A nomogram for predicting progress-free survival in primary extramedullary multiple myeloma using routine laboratory variables.

Objectives: Extramedullary involvement in multiple myeloma (MM) represents aggressive disease, with clinical stratification of primary extramedullary disease (EMD) remaining a challenge. In this study, we aimed to develop a credible nomogram utilizing routine laboratory variables to predict individual survival for primary EMD patients.

Methods: We retrospectively analyzed a cohort of 60 primary EMD patients, from January 2006 to December 2022.

Cysteine dioxygenase knockout and taurine deficiency impair mouse uterine adenogenesis by inhibiting epithelial cell proliferation and enhancing apoptosis.

Uterine glands and their secretions are essential for conceptus survival and development, with abnormalities in uterine gland morphogenesis (adenogenesis) are closely related to high rates of peri-implantation embryonic loss in humans and livestock. While uterine adenogenesis occurs postnatally in most mammals, the key regulatory factors and mechanisms governing this developmental event remains largely unexplored. Our recent study reveals that cysteine dioxygenase (CDO) is highly expressed in the uterus of adult mice, which is also rich in taurine.

Bioactive metal-protein matrix for promoting MRSA infection wound therapy through bioenergy-induced angiogenesis.

Wound healing impaired by multidrug-resistant bacteria (MDRB) remains a significant clinical challenge, primarily due to persistent bacterial infection, excessive inflammation, overproduction of reactive oxygen species (ROS), and compromised vascularization. Importantly, the cellular metabolic state plays a vital role in regulating cellular behavior, and strategies aimed at enhancing cellular energy metabolism hold great promise for promoting tissue regeneration. Herein, we present a multifunctional and bioactive silk fibroin-poly(citrate-curcumin)-metal-based biomimetic matrix (SFPC) designed to treat methicillin-resistant staphylococcus aureus (MRSA)-infected wounds by promoting bioenergy-induced angiogenesis.

Progression of disease within 6 months: revised early disease progression threshold for ENKTL.

The progression of disease (POD) within 24 months is well-established as an early indicator in various lymphomas. However, the aggressive nature of extranodal NK/T-cell lymphoma (ENKTL) necessitates a shorter assessment period. In this study, we examined POD metrics in 170 newly diagnosed ENKTL patients receiving asparaginase-based regimens.

Progress in the study of the effects of selective serotonin reuptake inhibitors (SSRIs) on the reproductive system.

In recent years, the increasing number of infertility cases has led to a greater research focus on the reproductive toxicity of drugs due to the fact that some classes of pharmacotherapeutic agents have been found to exert deleterious effects on the reproductive system. Depressive disorders are a class of common mental illnesses that seriously damage human health. The variety of antidepressant drugs is large and the incidence of adverse effects is high.

Pseudocavity on Thin-slice CT Can Be a Suggestion of Bronchiolar Adenoma: A Preliminary Study on 80 Cases With Bronchiolar Adenoma of the Lung.

Objectives: At present, the study of bronchiolar adenoma (BA) mainly focuses on its pathologic characteristics, but there is limited understanding of its clinical manifestations and imaging signs. This article aims to summarize the clinical manifestations and imaging features of 80 cases of BA, with the goal of achieving a comprehensive and systematic understanding of BA.

Materials And Methods: We retrospectively analyzed 80 patients with BA confirmed by surgical pathology in our hospital.

Multimodal ultrasonography features of the extramedullary plasmacytomas in multiple myeloma: a retrospective case series study.

Aims: To investigate the multimodal ultrasonography (US) features of extramedullary plasmacytomas (EMPs) in patients with multiple myeloma (MM).

Material And Methods: Nine patients with MM who were diagnosed EMPs and underwent multimodal ultrasonography were enrolled in this study. Clinical information and multimodal US results were retrospectively analyzed.

Towards automatical tumor segmentation in radiomics: a comparative analysis of various methods and radiologists for both region extraction and downstream diagnosis.

Objective: By discussing the difference, stability and classification ability of tumor contour extracted by artificial intelligence and doctors, can a more stable method of tumor contour extraction be obtained?

Methods: We propose a novel framework for the automatic segmentation of lung tumor contours and the differential diagnosis of downstream tasks. This framework integrates four key modules: tumor segmentation, extraction of radiomic features, feature selection, and the development of diagnostic models for clinical applications. Using this framework, we conducted a study involving a cohort of 1,429 patients suspected of lung cancer.

Advanced Thermoactive Nanomaterials for Thermomedical Tissue Regeneration: Opportunities and Challenges.

Nanomaterials usually possess remarkable properties, including excellent biocompatibility, unique physical and chemical characteristics, and bionic attributes, which make them highly promising for applications in tissue regeneration. Thermal therapy has emerged as a versatile approach for wound healing, nerve repair, bone regeneration, tumor therapy, and antibacterial tissue regeneration. By combining nanomaterials with thermal therapy, multifunctional nanomaterials with thermogenic effects and tissue regeneration capabilities can be engineered to achieve enhanced therapeutic outcomes.

Phase 1 study of isatuximab monotherapy in Chinese patients with relapsed/refractory multiple myeloma.

In this multi-center, Phase-1 study (NCT03733717), we characterized the pharmacokinetics (PK) of the anti-CD38 antibody isatuximab (Isa) after IV administration (primary objective), and evaluated safety, immunogenicity, and preliminary anti-myeloma activity in Chinese patients with relapsed/refractory multiple myeloma (RRMM). Isa 20-mg/kg was administered weekly (QW) in cycle 1, then biweekly (Q2W). Twenty-one extensively pretreated RRMM patients (median 4 prior lines; 95.

Tailoring Copper Single-Atoms-Stabilized Metastable Transition-Metal-Dichalcogenides for Sustainable Hydrogen Production.

Unconventional 1T' phase transition metal dichalcogenides (TMDs) show great potential for hydrogen evolution reaction (HER). However, they are susceptible to transitioning into the stable 2H phase, which reduces their catalytic activity and stability. Herein, we present a scalable approach for designing thermally stable 1T'-TMDs hollow structures (HSs) by etching CuS templates from pre-synthesized CuS@TMDs heterostructures, including 1T'-MoS, MoSe, WS, and WSe HSs.

Intrinsically bioactive multifunctional Poly(citrate-curcumin) for rapid lung injury and MRSA infection therapy.

Dysregulated inflammation after trauma or infection could result in the further disease and delayed tissue reconstruction. The conventional anti-inflammatory drug treatment suffers to the poor bioavailability and side effects. Herein, we developed an amphiphilic multifunctional poly (citrate-polyglycol-curcumin) (PCGC) nano oligomer with the robust anti-inflammatory activity for treating acute lung injury (ALI) and (MRSA) infected wound.

Solution-Processable Microstructuring of 1T'-Phase Janus MoSSe Monolayers for Boosted Hydrogen Production.

Janus monolayers of transition metal dichalcogenides (TMDs) offer versatile applications due to their tunable polymorphisms. While previous studies focused on conventional 2H-phase Janus monolayers, the scalable synthesis of an unconventional 1T' phase remains challenging. We present a novel solution strategy for fabricating Janus 1T'-MoOSe and MoSSe monolayers by growing sandwiched Se-Mo-O/S shells onto Au nanocores.

The risk and survival of multiple myeloma as the second primary malignancy in a single Chinese center.

Background: As the overall survival (OS) of patients with multiple myeloma (MM) improves, the incidence of second primary malignancy (SPM) in long-term complications increases. However, there are limited data regarding MM as a SPM. Therefore, this study aimed to determine the time trends in the incidence of MM, as well as the incidence and survival of patients with MM as the SPM.

Dynamic Single-Cell RNA-Seq reveals mechanism of Selinexor-Resistance in Chronic myeloid leukemia.

Chronic myeloid leukemia (CML) is a type of hematologic malignancies caused by BCR-ABL chimeric oncogene. Resistance to tyrosine kinase inhibitors (TKIs) leads to the progression of CML into advanced stages. Selinexor is a small molecule inhibitor that targets a nuclear transporter called Exportin 1.

SOX10 deficiency-mediated LAMB3 upregulation determines the invasiveness of MAPKi-resistant melanoma.

Melanoma that develops adaptive resistance to MAPK inhibitors (MAPKi) through transcriptional reprograming-mediated phenotype switching is associated with enhanced metastatic potential, yet the underlying mechanism of this improved invasiveness has not been fully elucidated. In this study, we show that MAPKi-resistant melanoma cells are more motile and invasive than the parental cells. We further show that LAMB3, a β subunit of the extracellular matrix protein laminin-332 is upregulated in MAPKi-resistant melanoma cells and that the LAMB3-Integrin α3/α6 signaling mediates the motile and invasive phenotype of resistant cells.

Ultrathin heteroatom-doped CeO nanosheet assemblies for durable oxygen evolution: Oxygen vacancy engineering to trigger deprotonation.

The manipulation of oxygen vacancies (OVs) in metal oxides has progressively emerged as a versatile strategy for improving their catalytic performance. In this study, we aim to enhance the oxygen evolution reaction (OER) performance of cerium oxide (CeO) by doping heteroatoms (Fe, Co, Ni) to generate additional OVs. We systematically analyzed both the morphology and electronic structure of the obtained CeO catalysts.

Sprayable self-assembly multifunctional bioactive poly(ferulic acid) hydrogel for rapid MRSA infected wound repair.

The repair of methicillin-resistant staphylococcus aureus (MRSA) infected wounds remains a serious challenge. Development of multifunctional bioactive hydrogels has shown promising potential in treating MRSA wound. Ferulic acid has special bioactivities including antioxidant antiinflammation antibacterial capacities but limited in lack of engineering strategy for efficient treatment of MRSA infected wound.

Nurses' Colleague Solidarity and Job Performance: Mediating Effect of Positive Emotion and Turnover Intention.

Background: Job performance is known as an essential reflection of nursing quality. Colleague solidarity, positive emotion, and turnover intention play effective roles in a clinical working environment, but their impacts on job performance are unclear. Investigating the association between nurses' colleague solidarity and job performance may be valuable, both directly and through the mediating roles of positive emotion and turnover intention.

Liquid extramedullary disease in multiple myeloma strongly predicts a poor prognosis and is associated with bortezomib resistance gene upregulation.

Background-aim: Patients with multiple myeloma (MM) relapse with extramedullary disease (EMD) exhibits an aggressive disease course and poor prognostic features. Myelomatous effusion (ME) is a rare subtype of EMD.

Methods: In this retrospective study, we analyzed the baseline characteristics and therapies of 14 EMD patients relapse with ME and 21 EMD patients relapse without ME.

Fine particulate matter exposure disturbs autophagy, redox balance and mitochondrial homeostasis via JNK activation to inhibit proliferation and promote EMT in human alveolar epithelial A549 cells.

Epidemiologic studies have demonstrated a direct correlation between fine particulate matter (FPM) exposure and the high risk of respiratory diseases. FPM can penetrate deep into the lung and deposit in the alveoli with breath, where it directly interacts with alveolar epithelial cell (APC). However, we know little about the effects nor mechanisms of FPM on APC.

Identification of evolutionary mechanisms of myelomatous effusion by single-cell RNA sequencing.

Myelomatous effusion (ME) is a rare manifestation of extramedullary multiple myeloma (MM) with limited therapeutic options and poor outcomes. The molecular mechanisms underlying ME are incompletely understood. We profiled transcriptomes of bone marrow, peripheral blood (PB), and pleural effusion/ascites from 3 patients with ME using single-cell RNA sequencing analysis.

A bionic "Trojan horse"-like gene delivery system hybridized with tumor and macrophage cell membrane for cancer therapy.

MiRNA-based gene therapy as a novel targeted therapy has yielded promising results in experimental cancer treatment, however, the inefficient delivery of miRNA to target tissues has limited its application in vivo. Here a unique dual-membrane-camouflaged miRNA21 antagomir delivery nanoplatform (M@NPs/miR21) with immune escape and homologous targeting properties was constructed by cancer cell membrane and macrophage membrane. Different from the single-cell membrane camouflage strategy, the dual-membrane camouflage miRNA21 antagomir delivery nanoplatform based on modification of CD47 protein with immune escape signal and galectin-3 protein with tumor cell aggregation enables efficient, safe and targeted therapy for colon cancer and lung metastases.