A prognostic model of platinum resistance in osteosarcoma: Key roles of BNIP3, MYC, and ACTA2.

Background: Platinum resistance poses a significant challenge in the treatment of osteosarcoma, leading to poor prognosis and limited therapeutic options. This study aims to develop a prognostic model by analyzing platinum-resistant genes (PRGs), focusing on their roles in lysosomal function and immune suppression.

Methods: We conducted a univariable Cox analysis to identify diagnostic-related genes (PRGs) from a training cohort of osteosarcoma patients.

From Carbon Nitrides to COFs: Opportunities and Prospects in Photocatalytic CO Reduction.

The continuing increase in atmospheric carbon dioxide (CO), a major greenhouse gas and accelerating climate change are driving demand for innovative mitigation strategies. The photocatalytic CO reduction reaction (PCORR) presents a promising and sustainable route to convert CO into useful hydrocarbons and fuels utilizing sunlight, thereby mitigating CO emissions. This review examines the developmental aspects of light-driven CO conversion using organic polymeric photocatalysts, focusing on carbon nitrides (CNs), covalent triazine frameworks (CTFs), and covalent organic frameworks (COFs).

Value of the spot sign combined with the blend sign for predicting the outcome of patients with intracerebral hemorrhage who have undergone stereotactic minimally invasive surgery.

Objective: This study aimed to explore the effect of combining the computed tomographic angiography (CTA) spot sign with the computed tomography (CT) blend sign for predicting the outcome of patients with intracerebral hemorrhage (ICH) who have undergone stereotactic minimally invasive surgery (sMIS).

Methods: Patients with ICH treated with sMIS between January 2018 and April 2023 at the affiliated hospital of Guizhou Medical University were retrospectively included. A modified Rankin scale (mRS) score of ≥3 at 3 months was defined as a poor outcome.

Advancements and prospects of near-infrared-light driven CO reduction reaction.

In the realm of photoconversion of CO into high-value chemicals, the importance of near-infrared (NIR) light is gradually gaining recognition. Relative to ultraviolet (UV) and visible light, NIR light (700-2500 nm), accounting for 50% of solar energy, offers unique advantages such as deeper penetration depth and stronger photothermal effects. Thus, utilizing NIR light can not only compensate for the inherent limitations of UV/visible light-based CO reduction systems, but also maximize the use of solar energy.

Coherently Coupled Frustrated Lewis Pairs in InO Nanoclusters for Selective CO Photoreduction to CH.

Co-catalysts integration presents unique opportunities to enhance photoactivity, yet selectivity control and mechanistic understanding within multistep reactions remain fundamental challenges hitherto. In this study, a reshaped kinetic landscape is demonstrated over coherently coupled surface frustrated Lewis pairs (FLPs) on carbon nitride matrix, which mediates directed CO-to-CH conversion with a selectivity of 65.3% (electron basis).

Apolipoprotein E-ε4 allele is associated with perihematomal brain edema and poor outcomes in patients with intracerebral hemorrhage.

Intracerebral hemorrhage (ICH) poses significant disability and mortality risks and perihematomal edema (PHE) plays a crucial role in ICH prognosis. The ApoE-ε4 allele has been implicated in exacerbating PHE and influencing neurological recovery post-ICH, yet, this specific association has not been explored much. This study aimed to investigate the correlation between ApoE-ε4 allele, PHE, and clinical prognosis in patients with ICH.

Out-of-Plane Single-Copper-Site Catalysts for Room-Temperature Benzene Oxidation.

Crafting single-atom catalysts (SACs) that possess "just right" modulated electronic and geometric structures, granting accessible active sites for direct room-temperature benzene oxidation is a coveted objective. However, achieving this goal remains a formidable challenge. Here, we introduce an innovative in situ phosphorus-immitting strategy using a new phosphorus source (phosphorus nitride, PN) to construct the phosphorus-rich copper (Cu) SACs, designated as Cu/NPC.

CO Enrichment Boosts Highly Selective Infrared-Light-Driven CO Conversion to CH by UiO-66/CoS Photocatalyst.

Photocatalytic CO reduction to high-value chemicals is an attractive approach to mitigate climate change, but it remains a great challenge to produce a specific product selectively by IR light. Hence, UiO-66/CoS composite is designed to couple the advantages of metallic photocatalysts and porous CO adsorbers for IR-light-driven CO-to-CH conversion. The metallic nature of CoS endows UiO-66/CoS with exceptional IR light absorption, while UiO-66 dramatically enhances its local CO concentration, revealed by finite-element method simulations.

Merging Platinum Single Atoms to Achieve Ultrahigh Mass Activity and Low Hydrogen Production Cost.

Single atom catalysts (SACs) with isolated active sites exhibit the highest reported mass activity for hydrogen evolution catalysis, which is crucial for practical applications. Here, we demonstrate that ultrahigh mass activity can also be achieved by rationally merging the isolated platinum (Pt) active sites in SAC. The catalyst was obtained by the thermodynamically driven diffusing and merging phosphorus-doped carbon (PC) supported Pt single atoms (Pt@PC) into Pt nanoclusters (Pt@PC).

Tin Nanoclusters Confined in Nitrogenated Carbon for the Oxygen Reduction Reaction.

The oxygen reduction reaction is essential for fuel cells and metal-air batteries in renewable energy technologies. Developing platinum-group-metal (PGM)-free catalysts with comparable catalytic performance is highly desired for cost efficiency. Here, we report a tin (Sn) nanocluster confined catalyst for the electrochemical oxygen reduction.

Comprehensive risk assessments and anesthetic management for children with osteogenesis imperfecta: A retrospective review of 252 orthopedic procedures over 5 years.

Background: Major anesthetic risks arise in orthopedic surgeries for children with osteogenesis imperfecta, a rare genetically inherited condition presenting diverse skeletal issues.

Aim: We aimed to investigate anesthetic risks, including difficult airway, hypo- and hyperthermia, blood loss, and pain, in connection with patient, anesthetic, and surgical factors.

Methods: Both descriptive and inferential statistics were employed to study the anesthetic risks and their predictors.

In Situ Construction of Flexible VNi Redox Centers over Ni-Based MOF Nanosheet Arrays for Electrochemical Water Oxidation.

Atomic-level design and construction of synergistic active centers are central to develop advanced oxygen electrocatalysts toward efficient energy conversion. Herein, an in situ construction strategy to introduce flexible redox sites of VNi centers onto Ni-based metal-organic framework (MOF) nanosheet arrays (NiV-MOF NAs) as a promising oxygen electrocatalyst is developed. The abundant redox VNi centers with flexible metal valence states of V and Ni enable NiV-MOF NAs excellent oxygen evolution reaction (OER) activity and a long-term stability under high current densities, achieving current densities of 10 and 100 mA cm at recorded overpotentials of 189 and 290 mV, respectively, and showing ignorable decay of initial activity at 100 mA cm after 100 h OER operation.

Operando Insight into the Oxygen Evolution Kinetics on the Metal-Free Carbon-Based Electrocatalyst in an Acidic Solution.

Operando insight into the catalytic kinetics under working conditions is important for further rationalizing the design of advanced catalysts toward efficient renewable energy applications. Here, we enable a ubiquitous carbon material as an efficient acidic oxygen evolution reaction (OER) electrocatalyst, synthesized via a facile and controllable "amino-assisted polymerization and carbonization" strategy. This as-developed metal-free amino-rich hierarchical-network carbon (amino-HNC) framework directly supported on carbon paper can catalyze OER at a quite low overpotential of 281 mV and a small Tafel slope of 96 mV dec in an acid solution, and maintain ∼98% of its initial catalytic activity after 100 h oxygen evolution operation.

Single-Site Active Cobalt-Based Photocatalyst with a Long Carrier Lifetime for Spontaneous Overall Water Splitting.

An active and stable photocatalyst to directly split water is desirable for solar-energy conversion. However, it is difficult to accomplish overall water splitting without sacrificial electron donors. Herein, we demonstrate a strategy via constructing a single site to simultaneously promote charge separation and catalytic activity for robust overall water splitting.

Fast Photoelectron Transfer in (C)-CN Plane Heterostructural Nanosheets for Overall Water Splitting.

Direct and efficient photocatalytic water splitting is critical for sustainable conversion and storage of renewable solar energy. Here, we propose a conceptual design of two-dimensional CN-based in-plane heterostructure to achieve fast spatial transfer of photoexcited electrons for realizing highly efficient and spontaneous overall water splitting. This unique plane heterostructural carbon ring (C)-CN nanosheet can synchronously expedite electron-hole pair separation and promote photoelectron transport through the local in-plane π-conjugated electric field, synergistically elongating the photocarrier diffusion length and lifetime by 10 times relative to those achieved with pristine g-CN.

Effect of fire engulfment on thermal response of LPG tanks.

A model has been developed to predict the thermal response of liquefied-pressure gases (LPG) tanks under fire, and three-dimensional numerical simulations were carried out on a horizontal LPG tank which was 60% filled. Comparison between numerical predictions and published experimental data shows close agreement. The attention is focused on the influence of different fire conditions (different fire scenarios, various engulfing degrees and flame temperatures) on thermal response of LPG tanks.

[Effects of elevating temperature on photodynamic reaction in laryngeal squamous carcinoma cells induced by delta-aminolevulinic acid].

Objective: To investigate effect of temperature on delta-aminolevulinic acid (ALA) induced photodynamic reaction in laryngeal squamous carcinoma cells.

Methods: Human laryngeal squamous carcinoma cells of the line Hep-2 cells were co-cultured with 2 mmol/L ALA (Group A) or without ALA (Group B) at the culturing temperature 19 - 46 degrees C. Three hours later cellular protoporphyrin IX (PpIX) level was determined by high performance liquid chromatography with fluorescent detection.