Co-delivery paclitaxel and IR783 as nanoparticles for potentiated chemo-photothermal-immunotherapy of triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is highly malignant and invasive, which is the major challenge of breast cancer treatment. Although chemo-immunotherapy is currently the most promising treatment option, its efficacy in treating TNBC is limited due to challenges such as low immune response rate and severe side effects. In this study, a nanocarrier PEI-GCP(Z)/mPEG with excellent water solubility and high drug-loading capacity was designed, and it was used to load the paclitaxel (PTX) and photosensitizer IR783 to prepare nanoparticles PEI-GCP(Z)/mPEG@PTX@IR783 (PPI).

Correction: TBAI-mediated electrochemical oxidative synthesis of quinazolin-4(3)-ones from 2-aminobenzamides and isothiocyanates.

Correction for 'TBAI-mediated electrochemical oxidative synthesis of quinazolin-4(3)-ones from 2-aminobenzamides and isothiocyanates' by Jingbin Huang , , 2025, , 4860-4865, https://doi.org/10.1039/d5ob00410a.

Electrooxidation-induced arylsulfonylation of xanthene derivatives with DABSO as an SO surrogate.

An electrochemical redox C(sp)-H arylsulfonylation of xanthenes has been developed using aryl diazonium tetrafluoroborates and DABSO as the arylsulfone source. This radical reaction proceeds the formation of arylsulfonyl radicals from the reaction between aryl diazonium tetrafluoroborates and DABSO, followed by a radical cross-coupling process. Notably, the reaction occurs in the absence of any catalyst or external oxidant, providing efficient sulfonylation of xanthenes with broad functional group compatibility.

TBAI-mediated electrochemical oxidative synthesis of quinazolin-4(3)-ones from 2-aminobenzamides and isothiocyanates.

A practical protocol has been established to access 2-aminoquinazolin-4(3)-one derivatives through the electrochemical desulfurative cyclization of 2-aminobenzamides and isothiocyanates. The protocol allows for the formation of C-N bonds under mild conditions without metal catalysts or external oxidants. The practicability of this strategy is demonstrated by its broad substrate scope, good functional group compatibility, and scale-up synthesis.

Pericardiectomy with routine cardiopulmonary bypass: a multicenter, randomized controlled trial.

Constrictive pericarditis is a result of chronic inflammation characterized by thickening and calcification of pericardial fibers, impaired diastolic filling, reduced cardiac output, and ultimately heart failure. The main objective of this multicenter trial is to evaluate whether conventional extracorporeal circulation pericardial resection has a better prognosis than pericardial resection without extracorporeal circulation. This study is a multicenter, randomized controlled, evaluator blinded, parallel group study with an advantageous framework.

Surgical treatment for infectious endocarditis in China.

This important topic of infectious endocarditis (IE) has been covered previously with large multicenter studies and reviews of national databases, most of which come from developed countries. While studies on IE in developing countries such as China are rare, a study of IE undergoing cardiac surgery in China was conducted to investigate retrospective risk factors for hospital mortality of cardiac surgery for IE. This study of patients with IE receiving cardiac surgery in the research period at our medical center was performed retrospectively; 896 patients were assigned to the hospital mortality group (n = 48) and none hospital mortality group (n = 848).

Effects of Phenoxazine Chromophore on Optical, Electrochemical and Electrochromic Behaviors of Carbazole-Thiophene Derivatives.

Phenoxazine, as an organic-small-molecule chromophore, has attracted much attention for its potential electrochromic applications recently. To develop appealing materials, phenoxazine chromophores were introduced at the N-position of carbazole-thiophene pigment, yielding two novel monomers (DTCP and DDCP), whose chemical structures were characterized by NMR, HRMS and FTIR. The results of the optical property study indicate that little influence could be observed in the presence of the phenoxazine chromophore.

Recent Progress of Substituted Allylboron Compounds in Catalytic Asymmetric Allylation Reactions.

The catalytic asymmetric allylation reaction involving allylboron species has emerged as a powerful tool to access highly stereoselective allylation products. In the early years, most of the researches focused on the reaction of unsubstituted allylboronates with ketones or imines. With the synthesis of complex substituted allylboronates, allylboronic acids and allyltrifluoroborates, the type of reactions and the variety of substrates are greatly expanded.

Application of nirmatrelvir/ritonavir for the treatment of severe COVID-19 in a 3-year-old child.

Introduction: Nirmatrelvir/ritonavir (Paxlovid) is an effective antiviral drug for treating coronavirus disease 2019 (COVID-19) in adults. However, Paxlovid treatment of children, especially those who are under 12 years and with severe underlying diseases, is rare.

Case Report: A three-year-old COVID-19 patient (weighing 14.

Vegetation Length is Associated with Long-term Survival in Patients Treated Surgically for Infective Endocarditis.

Background: The impact of vegetation length on therapeutic decision-making and prediction of long-term survival of patients with infective endocarditis is a highly topical issue. The aim of the study was to clarify the impact of vegetation length greater than 10 mm on long-term survival treated surgically for infective endocarditis.

Methods: Patients treated surgically for infective endocarditis in our hospital from January 2006 to November 2022 and were successfully followed up were included in the retrospective analysis.

Evodiamine encapsulated by hyaluronic acid modified zeolitic imidazolate framework-8 for tumor targeted therapy.

Evodiamine (EVO), a natural bioactive compound extracted from Evodia rutaecarpa, shows therapeutic ability against malignant melanoma. However, the poor solubility and bioavailability of EVO limit its clinical application. Metal-organic frameworks (MOFs) have shown excellent physical and chemical properties and are widely used as drug delivery systems.

Modifiable risk factors of immediate and long-term outcomes in the operable and inoperable with left-sided infective endocarditis.

Objectives: To evaluate the outcomes of left-sided infective endocarditis that can be operated on and cannot be operated on, and to focus on modifiable risk factors for immediate and long-term mortality.

Methods: This study retrospectively investigated patients with left-sided infective endocarditis who occurred in our medical center between January 2006 and November 2022.

Results: 48 in-hospital deaths occurred (5.

Cost-effectiveness of Sacituzumab Govitecan versus Single-agent Chemotherapy for Patients with Metastatic Triple-Negative Breast Cancer in China.

Introduction: Patients with metastatic triple-negative breast cancer (mTNBC) have poor prognosis and survival outcomes. Sacituzumab govitecan was newly approved into Chinese market for mTNBC. However, whether its price matches the survival benefit still needs exploring.

Pericardiectomy for Constrictive Pericarditis with or without Cardiopulmonary Bypass.

Aim: We aim to access the effect of pericardiectomy for constrictive pericarditis with or without cardiopulmonary bypass.

Methods: This was a review of pericardiectomy for constrictive pericarditis.

Results: Cardiopulmonary bypass is actually an important maneuver to attain complete relief of the constriction.

Soft tissue infection and osteomyelitis caused by Mycobacterium farcinogenes after heart surgery: Case report and literature review of human cases.

Mycobacterium farcinogenes (M. farcinogenes) is rapidly growing mycobacterium, belonging to non-tuberculous mycobacterial (NTM). M.

Results of the inoperable and operable with aortic valve endocarditis.

Objectives: To evaluate the results of the inoperable and operable with aortic valve endocarditis, focus on risk factors, significance, and management of destruction of the aortic annulus in aortic valve endocarditis.

Methods: The retrospective study was completed to investigate patients with aortic valve endocarditis undergoing cardiac surgery between January 2006 and November 2022 at our hospital.

Results: 512 patients were divided into group with destruction of the aortic annulus ( = 80) and without destruction of the aortic annulus ( = 432).

Loaded delta-hemolysin shapes the properties of membrane vesicles.

Background: Membrane vesicles (MVs) are nanoscale vesicular structures produced by bacteria during their growth and . Some bacterial components can be loaded in bacterial MVs, but the roles of the loaded MV molecules are unclear.

Methods: MVs of RN4220 and its derivatives were prepared.

Risk factors of prolonged intensive care unit stay following cardiac surgery for infective endocarditis.

Introduction: Prolonged intensive care unit (ICU) stay is common in serious patients undergoing cardiac surgery. Prolonged ICU stay is associated with increased mortality and worse prognosis. This study was conducted to determine the risk factors for prolonged ICU stay after cardiac surgery for infective endocarditis (IE) and we try to decrease the operative risk of mortality and morbidity of cardiac surgery for IE.

Surgical treatment of left-sided infective endocarditis with symptomatic neurological complications before surgery in China.

Introduction: We aimed to investigate surgical treatment of left-sided infective endocarditis with symptomatic neurological complications before surgery.

Methods: This was a retrospective study of patients with left-sided infective endocarditis and symptomatic neurological complications before surgery undergoing cardiac surgery between January 2006 and November 2022 at our hospital.

Results: Eight hundred thirty-two patients were divided into group with symptomatic neurological complications before surgery ( = 112) and without symptomatic neurological complications before surgery ( = 720).

Cost-effectiveness analysis of selexipag for the combined treatment of pulmonary arterial hypertension.

Adding selexipag to the combined treatment of endothelin receptor antagonists (ERA) and phosphodiesterase 5 inhibitor (PDE5i) reduces the risk of clinical worsening events in patients with pulmonary arterial hypertension (PAH) but at a considerably higher cost. This study evaluated the cost-effectiveness of adding selexipag to the combined treatment of ERA and PDE5i in patients with PAH from a Chinese healthcare system perspective. A Markov model was developed to assess costs and quality-adjusted life years (QALYs) of macitentan + tadalafil + selexipag vs.

A celastrol-based nanodrug with reduced hepatotoxicity for primary and metastatic cancer treatment.

Background: Cancer is the world's leading cause of death and a key hindrance to extending life expectancy. Celastrol, a bioactive compound derived from Tripterygium wilfordii, has been shown to have excellent antitumor activity, but its poor solubility and severe organ toxicity side effects have hampered its clinical application.

Methods: In this study, a self-assembled nanodrug (PLC-NP) was designed to deliver celastrol to tumor sites while efficiently reducing its side effects by conjugating celastrol with the bioactive material LMWH and P-selectin targeting peptide (PSN).

Impact of Vegetation Length on Clinical Complications During Surgical Intervention and Long-Term Survival in Infective Endocarditis.

We aimed to investigate the impact of vegetation length on clinical complications during surgical intervention and long-term survival in infective endocarditis. This was a retrospective study of patients with infective endocarditis who underwent cardiac surgery between January 2006 and November 2022 at our hospital. 896 patients were divided into 2 groups: group I (vegetation length <10 mm, n = 448) and group II (vegetation length ≥10 mm, n = 448).

Achievement of High Perpendicular Anisotropy and Modification of Heat Treatment Peeling in Micron-Thickness Nd-Fe-B Films Used for Magnetic MEMS.

Thick Nd-Fe-B permanent magnetic films with good perpendicular anisotropy have important applications in magnetic microelectromechanical systems (MEMSs). However, when the thickness of the Nd-Fe-B film reaches the micron level, the magnetic anisotropy and texture of NdFeB film will become worse, and it is also prone to peeling during heat treatment, which seriously limits their applications. In this paper, Si(100)/Ta(100 nm)/NdFeB(x = 14.

Microstructure Optimization and Coercivity Enhancement of Sintered NdFeB Magnet by Grain Boundary Diffusion of Multicomponent TbPrCuAlZn Films.

The use of magnetron sputtering film as a diffusion source was recently achieved in the industrial production of important grain-boundary-diffusion magnets. In this paper, the multicomponent diffusion source film is explored to optimize the microstructure of NdFeB magnets and improve their magnetic properties. Multicomponent TbPrCuAlZn films of 10 μm in thickness and single Tb films of 10 μm in thickness were deposited on commercial NdFeB magnets' surfaces by magnetron sputtering as diffusion sources for grain boundary diffusion.