Visualized breath-hold training for reducing respiratory motion artifacts in liver dynamic contrast-enhanced magnetic resonance imaging.

Background: Liver dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) plays a critical role in detecting hepatic lesions but is highly susceptible to respiratory motion artifacts. Although advancements in rapid magnetic resonance (MR) acquisition techniques have been made, breath-hold acquisitions are predominantly used for abdominal DCE-MRI due to their superior image quality. Therefore, prescan breath-hold training is essential to improving patients' compliance and minimizing respiratory artifacts.

Biodegradation of high-molecular-weight polycyclic aromatic hydrocarbons by a novel species of the genus isolated from the deep-sea region of the Kermadec Trench.

Polycyclic aromatic hydrocarbons (PAHs) are categorized as persistent organic pollutants due to their high toxicity and environmental persistence. In this study, a deep-sea bacterium, designed Naph2, was isolated from the sediments of the Kermadec Trench using PAH-enriched cultures. A comparative analysis of Overall Genome Relatedness Indices (OGRI) values between Naph2 and closely related strains within the genus indicated that the isolate represents a novel species, designated as sp.

Quantitative assessment of liver graft function using functional automated whole-liver score derived from gadoxetic acid-enhanced MRI: a prospective cohort study.

Objectives: Accurate and timely assessment of liver graft function is of great significance for the survival of liver grafts and liver transplant recipients. This study aimed to investigate the correlation between the functional automated whole-liver score (FAWLS) system derived from gadoxetic acid-enhanced magnetic resonance imaging (MRI) and quantitative measurements of liver graft function. Additionally, it sought to determine the utility of FAWLS in evaluating the severity of liver graft injury and monitoring treatment response following therapy, through an association analysis with liver biopsy findings to validate its effectiveness as a non-invasive diagnostic tool.

, a gene encoding anthranilic acid synthase, contributes to tryptophan biosynthesis and enhanced chaetoglobosin A production in W7.

Chaetoglobosin A (cheA) is a complex indole alkaloid exhibiting preferential cytotoxicity against plant pathogens, parasites, and tumor cells. However, the limited production and high synthesis costs of cheA impede its widespread application. Tryptophan serves as a precursor for cheA biosynthesis, and strategic modification of the expression of key genes represents a novel approach to enhance the target yield.

Functional Sodium MRI in the Measurement of Corticomedullary Sodium Content and Its Role in Differentiating Between Transplanted Kidneys With Superior and Inferior Graft Function.

Background: Sodium MRI (Na-MRI) measuring tissue sodium content may directly assess the corticomedullary gradient (CMG) in the kidney. However, it is understudied in transplanted kidneys.

Purpose: To investigate associations between CMG in renal graft and urine concentrating ability, estimated glomerular filtration rate (eGFR), and biopsy-determined fibrosis scores, and to determine if CMG could differentiate between renal grafts with superior and inferior graft function.

USP35 promotes hepatocellular carcinoma proliferation through GASC1-mediated ROCK2 upregulation.

Ubiquitin-specific protease 35 (USP35) regulates the oncogenic process of various cancers by stabilizing target proteins through deubiquitination. However, the function of USP35 in hepatocellular carcinoma (HCC) remains unclear. Our results demonstrated that USP35 was significantly over-expressed in HCC.

Interfacial cation engineering in δ-MnO nanosheets for efficient oxygen reduction reaction.

The cationic effect on δ-MnO nanosheets for the oxygen reduction reaction (ORR) is investigated by intercalating different interfacial cations (Li, Cs, diallyldimethylammonium (DADMA) and polydimethyl diallyl ammonium (PDDA)). Experimental and theoretical analyses demonstrate that interfacial cations can modulate the catalytic activity by tailoring the electronic structure and spatial water molecule distribution between δ-MnO nanosheets.

CoWO nanoparticles with dual active sites for highly efficient ammonia synthesis.

The electrochemical reduction reaction of NO (NORR) represents a promising green technology for ammonia (NH) synthesis. Among various electrocatalysts, Co-based materials have demonstrated considerable potential for the NORR. However, the NH production efficiency of Co-based materials is still limited due to challenges in the competitive hydrogen evolution reaction (HER) and hydrogenating oxynitride intermediates (*NO).

Storage and release of NO and I via layered double hydroxide in carbonate electrolyte for stable lithium metal battery.

The formation of inactive lithium (Li) in Li metal battery (LMB) primarily originates from the undesirable components of solid electrolyte interphase (SEI) and the growth of dendritic Li. LiNO has emerged as a promising electrolyte additive for mitigating interfacial instability and Li dendrite propagation through the in situ construction of nitride-rich SEI. However, the limited solubility of LiNO in carbonate electrolytes hinders its practical utilization.

The mechanistic action of mogroside V in the alleviation of oxidative aging.

Introduce: Diseases related to oxidative ageing are becoming increasingly evident in younger individuals. In this study, we investigated the mechanisms underlying the actions of mogroside V when used to treat anti-oxidative ageing.

Methods: We used D-galactose-induced LO2 cells and C57BL/6J mice as models to investigate the molecular mechanisms of mogroside V (MV) for the treatment of oxidative ageing.

Production and Functional Verification of 8-Gene (GGTA1, CMAH, β4GalNT2, hCD46, hCD55, hCD59, hTBM, hCD39)-Edited Donor Pigs for Xenotransplantation.

Gene-edited (GE) pig-to-human xenotransplantation continues to make breakthroughs, but which kind of gene combination is suitable for organ-specific transplantation remains unclear. In this study, we utilised CRISPR/Cas9 gene editing technology, PiggyBac transposon system, and serial somatic cell cloning technology to develop GTKO/CMAHKO/β4GalNT2KO/hCD46/hCD55/hCD59/hCD39/hTBM 8 gene-edited cloned (GEC) donor pigs and performed pig-to-non-human primate (NHP) transplantation to evaluate the effectiveness of these GEC pigs. The 8-GEC pigs were obtained by recloning with a 33-day-old 8-GEC fetus with O blood type, which was generated after cell transfection, screening of cell colonies, and somatic cell cloning.

Optimization of regions of interest sampling strategies for proton density fat-fraction MRI of hepatic steatosis before liver transplantation in ex vivo livers.

Objectives: The quantity of regions of interest (ROIs) constitutes the primary determinant of the time investment in image analysis. In the context of proton density fat-fraction (PDFF) magnetic resonance imaging (MRI) conducted on liver grafts in ex vivo conditions, this research systematically examines various ROI sampling strategies. The findings of this study furnish essential insights, offering a foundation for optimizing time efficiency while ensuring precise assessment of hepatic steatosis before the crucial process of liver transplantation.

Interlayer Confined Capacitive Response via Solvated Cointercalation in Graphite Layers.

Nanofluids confined within two-dimensional materials promote ionic flux, which is essential for achieving ultrahigh-rate capacitor-like responses and high charge storage capacity. Here, we offer quantitative and microscopic insights into the interlayer-confined electric double-layer (EDL) capacitive behavior arising from the cointercalation of Na-diglyme ([Na-G2]) into graphite layers. By leveraging nuclear magnetic resonance, electrochemical quartz crystal microbalance, embedded optical fiber sensors, and other techniques, it demonstrates that a nonconstant Na:G2 ratio during cointercalation into graphite with the evolution of the stages.

Reprogramming of lipids and amino acids metabolism is an early event in myocardium of type 1 diabetic rhesus monkeys.

Diabetic cardiomyopathy (DC) refers to the abnormal myocardial structure and performance induced by diabetes. Although numerous studies have been carried out, the pathophysiological mechanisms of cardiovascular disorders during diabetes have not been fully clarified. Here, we compared the cardiomyopathy of healthy rhesus monkeys and rhesus monkeys with a history of streptozocin induced type 1 diabetes (T1D) over 7 years.

Vitamin C alleviates intestinal damage induced by 17α-methyltestosterone in Carassius auratus.

17α-Methyltestosterone (MT), an environmental endocrine-disrupting chemical (EDC), is widely present in aquatic environments, posing potential threats to the health of aquatic organisms. This study aimed to explore the protective effects of Vitamin C (VC) against MT-induced intestinal injury in Carassius auratus and evaluate the optimal VC dosage. C.

Human breast milk-derived exosomes and their positive role on neonatal intestinal health.

Although the role of breast milk in promoting neonatal growth and maintaining intestinal homeostasis is well established, underlying mechanisms by which it protects the intestine from damage remain to be elucidated. Human breast milk-derived exosomes (HMDEs) are newly discovered active signaling vesicles with a diameter of 30-150 nm, which are key carriers of biological information exchange between mother and child. In addition, due to their ability to cross the gastrointestinal barrier, low immunogenicity, good biocompatibility and stability, HMDEs play an important role in regulating intestinal barrier integrity in newborns.

Male-assisted training and injury patterns: hypergraph-enhanced analysis of injuries in women's water polo.

Introduction: The aim of this study is to compare the injury patterns of female water polo players before and after the implementation of the Male-Assisted Female Training (MAFT) program. The study seeks to identify key factors influencing these changes and propose corresponding injury prevention measures.

Methods: We utilized pattern analysis and classification techniques to explore the injury data.

Atomistic Study on the Mechanical Properties of HOP-Graphene Under Variable Strain, Temperature, and Defect Conditions.

HOP-graphene is a graphene structural derivative consisting of 5-, 6-, and 8-membered carbon rings with distinctive electrical properties. This paper presents a systematic investigation of the effects of varying sizes, strain rates, temperatures, and defects on the mechanical properties of HOP-graphene, utilizing molecular dynamics simulations. The results revealed that Young's modulus of HOP-graphene in the armchair direction is 21.

Effects of combined exposure to 17α-methyltestosterone and polystyrene microplastics on lipid metabolism and the nervous system in Danio rerio.

Polystyrene (PS) microplastics are pervasive environmental pollutants that are harmful to aquatic organisms upon degradation. The synthetic androgen 17α-methyltestosterone (MT) is an environmental endocrine-disrupting chemical. This study aimed to systematically evaluate the combined histological and molecular effects of MT and PS exposure on the liver and brain tissues of Danio rerio with focus on lipid metabolism and neural function disruption.

Mechanism of vitamin C alleviating the immunotoxicity of 17α-methyltestosterone in Carassius auratus.

Background: In recent years, the use of endocrine-disrupting chemicals (EDCs) has become increasingly common, leading to severe environmental pollution and harm to aquatic organisms. 17α-Methyltestosterone (MT) is a synthetic androgen that can cause immunotoxicity in aquaculture, affecting fish health. To address this issue, this study aimed to investigate the effect of Vitamin C (VC) on MT-induced immunotoxicity and determine the optimal VC supplementation.

Molecular Dynamics Insights into Mechanical Stability, Elastic Properties, and Fracture Behavior of PHOTH-Graphene.

PHOTH-graphene is a newly predicted 2D carbon material with a low-energy structure. However, its mechanical stability and fracture properties are still elusive. The mechanical stability, elastic, and fracture properties of PHOTH-graphene were investigated using classical molecular dynamics (MD) simulations equipped with REBO potential in this study.

Two-dimensional nanomaterials based on rare earth elements for biomedical applications.

As a kind of star materials, two-dimensional (2D) nanomaterials have attracted tremendous attention for their unique structures, excellent performance and wide applications. In recent years, layered rare earth-based or doped nanomaterials have become a new important member of the 2D nanomaterial family and have attracted significant interest, especially layered rare earth hydroxides (LREHs) and layered rare earth-doped perovskites with anion-exchangeability and exfoliative properties. In this review, we systematically summarize the synthesis, exfoliation, fabrication and biomedical applications of 2D rare earth nanomaterials.

A nomogram incorporating Psoas muscle index for predicting tumor recurrence after liver transplantation: A retrospective study in an Eastern Asian population.

Background And Aims: Tumor recurrence significantly affects the prognostic outcomes for liver cancer patients following liver transplantation. However, existing predictive models often neglect the inclusion of body composition indicators. Hence, this research aimed to investigate the significance of the psoas muscle index (PMI) in evaluating the post-transplant prognosis of liver cancer.

Ex Tenebris Lux: Illuminating Reactive Oxygen and Nitrogen Species with Small Molecule Probes.

Reactive oxygen and nitrogen species are small reactive molecules derived from elements in the air─oxygen and nitrogen. They are produced in biological systems to mediate fundamental aspects of cellular signaling but must be very tightly balanced to prevent indiscriminate damage to biological molecules. Small molecule probes can transmute the specific nature of each reactive oxygen and nitrogen species into an observable luminescent signal (or even an acoustic wave) to offer sensitive and selective imaging in living cells and whole animals.

Peteryoungia algae sp. nov. isolated from seaweeds of Gouqi Island, China, and its unique genetic features among Peteryoungia strains.

A Gram-stain-negative, light khaki, strictly aerobic, rod-shaped, motile via multiple flagella, and catalase- and oxidase-positive bacterium, designated as SSM4.3, was isolated from the seaweed of Gouqi Island in the East China Sea. The novel isolate grows at 0-5.