Combined transcriptome and metabolome analysis of tilapia response to hypoxia and Streptococcus agalactiae co-exposure.

Deterioration of water quality, especially low dissolved oxygen, has contributed to outbreaks of streptococcal disease in tilapia. It has been reported that hypoxia increases the mortality of tilapia during Streptococcus agalactiae infection. However, the underlying mechanism of the increased susceptibility of tilapia to S.

Galla Chinensis as an antiviral agent: Targeting Micropterus salmoides rhabdovirus infection.

Being a major pathogen affecting the health of largemouth bass (Micropterus salmoides) aquaculture, Micropterus salmoides rhabdovirus (MSRV) causes significant economic losses. Galla chinensis, a traditional Chinese medicinal herb, possesses diverse biological activities, including antiviral properties. This study evaluated the role of Galla chinensis in MSRV infection in vitro and investigated its mechanism of action.

Use of clinical care classification terminology in the nursing field: A scoping review.

Background: Clinical Care Classification terminology, a category of standardized nursing terminologies, has a clear hierarchical structure, well-defined processes, and a scientifically grounded coding system. In the era of information technology, reviewing the progress of Clinical Care Classification terminology in the field of nursing is crucial for the future selection and standardization of nursing terminology.

Objective: This review aims to examine the application and impact of Clinical Care Classification terminology in the nursing field.

Interventions and Their Effectiveness to Reduce HIV-Related Stigma Among Women Living With HIV: A Systematic Review Protocol.

Background: HIV-related stigma is a significant barrier to accessing public health resources and achieving health equity in women living with HIV (WLWH). The complexity of eliminating stigma against WLWH is compounded by the dual characteristics of HIV and its chronic nature. In addition, WLWH often face weak social support.

Efficacy of a culturally tailored intervention on perceived stigma among women living with HIV/AIDS in China: A randomized clinical trial.

Background: Despite evidence supporting the efficacy of culturally tailored interventions in reducing stigma, such approaches are lacking for women living with HIV/AIDS (WLWHAs) in China. We conducted this study to determine the efficacy of the culturally tailored Helping Overcome Perceived Stigma (HOPES) intervention in reducing perceived stigma among WLWHAs in China.

Methods: A single-blinded, two-arm parallel-group randomized clinical trial was conducted from 2023 to 2024 in South and Southwest China.

Antiviral activity of epicatechin against Singapore grouper iridovirus in vitro and in vivo.

As the main highly pathogenic pathogen of grouper, Singapore grouper iridovirus (SGIV) can give rise to significant economic losses in grouper aquaculture. Epicatechin (EC) belongs to flavonoids, which primarily derived from the traditional Chinese medicinal plants, green tea. In this study, the role of EC in SGIV infection was evaluated in vitro and in vivo.

Mental Health Symptoms Between Developed and Developing Regions for People Living With HIV in China: A Network Analysis of 40 Psychological Symptom Scales.

Background: People living with HIV (PLWH) frequently encounter mental health symptoms. Yet, a notable gap exists regarding the divergence in core mental health symptoms among PLWH across developed and developing regions. This study aims to explore the differences in mental health symptom networks among PLWH in both developed and developing regions.

Dynamic Network Analysis of Mental Health Symptoms Among Persons Living With HIV.

Aim: This study aims to develop dynamic networks and examine the longitudinal relationships of mental health symptoms among persons living with HIV (PLWH).

Design: A longitudinal study.

Methods: We collected data between October 2022 and December 2022 using Wenjuanxing (Questionnaire Star), an online survey platform.

The impact of disease uncertainty on caregiving readiness among family caregivers of Chinese children with congenital cataracts: A multicenter cross-sectional survey.

Purpose: To explore the factors associated with caregiving readiness among family caregivers of Chinese children with congenital cataracts, with a focus on the relationship with disease uncertainty.

Design And Methods: This multicenter cross-sectional approach included 129 family caregivers from three tertiary hospitals. Data were collected between January and June 2023.

The Application of Voice Biomarkers in Frailty: A Scoping Review.

Background: With an increasing prevalence of frailty among older adults, effective classification and management strategies for frailty have become imperative. Voice biomarkers, offering insights into the overall health status of older adults, hold promise for enhancing the management of this multifaceted geriatric syndrome.

Objectives: This scoping review aims to consolidate existing knowledge regarding the relationship between frailty and voice biomarkers.

Reducing Stigma in Chinese Women Living With HIV/AIDS: Mixed Methods Cluster Randomized Controlled Trial Protocol.

Background: Perceived stigma significantly impedes access to public health resources for women living with HIV/AIDS, highlighting the crucial need for interventions to empower individuals to overcome such barriers.

Objectives: This paper outlines the protocol for a pilot study aimed at evaluating the efficacy of the Helping Overcome PErceived Stigma (HOPES) intervention employing the mixed methods-grounded in narrative transportation-theory in reducing perceived stigma among women living with HIV/AIDS.

Methods: A total of 100 women living with HIV/AIDS will be randomized into two groups: the HOPES group and the control group.

Effectiveness of an HIV peer support precision matching platform: a randomized controlled trial protocol.

Background: Peer support is a promising and significant way for people living with HIV (PLWH) to improve their health outcomes. Matching PLWH with HIV peer volunteers can effectively stimulate and mobilize the function of peer support in health management. We develop the online platform Aspark, which features a precision matching function for PLWH and volunteers.

Radiomics Signatures Based on Computed Tomography for Noninvasive Prediction of CXCL10 Expression and Prognosis in Ovarian Cancer.

Background: Ovarian cancer (OC) is an aggressive gynecological tumor usually diagnosed with malignant ascites and even observed widespread metastasis or distant spread.

Aims: We aimed to develop and identify radiomics models according to computed tomography (CT) for preoperative prediction of CXCL10 expression and prognosis in patients with OC.

Methods: Genomic data with CT images and corresponding clinicopathological parameters were extracted from The Cancer Imaging Archive (TCIA) and The Cancer Genome Atlas (TCGA).

The effect of different types of water sources on dental unit waterline contamination: A systematic review and meta analysis.

To systematically review the effect of different types of water sources on dental unit waterline (DUWL) contamination. 5 databases were searched from their inception to December 23, 2023. Two reviewers independently extracted the data and assessed the quality of the literature.

Evaluating cognitive assessment tools for patients with major depressive disorder receiving electroconvulsive therapy: A systematic review and meta-analysis.

Background: Major Depressive Disorder (MDD) affects 350 million people worldwide. Electroconvulsive therapy (ECT) is effective, yet research on cognitive assessments post-treatment is lacking. This study systematically reviews and meta-analyzes the effectiveness of cognitive assessment tools post-ECT to optimize MDD treatment.

Heterogeneous fibroblasts contribute to fibrotic scar formation after spinal cord injury in mice and monkeys.

Spinal cord injury (SCI) leads to fibrotic scar formation at the lesion site, yet the heterogeneity of fibrotic scar remains elusive. Here we show the heterogeneity in distribution, origin, and function of fibroblasts within fibrotic scars after SCI in mice and female monkeys. Utilizing lineage tracing and single-cell RNA sequencing (scRNA-seq), we found that perivascular fibroblasts (PFs), and meningeal fibroblasts (MFs), rather than pericytes/vascular smooth cells (vSMCs), primarily contribute to fibrotic scar in both transection and crush SCI.

Psychological profiles among people with HIV: A latent profile analysis and examination of the relationship with interpersonal personality.

People living with HIV (PWH) often experience an increased vulnerability to psychiatric disorders as a result of social stigma and discrimination. This study utilized latent profile analysis on a sample of 3040 Chinese PWH to identify distinct psychological profiles. Furthermore, the study investigated the relationships between these profiles with interpersonal personalities, demographic characteristics, social variables and disease-related variables using a three-step regression (R3STEP).

CST2 promotes cell proliferation and regulates cell cycle by activating Wnt-β-catenin signalling pathway in serous ovarian cancer.

Background: Cystatin SA (CST2) plays multiple roles in different types of malignant tumours; however, its role in serous ovarian cancer (SOC) remains unclear. Therefore, we aimed to investigate the expression levels, survival outcomes, immune cell infiltration, proliferation, cell cycle, and underlying molecular mechanisms associated with the CST2 signature in SOC.

Methods: The Cancer Genome Atlas database was used to acquire clinical information and CST2 expression profiles from patients with SOC.

Psychometric properties of stigma and discrimination measurement tools for persons living with HIV: a systematic review using the COSMIN methodology.

Background: The development of antiretroviral therapy broadly extends the life expectancy of persons living with HIV (PLHIV). However, stigma and discrimination are still great threat to these individuals and the world's public health care system. Accurate and reproducible measures are prerequisites for robust results.

Dose‒Response Effects of Patient Engagement on Anxiety and Depression in a Cognitive-Behavioral Intervention: Secondary Analysis of a Pilot Randomized Controlled Trial and a Clinical Controlled Trial.

Understanding the dose‒response relationship between patient engagement in cognitive behavioral therapy (CBT) and health outcomes is critical for developing and implementing effective CBT programs. In studies of CBT interventions, patient engagement is measured only at a single time point, and outcomes are typically assessed before and after the intervention. Examination of the dose‒response relationship between patient engagement in CBT and outcomes is limited.

Exploring the experiences of peer support participation for HIV peer volunteers: A meta-synthesis of qualitative research.

Background: Gaining insights and feedback from HIV peer volunteers about their peer support practice is crucial for optimizing and enhancing the effectiveness and sustainability of peer support for people with HIV. There is a dearth of systematic reviews that explore the experiences of HIV peer volunteers about their peer support experience. This study aims to consolidate qualitative research on the experiences of peer support participation for HIV peer volunteers, to provide inspiration and reference for HIV peer support practice.

Psychometric and Circumplex Properties Evaluation of the International Personality Item Pool-Interpersonal Circumplex (IPIP-IPC) in Chinese People Living with HIV (PLWH).

Background And Purpose: With the improved life expectancy of people living with HIV (PLWH) due to widespread use of antiretroviral therapy (ART), there is a greater emphasis on enhancing long-term well-being and overall quality of life for PLWH. Understanding interpersonal personalities of PLWH can gain further insight into how to improve the overall quality of life in this population. The International Personality Item Pool-Interpersonal Circumplex (IPIP-IPC) scale has been developed to assess interpersonal personalities of individuals, and this scale has been translated into Chinese.

Mimicked Spinal Cord Fibers Trigger Axonal Regeneration and Remyelination after Injury.

Spinal cord injury (SCI) causes tissue structure damage and composition changes of the neural parenchyma, resulting in severe consequences for spinal cord function. Mimicking the components and microstructure of spinal cord tissues holds promise for restoring the regenerative microenvironment after SCI. Here, we have utilized electrospinning technology to develop aligned decellularized spinal cord fibers (A-DSCF) without requiring synthetic polymers or organic solvents.