Metal-free pyridinium salts with strong room-temperature phosphorescence and microsecond radiative lifetime.

Easily processed metal-free phosphorescent luminophores with a fast rate of phosphorescence are emerging as promising materials for advanced optoelectronics. Alkylation of a modified vitamin B6 vitamer (pyridoxine) affords a family of pyridinium-derived ionic pairs 1-7 exhibiting variable anion-π interactions in the solid state. Such a noncovalent cation-anion network promotes tunable room-temperature phosphorescence (RTP, = 510-565 nm) in crystalline materials stemming from anion(I)-π(pyridinium) charge transfer.

Giant Room-Temperature Chiral Quantum Emission (g >0.4) From Lattice-Symmetry-Broken Perovskites.

Chiral quantum emitters attract significant interest for their unique non-reciprocal photon-mediated properties and potential in quantum operations. Achieving chiral quantum emission has traditionally required sophisticated techniques like high magnetic fields or cryogenic temperatures, and room-temperature circularly polarized luminescence (CPL) from individual quantum emitters is rarely reported. Here, it is shown that certain CsPbI perovskite quantum dots (PQDs) exhibit both room-temperature quantum emission and intrinsic CPL.

Unveiling research landscapes in erectile dysfunction: a bibliometric analysis comparing basic scientific research and clinical studies.

Introduction: Erectile dysfunction (ED) is a highly prevalent male sexual disorders, affecting million of men worldwide. Given the volume of literature in ED, bibliometric analyses will provide an important resource to highlight landmark articles.

Objectives: To evaluate the publication trends and impacts between basic scientific research and clinical studies through bibliometric analysis of ED literature between 1998 and 2023.

Dual-Mode Photonic Synapse Based on a Lead-Free 2D Ruddlesden-Popper Perovskite for Neuromorphic Vision.

Inspired by the human visual system, photonic synapses with photonic sensing and data memorization offer a promising alternative to traditional von Neumann architectures for neuromorphic computing. This study introduces a multifunctional artificial photonic synapse based on solution-processed PEASnI 2D Ruddlesden-Popper perovskite. By modulation of the applied bias voltage, the PEASnI device can switch between two distinct optoelectronic modes.

[Efficacy and safety of Compound Xuanju Capsules combined with Western medicine in the treatment of type Ш prostatitis with erectile dysfunction: A meta analysis].

Objective: To systematically evaluate the effect and safety of the combination of Compound Xuanju Capsules (CXC) and Western medicine (WM) in the treatment of type Ш prostatitis complicated by ED.

Methods: We searched for randomized controlled trials (RCT) on the treatment of type Ш prostatitis complicated by ED with CXC+WM or WM in the Chinese and English databases CNKI, VIP, Wanfang Digital, Duxiu Academic Search and Chaoxing Electronic Book Information Retrieval, Fangzheng Apabi Electronic Book, Google Scholar Search, Web of Science, Scopus, PubMed, and others from their establishment to April 2024. According to the Cochrane Handbook requirement, we subjected the identified RCTs to meta-analysis using the RevMan 5.

Near-infrared photobiomodulation therapy for age-related erectile dysfunction: molecular and physiological restoration in a mouse model.

Age-related erectile dysfunction (ARED) represents a significant clinical challenge due to the interplay between chronic comorbidities and age-related physiological decline. This study investigated the therapeutic potential of near-infrared photobiomodulation therapy (NIR-PBMT) in ARED mice, focusing on molecular and physiological mechanisms of complex erectile function restoration. Aged mice received NIR-PBMT (4 J cm-2) every 48 h for 2 weeks.

Single-cell RNA sequencing uncovers abnormal Sertoli-cell elevation and testicular niche impairment in the transfemales's testis.

Background: Transgender women (transfemales) often undergo gender-affirming hormone therapy (GAHT). However, the testicular impacts of feminising hormones present heterogeneity due to the complexity of testicular regulatory mechanisms.

Method: In this study, we analyzed approximately 49,385 single-cell transcriptomes from transfemale human testicular tissue, comparing cellular composition with that of cisgender male individuals across a range of ages.

The Global State of Contemporary Andrology Practice: A Comprehensive Analysis of Clinical Practice, Training Pathways, and Emerging Challenges.

Purpose: This study evaluates the current state of andrology practice worldwide, identifies challenges faced by clinicians, and explores training, certification, and research opportunities. It also seeks to redefine the qualifications necessary to be recognized as an andrologist and to propose areas for standardization and improvement.

Materials And Methods: A global, cross-sectional survey was conducted using a 48-question online questionnaire designed by international experts.

Dual-Parameter Hypoxia Sensing in Spermatozoa: A Transformative Nitroreductase/Viscosity Fluorescent Probe Unravels Metabolic Dysregulation Biomarkers for Andrological Diagnostics.

Sperm energy metabolism, including oxidative phosphorylation and glycolysis, is critical for sperm function. Environmental stressors like hypoxia can disrupt metabolic activities, potentially leading to fertilization failure. As an NADH-dependent flavin reductase, altered nitroreductase (NTR) levels may reflect hypoxic metabolic abnormalities.

Development of an allosteric adhesion GPCR nanobody with therapeutic potential.

Allosteric modulation of receptor responses to endogenous agonists has therapeutic value, maintaining ligand profiles, reducing side effects and restoring mutant responses. Adhesion G-protein-coupled receptors (aGPCRs), with large N termini, are ideal for allosteric modulator development. We designed a nanobody strategy targeting ADGRG2 N-terminal fragments and got a specific nanobody Nb23-bi, which promoted dehydroepiandrosterone (DHEA)-induced ADGRG2 activation and reversed mutant-induced dysfunctions.

Alterations in Semen Quality and Immune-Related Factors in Men with Infertility who Recovered from COVID-19.

The emergence of coronavirus disease 2019 (COVID-19) has triggered research into its impact on male reproductive health. However, studies exploring the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on semen quality in infertile men remain limited. Herein, we enrolled 781 male infertile patients who recovered from COVID-19 and analyzed their semen and blood samples collected at different time points.

Microdissection testicular sperm extraction for men with nonobstructive azoospermia who have a testicular tumor in situ at the time of sperm retrieval.

Oncological microdissection testicular sperm extraction (onco-micro-TESE) represents a significant breakthrough for patients with nonobstructive azoospermia (NOA) and a concomitant in situ testicular tumor, to be managed at the time of sperm retrieval. Onco-micro-TESE addresses the dual objectives of treating both infertility and the testicular tumor simultaneously. The technique is intricate, necessitating a comprehensive understanding of testicular anatomy, physiology, tumor biology, and advanced microsurgical methods.

Anatomical considerations, testicular, and scrotal anatomy of nonobstructive azoospermia patients.

Infertility, defined as the inability to conceive after 1 year of regular unprotected intercourse, impacts 10%-20% of couples globally. Both male and female factors contribute equally to this condition. Azoospermia, particularly nonobstructive azoospermia (NOA), which affects 10%-15% of infertile men, represents a significant challenge in male infertility.

Highly Efficient Manganese Bromides with Reversible Luminescence Switching through Amorphous-Crystalline Transition.

While luminescent stimuli-responsive materials (LSRMs) have become one of the most sought-after materials owing to their potential in optoelectronic applications, the use of earth-scarce lanthanides remains a crucial problem to be solved for further development. In this work, two manganese-based LSRMs, ()-(+)-1-phenylethylammonium manganese bromide, (R-PEA)MnBr, and ()-(-)-1-phenylethylammonium manganese bromide, (S-PEA)MnBr, are successfully demonstrated. Both (R-PEA)MnBr and (S-PEA)MnBr show a kinetically stable red-emissive amorphous state and a thermodynamically stable green-emissive crystalline state at room temperature, where the fully reversible transition can be done through melt-quenching and annealing processes.

Bright Structural-Phase-Pure CsPbI Core-PbSO Shell Nanoplatelets With Ultra-Narrow Emission Bandwidth of 77 meV at 630 nm.

Achieving a narrow emission bandwidth is long pursued for display applications. Among all primary colors, obtaining pure red emission with high visual perception is the most challenging. In this work, CsPbI halide perovskite nanoplatelets (NPLs) with rigorously controlled 2D  [PbI] octahedron layer number (n) are demonstrated.

Identification and validation of new fatty acid metabolism-related mechanisms and biomarkers for erectile dysfunction.

Background: Erectile dysfunction (ED) is a common condition affecting middle-aged and elderly men.

Aim: The study sought to investigate differentially expressed fatty acid metabolism-related genes and the molecular mechanisms of ED.

Methods: The expression profiles of GSE2457 and GSE31247 were downloaded from the Gene Expression Omnibus database and merged.

Long-term tadalafil once daily in Chinese men with erectile dysfunction: a 2-year final analysis of a post-marketing, multicenter, randomized, open-label trial.

The long-term safety and effectiveness of once-daily tadalafil is crucial, but limited data are available in Chinese patients with erectile dysfunction (ED). In this post-marketing, multicenter, randomized, open-label trial with 2-year follow-up, 635 ED cases were randomized to receive daily oral tadalafil 2.5 mg or 5 mg for 3 months, of whom 580 continued once-daily tadalafil 5 mg for 21 months.

An Ion Concentration Polarization Microplatform for Efficient Enrichment and Analysis of .

Strategies for rapid, effective nucleic acid processing hold tremendous significance to the clinical analysis of circulating tumor DNA (), a family of important markers indicating tumorigenesis and metastasis. However, traditional techniques remain challenging to achieve efficient DNA enrichment, further bringing about complicated operation and limited detection sensitivity. Here, we developed an ion concentration polarization microplatform that enabled highly rapid, efficient enrichment and purification of from a variety of clinical samples, including serum, urine, and feces.

Highly Efficient MAPbI-Based Quantum Dots Exhibiting Unusual Nonblinking Single Photon Emission at Room Temperature.

Highly emissive semiconductor nanocrystals, or so-called quantum dots (QDs) possess a variety of applications from displays and biology labeling, to quantum communication and modern security. Though ensembles of QDs have already shown very high photoluminescent quantum yields (PLQYs) and have been widely utilized in current optoelectronic products, QDs that exhibit high absorption cross-section, high emission intensity, and, most important, nonblinking behavior at single-dot level have long been desired and not yet realized at room temperature. In this work, infrared-emissive MAPbI-based halide perovskite QDs is demonstrated.

Sperm retrieval outcomes of contralateral testis in men with nonobstructive azoospermia and unsuccessful unilateral microdissection testicular sperm extraction.

▪▪▪.