Ultrasound-assisted gram-scale synthesis of nano-tubular ag-MOF and its hybridization with yellow/green carbon quantum dots: membrane-based turn-on fluorescence recognition for procaterol.

Procaterol, a third-generation long-acting β₂-adrenergic receptor agonist, is widely used in asthma and chronic obstructive pulmonary disease (COPD) treatment. Rapid and sensitive detection of Procaterol is essential for both clinical monitoring and environmental surveillance. This study presents a facile and gram-scale synthesis of tubular silver-based Metal-organic framework (MOF) MONT by employing an ultrasonic-assisted green synthesis strategy (20 kHz ultrasound, 100 W power, 30 min).

Multifunctional dynamic cerium-polypeptide hydrogel with antibacterial antioxidative anti-inflammatory for multidrug-resistant bacterial infected wound healing.

Bacterial infection, especially multidrug-resistant (MDR) bacterial infection, is a great challenge in clinical wound repair, highlighting the urgent to develop antibacterial hydrogel dressing. In this work, a multifunctional cerium-polypeptide hydrogel (FEPC) with comprehensive antibacterial, antioxidant, anti-inflammatory and angiogenesis ability was developed for the treatment of methicillin-resistant (MRSA) infected wounds. The FEPC hydrogel was constructed using Ce and antibacterial polypeptide co-crosslinked γ-polyglutamic acid (γ-PGA) through double dynamic electrostatic and coordination interaction.

Interpretable machine learning approaches for predicting prostate cancer by using multiple heavy metal exposures based on the data from NHANES 2003-2018.

Environmental pollution plays a major role in the development of prostate cancer (PCA). However, there has been no research on machine learning (ML) modelling between multiple heavy metal exposures and PCA risk. Based on the 8022 samples from the 2003-2018 National Health and Nutrition Examination Survey (NHANES) database, we utilized the information pertaining to the concentrations of 18 blood and urinary heavy metals and minerals as well as 14 covariates.

Microplastic pollution threatens mangrove carbon sequestration capacity.

Microplastics are a pervasive environmental pollutant, altering microbial communities and disrupting global biogeochemical cycles. Mangrove forests, critical blue carbon habitats, are significant sinks for microplastic accumulation, yet they also cycle large amounts of methane, a potent greenhouse gas. The effect of plastic pollution on methane dynamics in these vital habitats remains, however, poorly understood.

Circ_0084927 promotes progression of intrahepatic cholangiocarcinoma by sponging miR-4725-5p to activate the PDPK1/AKT/mTOR signaling pathway.

Background: Numerous studies have indicated that circular RNAs (circRNA) are involved in the regulation of various malignant tumors, including intrahepatic cholangiocarcinoma (ICC). However, the exact role of circRNA in the progression of ICC and their underlying regulatory mechanisms remain to be further elucidated.

Methods: We investigated the dysregulation of circRNA expression profiles in five pairs of ICC tissues and adjacent normal tissues through high-throughput sequencing, revealing a significant upregulation of circ_0084927.

Correlation of serum trace elements with clinical features and gut microbiota in patients with Crohn's disease.

Changes of several trace elements have been reported to contribute to the pathogenesis of Crohn's disease (CD), which is associated with gut microbiota imbalance. This study aimed to investigate changes in trace elements in Chinese CD patients, and explore the correlation of trace element status with clinical features and gut microbiota. Eighty CD patients and 45 healthy volunteers were enrolled between July 2022 and November 2022.

Trajectories of Cognitive Change and Their Association with All-Cause Mortality Among Chinese Older Adults: Results from the Chinese Longitudinal Healthy Longevity Survey.

The analysis of cognitive trajectories is relatively underexplored in China. Furthermore, most previous studies examining the association between cognitive function and mortality have been limited to cross-sectional perspectives. This study aims to identify distinct cognitive trajectories and the corresponding influencing factors and investigate the impact of these trajectories on all-cause mortality in Chinese older adults.

CircMFN2/miR-361-3p/ELK1 feedback loop promotes glutaminolysis and the progression of hepatocellular carcinoma.

Current evidence indicates that circRNAs are involved in the development of multiple malignancies including hepatocellular carcinoma (HCC). However, the specific functions of circRNAs in HCC metabolism and progression and their underlying regulatory mechanisms remain unclear. We have identified a novel circRNA circMFN2, by bioinformatics analysis of circRNA microarray data from the GEO database.

Class A1 scavenger receptor antibody improves murine colitis by influencing macrophage and gut microbiota.

This study aimed to investigate whether class A1 scavenger receptor (SR-A1) regulated macrophage polarization and gut microbial alteration during intestinal inflammation of colitis. A murine colitis model was established by feeding with dextran sulfate sodium (DSS), and treatment groups were injected intravenously with SR-A1 antibody. Results showed a preventive effect on colitis symptoms and fewer inflammatory cell infiltrates in treatment groups.

A hybrid unsupervised clustering method for predicting the risk of dental implant loss.

Objectives: The aim of this study was to predict the risk of dental implant loss by clustering features associated with implant survival rates.

Materials And Methods: Multiple clinical features from 8513 patients who underwent single implant placement were retrospectively analysed. A hybrid method integrating unsupervised learning algorithms with survival analysis was employed for data mining.

Bioactive poly(salicylic acid)-poly(citric acid) scaffolds improve diabetic wound repair via regulating HIF-1α, Nrf2 and macrophage.

Diabetic wounds environment is over-oxidized, over-inflammatory, leading to difficulties in regenerating blood vessels, and retardation of healing in diabetic wounds. Therefore, diabetic wounds can be treated from the perspective of scavenging oxidative free radicals and reducing the level of inflammation. Herein, we report a bioactive poly(salicylic acid)-poly(citric acid) (FPSa-PCG) hydrogel for diabetic wound repair.

Crosstalk Between circRNA and Tumor Microenvironment of Hepatocellular Carcinoma: Mechanism, Function and Applications.

Hepatocellular carcinoma (HCC) is one of the most common aggressive tumors in the world. Despite the availability of various treatments, its prognosis remains poor due to the lack of specific diagnostic indicators and the high heterogeneity of HCC cases. CircRNAs are noncoding RNAs with stable and highly specific expression.

Predictive value of HTS grade in patients with intrahepatic cholangiocarcinoma undergoing radical resection: a multicenter study from China.

Background: Intrahepatic cholangiocarcinoma (ICC) is a highly malignant tumor with a poor prognosis. This study aimed to investigate whether Hemoglobin, Albumin, Lymphocytes, and Platelets (HALP) score and Tumor Burden Score (TBS) serves as independent influencing factors following radical resection in patients with ICC. Furthermore, we sought to evaluate the predictive capacity of the combined HALP and TBS grade, referred to as HTS grade, and to develop a prognostic prediction model.

Rethinking Lightweight Salient Object Detection via Network Depth-Width Tradeoff.

Existing salient object detection methods often adopt deeper and wider networks for better performance, resulting in heavy computational burden and slow inference speed. This inspires us to rethink saliency detection to achieve a favorable balance between efficiency and accuracy. To this end, we design a lightweight framework while maintaining satisfying competitive accuracy.

Capsulized Fecal Microbiota Transplantation Induces Remission in Patients with Ulcerative Colitis by Gut Microbial Colonization and Metabolite Regulation.

Fecal microbiota transplantation (FMT) can induce clinical remission in ulcerative colitis (UC) patients. Enemas, nasoduodenal tubes, and colonoscopies are the most common routes for FMT administration. However, there is a lack of definitive evidence regarding the effectiveness of capsulized FMT treatment in UC patients.

Boosting Broader Receptive Fields for Salient Object Detection.

Salient Object Detection has boomed in recent years and achieved impressive performance on regular-scale targets. However, existing methods encounter performance bottlenecks in processing objects with scale variation, especially extremely large- or small-scale objects with asymmetric segmentation requirements, since they are inefficient in obtaining more comprehensive receptive fields. With this issue in mind, this paper proposes a framework named BBRF for Boosting Broader Receptive Fields, which includes a Bilateral Extreme Stripping (BES) encoder, a Dynamic Complementary Attention Module (DCAM) and a Switch-Path Decoder (SPD) with a new boosting loss under the guidance of Loop Compensation Strategy (LCS).

Photoactivated MXene Nanosheets for Integrated Bone-Soft Tissue Therapy: Effect and Potential Mechanism.

The bone defects caused by trauma are inevitably accompanied by soft tissue damage. The development of multifunctional bioactive biomaterials with integrated bone and soft tissue regeneration is necessary and needed urgently in orthopedics. In this work, we found that the photoactivated MXene (TiCT) nanosheet showed positive effects on promoting both bone and soft tissue regeneration.

Multi-layer-structured bioactive glass nanopowder for multistage-stimulated hemostasis and wound repair.

Current treatments for full-thickness skin injuries are still unsatisfactory due to the lack of hierarchically stimulated dressings that can integrate the rapid hemostasis, inflammation regulation, and skin tissue remodeling into the one system instead of single-stage boosting. In this work, a multilayer-structured bioactive glass nanopowder (BGN@PTE) is developed by coating the poly-tannic acid and ε-polylysine onto the BGN facile layer-by-layer assembly as an integrative and multilevel dressing for the sequential management of wounds. In comparison to BGN and poly-tannic acid coated BGN, BGN@PTE exhibited the better hemostatic performance because of its multiple dependent approaches to induce the platelet adhesion/activation, red blood cells (RBCs) aggregation and fibrin network formation.

Novel deep learning-based computer-aided diagnosis system for predicting inflammatory activity in ulcerative colitis.

Background And Aims: Endoscopy is increasingly performed for evaluating patients with ulcerative colitis (UC). However, its diagnostic accuracy is largely affected by the subjectivity of endoscopists' experience and scoring methods, and scoring of selected endoscopic images cannot reflect the inflammation of the entire intestine. We aimed to develop an automatic scoring system using deep-learning technology for consistent and objective scoring of endoscopic images and full-length endoscopic videos of patients with UC.