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Introduction: Erectile dysfunction (ED) is a highly prevalent male sexual disorders, affecting million of men worldwide. Given the volume of literature in ED, bibliometric analyses will provide an important resource to highlight landmark articles.
Objectives: To evaluate the publication trends and impacts between basic scientific research and clinical studies through bibliometric analysis of ED literature between 1998 and 2023.
Methods: We searched for articles in the Web of Science database from 1 January 1998 to 31 December 2023 using MeSH terms specific to ED. Relevant articles were divided into basic scientific research and clinical studies. A bibliometric analysis was performed by using "Citespace" and "VOSviewer" software.
Results: A total of 6450 studies were identified, with 4808 in clinical studies and 1642 basic scientific research. The USA has the highest publication rate with 1851 articles, followed by China (853) and Italy (635). The University of California, San Francisco ranked first in basic scientific research with 68 research papers, while the University of Florence led the clinical research with 133 papers. The Journal of Sexual Medicine and the Journal of Urology were found to have the highest academic influence. Clinical research papers receive more citations than basic scientific ones. Notably, vardenafil emerged as the most frequently used keyword in ED research over the past decade, ranking first in both basic scientific and clinical studies.
Conclusion: Bibliometric analyses can provide an in-depth analysis in distinguishing ED literature. There is a need to foster multi-center international collaborations and new emphasis on novel technology and recent scientific advances.
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http://dx.doi.org/10.1093/sxmrev/qeaf048 | DOI Listing |
Proc Natl Acad Sci U S A
September 2025
State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug De
Proliferative retinopathy is a leading cause of irreversible blindness in humans; however, the molecular mechanisms behind the immune cell-mediated retinal angiogenesis remain poorly elucidated. Here, using single-cell RNA sequencing in an oxygen-induced retinopathy (OIR) model, we identified an enrichment of sorting nexin (SNX)-related pathways, with SNX3, a member of the SNX family that is involved in endosomal sorting and trafficking, being significantly upregulated in the myeloid cell subpopulations of OIR retinas. Immunostaining showed that SNX3 expression is markedly increased in the retinal microglia/macrophages of mice with OIR, which is mainly located within and around the neovascular tufts.
View Article and Find Full Text PDFAcc Chem Res
September 2025
Department of Chemistry, FRQNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street W, Montréal, Québec H3A 0B8, Canada.
ConspectusMolecular photochemistry, by harnessing the excited states of organic molecules, provides a platform fundamentally distinct from thermochemistry for generating reactive open-shell or spin-active species under mild conditions. Among its diverse applications, the resurgence of the Minisci-type reaction, a transformation historically reliant on thermally initiated radical conditions, has been fueled by modern photochemical strategies with improved efficiency and selectivity. Consequently, the photochemical Minisci-type reaction ranks among the most enabling methods for C()-H functionalizations of heteroarenes, which are of particular significance in medicinal chemistry for the rapid diversification of bioactive scaffolds.
View Article and Find Full Text PDFBrief Bioinform
August 2025
School of Computer Science, Xi'an Polytechnic University, 710048, Xi'an, China.
Cancer, with its inherent heterogeneity, is commonly categorized into distinct subtypes based on unique traits, cellular origins, and molecular markers specific to each type. However, current studies primarily rely on complete multi-omics datasets for predicting cancer subtypes, often overlooking predictive performance in cases where some omics data may be missing and neglecting implicit relationships across multiple layers of omics data integration. This paper introduces Multi-Layer Matrix Factorization (MLMF), a novel approach for cancer subtyping that employs multi-omics data clustering.
View Article and Find Full Text PDFCell Biochem Biophys
September 2025
School of Natural Sciences, Macquarie University Sydney, Macquarie Park, NSW, Australia.
Metab Brain Dis
September 2025
Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443002, Hubei, China.
Demyelinating diseases, a prevalent group of neurological disorders, lead to impaired nerve conduction and sensorimotor dysfunctions. Despite existing treatments demonstrating some efficacy, their limitations have driven research toward exploring natural remedies. This review summarizes the therapeutic potential of four traditional tonic Chinese herbal medicines-ginsenosides, deer antler polypeptides, resveratrol, and ginkgo leaf extracts-for demyelinating diseases.
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