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In recent years, there has been a significant increase in academic interest regarding the sleep quality of university students. Physical exercise has been extensively studied for its association with sleep quality in this population. However, the roles of anxiety and subjective well-being in mediating the relationship between physical exercise and sleep quality require further investigation. This study examines the interplay between physical exercise (independent variable), sleep quality (dependent variable), and the chain mediating effects of anxiety (mediator 1) and subjective well-being (mediator 2). A sample of 4,142 university students (1,525 males and 2,617 females; mean age = 19.05 ± 1.16 years) participated in this study. Cross-sectional self-report measures were used to assess physical exercise, anxiety levels, subjective well-being, and sleep quality. SPSS software facilitated descriptive statistics and correlation analyses. Subsequently, the SPSS PROCESS macro was employed to test and construct the chain mediation model described in the background and objective. The findings revealed a significant positive relationship between physical exercise and both sleep quality and subjective well-being, whereas a significant negative correlation was observed between physical exercise and anxiety. Furthermore, anxiety exhibited a negative association with sleep quality and subjective well-being. Importantly, anxiety and subjective well-being were found to sequentially mediate the link between physical exercise and sleep quality. By integrating clinical psychological (anxiety) and positive psychological (subjective well-being) factors, this study provides deeper insights into the mechanisms through which physical exercise influences sleep quality in college students. Encourage college students to engage in regular physical exercise, as this is often linked to anxiety, subjective well-being, and sleep quality, thereby leading to a higher quality of life.
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http://dx.doi.org/10.1038/s41598-025-16017-1 | DOI Listing |
JAMA Intern Med
September 2025
Bayer CC AG, Basel, Switzerland.
Importance: There is an unmet need for long-term, safe, effective, and hormone-free treatments for menopausal symptoms, including vasomotor symptoms (VMS) and sleep disturbances.
Objective: To evaluate the 52-week efficacy and safety of elinzanetant, a dual neurokinin-targeted therapy, for treating moderate to severe VMS associated with menopause.
Design, Setting, And Participants: OASIS-3 was a double-blind, placebo-controlled, randomized phase 3 clinical trial that was conducted at 83 sites in North America and Europe from August 27, 2021, to February 12, 2024, and included postmenopausal women aged 40 to 65 years who were seeking treatment for moderate to severe VMS (no requirement for a minimum number of VMS events per week).
JAMA Netw Open
September 2025
School of Rehabilitation Science, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Importance: The cost-effectiveness of adding early in-bed cycling to usual physiotherapy among adults receiving mechanical ventilation in the intensive care unit (ICU) compared with usual physiotherapy alone is unknown.
Objective: To evaluate the cost-effectiveness of in-bed cycling plus usual physiotherapy compared with usual therapy alone in the Critical Care Cycling to Improve Lower Extremity Strength (CYCLE) randomized clinical trial.
Design, Setting, And Participants: This trial-based economic evaluation with a 90-day time horizon compared early cycling plus usual physiotherapy vs usual physiotherapy alone from a societal perspective.
Crohns Colitis 360
July 2025
Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, United States.
Introduction: Acute severe ulcerative colitis (ASUC) typically requires hospitalization for intravenous (IV) corticosteroid treatment and monitoring. In response to the need to reduce inpatient stays, especially during the COVID-19 pandemic, outpatient treatment models have gained interest. This study evaluated the feasibility, safety, and patient satisfaction of outpatient IV corticosteroid treatment for ASUC.
View Article and Find Full Text PDFSAGE Open Nurs
September 2025
Nursing College, Palestine Polytechnic University, Hebron, Palestine.
Background: Nurse burnout remains a significant global challenge, exacerbated by rotating shift work, which disrupts circadian rhythms and contributes to psychological strain. Burnout is characterized by emotional exhaustion, depersonalization, and reduced personal accomplishment-outcomes that can compromise patient care and workforce stability.
Objective: This systematic review examines the association between rotating shift work and nurse burnout, focusing on how specific shift characteristics influence each burnout dimension and exploring contextual moderators such as organizational support and work environment.