Efficacy and Safety of Unilateral Interlaminar Endoscopic Decompression for Lumbar Spinal Stenosis: A Retrospective Study of 176 Cases With a 3-6 Year Follow-Up.

Objective: Spinal endoscopic surgery is widely acknowledged as an effective and minimally invasive approach for treating lumbar disc herniation. Comprehensive descriptions of the endoscopic decompression technique for lumbar spinal stenosis (LSS) are limited in existing literature. With a focus on long-term follow-up outcomes, this study investigates the safety and efficacy of endoscopic decompression using a unilateral interlaminar approach.

Directing cell delivery to murine atherosclerotic aortic lesions via targeting inflamed circulatory interface using nanocarriers.

Stem cell therapy holds significant potential for many inflammatory diseases and regenerative medicine applications. However, delivery of therapeutic cells to specific disease sites after systemic administration without indiscriminate trafficking to other non-target tissues is a major limitation of current cell therapies. Here, we describe a novel nanocarrier-directed targeted cell delivery system that enables cell surface coating with dendrimer nanocarriers containing adhesion moieties to serve as a global positioning system "GPS" to guide circulating cells to targeted lesions and mediate the anchoring of cells at the inflammation site.

Discovery of novel fusidic acid derivatives in mitigating LPS-induced acute liver injury by modulating RIPK1.

Inflammation plays a crucial role in the onset and progression of sepsis, affecting the overall trajectory of the condition. Additionally, sepsis can result in acute liver injury, which in turn may cause damage to multiple organ systems. Fusidic acid (FA) is a natural product with a steroidal structure and has good anti-inflammatory activity without the hormonal side effects of steroidal anti-inflammatory drugs, so it has potential applications in the development of anti-inflammatory drugs.

Mobilization of mercury, thallium and arsenic in soil hydrological processes in karst catchment, southwest China.

Soils are natural pools of potentially toxic elements (PTEs), and their hydrological processes, such as runoff, infiltration, and groundwater migration, profoundly influence the migration and transformation of PTEs through biogeochemical cycling. These hydrological processes were controlled by multiple factors, including vegetation cover and land uses. This study investigates sources, spatial patterns, and migration mechanisms of mercury (Hg), thallium (Tl), and arsenic (As) in rainfall-runoff and groundwater migration processes in Lanmuchang catchment, a typical karst region in southwest China.

Short-wall roadway backfill method for sustainable mining.

It is crucial to control surface subsidence and utilize solid wastes for sustainable mining. This paper proposes a short-wall roadway backfill mining method with advantages in avoiding surface subsidence and utilizing solid wastes. A mechanical model is developed to predict roof fractures based on tensile stress.

Watershed runoff as a dominant pathway for mercury loading into a karst lake as unraveled by a novel mercury isotope and flux balance model.

Identification of sources, transport pathways, and transformation mechanisms of mercury (Hg) is fundamental to our understanding of the biogeochemical cycling of Hg in lake ecosystems. In this study, we conducted a comprehensive investigation on the isotopic compositions of Hg in water columns, sediments, atmospheric deposition endmembers, watershed river, and runoff in Hongfeng Lake (HFL) ecosystem in southwestern China. We observed significant difference in δHg between dissolved Hg (DHg) and particulate Hg (PHg) in lake, river, and runoff samples, with lighter isotopes preferentially adsorbed onto particulate matter.

Targeting ferroptosis for precision medicine in cervical cancer.

Cervical cancer (CC) is a prevalent malignant tumor in the female reproductive system, with rising incidence rates among younger women posing a significant public health challenge. Human papillomavirus (HPV) infection is the primary cause, driving carcinogenesis by promoting abnormal proliferation of tumor cells. Ferroptosis is a form of regulated necrosis that is caused by an iron-dependent accumulation of lipid peroxides with rupture of the plasma membrane.

Comprehensive analysis of growth performance, antioxidant capacity, digestive enzyme activity, and transcriptomics provides insights into the chronic high-temperature stress response of brass gudgeon (Coreius heterodon) in the Yangtze River.

Global warming poses a serious threat to both wild and farmed fish. The brass gudgeon (Coreius heterodon) is a unique species of the Yangtze River and has important scientific value for studies of the impact of climate change. In this study, brass gudgeon were cultured for 40 days at 22 °C as control group, and at 27°C and 32°C as mild and severe high-temperature groups, respectively.

Modeling trace elements over Athabasca oil sands region in Alberta, Canada using WRF-Chem.

The Athabasca Oil Sands Region (AOSR) in northern Alberta, Canada is a significant source of particulate elements, which may cause negative effects on human and ecosystem health. This study simulates the transport and deposition of eight elements (Al, Ca, Fe, K, Mn, Si, Ti, and Zn) in the AOSR during 2016-2017 using WRF-Chem with a recently developed regional-scale emission database of elements as model input. Point and area emissions of the elements were gridded in the model domain, with stack emissions also considering the plume rise.

Transport and transformation of colloidal and particulate mercury in contaminated watershed.

Submicron colloids ubiquitously present in aquatic environments and can facilitate long transport of absorbed contaminants. Impact of particle size distribution on mercury (Hg) mobility and transformation in the complex aqueous matrices is still unclear. In this study, we considered Hg mine wastes as a natural Hg releasing source to local rivers, and collected water samples from the source to the downstream during high and low flow periods.

The anti-inflammatory effects of saponins from natural herbs.

Inflammation is a protective mechanism that also starts the healing process. However, inflammatory reaction may cause severe tissue damage. The increased influx of phagocytic leukocytes may produce excessive amount of reactive oxygen species, which leads to additional cell injury.

Design and Synthesis of Hederagenin Derivatives for the Treatment of Sepsis by Targeting TAK1 and Regulating the TAK1-NF-κB/MAPK Signaling.

Sepsis is a systemic inflammatory response caused by infection and is a leading cause of death worldwide. We designed and synthesized a series of hederagenin analogues with anti-inflammatory activity. The most effective compound, , reduced the release of TNF-α and IL-6 in RAW264.

Predictive Factors for New-Onset Left Bundle Branch Block in Patients with Left Ventricular Systolic Dysfunction and Its Prognostic Value.

It remains unclear whether elevated ventricular wall pressure and left ventricular enlargement in patients with left ventricular systolic dysfunction (LVSD) can lead to left bundle branch block (LBBB). In this study, 801 consecutive hospitalized patients with a left ventricular ejection fraction of < 50% were enrolled. The primary outcome was the occurrence of new-onset LBBB or heart failure-related hospitalization, all-cause mortality, ventricular tachycardia, or implantation of an implantable cardioverter-defibrillator (ICD) /cardiac resynchronization therapy (CRT).

Atmospheric Mercury Concentrations and Isotopic Compositions Impacted by Typical Anthropogenic Mercury Emissions Sources.

Coal-fired power plants (CFPPs) and cement plants (CPs) are important anthropogenic mercury (Hg) emission sources. Mercury speciation profiles in flue gas are different among these sources, leading to significant variations in local atmospheric Hg deposition. To quantify the impacts of Hg emissions from CFPPs and CPs on local-scale atmospheric Hg deposition, this study determined concentrations and isotopes of ambient gaseous elemental mercury (GEM), particulate-bound mercury (PBM), and precipitation total Hg (THg) at multiple locations with different distances away from a CFPP and a CP.

Combating air pollution significantly reduced air mercury concentrations in China.

In the past decade, China has motivated proactive emission control measures that have successfully reduced emissions of many air pollutants. For atmospheric mercury, which is a globally transported neurotoxin, much less is known about the long-term changes in its concentrations and anthropogenic emissions in China. In this study, over a decade of continuous observations at four Chinese sites show that gaseous elemental mercury (GEM) concentrations continuously increased until the early 2010s, followed by significant declines at rates of 1.

Influence of sources and atmospheric processes on metal solubility in PM in urban Guangzhou, South China.

Water-soluble metals exert a significant influence on human and ecosystem health. In this study, a comprehensive investigation was undertaken to elucidate the solubilities of metals in PM and potential influencing factors during the dry season of 2019-2020 in urban Guangzhou, South China. The observed average solubility was <20 % for Al, Fe, Sn, and Ti; 20-40 % for V, Cr, Sb, Pb, and Ni; 40-60 % for Ba and Cu; and 60-80 % for Zn, As, Se, Cd, and Mn.

Protective effects of flavonoids against intracerebral and subarachnoid hemorrhage (Review).

Intracerebral hemorrhage (ICH), known as non-traumatic cerebrovascular rupture and hemorrhage, often occurs in the deep basal brain segment. It is known for its high morbidity and mortality rates. Subarachnoid hemorrhage (SAH) is a clinical syndrome caused by the rupture of blood vessels at the base or surface of the brain that allows blood to flow directly into the subarachnoid space.

C-phycocyanin reinforces autophagy to block pulmonary fibrogenesis by inhibiting lncIAPF biogenesis.

Pulmonary fibrosis is a chronic and irreversible progressive lung disease caused by various factors, such as age and environmental pollution. With countries stepping into an aging society and the seriousness of environmental pollution caused by global industrialization, the incidence of pulmonary fibrosis is annually increasing. However, no effective drug is available for pulmonary fibrosis treatment.

Epidemiology and prognostic nomogram for locally advanced gastric signet ring cell carcinoma: A population-based study.

Background: Gastric signet ring cell carcinoma (GSRC) represents a specific subtype of gastric cancer renowned for its contentious epidemiological features, treatment principles, and prognostic factors.

Aim: To investigate the epidemiology of GSRC and establish an improved model for predicting the prognosis of patients with locally advanced GSRC (LAGSRC) after surgery.

Methods: The annual rates of GSRC incidence and mortality, covering the years 1975 to 2019, were extracted from the Surveillance, Epidemiology, and End Results (SEER) database to explore the temporal trends in both disease incidence and mortality rates using Joinpoint software.

Mercury sources, transport, and transformation in rainfall-runoff processes: Mercury isotope approach.

Mercury (Hg) in runoff water poses significant ecological risks to aquatic ecosystems that can affect organisms. However, accurately identifying the sources and transformation processes of Hg in runoff water is challenging due to complex natural conditions. This study provides a comprehensive investigation of Hg dynamics in water from rainfall to runoff.

Using Mercury Stable Isotopes to Quantify Directional Soil-Atmosphere Hg(0) Exchanges in Rice Paddy Ecosystems: Implications for Hg(0) Emissions to the Atmosphere from Land Surfaces.

Gaseous elemental mercury [Hg(0)] emissions from soils constitute a large fraction of global total Hg(0) emissions. Existing studies do not distinguish biotic- and abiotic-mediated emissions and focus only on photoreduction mediated emissions, resulting in an underestimation of soil Hg(0) emissions into the atmosphere. In this study, directional mercury (Hg) reduction pathways in paddy soils were identified using Hg isotopes.

Contribution of emissions from the oil sands activities in Alberta, Canada to atmospheric concentration and deposition of nitrogen and sulfur species at a downwind site.

Oil sands activities in the Athabasca Oil Sands Region in Alberta, Canada, are large sources of atmospheric NO and SO. This study investigated the impact of oil sands emissions on the atmospheric deposition of nitrogen and sulfur species at a downwind site, about 350 km from the oil sands facilities. Measurement data are from the Canadian Air and Precipitation Monitoring Network (CAPMoN) from 2015 to 2019, including ambient concentrations of HNO, pNO, NO, pNH, NH, SO, pSO and base cations, as well as concentrations of NO, SO, NH, and base cations in precipitation.

Kaempferol mitigates sepsis-induced acute lung injury by modulating the SphK1/S1P/S1PR1/MLC2 signaling pathway to restore the integrity of the pulmonary endothelial cell barrier.

Sepsis-induced acute lung injury (SALI) is the common complication of sepsis, resulting in high incidence and mortality rates. The primary pathogenesis of SALI is the interplay between acute inflammation and endothelial barrier damage. Studies have shown that kaempferol (KPF) has anti-sepsis properties.

Neonicotinoid insecticides in paddy fields: Dissipation dynamics, migration, and dietary risk.

Neonicotinoid insecticides (NNIs) have caused widespread contamination of multiple environmental media and posed a serious threat to ecosystem health by accidently injuring non-target species. This study collected samples of water, soil, and rice plant tissues in a water-soil-plant system of paddy fields after spaying imidacloprid (IMI), thiamethoxam (THM), and clothianidin (CLO) to analyze their distribution characteristics and migration procedures and to assess related dietary risks of rice consumption. In the paddy water, the concentrations of NNIs showed a dynamic change of increasing and then decreasing during about a month period, and the initial deposition of NNIs showed a trend of CLO (3.