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A discrete platinum(II)-metallacycle was designed using perylene bisimide fluorophore (PPy) and 90° Pt(II) (Pt) units as key components, synthesized through a "coordination-driven self-assembly" approach, which can be applied in imaging-guided synergistic cancer photothermal-chemotherapy.
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http://dx.doi.org/10.1039/d5cc00009b | DOI Listing |
Cancer
September 2025
Department of Biostatistics, Brown University School of Public Health, Providence, Rhode Island, USA.
Background: Opioid exposure during cancer therapy may increase long-term unsafe opioid prescribing. This study sought to determine the rates of coprescription of benzodiazepine and opioid medications and new persistent opioid use after surgical treatment of early-stage cancer.
Methods: A retrospective cohort study was conducted among a US veteran population via the Veterans Affairs Corporate Data Warehouse database.
Neuroimage
September 2025
The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, P.R. China; Brain-Computer Interface & Brain-Inspired Intelligence Key Laboratory of Sichuan Province, University of Electronic
Functional magnetic resonance imaging (fMRI) opens a window on observing spontaneous activities of the human brain in vivo. However, the high complexity of fMRI signals makes brain functional representations intractable. Here, we introduce a state decomposition method to reduce this complexity and decipher individual brain functions at multiple levels.
View Article and Find Full Text PDFEnviron Res
September 2025
Institute of Environmental Medicine, Karolinska Institutet, Solnavägen 4, SE-113 65 Stockholm, SWEDEN.
Cardiovascular disease (CVD) is the leading cause of death in Europe, with myocardial infarction (MI) being one of its most severe manifestations. While many risk factors for CVD are well known, occupational exposures remain relatively understudied-especially in analyses that adjust for co-occurring workplace exposures. This study aimed to examine the association between occupational exposure to chemicals and particles and the risk of first-time MI.
View Article and Find Full Text PDFWomens Health (Lond)
September 2025
Worldwide Medical and Safety, Pfizer Inc, New York, NY, USA.
Background: Endometriosis symptoms have multifaceted manifestations, and there are few approved nonsurgical treatment options. Gonadotropin-releasing hormone (GnRH) agonists/antagonists for endometriosis vary on efficacy, safety profile, and out-of-pocket (OOP) cost, among other features.
Objectives: This study quantified the importance that women with endometriosis in the United States (US) placed on pain and non-pain features that differ among these medications.
Individual belief in a rigid definition of gender underlies significant social costs, from the gender pay gap, violence and discrimination against transgender and gender diverse people, to global economic losses. These beliefs are often rooted in essentialist thinking that gender is distinct, non-overlapping, unchangeable, and biologically based. Gender is a multidimensional social concept, partly informed by perceptions of sex, which is a distinct concept referring to a collection of biological traits.
View Article and Find Full Text PDF