Anionically-Reinforced Nanocellulose Separator Enables Dual Suppression of Zinc Dendrites and Polyiodide Shuttle for Long-Cycle Zn-I Batteries.

Zn-I batteries have emerged as promising next-generation energy storage systems owing to their inherent safety, environmental compatibility, rapid reaction kinetics, and small voltage hysteresis. Nevertheless, two critical challenges, i.e.

N-Doped Nonalternant Nanoribbons with up to 29 Linearly-Fused Rings and High Charge-Carrier Mobilities.

The synthesis of nonalternant graphene nanoribbons (GNRs)-carbon-based nanostructures featuring fused pentagonal or heptagonal rings that disrupt hexagonal symmetry-has remained a significant challenge despite their unique electronic properties, such as tunable bandgaps and topological states. Unlike conventional alternant hydrocarbons (e.g.

TGF-β-Driven Atrial Fibrosis in Atrial Fibrillation: From Mechanistic Insights to Targeted Therapies.

The prevalence of atrial fibrillation (AF), one of the most common cardiac arrhythmias, has significantly increased, especially within the aging population. Atrial fibrosis, a hallmark of the structural changes seen in AF, is characterized by abnormal activation and proliferation of atrial fibroblasts accompanied by excessive deposition of extracellular matrix. The initiation and progression of fibrosis are regulated by multiple profibrotic cytokines, with transforming growth factor-beta (TGF-β) serving as the primary mediator.

Early-life DEHP exposure disrupts adult male drosophila sleep homeostasis via Kyat-KYNA-NMDAR pathway in the brain.

Sleep quality is associated with exposure to environmental chemicals, and model organisms such as fruit flies are ideal for studying the genetic basis of sleep. Using the Drosophila melanogaster model, this study innovatively explores the long-term effects of early-life exposure to the plasticizer di-(2-ethylhexyl) phthalate (DEHP) on adult sleep quality and the underlying mechanisms. Results showed that early-life DEHP exposure reduced adult fruit fly total sleep time and increased sleep number, with more significant sleep phenotype changes in males.

Consensus clustering based on CT radiomics has potential for risk stratification of patients with clinical T1 stage lung adenocarcinoma.

Background: This study aimed to clinically risk-classify patients with clinical stage T1 LUAD based on consensus clustering of CT radiomics to help clinics provide personalized treatment strategies for patients with early stage LUAD.

Materials: Clinical, pathological and CT imaging data of patients who underwent surgical resection and pathologically confirmed lung adenocarcinoma from September 2018 to May 2021 were retrospectively analysed. The clinical and pathological information included age, gender, smoking history, tumor location, pathological subtype, infiltration level, lymph node metastasis (LNM), visceral pleural infiltration (VPI), lymphovascular invasion (LVI), spread through air space (STAS), Ki-67 proliferation index, and gene mutation information.

Preoperative Prognosis Prediction for Pathological Stage IA Lung Adenocarcinoma: 3D-Based Consolidation Tumor Ratio is Superior to 2D-Based Consolidation Tumor Ratio.

Background: The two-dimensional computed tomography measurement of the consolidation tumor ratio (2D-CTR) has limitations in the prognostic evaluation of early-stage lung adenocarcinoma: the measurement is subject to inter-observer variability and lacks spatial information, which undermines its reliability as a prognostic tool. This study aims to investigate the value of the three-dimensional volume-based CTR (3D-CTR) in preoperative prognosis prediction for pathological Stage IA lung adenocarcinoma, and compare its predictive performance with that of 2D-CTR.

Methods: A retrospective cohort of 980 patients with pathological Stage IA lung adenocarcinoma who underwent surgery was included.

Stable Diradical-Derived Conjugated Radical Polymers.

Conjugated radical polymers (RPs) with polyradical structures in an π-conjugated polymeric backbone have the potential to serve as both model molecules for spin-correlated condensed matters and as materials for optoelectronics and spin-based quantum applications. However, preparing RPs of this type with high stability and spin-delocalized nature presents a significant challenge. We report herein two ambient-stable conjugated RPs (RPH and RPC), synthetically obtained by an unprecedented straightforward copolymerization of two brominated diradical monomers (diradical characters up to 0.

Childhood triglyceride-glucose index and pre-hypertension in adulthood: a prospective cohort study.

Background: The triglyceride-glucose (TyG) index serves as a surrogate marker for insulin resistance. Multiple studies have demonstrated a positive correlation between the TyG index and blood pressure, indicating that a high TyG index is related to a greater risk of developing pre-hypertension (pre-HTN) and hypertension (HTN). However, the relationship between changes in the TyG index during childhood and pre-HTN in adulthood requires further clarification.

Placental RTN3L-dependent ER-Phagy Contributes to Fetal Testicular Dysplasia Upon Environmental Stress.

Prenatal environmental stress damages fetal testicular development, leading to male infertility. However, the precise mechanisms underlying the impact of gestational environmental stress on fetal testicular development require further investigation. This study demonstrates that gestational environmental stressor cadmium exposure caused placental estradiol synthesis inhibition and fetal testicular dysplasia.

The fabrication of 1,2-dicarbonyl compound-caging isothermal exponential amplification strategy and its application in the highly sensitive detection of tumor exosomal miRNA.

Exponential amplification reaction (EXPAR) possesses the advantage of high amplification efficiency, producing large amount of short nucleic acids in a short time. However, primer-independent DNA autosynthesis and nonspecific amplification caused by DNA self-synthesis increase the risk of high background signals, limiting its application in the fabrication of ultrasensitive sensors. In this study, we developed a new strategy called 1,2-dicarbonyl compound-caging EXPAR (caging-EXPAR) by innovatively modifying EXPAR templates with 1,2-dicarbonyl compounds.

Di (2-ethylhexyl) phthalate reduces sperm motility by decreasing sperm tail energy supply.

Di (2-ethylhexyl) phthalate (DEHP) is widespread in the environment. It can impair sperm function through damaging the sperm development process. However, few studies have focused on the sperm tail that is directly related to sperm motility.

Utilizing alternative in vivo animal models for food safety and toxicity: A focus on thermal process contaminant acrylamide.

Rodent models have traditionally been used to assess the toxicity of food chemicals, but this approach is costly, time-consuming, and raises ethical concerns. Alternatively, non-mammalian models such as Drosophila melanogaster, Danio rerio, and Caenorhabditis elegans have been shown to be suitable for studying the toxicity of food hazards. Their advantages include low cost, short life cycles, adaptability to high-throughput screening, and adherence to the 3R principles of replacement, reduction, and refinement.

Non-alternant Benzodifluoranthene Tetraimides from 7,8,9,10-Fluoranthene Diimides: Synthesis, Structure, and Optical-Limiting Properties.

A novel tetraimide-functionalized non-alternant π-conjugated system, namely, benzodifluoranthene tetraimides (BDFTI), has been designed and synthesized through highly efficient UV-photocyclization of a vinyl-bridged fluoranthene diimide dimer (i. e., FDI-V).

Highly 002-Oriented Dendrite-Free Anode Achieved by Enhanced Interfacial Electrostatic Adsorption for Aqueous Zinc-Ion Batteries.

Rechargeable aqueous zinc-ion batteries (AZIBs) are gaining recognition as promising next-generation energy storage solution, due to their intrinsic safety and low cost. Nevertheless, the advancement of AZIBs is greatly limited by the abnormal growth of zinc dendrites during cycling. Electrolyte additives are effective at suppressing zinc dendrites, but there is currently no effective additive screening criterion.

Ambipolar conjugated ladder polymers by room-temperature Knoevenagel polymerization.

Two soluble conjugated ladder polymers (cLPs), decorated with multiple electron-poor species (, cyano groups, fused pentagons, and N-heterocyclic rings), have been synthesized from the newly developed tetraketo-functionalized double aza[5]helicene building blocks using a single-step Knoevenagel polycondensation strategy. This facile approach features mild conditions (, room temperature) and high efficiency, allowing us to quickly access a nonalternant ladder-like conjugated system with the formation of multicyano substituents in the backbone. Analysis by H NMR, FT-Raman, and FT-IR spectra confirms the successful synthesis of the resulting cLPs.

Associations between urinary level of bisphenol A, phthalates, 8-iso-prostaglandin-F2α, and emotional and behavioral problems among Chinese adolescents.

Background: Emotional and behavioral problems (EBPs) of adolescents is a worldwide public health problem. Bisphenol A (BPA) and phthalate (PAEs) are prevalent and potentially toxic to human health. Therefore, this study aimed to investigate the associations between urinary level of BPA, PAEs, 8-iso-prostaglandin-F2α (8-iso-PGF2α), and EBPs.

Pubertal exposure to Microcystin-LR arrests spermatogonia proliferation by inducing DSB and inhibiting SIRT6 dependent DNA repair in vivo and in vitro.

The reproduction toxicity of pubertal exposure to Microcystin-LR (MC-LR) and the underlying mechanism needs to be further investigated. In the current study, pubertal male ICR mice were intraperitoneally injected with 2 μg/kg MC-LR for four weeks. Pubertal exposure to MC-LR decreased epididymal sperm concentration and blocked spermatogonia proliferation.

Trends in gut-heart axis and heart failure research (1993-2023): A bibliometric and visual analysis.

Background: The incidence of heart failure, the terminal stage of several cardiovascular diseases, is increasing owing to population growth and aging. Bidirectional crosstalk between the gut and heart plays a significant role in heart failure. This study aimed to analyze the gut-heart axis and heart failure from a bibliometric perspective.

Role of sleep in asthenospermia induced by di (2-ethyl-hexyl) phthalate.

Di (2-ethyl-hexyl) phthalate (DEHP) mainly enters the human body through the digestive tract, respiratory tract, and skin. At the same time, it has reproductive and developmental toxicity, neurotoxicity, and so on, which can cause the decrease of sperm motility. Asthenospermia is also known as low sperm motility, and the semen quality of men in some areas of China is declining year by year.

Hypertension in non-obese children and BMI in adulthood: the Bogalusa heart study.

Objective: This study explored the association between hypertension(HTN) in non-obese children body mass index (BMI) in adulthood.

Methods: A retrospective analysis of 1111 participants from the Bogalusa Heart Study was conducted, in which data on hypertension history during childhood in non-obese children, anthropometric and cardiovascular risk factors and other indicators from cross-sectional examinations in adulthood were collected. BMI was used as both a continuous and a categorical variable, and multivariate linear regression modelling and logistic regression modelling were used.

CoP/Co heterojunction on porous g-CN nanosheets as a highly efficient catalyst for hydrogen generation.

Designing non-precious catalysts to synergistically achieve a facilitated exposure of abundant active sites is highly desired but remains a significant challenge. Herein, a hetero-structured catalyst CoP-Co supported on porous g-CN nanosheets (CoP-Co/CN-I) was prepared by pyrolysis and P-inducing strategy. The optimal catalyst achieves a turnover frequency (TOF) of 26 min at room temperature and the apparent activation energy (E) is 35.

Development of a Clinicopathological-Radiomics Model for Predicting Progression and Recurrence in Meningioma Patients.

Rationale And Objectives: Tumor progression and recurrence（P/R）after surgical resection are common in meningioma patients and can indicate poor prognosis. This study aimed to investigate the values of clinicopathological information and preoperative magnetic resonance imaging (MRI) radiomics in predicting P/R and progression-free survival (PFS) in meningioma patients.

Methods And Materials: A total of 169 patients with pathologically confirmed meningioma were included in this study, 54 of whom experienced P/R.