Important role of tumor deposits and negative lymph nodes in prognosis of N1c colorectal cancer patients.

Background: The number of tumor deposits (TDs) does not play a part in the current tumor node metastasis staging. Negative lymph node (NLN) status is associated with the prognosis of colorectal cancer (CRC), but its clear role in N1c stage remains to be defined.

Aim: To evaluate the combination of TDs and NLNs as potential prognostic indicators in N1c CRC.

Prevalence of radiographic knee osteoarthritis in China: a national survey of thirty thousand, four hundred and fifty five individuals cross-sectional study.

Background: Knee osteoarthritis (KOA) is a major health burden for adults and the elderly globally; however, national radiological and epidemiological data and predictive models for KOA are lacking in China. Most of the existing studies are limited to regional samples, which cannot accurately reflect disease burden and risk factors.

Objectives: This study aimed to systematically analyze the prevalence and risk factors of adult radiology KOA in China for the first time using a national representative sample and to develop a prediction model to provide a basis for public health strategies.

Shear wave elastography for noninvasive assessment of intracompartmental pressure in tibial plateau fractures: a cross-sectional study.

Background: This study aimed to investigate the utility of shear wave elastography (SWE) as a noninvasive diagnostic tool for assessing anterior compartment intracompartmental pressure (ICP) in patients with tibial plateau fractures, facilitating early detection of high compartment pressure (HCP) to mitigate acute compartment syndrome (ACS) risks.

Methods: In this cross-sectional study conducted from January 2024 to March 2025 at a tertiary hospital in China, 170 patients aged 18-65 years with tibial plateau fractures diagnosed within 48 h were enrolled. Demographic data, injury mechanisms, Schatzker classification, and laboratory parameters were collected.

Understanding the Aroma Profiles of Hui Li Red Sichuan Pepper ( Maxim) Across Harvesting Periods Using Sensory Evaluation, E-Nose and GC-IMS Techniques.

This study investigated aroma changes in Hui Li red Sichuan pepper across five different harvesting times within their typical optimum period based on 24 traditional solar terms, employing sensory evaluation, electronic nose (E-nose), gas chromatography-ion mobility spectrometry (GC-IMS) combined with relative odour activity value (ROAV) and partial least squares discriminant analysis (PLS-DA). Sensory analysis indicated that peppers were characterised by green, citrus, minty, sweet, woody, and peppery numbing aroma attributes. E-nose revealed the greatest aroma difference in peppers occurred between the early and late optimum harvest stages.

An Examination of the Relationship Between Spinal-Pelvic Morphology and Lower Lumbar Facet Joint Remodeling in Individuals with Mild Degenerative Lumbar Spondylolisthesis.

Objective: To examine the relationship between spinal-pelvic morphology based on pelvic incidence angle and facet joint characteristics in the lower lumbar spine of patients with mild degenerative lumbar spondylolisthesis.

Methods: The study involved 167 patients with mild degenerative lumbar spondylolisthesis and patients with 100 nonlumbar spondylolisthesis. Morphologic parameters of L4-5 and L5-S1 facet joints and intervertebral discs were assessed using 3D CT images, including facet joint angle, pedicle-facet angle, asymmetry, and osteoarthritis.

Noninvasive Compartmental Pressure Assessment With iCare in Healthy Individuals of Different Ages.

Objective: Acute compartment syndrome is a major orthopedic emergency due to elevated pressure in the closed muscle compartment, and prompt evaluation and fasciotomy are always needed. However, the gold standard indicator of fasciotomy is still under debate. To date, few studies have investigated the variations in compartmental pressure at different locations in people of different ages.

Deciphering the Overlapping Immune Mechanism Between Depression and Breast Cancer.

Depression and breast cancer (BC) demonstrate significant clinical comorbidity, yet their shared molecular mechanisms remain unclear, particularly regarding immune pathway regulation. This study systematically analyzed Depression-associated gene expression profiles (Gene Expression Omnibus (GEO) database) and BC transcriptomic data (The Cancer Genome Atlas (TCGA) database), identifying overlapping differentially expressed genes (DEGs). Functional enrichment (Gene Ontology (GO)/Kyoto Encyclopedia of Genes and Genomes (KEGG)) and protein-protein interaction (PPI) network analyses (STRING/Cytoscape) were employed to elucidate biological processes, followed by least absolute shrinkage and selection operator (LASSO) regression and receiver operating characteristic (ROC) curve validation to prioritize key genes.

Otubain 2 stabilizes TNF‑receptor associated factor 3 to accelerate bone fracture healing.

Increased incidence of traumatic fracture markedly effects the quality of life of patients. Using a rat model of femur fracture, the present study aimed to investigate the effects of otubain 2 (OTUB2), a deubiquitinating enzyme, on bone fracture healing. Bone marrow mesenchymal stem cells (BMSCs) were harvested from the marrow cavity of rat femurs and tibiae and subsequently subjected to osteogenic differentiation .

Risk factors for deep venous thrombosis following total hip arthroplasty: a meta-analysis.

Objective: We aim to investigate the predictors of deep venous thrombosis (DVT) following total hip arthroplasty (THA) by meta-analysis.

Methods: We collected potential indicators of DVT from related literature in the English databases of PubMed, Embase, and the Cochrane Library. We used RevMan 5.

National preoperative HIV prevalence in China: a retrospective analysis of 4,753,874 surgical patients.

The China National HIV Study (CNHS) on the surgical patient population aimed to investigate the preoperative HIV positive rate and secular trends in the surgical patient population of China. The CNHS included a nationally representative sample of participants who were diagnosed with HIV infection between 2009 and 2018 during preoperative screening selected from 27 comprehensive hospitals in nine provinces using a stratified random sampling methodology. The preoperative HIV positive rate was estimated according to age, sex, occupation, urbanization, and hospital level.

Identifying potential biomarkers for early evaluating mechanical compression injuries to skeletal muscle through proteomic analysis: A rat model.

The skeletal muscle is highly susceptible to injury in daily life. Severe skeletal muscle injuries often result in incomplete regeneration, leading to functional impairment. In clinical practice, understanding the extent of skeletal muscle injury in limb trauma patients is crucial for selecting treatment modalities and assessing prognosis.

Advances in spatial transcriptomics and its application in the musculoskeletal system.

While bulk RNA sequencing and single-cell RNA sequencing have shed light on cellular heterogeneity and potential molecular mechanisms in the musculoskeletal system in both physiological and various pathological states, the spatial localization of cells and molecules and intercellular interactions within the tissue context require further elucidation. Spatial transcriptomics has revolutionized biological research by simultaneously capturing gene expression profiles and in situ spatial information of tissues, gradually finding applications in musculoskeletal research. This review provides a summary of recent advances in spatial transcriptomics and its application to the musculoskeletal system.

The role of perioperative transfusion in mortality in geriatric patients with intertrochanteric fracture.

The primary purpose was to assess the incidence and predictors for mortality in Chinese geriatric patients with perioperative transfusion following intertrochanteric fracture (IF) surgery. A total of 1260 patients who received perioperative transfusion following IF surgery between Jan. 2016 and Dec.

All-Cause Mortality Risk in Elderly Patients with Femoral Neck and Intertrochanteric Fractures: A Predictive Model Based on Machine Learning.

Introduction: The aim of this study was to identify the influencing factors for all-cause mortality in elderly patients with intertrochanteric and femoral neck fractures and to construct predictive models.

Methods: This study retrospectively collected elderly patients with intertrochanteric fractures and femoral neck fractures who underwent hip fractures surgery in the Third Hospital of Hebei Medical University from January 2020 to December 2022. Cox proportional hazards regression is used to explore the association between fractures type and mortality.

Establishment of fracture blister model and analysis of plasma protein markers in rats.

Purpose: Fracture blister (FB) is a frequent complication in orthopedic surgery. The primary objective of this study was to refine the animal model of FB and to identify plasma protein markers associated with its development and progression.

Methods: In this study, Sprague-Dawley (SD) rats were used as experimental subjects.

The role of pelvic coronal parameters in determining sagittal balance: a prospective radiographic analysis of pelvic spinopelvic alignment in Chinese asymptomatic Han adolescents.

Background: Adolescent idiopathic scoliosis (AIS) is a complex three-dimensional spinal deformity where sagittal alignment significantly influences clinical outcomes. This study aims to analyze spinopelvic balance parameters in asymptomatic adolescents without scoliosis, examining the correlation between pelvic coronal parameters and sagittal balance parameters to validate their use as preliminary indicators in assessing pelvic rotation.

Methods: A prospective study was conducted involving 354 adolescents (199 females, 155 males) aged 6-18 years who underwent full-length anteroposterior (AP) and lateral spine radiographs at The Third Hospital of Hebei Medical University between October 2022 and December 2023.

Elucidating predictors of preoperative acute heart failure in older people with hip fractures through machine learning and SHAP analysis: a retrospective cohort study.

Background: Acute heart failure (AHF) has become a significant challenge in older people with hip fractures. Timely identification and assessment of preoperative AHF have become key factors in reducing surgical risks and improving outcomes.

Objective: This study aims to precisely predict the risk of AHF in older people with hip fractures before surgery through machine learning techniques and SHapley Additive exPlanations (SHAP), providing a scientific basis for clinicians to optimize patient management strategies and reduce adverse events.

High posterior tibial slope increases anterior cruciate ligament elongation in unicompartmental knee arthroplasty during early-flexion of lunge.

Background: In-silico and in-vitro studies have revealed an appropriate posterior tibial slope (PTS) is critical for normal anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) tension and knee biomechanical behavior of unicompartmental knee arthroplasty (UKA). However, the effects of PTS on in-vivo elongation of ACL and PCL in UKA remains unknown. The study aimed to quantify in-vivo ACL and PCL elongations during lunge and analyze their relations with PTS.

Hounsfield unit correlates with intervertebral disc degeneration in premenopausal and menopausal women: a radiological study.

Objectives: This study aims to investigate whether Hounsfield unit (HU) value is correlated with intervertebral disc (IVD) degeneration (IVDD) by comparing premenopausal with menopausal women patients.

Methods: A total of 101 female patients who underwent treatment in our hospital between February 2022 and February 2023 were retrospectively reviewed and included in this study. All patients were divided into either the premenopausal group or the menopausal group, according to age and menopause status.

Comparative diabetes mellitus burden trends across global, Chinese, US, and Indian populations using GBD 2021 database.

Diabetic mellitus (DM) poses a significant challenge and stress to global health, comparing the burden of disease in the world's three most populous countries while projecting changes in trends in age-standardized rate (ASR) -deaths and disability adjusted life years (DALYs) up to 2050. Using GBD2021 data, we examined DM trends in China, US, India and globally for 1990-2021, and projected deaths and DALYs for DM (types 1 and 2) for 2022-2050 using Bayesian age-period-cohort (BAPC) model. It was found that the ASR-DALYs and deaths for T1DM are trending downward globally, while those for T2DM are trending upward.

A nomogram for predicting ischaemic muscle sequelae after revascularization in patients with traumatic femoral-popliteal artery injuries: a retrospective cohort study.

Purpose: This study aimed to investigate the incidence and associated risk factors of ischaemic muscle sequelae in patients with traumatic femoropopliteal artery injuries following revascularization, as well as to develop a nomogram to predict the risk of ischaemic muscle sequelae.

Methods: Data from patients with acute traumatic femoropopliteal artery injuries between January 2008 and December 2022 were collected. All patients with successful limb salvage were divided into two groups based on the occurrence of ischaemic muscle sequelae: the ischemic muscle sequelae group (IG) and the non-ischaemic muscle sequelae group (NG).

Schistosomiasis trends and control efforts: a global perspective from 1990 to 2050.

Background: Schistosomiasis is a chronic parasitic disease primarily endemic to tropical and subtropical regions, posing significant challenges to public health and economic development. Despite progress in global control efforts, the disease continues to be a major public health concern in high-burden countries such as China, Brazil, and Nigeria. This study seeks to assess the effectiveness of schistosomiasis control measures in these countries and on a global scale.

Investigation of spinopelvic sagittal alignment and its correlations in asymptomatic pediatric populations.

The sagittal alignment of the cervical spine and its relationship with spinopelvic parameters plays a crucial role in maintaining overall postural balance. This study aims to provide normative values for these parameters in asymptomatic pediatric subjects, aiding in the enhancement of treatment and evaluation strategies for spinal deformities and disorders. Conducted at the Third Hospital of Hebei Medical University, this retrospective study included 307 asymptomatic pediatric volunteers aged 4-18 years, screened for scoliosis from January 2021 to July 2023.

Deep vein thrombosis in patients with patellar fractures: Assessing incidence rates and identifying risk factors.

Background: Deep Vein Thrombosis (DVT) represents a significant complication following orthopedic injuries, particularly patellar fractures. Despite the prevalence, comprehensive studies assessing the incidence rates and identifying specific risk factors in patellar fracture patients are limited.

Methods: This retrospective analysis reviewed electronic medical records from 3311 patients treated for patellar fractures at two tertiary hospitals between November 2013 and January 2023.

Development of a predictive model for post-surgical chronic pain: a retrospective analysis of calcaneal fracture patients.

Background: Chronic pain following calcaneal fracture surgery substantially diminishes patients' quality of life, yet effective risk prediction tools remain scarce. This study aimed to develop and validate a reliable predictive model for assessing the risk of chronic pain development after calcaneal fracture surgery.

Methods: This retrospective analysis examined 398 patients who underwent calcaneal fracture surgery between January 2022 and July 2023.