Exploring the effects of capsule in microcirculatory dysfunction model rats through laser speckle contrast imaging and metabolomics.

Background: Microcirculatory dysfunction leads to a number of diseases and worsen prognosis. Blood-activating drugs like capsule may improve circulation, but its pharmacological effects in microcirculatory dysfunction remain unclear.

Objective: The purpose of this study is to determine the pharmacological effect of capsules in treating microcirculatory dysfunction.

A Streamlined One-Step Bioprocess for Isomaltulose Production in Bacillus subtilis Through Multicopy Genomic Integration of Sucrose Isomerase Gene.

Isomaltulose, a sucrose isomer with a low glycemic index and non-cariogenic properties, is extensively used in the food industry. The industrial production of this functional sugar relies on enzymatic biotransformation using sucrose isomerase (SIase). However, conventional bioprocesses involve expressing and isolating the SIase enzyme, followed by using the purified SIase to convert sucrose into isomaltulose, resulting in a multi-step and high-cost process that hindered the broader applications of isomaltulose.

Wheat TaNADPO Promotes Spot Blotch Resistance.

Bipolaris sorokiniana is a prevalent fungal pathogen that resides in the soil and affects various parts of wheat, leading to diseases such as spot blotch, common root rot, head blight and black point. The genetic mechanisms that confer resistance in wheat against this pathogen are not completely known. In this research, 1302 wheat germplasms from around the world were evaluated for resistance to spot blotch at the seedling stage, and it was found that merely 3.

Voluntary frontier settlement and independent agency within China.

Voluntary frontier settlement has led to independent agency in Western and a few non-Western societies. This study suggests that Northeast China was constructed as a new region with voluntary frontier settlers during 1860-1920, and examined whether voluntary frontier settlement predicted individualistic differences by comparing inhabitants from Northeast China (N = 479) to those in contrast region where their ancestors originated (N = 520) with multiple cultural tasks. Results showed that inhabitants of Northeast China were higher in self-reported individualism and happiness related to more socially disengaging emotions, and fewer in-group favoritism and less holistic thought compared to the inhabitants of North China.

Heterologous expression of the barley-specific HvbZIP87 transcription factor in wheat enhances broad-spectrum disease resistance with balanced yield.

Introduction: NPR1, a protein that interacts with bZIP transcription factors known as TGAs, plays a pivotal role in coordinating systemic acquired resistance (SAR) in plants. Nevertheless, the molecular intricacies governing SAR in the Triticeae family, which includes crops like wheat and barley, are still largely enigmatic.

Objectives: We identified HvbZIP87, a barley-specific transcription factor, induced in SAR, more strongly in transgenic barley with HvNPR1 knocked down.

Achievement Motivation and Performance in Wargames: Creativity as a Mediator.

Computer-based wargames provide an experimental platform for studying cognitive antecedents and behavioral outcomes in dynamic scenarios. Our study examines how achievement motivation influence wargame players' performance through the mechanism of creativity. In Study 1, we simplified the achievement motivation scale and revised the creativity scale for wargame contexts in China.

Manipulation of the brown glume and internode 1 gene leads to alterations in the colouration of lignified tissues, lignin content and pathogen resistance in wheat.

Lignin is a crucial component of the cell wall, providing mechanical support and protection against biotic and abiotic stresses. However, little is known about wheat lignin-related mutants and their roles in pathogen defence. Here, we identified an ethyl methanesulfonate (EMS)-derived Aegilops tauschii mutant named brown glume and internode 1 (bgi1), which exhibits reddish-brown pigmentation in various tissues, including internodes, spikes and glumes.

Neuroprotective effects of Anshen Bunao Syrup on cognitive dysfunction in Alzheimer's disease rat models.

Alzheimer's disease (AD) presents a significant challenge due to its prevalence and lack of cure, driving the quest for effective treatments. Anshen Bunao Syrup, a traditional Chinese medicine known for its neuroprotective properties, shows promise in addressing this need. However, understanding its precise mechanisms in AD remains elusive.

Development of an engineered Bacillus subtilis strain for antibiotic-free sucrose isomerase production.

Sucrose isomerase (SIase) catalyzes the hydrolysis and isomerization of sucrose into isomaltulose, a functional sugar extensively used in the food industry. However, the lack of safe and efficient heterologous expression systems for SIase has constrained its production and application. In this study, an engineered Bacillus subtilis strain for antibiotic-free SIase production was developed via a food-grade expression system.

Genome-Wide Association Studies on Chinese Wheat Cultivars Reveal a Novel Crown Rot Resistance Quantitative Trait Locus on Chromosome 3BL.

crown rot (FCR), primarily caused by , has emerged as a new threat to wheat production and quality in North China. Genetic enhancement of wheat resistance to FCR remains the most effective approach for disease control. In this study, we phenotyped 435 Chinese wheat cultivars through FCR inoculation at the seedling stage in a greenhouse.

Enhancement of broad-spectrum disease resistance in wheat through key genes involved in systemic acquired resistance.

Systemic acquired resistance (SAR) is an inducible disease resistance phenomenon in plant species, providing plants with broad-spectrum resistance to secondary pathogen infections beyond the initial infection site. In , SAR can be triggered by direct pathogen infection or treatment with the phytohormone salicylic acid (SA), as well as its analogues 2,6-dichloroisonicotinic acid (INA) and benzothiadiazole (BTH). The SA receptor non-expressor of pathogenesis-related protein gene 1 (NPR1) protein serves as a key regulator in controlling SAR signaling transduction.

High-Level Expression and Biochemical Characterization of a Maltotetraose Amylase in Pichia pastoris X-33 for Maltotetraose Production.

Maltotetraose amylase, which catalyzes the hydrolysis of amylaceous polysaccharides into maltooligosaccharides with maltotetraose as the main product, is extensively used in the food industry. However, the lack of efficient expression system for maltotetraose amylase has hampered its production and application. In this study, high-level production of a maltotetraose amylase mutant (referred to as Pp-Mta∆CBM) from Pseudomonas saccharophila was achieved in Pichia pastoris X-33.

An integrated non-targeted and targeted analysis approach for identification of semi-volatile organic compounds in indoor dust.

Household dust contains a wide variety of semi-volatile organic compounds (SVOCs) that may pose health risks. We developed a method integrating non-targeted analysis (NTA) and targeted analysis (TA) to identify SVOCs in indoor dust. Based on a combined use of gas and liquid chromatography with high-resolution mass spectrometry, an automated, time-efficient NTA workflow was developed, and high accuracy was observed.

Climatic and Economic Background Determine the Disparities in Urbanites' Expressed Happiness during the Summer Heat.

Climate-change-induced extreme weather events increase heat-related mortality and health risks for urbanites, which may also affect urbanites' expressed happiness (EH) and well-being. However, the links among EH, climate, and socioeconomic factors remain unclear. Here we collected ∼6 million geotagged tweets from 44 Chinese prefecture-level cities based on and performed a quadratic regression model to explore the relationships between summer heat and EH.

Sino-India difference in collectivism and its association with cultural heritage concerning argumentation.

Cross-cultural studies from a global perspective contend that China and India are both collectivistic cultures. However, it remains unclear whether and why China and India differ in their collectivism. This study examines whether the cultural heritage concerning argumentation explains why Chinese people are more collectivistic than Indians.

Exploring the impact of Chuangguandong Movement on individualism in China based on Sina Weibo information.

The voluntary frontier settlement hypothesis holds that frontier movements can promote the formation of individualism in the frontier area. The Chuangguandong Movement is one of China's voluntary frontier movements that potentially had a positive impact on the formation of high individualism in the northeastern provinces. Previous studies used independent/interdependent measures of self-construal scale, symbolic self-inflation, nepotism tasks, and percentage of most common names, to examine the differences in the independence between Heilongjiang and Shandong residents, which may be related to the Chuangguandong Movement.

Exogenous expression of barley HvWRKY6 in wheat improves broad-spectrum resistance to leaf rust, Fusarium crown rot, and sharp eyespot.

Systemic acquired resistance (SAR) is a broad-spectrum plant defense phenomena controlled by the salicylic acid receptor NPR1. Key regulators of the SAR signaling pathway showed great potentials to improve crop resistance to various diseases. In our previous investigation, a barley transcription factor gene HvWRKY6 was identified as downstream of NPR1 during SAR.

Analysis of the Mediating Role of Psychological Empowerment between Perceived Leader Trust and Employee Work Performance.

High levels of trust between employees and leaders moderate the relationship between organizational management practices. A collaborative environment encourages employees to have more Psychological Empowerment, which in turn leads to better performance. Based on Intrinsic Work Motivation and Self-Evaluation, this paper uses Perceived Leader Trust as an independent variable, Employee Work Performance as a dependent variable, and introduces Psychological Empowerment to explore the internal mechanism of perceived trust.

Impacts of the COVID-19 Pandemic on the Bereaved: A Study of Bereaved Weibo Users.

The global COVID-19 pandemic may significantly affect the experiences of death and bereavement. This study aimed to learn from recent outbreaks of infectious diseases and further understand their impacts on bereavement. We obtained psychological status scores for 32 individuals bereaved due to COVID-19 and 127 individuals bereaved due to non-COVID-19 causes using the online ecological recognition (OER) approach.

Climato-Economic Origins of Variations in Uniqueness of Nickname on Sina Weibo.

In the world of social media, people are free to choose names based on their preferences, which may potentially reflect certain levels of uniqueness. In this study, we have attempted to explore the possibility of applying the ecological theory of individualism/collectivism in the context of social media. We, thus, examined provincial variations in the uniqueness of nicknames among more than 13 million Sina Weibo users.

Increase of Collectivistic Expression in China During the COVID-19 Outbreak: An Empirical Study on Online Social Networks.

The pathogen-prevalence hypothesis postulates that collectivism would be strengthened in the long term in tandem with recurrent attacks of infectious diseases. However, it is unclear whether a one-time pathogen epidemic would elevate collectivism. The outbreak of COVID-19 and the widespread prevalence of online social networks have provided researchers an opportunity to explore this issue.

Historical Sustenance Style and Social Orientations in China: Chinese Mongolians Are More Independent Than Han Chinese.

In this study, we examined the Chinese Han and Mongolian, two ethnic groups that belong to the same national and geographic regions but vary in their degrees of social interdependence and independence. We assumed that the Mongolian, who have traditionally been known as a herding community, exhibit a greater independent social orientation compared to the Han Chinese, who have traditionally been known as an agrarian community. Through three different studies we used the explicit measurement of self-construal, implicit cultural task of self - inflation and the practice of name-giving (i.