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In the context of a rapidly expanding global population, mulberry leaf protein emerges as an emerging source of plant protein, with most applications currently at Technology Readiness Level (TRL), presenting substantial potential for application in functional foods and nutraceuticals. This paper analyzes three key advantages of mulberry leaf protein. Firstly, the abundant and inexpensive production of mulberry leaves establishes a solid foundation for large-scale protein extraction. Secondly, advancements in the preparation processes and production technology for mulberry leaf protein have further enhanced its viability. Thirdly, mulberry leaf protein boasts excellent nutritional value and outstanding functional properties, along with multiple biological activities, including antioxidant effects, aging delay, and blood-pressure-lowering activity. These superior qualities considerably broaden its range of applications. Furthermore, this paper evaluates existing research (before 30 June 2025) while exploring prospective avenues for future investigation. The findings of this review are important for enhancing the understanding of the potential applications of mulberry leaf protein in food science and nutrition. The aim is to provide new ideas for the efficient utilization of mulberry leaf protein resources and the establishment of a global food security system.
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http://dx.doi.org/10.3390/foods14152602 | DOI Listing |
Neurochem Int
August 2025
Department of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, 33378, Taiwan. Electronic address:
In Alzheimer's disease (AD), Tau aggregates trigger microglial activation to release inflammatory factors and cause mitochondrial dysfunction, oxidative stress, and neuronal damage. With abundant potent antioxidants, mulberry (Morus alba L.) leaf extract has the potential to treat diseases associated with neuroinflammation, mitochondrial dysfunction, and oxidative stress.
View Article and Find Full Text PDFBiol Futur
August 2025
CSB-Central Sericultural Research & Training Institute, Srirampura, Mysuru, Karnataka, 570008, India.
Micronutrients contribute significantly to homeostasis at the cellular, physiological, and biological interface of silkworm growth and development. The silkworm cocoon traits are highly physiologically dependent, controlled by the optimum availability of micronutrient concentrations. Keeping this in view, two micronutrients, i.
View Article and Find Full Text PDFJ Ethnopharmacol
August 2025
Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address:
Ethnopharmacological Relevance: Mulberry leaf (Morus alba L.), traditionally recorded in "Compendium of Materia Medica" for diabetes treatment. Mulberry leaf water extract (MLE) has also been shown in modern studies to improve blood glucose levels while restoring gut microbiota homeostasis and increasing short-chain fatty acids (SCFAs) levels.
View Article and Find Full Text PDFBiochem Biophys Res Commun
September 2025
Foshan Kunpeng Institute of Modern Agriculture, Chinese Academy of Agricultural Sciences, Foshan, 528225, PR China; Shenzhen Institute of Agricultural Genomics, Chinese Academy of Agricultural Sciences (Shenzhen Branch of Guangdong Laboratory for Lingnan Modern Agriculture), Shenzhen, 518124, PR Chi
This study identifies a novel antimicrobial peptide, Squ8, from fermented mulberry leaves via LC-MS. The peptide (amino acid sequence RMGAGMAK, 820 Da) features an α-helical structure, +2 net charge, 50 % hydrophobicity, and antibacterial activity against Gram-negative/positive bacteria. Unlike many antimicrobial peptides that are easily inactivated under extreme temperatures or pH conditions, Squ8 retains its activity under such circumstances and has a low hemolysis rate, thus demonstrating excellent stability and safety.
View Article and Find Full Text PDFFoods
July 2025
Institute of Sericulture and Apiculture, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.
In the context of a rapidly expanding global population, mulberry leaf protein emerges as an emerging source of plant protein, with most applications currently at Technology Readiness Level (TRL), presenting substantial potential for application in functional foods and nutraceuticals. This paper analyzes three key advantages of mulberry leaf protein. Firstly, the abundant and inexpensive production of mulberry leaves establishes a solid foundation for large-scale protein extraction.
View Article and Find Full Text PDF