Screening, UV Mutagenesis, and Exploration of Enzymatic Degradation Mechanisms in the Highly Efficient Polyurethane-Degrading Bacillus sp. J-11.

Aims: This research aims to screen and identify a microbial strain capable of efficiently degrading waterborne polyurethane used in the biomedical field. Furthermore, the research seeks to enhance the strain's degradation capability through ultraviolet mutagenesis and elucidate its enzymatic degradation mechanism.

Methods And Results: We successfully isolated the target strain from the soil sample and identified it as Bacillus sp.

Efficacy of hepatic artery infusion chemotherapy combined with tyrosine kinase inhibitors (TKIs) in advanced hepatocellular carcinoma: a comparison with transarterial chemoembolization combined with TKIs.

BackgroundHepatic artery infusion chemotherapy (HAIC) combined with tyrosine kinase inhibitors (TKIs) shows promise for treating advanced hepatocellular carcinoma (HCC).PurposeTo compare the efficacy and safety of HAIC versus transarterial chemoembolization (TACE), each combined with TKIs, in patients with advanced HCC.Material and MethodsThis retrospective study analyzed 86 patients with unresectable HCC, predominantly Barcelona Clinic Liver Cancer (BCLC) stage B/C and with well-preserved liver function, treated at a tertiary medical center between January 2019 and December 2022.

Proteomics and metabolomics studies in pigmented villonodular synovitis uncover the regulation of monocyte differentiation by the ADGRE5-NF-κB pathway.

Background: Pigmented villonodular synovitis (PVNS), or tenosynovial giant cell tumor (TGCT), is a locally aggressive soft tissue tumor primarily affecting the synovium of joints, particularly the knee. In PVNS, the synovial tissue thickens and becomes aggressive, leading to joint destruction, a process reminiscent of the tissue remodeling seen in autoimmune diseases. Despite being considered benign, PVNS often leads to severe joint damage and has a high recurrence rate following treatment.

A case report of advanced small intestinal stromal tumor with KIT gene mutation and BRCA2 deletion after multi-line treatments.

This study reports a 40-year-old male with small intestinal stromal tumor (SIST). After initial surgery and adjuvant imatinib, the tumor recurred. The patient then received multiple rounds of treatment with targeted drugs and surgical interventions.

Nanozyme-driven self-assembled rhein gels for osteoarthritis therapy: Alleviating chondrocyte inflammation by reprogramming macrophages.

Osteoarthritis (OA), the fourth leading cause of global disability, is marked by progressive cartilage loss, synovial inflammation, and dysregulated bone remodeling. Current therapeutic strategies are hindered by systemic adverse effects and insufficient intra-articular drug bioavailability, underscoring the demand for enhanced delivery mechanisms. In this study, we developed a CeO nanozyme-driven gel system synergistically integrated with the herbal monomer rhein (RH).

Performance comparison of two telescope configurations for backscattered light in space gravitational wave detection.

In space-based gravitational wave detection telescopes, backscattered light generated by the optical elements of the telescope interferes with the received signals, affecting interference measurements. Therefore, the analysis and suppression of backscattered light are crucial issues that must be considered in the telescope. In this paper, the results of a numerical model and simulation analysis are compared to analyze the stray light performance of two existing optical design schemes for telescopes.

Fetal exposure to famine increases the risk of cardiovascular disease in adulthood: findings from a population-based screening study.

Introduction: Undernutrition during early life may increase the risk of chronic diseases in adulthood. The study aimed to investigate whether fetal exposure to famine would increase the risk of cardiovascular disease (CVD) in adulthood.

Materials And Methods: Data were collected from 16 sites in Henan by the China Patient-centered Evaluative Assessment of Cardiac Events (PEACE) Million Persons Project.

Molecular mechanisms of dose-dependent regulation of hepatic lipid metabolism by BaP through modulation of AhR binding to XRE1 or XRE3.

Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon and a potent environmental pollutant, has been implicated in the dysregulation of lipid metabolism and metabolic diseases, warranting investigation into its effects on liver functions, particularly regarding fibroblast growth factor 21 (FGF21) mediated pathways. This study aimed to elucidate the effects of BaP on liver lipid metabolism and FGF21 expression via the aryl hydrocarbon receptor (AhR), with a focus on the regulatory interactions between BaP and xenobiotic response elements (XRE) within the promoter region of FGF21. Utilizing HepG2 cells, lipid accumulation was assessed through Oil Red O and Nile Red staining, while the expression of FGF21 protein was quantified by Western blotting and immunofluorescence techniques.

MARCH5 Promotes Cardiac Hypertrophy by Regulating Akt/mTOR/Gsk-3β/GATA4 Signalling Pathway.

This study aims to elucidate the role of MARCH5 in cardiac hypertrophy, thereby providing a theoretical foundation for novel therapeutic strategies for cardiac hypertrophy and heart failure. The expression of MARCH5 in cardiac hypertrophy models was assessed using immunohistochemistry, western blot (WB) and RT-qPCR. Gain- and loss-of-function experiments of MARCH5 in cardiac hypertrophy were conducted both in vitro and in vivo.

Protein regulatory network mediated by palmitoylation modifications in the pathological progression of Parkinson's disease: a narrative review.

Palmitoylation is a reversible lipid modification regulated by palmitoyl transferases and acyl-protein thioesterases, in which palmitic acid is attached to protein cysteine residues. This modification plays a pivotal role in modulating membrane localization and protein stability, and its dysregulation is closely associated with various neurodegenerative diseases, including Parkinson's disease (PD). In PD, synaptotagmin-11, encoded by the PD risk gene , has been shown to reduce physiological α-synuclein (α-syn) tetramer formation while promoting the aggregation-prone monomeric form in a palmitoylation-dependent manner.

Chronic lipopolysaccharide exposure promotes cognitive impairments by activating TRPC6-AIM2 inflammasome signaling and the regulation of ginsenoside Rg1 in Trpc6 mice.

Background: Chronic neuroinflammation is a pivotal pathogenesis in neurodegenerative diseases (NDDs). Transient receptor potential canonical protein 6 (TRPC6) has an essential role in the maintenance of calcium homeostasis in cells. Our previous study indicated that TRPC6 signaling is involved in Aβ deposition and NLRP1 inflammasome activation in type 2 diabetes mellitus-associated cognitive dysfunction.

Splicing factor 3b subunit 1 mutation patterns and prognostic implications in myelodysplastic syndromes, acute myeloid leukemia, and chronic lymphocytic leukemia: A retrospective study of 1691 cases.

Background: Splicing factor 3b subunit 1 (SF3B1) mutations have been implicated in hematologic malignancies, but the clinical significance of distinct SF3B1 mutation variants remain unclear.

Methods: The objective of this study was to evaluate clinicopathologic features, mutational profiles, and outcomes of 1691 patients with hematologic malignancies, including myelodysplastic syndromes (MDS; n = 402), acute myeloid leukemia (AML; n = 758), and chronic lymphocytic leukemia (CLL; n = 531).

Results: The frequency of SF3B1-mutated (SF3B1) MDS, AML, and CLL was 70 of 402 patients (17.

Educational impacts of generative artificial intelligence on learning and performance of engineering students in China.

With the rapid advancement of generative artificial intelligence (AI), its potential applications in higher education have attracted significant attention. This study investigated how 148 students from diverse engineering disciplines and regions across China used generative AI, focusing on its impact on their learning experience and the opportunities and challenges it poses in engineering education. Based on the surveyed data, we explored four key areas: the frequency and application scenarios of AI use among engineering students, its impact on students' learning and performance, commonly encountered challenges in using generative AI, and future prospects for its adoption in engineering education.

Closed-loop cathode recycling of spent lithium batteries via green deep eutectic solvents and oxalic acid.

The eco-friendly recovery of strategic metals from spent lithium-ion batteries is pivotal for realizing circular economy goals. This study introduces a low-viscosity hydrated deep eutectic solvent (DES) composed of citric acid (CA) and choline chloride (ChCl) for the efficient extraction of crucial metals from spent LiNiCoMnO (NCM) cathodes. The leaching parameters were optimized within response surface methodology (RSM), and maximum extraction efficiencies of 97.

Erratum: MiR-1205 functions as a tumor suppressor by disconnecting the synergy between KRAS and MDM4/E2F1 in non-small cell lung cancer.

[This corrects the article on p. 312 in vol. 9, PMID: 30906631.

Switching off Competing Hydrogen Formation in CO Electroreduction via Substrate Defect Engineering.

Carbon nanotubes (CNTs) are widely used as supports for immobilizing molecular electrocatalysts, such as for CO reduction (COR), with π-π interactions often assumed to govern the catalyst immobilization. However, the nature of catalyst/CNTs interactions remains insufficiently understood. Here, nickel phthalocyanine (NiPc) is investigated, a benchmark COR catalyst, supported on CNTs.

METTL3-dependent m6A modification of ERO1A mRNA regulates trophoblast migration and invasion in early-onset severe preeclampsia.

Introduction: N6-methyladenosine (m6A) is a common epigenetic modification of eukaryotic RNA that plays a vital role in the physiological and pathogenesis of preeclampsia (PE). Methyltransferase-like 3 (METTL3) is a methyltransferase of m6A. However, the function of METTL3 in early onset severe pre-eclampsia (EO-sPE) remains to be studied.

Targeting macrophage glucose metabolism: Polysaccharide-iron nanozyme-mediated reactive oxygen species/iron homeostasis restoration ameliorates inflammatory bowel disease with anemia comorbidity.

Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder characterized by intestinal inflammation, with frequent progression to complications including intestinal stenosis, obstruction, and perforation. The sustained inflammatory burden and gastrointestinal bleeding in IBD culminate in systemic iron depletion, predisposing patients to iron deficiency anemia (IDA). Here, we report a rationally engineered nanozyme, Radix Paeoniae Alba polysaccharide‑iron complexes (PPFeCs), designed to integrate superoxide dismutase-/catalase-mimicking antioxidase activities with bioavailable iron delivery for simultaneous management of IBD and its IDA comorbidity.

IB-AGC: Annual 25 km global live biomass carbon product from SMOS L-band passive microwave vegetation optical depth.

Monitoring aboveground biomass carbon (AGC) stocks and their changes is crucial for understanding the global carbon cycle and the impact of climate change. Among remotely sensed methods, the use of the L-band (1.4 GHz) vegetation optical depth (L-VOD) derived from passive microwave satellite observations, offers rapid updates for timely monitoring of interannual AGC changes.

Amino Acid Ionic Liquid Two-Phase System: Construction and Its Application for Green Gold Recovery from E-waste Thiosulfate Leachate.

Although gold extraction from electronic waste using thiosulfate is a highly promising approach, the recovery of gold from thiosulfate leaching solutions still poses a significant challenge. To enable more environmentally friendly gold recycling, aqueous two-phase systems (ATPSs) composed of guanidinium amino acid ionic liquids (TMG-AA ILs) and phosphates were developed for extracting gold from thiosulfate-leached solutions of electronic waste. Key parameters affecting Au(I) extraction were systematically investigated, including the types and concentrations of TMG-AA ILs and inorganic salts, initial gold concentration, temperature, and reaction time.

Association of weight-adjusted waist index with all-cause and cardiovascular disease mortality among rheumatoid arthritis population: a cohort study from the NHANES 1999-2018.

Background: Rheumatoid arthritis (RA) represents a pressing global health challenge. While obesity is a controllable risk factor for RA patients, traditional body measurements like body mass index (BMI) have shown limitations in assessing risk. The weight-adjusted waist index (WWI), a new measurement method, provides better insight into belly fat distribution patterns.

Case Report: subhepatic appendicitis complicated by hepatic abscess as the initial presentation of primary diffuse large B-cell lymphoma of the appendix: first reported case.

Subhepatic appendicitis complicated by hepatic abscess is an uncommon clinical condition due to anatomical variations in the appendix's position. Here, we report an unusual case of a 56-year-old male who initially presented with right abdominal pain and fever, misdiagnosed as bilateral kidney stones and urinary tract infection. Subsequent abdominal CT(Computed Tomography) scans revealed subhepatic appendicitis with a hepatic abscess located in segment VI of the liver.

Selective and Energy Efficient Electrocatalytic CO-to-Ethanol Conversion through Anion Modulation.

Ethanol, with its high market value and stable global demand, stands out as an attractive product of electrocatalytic CO reduction. However, achieving high ethanol selectivity and energy efficiency at industrial current densities remains challenging. In this study, we employed a blended anion modulation strategy to enhance the selectivity and energy efficiency of CO-to-ethanol conversion.

Realization of Spin-locked Acoustic Helical Landau Levels in both Hexagonal and Square Lattices.

Topological zeroth-order Landau levels offer a promising avenue for steering acoustic and electromagnetic waves. However, the helical Landau levels in 2D acoustic systems remain an unresolved challenge. Moreover, previous studies on zeroth-order Landau levels have primarily focused on hexagonal lattices, leaving their counterparts in square lattices largely unexplored.