Analysis of potential profiles of health literacy in chronic heart failure patients.

Purpose: This study aimed to explore health literacy profiles in patients with heart failure and identify heterogeneous subgroups within the chronic heart failure population. Through investigating the health literacy of heart failure patients, we analyzed the factors influencing patients' health literacy levels, aiming to provide evidence-based guidance for improving health literacy in this patient population.

Methods: This study employed a cross-sectional design.

Screening and validation of optimal real-time PCR reference genes for Abelmoschus Manihot.

Abelmoschus Manihot is an important medicinal and edible plant known for its functional secondary metabolites. However, little is known about the key genes involved in production of secondary metabolites in A. manihot.

A water-soluble cationic [2]biphenyl-extended pillar[6]arene: synthesis, host-guest interaction with hemin and application in chemodynamic/photodynamic cancer therapy.

A water-soluble cationic [2]biphenyl-extended pillar[6]arene (CBpExP) was designed and synthesized successfully. It could form a stable 1 : 1 complex with hemin, thereby enhancing the stability of hemin in water, and can be further applied in cancer CDT and PDT.

Discovery of Novel 2,4,5-Trisubstituted Pyrimidine Derivatives as Potent and Selective FGFR Inhibitors against Gatekeeper Mutants for the Treatment of NSCLC.

Fibroblast growth factor receptors (FGFRs) play a critical role in the regulation of cancer cell proliferation, differentiation, and migration. However, the development of acquired resistance to FGFR inhibitors remains a major challenge in treating non-small cell lung cancer (NSCLC), particularly due to mutations at the gatekeeper residue. In this study, we report the discovery of a series of irreversible FGFR inhibitors targeting gatekeeper mutations in FGFR1-3, utilizing a 2,4,5-trisubstituted pyrimidine scaffold.

A discrete platinum(II)-metallacycle with enhanced red emission for imaging-guided synergistic cancer photothermal-chemotherapy.

A discrete platinum(II)-metallacycle was designed using perylene bisimide fluorophore (PPy) and 90° Pt(II) (Pt) units as key components, synthesized through a "coordination-driven self-assembly" approach, which can be applied in imaging-guided synergistic cancer photothermal-chemotherapy.

Oxygen self-supplying porphyrinic MOFs to alleviate tumor hypoxia for starvation-amplified photodynamic therapy.

An oxygen self-supplying nanoplatform utilizing perfluorocarbon-functionalized porphyrinic MOFs was developed to alleviate tumor hypoxia. This strategy combines external oxygen-delivery with oxygen generation cascade reactions, resulting in enhanced synergistic effects for both cancer starvation therapy and robust photodynamic therapy.

Exosomes in Oral Diseases: Mechanisms and Therapeutic Applications.

Exosomes, small extracellular vesicles secreted by various cells, play crucial roles in the pathogenesis and treatment of oral diseases. Recent studies have highlighted their involvement in orthodontics, periodontitis, oral squamous cell carcinoma (OSCC), and hand, foot, and mouth disease (HFMD). Exosomes have a positive effect on the inflammatory environment of the oral cavity, remodeling and regeneration of oral tissues, and offer promising therapeutic options for bone and periodontal tissue restoration.

Levy Sooty Tern Optimization Algorithm Builds DNA Storage Coding Sets for Random Access.

DNA molecules, as a storage medium, possess unique advantages. Not only does DNA storage exhibit significantly higher storage density compared to electromagnetic storage media, but it also features low energy consumption and extremely long storage times. However, the integration of DNA storage into daily life remains distant due to challenges such as low storage density, high latency, and inevitable errors during the storage process.

Bacillus-derived consortium enhances Ginkgo biloba's health and resistance to Alternaria tenuissima.

Background: Bacillus, as a plant-growth-promoting rhizobacteria, can enhance the resistance of plants to phytopathogens. In our study, Bacillus strains showing excellent biocontrol were screened and used to control ginkgo leaf blight (Alternaria tenuissima).

Results: Four biocontrol Bacillus strains-Bsa537, Bam337, Bso544, and Bsu503-were selected from 286 isolates based on their capacity to inhibit pathogens and promote plant growth.

Identification of the CONSTANS-like family in Cymbidium sinense, and their functional characterization.

Background: Cymbidium sinense is an orchid that is typically used as a potted plant, given its high-grade ornamental characteristics, and is most frequently distributed in China and SE Asia. The inability to strictly regulate flowering in this economically important potted and cut-flower orchid is a bottleneck that limits its industrial development. Studies on C.

Design, synthesis, and biological evaluation of 1,6-naphthyridine-2-one derivatives as novel FGFR4 inhibitors for the treatment of colorectal cancer.

Aberrant FGFR4 signaling has been implicated in the development of several cancers, making FGFR4 a promising target for cancer therapy. Several FGFR4-selective inhibitors have been developed, yet none of them have been approved. Herein, we report a novel series of 1,6-naphthyridine-2-one derivatives as potent and selective inhibitors targeting FGFR4 kinase.

The transcription factor VaNAC72-regulated expression of the VaCP17 gene from Chinese wild Vitis amurensis enhances cold tolerance in transgenic grape (V. vinifera).

Papain-like cysteine proteases (PLCP) play diverse roles in plant biology. In our previous studies, a VaCP17 gene from the cold-tolerant Vitis amurensis accession 'Shuangyou' was isolated and its role in cold tolerance was preliminarily verified in Arabidopsis. Here, we confirmed the function of VaCP17 in cold tolerance by stably overexpressing VaCP17 in the cold-sensitive Vitis vinifera cultivar 'Thompson Seedless' and transiently silencing VaCP17 in 'Shuangyou' leaves.

Feasibility and effectiveness of disinfection of gloves during routine care: a scoping review protocol.

Introduction: Disinfecting gloves during patient care has potential benefits and risks. In recent years, disinfection of disposable medical gloves for prolonged use has occurred in clinical practice. However, there is limited high-level evidence to know if this practice can prevent nosocomial infections, reduce microbial levels on the glove surface.

Discovery of β-cyclocitral-derived mono-carbonyl curcumin analogs as anti-hepatocellular carcinoma agents via suppression of MAPK signaling pathway.

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with a high recurrence and mortality rate. In this study, a series of β-cyclocitral-derived mono-carbonyl curcumin analogs were synthesized and their anticancer properties were evaluated. Among the series, A19 exhibited the strongest cytotoxic activity by inhibiting cell viability and colony formation, inducing cell cycle G2/M phase arrest and cell apoptosis of HCC HepG2 and Huh-7 cells, while having almost no cytotoxicity on normal liver MIHA cells.

Levy Equilibrium Optimizer algorithm for the DNA storage code set.

The generation of massive data puts forward higher requirements for storage technology. DNA storage is a new storage technology which uses biological macromolecule DNA as information carrier. Compared with traditional silicon-based storage, DNA storage has the advantages of large capacity, high density, low energy consumption and high durability.

VyUSPA3, a universal stress protein from the Chinese wild grape Vitis yeshanensis, confers drought tolerance to transgenic V. vinifera.

VyUSPA3 from the Chinese wild grape Vitis yeshanensis interacts with ERF105, PUB24 and NF-YB3, and overexpression of the VyUSPA3 gene in V. vinifera cv. 'Thompson Seedless' confers drought tolerance.

The transcription factor VaMYC2 from Chinese wild Vitis amurensis enhances cold tolerance of grape (V. vinifera) by up-regulating VaCBF1 and VaP5CS.

Cultivated grapes, one of the most important fruit crops in the world, are sensitive to low temperature. Since Chinese wild grape Vitis amurensis is highly tolerant to cold, it is imperative to study and utilize its cold-tolerance genes for molecular breeding. Here, a VaMYC2 gene from V.

cyy260 suppresses the proliferation, migration and tumor growth of osteosarcoma by targeting PDGFR-β signaling pathway.

Osteosarcoma (OS) is a group of malignant tumors with high rates of malignancy and metastasis. OS most commonly affects adolescents and young individuals. However, owing to the lack of effective targeted treatments, the 5-year survival rate for OS is still around 20%.

Incidence of and risk factors for post-intensive care syndrome among Chinese respiratory intensive care unit patients: A cross-sectional, prospective study.

Background: Patients transferred from the respiratory intensive care unit (ICU) can experience post-intensive care syndrome (PICS), which comprises cognitive, psychological, and physical disorders that seriously affect the quality of life. Therefore, it was necessary to explore the incidence of and the risk factors for PICS among respiratory ICU patients.

Objectives: This study evaluated PICS among respiratory ICU patients and explored the risk factors for PICS.