Postoperative Vocal Cord Paralysis After Retrieval of a Fishbone Penetrating the Recurrent Laryngeal Nerve.

A migratory fishbone is not a rare case in otorhinolaryngology clinics in Asia. Deep neck infection is a common complication, and several cases of preoperative vocal cord paralysis have been reported. However, postoperative vocal cord paralysis after the retrieval of a fishbone penetrating the recurrent laryngeal nerve has not been documented.

Isoquinoline as an Electrolyte Additive for Electrolytic Zn-MnO Batteries: Superior Cycling Stability and Areal Capacity.

Aqueous electrolytic Zn-MnO batteries hold great promise for energy storage applications owing to their high theoretical electromotive force and energy density. However, the zinc anode suffers from severe corrosion in strongly acidic electrolytes, leading to hydrogen evolution, low zinc utilization, and premature battery failure. To address these challenges, isoquinoline is introduced as an additive in a chloride-based acidic electrolyte.

IDO-1 Promotes Pulmonary Vascular Remodeling Via Kynurenine Pathway in Pulmonary Arterial Hypertension.

Background: Activation of the plasma kynurenine pathway (KP) may contribute to the progression of pulmonary arterial hypertension (PAH). We investigated the functional role and molecular mechanisms of KP activation in PAH.

Methods: KP activity was measured in the lungs and plasma of humans and rodents with pulmonary hypertension (PH).

Whole exome sequencing unravels genetic architecture and its clinical implications in pediatric pulmonary arterial hypertension.

Background: Pulmonary arterial hypertension (PAH) is a severe disease with significant genetic predisposition. While genetic architecture and clinical implications in pediatric PAH remain unclear.

Methods: We retrospectively analyzed clinical and genetic data from 218 pediatric PAH patients including 115 idiopathic/heritable PAH (IPAH/HPAH) and 103 PAH associated with congenital heart disease (PAH-CHD) admitted to our center between 2011 and 2023.

Active Component Design of Amorphous SnP/SnS and Interfacial Bonding Engineering in N/P/S-Doped Hard Carbon for High-Rate Sodium-Ion Hybrid Capacitors.

Sodium-ion hybrid capacitors （SIC）face critical challenges from the kinetic mismatch and cycling life imbalance between battery-type anodes and capacitive cathodes. A slope-dominant N/P/S-doped hard carbon anode (Sn0.1@NSPC) with nearly plateau-free sloping charge-discharge curves, embedded with amorphous SnP/SnS composites, is developed.

Functional Graphene Coatings in Electrochemical Energy Technology-Beyond Corrosion Protection.

Coating the surfaces of active masses and auxiliary components in devices of electrochemical energy technology with graphene and closely related materials has been suggested and experimentally verified in numerous examples. The results in terms of improved performance are promising and suggest the need for further research and technological development. This report provides a complete overview, providing details that are relevant for understanding the way in which these coatings work.

Predictive model for initial response to first-line treatment in children with infantile epileptic spasms syndrome.

Background: Previous studies have suggested that factors such as the treatment interval and aetiology may influence the initial response rate to first-line treatment for infantile epileptic spasms syndrome (IESS). However, few children with IECSS have undergone clinically accessible tests to determine the aetiology.

Methods: Using a dataset from our previously published research, we constructed and tested a predictive model for the initial response to first-line treatment in children with IESS.

Favorable Desolvation and Uniform Zn Deposition of Silica Modified Zn Anode for High Performance Aqueous Zn-Ion Batteries.

The instability of Zn anode resulting from corrosion and dendritic growth remain impeding the development of aqueous zinc-ion batteries (AZIBs). In addition, the desolvation on the Zn surface is sluggish, which hinders the reaction kinetics and fast charge/discharge behavior of AZIBs. Herein, the uniform Zn deposition and fast desolvation are realized by using a hydrophilic fumed nano-silica coating with zinc alginate (Alg) as a functional binder (Alg/SiO@Zn).

AI Learning for Pediatric Right Ventricular Assessment: Development and Validation Across Multiple Centers.

Background: Congenital and acquired heart disease affects ∼1% of children globally, with right ventricular (RV) dysfunction being a common and complex issue due to conditions like congenital heart disease (CHD), pulmonary hypertension (PH), and prematurity. Accurate RV assessment is challenging due to its unique geometry, interventricular interactions, and morphological variability in pediatric patients. Fractional area change (FAC), a key echocardiographic measure, correlates strongly with disease severity, aiding in timely intervention and prognosis.

Unveiling the superiority: single catheter multisite epidural blood patch for the treatment of spontaneous intracranial hypotension.

Spontaneous intracranial hypotension (SIH) is a rare clinical condition that may occur due to cerebrospinal fluid leakage. The purpose of this study was to compare the safety and efficacy of single catheter multisite epidural blood patch(CA-EBP) with standard procedures, including blinded and targeted epidural blood patch (EBP) for the treatment of SIH, and to investigate the effectiveness of dexamethasone as an adjuvant. Clinical data of 68 patients with postoperative SIH who underwent EBP between March 2022 and May 2024.

A Separator with Double Layers Individually Modified by LiAlO Solid Electrolyte and Conductive Carbon for High-performance Lithium-Sulfur Batteries.

The "shuttle effect" and the unchecked growth of lithium dendrites during operation in lithium-sulfur (Li-S) batteries seriously impact their practical applications. Besides, the performances of Li-S batteries at high current densities and sulfur loadings hold the key to bridge the gap between laboratory research and practical applications. To address the above issues and facilitate the practical utilization of Li-S batteries, the commercial separator is modified with solid electrolyte (nanorod LiAlO, LAO) and conductive carbon (Super P) to obtain a double coated separator (SPLAOMS).

Bioassay and NMR-HSQC-Guided Isolation and Identification of Phthalide Dimers with Anti-Inflammatory Activity from the Rhizomes of .

Under the guidance of a bioactivity-guided approach and HSQC characteristic signals, nine pairs of phthalic dimers, angesilides A-I (-), with complex polycyclic skeletons featuring bridged, fused, and spiro ring systems were discovered from the rhizomes of . Their structures and absolute configurations were established by comprehensive spectroscopic methods, X-ray diffraction analysis, and chiral separation. Plausible biosynthetic pathway for - was proposed.

Mitochondrial Amount Determines Doxorubicin-Induced Cardiotoxicity in Cardiomyocytes.

Doxorubicin, an anthracycline commonly used for treating cancer patients, is known for its cardiotoxic side-effects. Although dose-dependent, but susceptibility remains variable among patients, and childhood-exposure-adult-onset remains challenging. Besides topoisomerase toxicity, Doxorubicin is also toxic to the mitochondria yet the underlying late onset mechanism remains elusive.

Mining of antioxidant sesquiterpene lactones from the aerial parts of Saussurea involucrata with feature-based molecular network strategy.

Sesquiterpene lactones (SLs) are a class of natural products with diverse structural scaffoldings and biological activities, making them intriguing objects in the fields of pharmaceutical industry, drug development, and pharmacology. Herein, fifteen SLs, including eleven undescribed SLs compounds sauruintones A-K (1-8 and 13-15), were isolated and identified from the aerial parts of Saussurea involucrata. Their structures were characterized by using mass spectrometry, spectroscopic methods, computational calculations, and single crystal X-ray diffraction.

Development of differential diagnostic models for distinguishing between limb-girdle muscular dystrophy and idiopathic inflammatory myopathy.

Objective: Limb-girdle muscular dystrophy (LGMD) is usually confused with idiopathic inflammatory myopathy (IIM) in clinical practice. Our study aimed to establish convenient and reliable diagnostic models for distinguishing between LGMD and IIM.

Methods: A total of 71 IIM patients, 24 LGMDR2 patients and 22 LGMDR1 patients diagnosed at our neuromuscular center were enrolled.

A Solid Electrolyte Based on Sodium-Doped LiNaTiO with PVDF for Solid State Lithium Metal Battery.

Solid-state batteries (SSBs) present a potential pathway for advancing next-generation lithium batteries, characterized by exceptional energy density and enhanced safety performance. Solid-state electrolytes have been extensively researched, yet an affordable option with outstanding electrochemical performance is still lacking. In this work, LiNaTiO (LNTO)-based composite solid electrolytes (CSEs) were developed to enhance the interface stability and electronic insulation.

Discovery of novel 2,4-diarylaminopyrimidine hydrazone derivatives as potent anti-thyroid cancer agents capable of inhibiting FAK.

In this work, thirty 2,4-diarylaminopyrimidine-based hydrazones were designed, synthesised, and their anti-thyroid cancer activity were explored. The majority of compounds exhibit moderate to excellent cytotoxic activity against FAK overexpressing TPC-1 cells, with IC values ranging from 0.113 to 1.

A larval expressed chemosensory protein involved in recognition of anthocyanins in Spodoptera litura (Lepidoptera: Noctuidae).

Anthocyanins are secondary metabolites which act as diverse functions during plant growth. Insects can discriminate host plants by their sensitive gustatory systems. It is hypothetical that chemosensory proteins (CSPs) play a crucial role in regulating this behavioral process.

Clinical and Genetic Profile of Chinese Children With Danon Disease: A Single-Center Retrospective Cohort Study.

Background: Danon disease (DD) is a rare X-linked dominant lysosomal storage disorder. Studies on DD pediatric patients are limited owing to the small number of cases and challenges in early detection.

Methods: We retrospectively analysed clinical and genetic data of 29 pediatric patients who visited our hospital for treatment or genetic counselling for DD from July 2014 to December 2023.

Confined Polyethylene Glycol Anchored in Kaolinite as High Ionic Conductivity Solid-State Electrolyte for Lithium Batteries.

Solid-state electrolytes (SSEs) have garnered significant attention as critical materials for enabling safer, energy-dense, and reversible electrochemical energy storage in batteries. Among the various types of solid electrolytes developed, composite polymer electrolytes (CPEs) have stood out as some of the most promising candidates due to their well-rounded performance. In this study, we choose polyethylene glycol (PEG) as the covalent grafting intercalant and lithium perchlorate as carrier source to prepare a fast lithium ion conductor, K-PEG-Li doped with clay-based active filler as a CPE.

Effectiveness Analysis of Awake Computed Tomography-Guided Double-Needle Percutaneous Radiofrequency Thermocoagulation for the Treatment of Glossopharyngeal Neuralgia.

Background: Percutaneous radiofrequency thermocoagulation (PRT) is an established treatment for glossopharyngeal neuralgia (GPN). However, the effectiveness of conventional single-needle PRT is limited due to the glossopharyngeal nerve's unique anatomical location.

Objectives: A major objective of our study was to evaluate the effectiveness and long-term outcomes of computed-tomography (CT)-guided double-needle PRT for patients with GPN.

Causal associations between frailty and low back pain: a bidirectional two-sample mendelian randomization study.

Background: Previous observational studies have revealed a potentially robust bidirectional relationship between frailty and low back pain (LBP). However, the precise causal relationship remains unclear.

Methods: To examine the potential causal association between frailty and LBP, we conducted bidirectional two-sample Mendelian randomization analysis (MR) study.

The extracapsular capsule phenomenon of percutaneous balloon compression provides adequate compression of the third branch of the trigeminal nerve: a retrospective study.

Background: Percutaneous balloon compression (PBC) is an effective, low-cost, and simple treatment for primary trigeminal neuralgia (TN). However, PBC has poor efficacy and no better solution for the third branch (V3) of TN.

Methods: Clinical data of 52 patients with trigeminal neuralgia treated with PBC were retrospectively analyzed.

Clinico-sero-pathological profiles and risk prediction model of idiopathic inflammatory myopathy (IIM) patients with different perifascicular changes.

Aims: To explore the clinico-sero-pathological characteristics and risk prediction model of idiopathic inflammatory myopathy (IIM) patients with different muscular perifascicular (PF) changes.

Methods: IIM patients in our center were enrolled and the clinico-sero-pathological data were retrospectively analyzed. A decision tree model was established through machine learning.