of a timing theory-based case management model on inpatient management efficiency, self-management capacity, and complication rates in patients with type 2 diabetes mellitus (T2DM). We retrospectively analyzed 120 inpatients with T2DM admitted between December 2023 and March 2024. Patients were divided into 2 groups based on the type of nursing care they received: an observation group (n = 60), which received a timing theory-based case management model, and a control group (n = 60), which received routine nursing care.

Assessing the effects of naltrexone-bupropion on hepatic steatosis and fibrosis in patients with T2DM and overweight or obesity: Insights from a placebo-controlled trial.

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is prevalent among individuals with overweight or obesity and type 2 diabetes (T2DM), increasing the risk for liver-related and cardiovascular complications. Lifestyle changes to reduce body weight are the primary intervention to decrease the risk of MASLD and liver fibrosis. This study aimed to evaluate the impact of a pharmacological intervention with naltrexone/bupropion (NB) on hepatic steatosis and fibrosis risk in patients with T2DM using non-invasive tests.

GAN-Based Domain Adaptation for Image-Aware Layout Generation in Advertising Poster Design.

Layout plays a crucial role in graphic design and poster generation. Recently, the application of deep learning models for layout generation has gained significant attention. This paper focuses on using a GAN-based model conditioned on images to generate advertising poster graphic layouts, requiring a dataset of paired product images and layouts.

Natural tricyclic and hyper-polycyclic aromatic hydrocarbons: structure, biosynthesis, bioactivity, and synthesis.

Covering: 1950 to up to the end of 2024Natural products containing polycyclic aromatic hydrocarbons (PAHs) feature at least two fused aromatic ring systems, conforming to Hückel's rule and representing an important class of secondary metabolites with a wide range of biological activities. Among them, the subtype of natural products containing tricyclic and greater than tricyclic systems has been neglected for a long time. This review summarizes the isolation, structural features, bioactivities, biosynthetic pathways, and chemical synthesis of this special subtype reported over the past decades.

Efficient workflow scheduling using an improved multi-objective memetic algorithm in cloud-edge-end collaborative framework.

With the rapid advancement of large-scale model technologies, AI agent frameworks built on foundation models have become a central focus of artificial-intelligence research. In cloud-edge-end collaborative computing frameworks, efficient workflow scheduling is essential to reducing both server energy consumption and overall makespan. This paper addresses this challenge by proposing an Improved Multi-Objective Memetic Algorithm (IMOMA) that simultaneously optimizes energy consumption and makespan.

Immune cells, inflammatory proteins, and sepsis: A mediation Mendelian randomization study.

Immune cells are known to be associated with sepsis. However, whether these associations represent a causal relationship and whether inflammatory proteins act as mediators remain unclear. A mediation Mendelian Randomization (MR) approach was employed to assess the correlation between immune cells and sepsis, along with the mediating effects of inflammatory proteins in this relationship.

[Assessment and Driving Force Analysis of Ecological Quality in Jiangsu Province's Counties Based on EQI and Geographic Detectors].

In recent years， with the rapid urbanization process in Jiangsu Province， the ecological land and ecological environment have undergone significant changes， posing severe challenges to the ecological quality. In order to effectively monitor the ecological quality of Jiangsu Province， promote ecosystem restoration， and strengthen ecological construction as well as biodiversity conservation， Jiangsu Province was selected as the study area， and the ecological quality index （EQI） was used to comprehensively assess the ecological quality of Jiangsu Province in 2022 by selecting 12 indexes in three aspects： ecological pattern， ecological function， and ecological stress， and analyzing the impact factors by using a geographic detector. The research results indicate that： ① The average value of the ecological quality index in Jiangsu Province was 50.

Consistency of Mini-Nutritional Assessment short form and Nutritional Risk Screening 2002 in nutritional evaluation of diabetic foot patients.

Background: Malnutrition has numerous adverse effects on the treatment and prognosis of diabetic foot (DF) patients, making it essential to determine the nutritional state to recognize malnutrition as early as possible. However, there is currently no acknowledged nutritional screening instrument for DF patients. This research aimed to identify the most appropriate nutritional assessment tool for this population.

Physically Based Facial Texture Generation in the Wild.

Automatic 3D facial texture generation has gained significant interest recently. However, existing approaches may lack compatibility with the widely used physically based rendering (PBR) pipeline or rely on 3D data captured by sophisticated systems such as Light Stage. In this paper, we propose a multistage framework to achieve text-driven physically based facial texture generation in the wild, which eliminates the reliance on expensive, controlled capture environments.

Steatotic Liver Disease as a Risk Enhancer in the Presence of Metabolic Syndrome.

Background & Aims: Steatotic liver disease (SLD) is an overarching term to encompass metabolic-dysfunction associated steatotic liver disease (MASLD), MASLD with increased alcohol intake (MetALD), and alcohol-associated liver disease (ALD). However, the impact of metabolic syndrome (MetS) on the association between SLD and mortality risk remains uncertain. This study aims to compare all-cause and cause-specific mortality across SLD subtypes stratified by MetS.

Pediatric lung transplantation in China, 2019-2023.

Background: Pediatric lung transplant (pLTX) is a rare procedure globally; its characteristics and survival outcomes in China remain unknown.

Methods: This retrospective study analyzed data from pLTX recipients aged ≤ 17 years between January 2019 and December 2023 from the China Lung Transplantation Registry. Pre-, intra-, and post-operative characteristics were described and compared between children aged 2-11 years and 12-17 years and between pLTX conducted in centers with high and low transplant volumes.

Efficacy prediction of systemic immune-inflammation index and prognostic nutritional index in breast cancer patients and their variations after neoadjuvant chemotherapy.

Objective: The purpose of this study was to evaluate the predictive values of systemic immune-inflammatory index (SII), prognostic nutrition index (PNI), change of SII (ΔSII), change of PNI (ΔPNI) and ΔPNI-ΔSII score in patients with neoadjuvant chemotherapy for breast cancer.

Methods: We enrolled in a retrospective study involving 72 patients with breast cancer between February 2020 and January 2022. All patients had clinical features of axillary lymph node metastasis and received neoadjuvant therapy.

Characteristic of motor-related cortical network during stimulating at the affected or bilateral limbs of stroke patients by acupuncture.

Background: The compensatory pattern between the two hemispheres after stroke has been the focus of research. Some evidence suggests bilateral stimulation more effectively engages networks across both hemispheres compared to the affected side only.

Objectives: To explore whether the stimulating at bilateral limbs of stroke patients by acupuncture may better engage compensatory reorganization between the hemispheres compared to stimulating at the hemiplegic limb.

Photoexcited nitroarene-enabled carbon chain-elongated oxidation of alkenes via tandem oxidative cleavage and dipolar cycloaddition.

Oxidation of alkenes with O and photoexcited nitroarenes represents one of the most attractive organic chemical transformations for the synthesis of oxygen-enriched molecules. However, known achievements are mainly limited to carbon chain-shortened oxidation and carbon chain-retained oxidation of alkenes. Given that constructing higher molecular complexity is the core goal of modern synthesis, the development of chain-elongated oxidation of alkenes would be in high demand but still remains an elusive challenge so far.

Detecting emotional disorder with eye movement features in sports watching.

Introduction: Digital technologies have significantly advanced the detection of emotional disorders (EmD) in clinical settings. However, their adoption for long-term monitoring remains limited due to reliance on fixed testing formats and active user participation. This study introduces a novel approach utilizing common ball game videos-table tennis-to implicitly capture eye movement trajectories and identify EmD through natural viewing behavior.

Astronaut dose coefficients calculated using GEANT4 and comparison with ICRP123.

Fluence-to-dose conversion coefficients are fundamental ingredients to calculate astronaut radiation dose in space. For this purpose, the conversion coefficients for isotropic radiation provided by the International Commission on Radiological Protection in Publication 123 (ICRP123) are widely used. Understanding the uncertainties in these coefficients is important for a precise calculation of radiation dose.

A Lung Epithelioid Hemangioendothelioma Subtype with YAP1::TFE3 Fusion: A Case Report.

Epithelioid hemangioendothelioma (EHE) is a rare and low-grade malignant endothelial sarcoma. Based on disease-defining mutations, approximately 95% of EHEs have the conventional gene fusion, while approximately 5% are the Yes-associated protein-1 (YAP1):: transcription factor binding to IGHM enhancer 3 (TFE3) fused tumor subtype according to the World Health Organization classification. Although this tumor type is well recognized, EHE, especially the :: fused tumor subtype, represents a diagnostic challenge in routine practice due to its rarity and morphologic overlap with other epithelioid tumors, including other benign and malignant epithelioid vascular neoplasms or carcinomas.

Achievement Motivation and Performance in Wargames: Creativity as a Mediator.

Computer-based wargames provide an experimental platform for studying cognitive antecedents and behavioral outcomes in dynamic scenarios. Our study examines how achievement motivation influence wargame players' performance through the mechanism of creativity. In Study 1, we simplified the achievement motivation scale and revised the creativity scale for wargame contexts in China.

Cross-cultural adaptation, reliability, and validity of a Chinese version of the swallowing impairment score.

Introduction: The impact of thyroidectomy on swallowing is prevalent. Difficulties in swallowing can lead to malnutrition, destress and a decline in quality of life. The Swallowing Impairment Score (SIS-6) is a uniquely self-evaluation questionnaire aimed at comprehensively assessing the swallowing impairment status in patients after thyroidectomy.

Distinct features of three clinical subtypes in 533 patients with primary hypertrophic osteoarthropathy.

Background: Primary hypertrophic osteoarthropathy (PHO) is a rare genetic disorder classified into clinical subtypes and genetic subtypes. Previous clinical studies have primarily focused on case reports and family analyses, largely characterizing the genetic subtypes. However, there remains a long-standing gap in understanding the characteristics of the different clinical subtypes of PHO.

Clinical Manifestations and Prognosis of Chronic Kidney Disease after Hematopoietic Stem Cell Transplantation.

Introduction: Kidney disease is a common complication of hematopoietic stem cell transplantation (HSCT). However, there is limited research on the clinical pathology and prognosis of patients who develop chronic kidney disease (CKD) after HSCT.

Methods: A retrospective analysis was conducted on 50 patients diagnosed with CKD through kidney biopsy between September 2008 and May 2024.

Inhibition of lens-induced myopia in guinea pigs using a far-induced infrared ray material.

Purpose: Numerous studies have demonstrated a close relationship between choroidal thickness (ChT), sclera/choroidal hypoxia, and the onset and progression of myopia. Far-infrared (FIR) therapy is a traditional method used to enhance microcirculation. In this study, we estimated the effectiveness of FIR in myopia control and explored its underlying mechanisms.

Constructing Porous Polyacrylonitrile/Polyethylenimine Microspheres by Polymer Crystallization Vapor-Induced Phase Separation for Efficient Adsorption and Separation of Chromium Ion.

The development of cost-effective wastewater treatment technologies is imperative for heavy metal pollution mitigation, which presents considerable risks to water supplies, ecosystems, and human health. In this context, polyacrylonitrile/polyethylenimine porous microspheres (PAN/PEI PM) were synthesized through a dual-phase strategy combining polymer crystallization and vapor-induced phase separation, leading to effective removal of hexavalent chromium (Cr(VI)) from wastewater. The PAN/PEI PM, characterized by a substantial number of amino groups and a relatively uniform particle size ranging from 1.