The relationship between nursing students' psychological capital and occupational stigma in the Chinese context: A potential profiling analysis.

Aims: The aim of the present study is to analyse latent profiles of psychological capital and the demographic characteristics of undergraduate nursing students and to explore the relationship between each category and their awareness of occupational stigma.

Background: The conventional external view of nurses and a lack of a sense of professional identity may cause nursing students to leave the field. The psychological qualities of nursing students and how they relate to professional stigma must be studied to eliminate professional stigma through positive psychology.

Breaking Acid-Induced Fluorescence Quenching in Fluorescein Derivatives: Surfactant-Directed Aggregation Control for On-Demand Multiple Encryption.

The inactivation of fluorescein derivatives due to proton attack under acidic conditions completely limits the optical properties and hinders a wide range of applications. Aggregation-related quenching is found to be another fundamental trait in addition to spirocyclization. Self-assembled dispersions of surfactants have been shown to precisely break the quenching limitation, thereby fully restoring or even enhancing the original optical properties.

A multifunctional nanozyme hydrogel film with antibacterial and antioxidant activity for fruit packaging and freshness preservation.

Hydrogel films have emerged as a significant focus in the field of food preservation, particularly those with multifunctional properties that show considerable promise in both protecting food and monitoring its condition. This research details the development of an antioxidant nanozyme (CuLyz) designed to preserve freshness, achieved by chelating copper ions with lysozyme (Lyz). Subsequently, a multifunctional hydrogel film (PVA/TA/CuLyz) was created, incorporating polyvinyl alcohol (PVA), tannic acid (TA), and CuLyz.

Schisandrol A-loaded mesenchymal stem cell exosomes modulate FTO/miR-21/WNT5A axis to promote skin healing.

Background: Schisandrol A (SA), the primary active component of Schisandra chinensis, exhibits antioxidant properties, safeguarding cells from oxidative damage. However, its effect on wound healing remains elusive, and its low water solubility restricts its utilization efficiency.

Objective: This study aimed to explore the impact of SA on HaCaT cell proliferation and migration through in vitro experiments, thereby providing deeper insights into its role in skin wound healing.

Enhancing spatial navigation performance through boundary cues in the virtual environment.

Spatial navigation refers to the ability to determine one's position in an environment and successfully reach a target destination. This process relies on both self-motion cues and environmental cues, with boundary cues being particularly influential. This study investigates how different characteristics of boundaries affect spatial memory during virtual navigation.

Antimicrobial peptide-targeted photodynamic therapy for preventing periodontal plaque biofilm formation through the disruption of quorum sensing system.

Owing to high rates of antibiotic resistance, the elimination of periodontal plaque biofilms has become a significant clinical challenge. In this context, metal-organic framework (MOF)-based photodynamic therapy (PDT) has emerged as a novel antimicrobial treatment option. However, this therapeutic strategy suffers from drawbacks such as the insufficient generation of reactive oxygen species and the lack of targeted biofilm clearance, which greatly hinder its clinical application.

Prognostic nutritional index as a potential predictor of prognosis in patients with sepsis: a retrospective cohort study.

Background: Sepsis patients often have immune dysfunction and malnutrition, which is a high-risk disease for death in critically ill patients. Although various biomarkers can predict the prognosis of sepsis patients, they are cumbersome to implement clinically. This study evaluates the prognostic potential of the Prognostic Nutritional Index (PNI) to fill this gap.

Linear inverse association between prognostic nutritional index and colorectal cancer risk based on NHANES data.

Despite the Prognostic Nutritional Index (PNI) serving as a crucial prognostic marker for predicting survival outcomes in cancer patients, its association with the risk of Colorectal Cancer (CRC) is not well comprehended. We hypothesized that lower PNI levels are associated with a higher risk of CRC. The datasets from the National Health and Nutrition Examination Survey (NHANES) spanning from 2007 to 2016 were employed in this study, incorporating data on demographics, laboratory tests, and questionnaires.

Responding after Hurricane Helene: Rapidly Estimating Impacts to Environmental Health Services in North Carolina.

Hurricane Helene caused catastrophic flooding and infrastructure damage across the mountainous regions of western North Carolina. Responding agencies had to make real-time decisions about emergency response, infrastructure repair, and aid allocation. Here, we describe how our decade-long transdisciplinary research program supported data-driven recovery decisions in the days following a storm through the development of a novel emergency response decision support system (DSS).

Comparison of Non-liposuction and Liposuction Techniques in Single-port Endoscopic Subcutaneous Mastectomy for Gynecomastia: A Retrospective Analysis.

Background: Gynecomastia (GM) is a common benign proliferation of male breast tissue that can significantly impact patients' physical and mental health. Endoscopic subcutaneous mastectomy (ESCM) has emerged as a promising minimally invasive approach for treating GM. However, the relative efficacy of different techniques for creating operative space during ESCM remains unclear.

Emerging role of circular RNAs in gastric cancer: From basic biology to clinical applications (Review).

Despite considerable advances in cancer treatment, gastric cancer (GC) remains a formidable challenge for oncologists worldwide, especially due to the poor survival rates associated with advanced‑stage cases. Circular RNAs (circRNAs) stand out as potential targets for more effective therapeutic strategies. The present review synthesizes insights into the roles of circRNAs in GC, highlighting their multifaceted influence on cancer progression and behaviors.

Comprehensive analysis of prognosis and drug sensitivity of programmed cell death pattern-related genes in gastric cancer patients.

Currently, effective prediction models for patients with advanced and postoperative gastric cancer (GC) are lacking. Programmed cell death (PCD) plays a crucial role in the development and metastasis of malignant tumors. This study aimed to investigate the underlying PCD-related molecular mechanisms and develop predictive models for GC.

Examining the Impact of Digital Inclusion on Depression Among Older Adults in China: Mediating Role of Noncognitive Abilities.

Background: In the digital and intelligent era, a considerable number of older adults in China still have a low level of digital inclusion. Although existing literature has explored the relationship between the use of the internet and depression among older adults to some extent, it mainly focused on surface aspects rather than delving into the underlying mechanism of action among digital inclusion, depression, and noncognitive abilities, which remains unclear.

Objective: This study aims to explore the mediating role of noncognitive abilities between digital inclusion and depression among older adults in China, as well as the parallel mediating roles of each dimension of the Big Five personality traits in the relationship between them.

Revealing the Incidence of the Accelerated Blood Clearance Phenomenon of PEGylated Liposomes in Individuals Using a Drug-Release Reporter Liposome.

Anti-polyethylene glycol (PEG) antibodies exist in many individuals and may lead to accelerated blood clearance (ABC) of PEGylated liposomes. However, the prevalence of the ABC phenomenon in individuals has remained unclear due to the absence of an effective prediction method. In this study, a drug-release reporter liposome is developed by encapsulating rapidly activated 7-ethyl-10-hydroxycamptothecin (SN38)-glutathione (GSH) within the liposomes, enabling to accurately assess drug release in plasma based on the SN38/(SN38+SN38-GSH) ratio.

Research on an automatic light field refocusing method for a camera array.

Light field information includes the position and angle information of light in space. A camera array is one of the methods for obtaining light field information, which combines and arranges multiple cameras in space to achieve multi-angle imaging of the same target. Based on the light field information, a computational imaging method can be used to achieve refocusing technology for a camera array (also known as optical synthetic aperture imaging technology).

Impact of Pre-miR-218 rs11134527 Polymorphism on Ischemic Stroke in a Chinese Han Population: A Case-Control Study.

Introduction: Ischemic stroke (IS) exhibits a high mortality rate, and its pathogenesis is intricately linked to genetic factors. This study was to examine the association between the precursor microRNA-218 (pre-miR-218) rs11134527 polymorphism and genetic susceptibility to IS in the Han Chinese population.

Methods: The study included 320 IS patients and 290 healthy controls.

Total Flavonoids of Engelhardia roxburghiana Wall. Attenuated Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism and Inflammation Through Targeting SREBP1 and PPARα.

This research delved into the effects and mechanisms of total flavonoids of Engelhardia roxburghiana Wall. (TFER) on nonalcoholic fatty liver disease (NAFLD). High-fat diet-induced NAFLD rat models and palmitic acid-induced HepG2 cell models were employed.

Barriers to Oral Hygiene Self-Management Among Patients with Oral Cancer Treated with Radiotherapy: A Qualitative Study Using the COM-B Model.

Purpose: This study aimed to assess the factors that hinder self-oral hygiene management behaviour in patients with oral cancer undergoing radiotherapy to inform intervention programme development.

Materials And Methods: Based on the capability, motivation, and opportunity-behaviour (COM-B) model, a qualitative study was conducted involving 18 patients with oral cancer receiving radiotherapy at a tertiary hospital from March to June 2024. Semi-structured face-to-face interviews were performed to investigate the oral hygiene self-management experience of patients.

Prediction of depression risk in middle-aged and elderly Cardiovascular-Kidney-Metabolic syndrome patients by social and environmental determinants of health: an interpretable machine learning approach using longitudinal data from China.

Background: Cardiovascular-Kidney-Metabolic (CKM) syndrome is a systemic disease characterized by pathophysiological interactions between the cardiovascular system, chronic kidney disease, and metabolic risk factors. In China, the prevalence of CKM in middle-aged and elderly patients is relatively high. The current research lacks an exploration into the impact of social and environmental determinants of health on depression in CKM patients.

Miniaturized Soft and Stretchable Multilayer Circuits through Laser-Defined High Aspect-Ratio Printing.

Stretchable electronics enable seamless integration of wearables with the human body, thereby creating new opportunities in biomedical applications. Miniaturized multilayer stretchable printed circuit boards are key for achieving high functional density circuits with minimal footprint. However, current microfabrication technologies struggle with simultaneously achieving tissue-like softness (<<1 MPa), high resolution and low sheet resistance.

Dual-Potential Ratiometric Electrochemiluminescent Immunosensor Modulated by the Single Luminophore Gd-Ru-MOFs.

Multi-signal ratiometric electrochemiluminescence (ECL) sensors have attracted considerable attention owing to their remarkable sensitivity and precision. Here, a novel dual-potential ratiometric ECL sensor has been developed for the ultrasensitive detection of estriol (E3), employing Gd-Ru metal-organic frameworks (Gd-Ru-MOFs) as the single luminophore. The Gd-Ru-MOFs, synthesized with meso-tetra(4-carboxyphenyl)porphine (TCPP) and tris(4,4'-dicarboxylicacid-2,2'-bipyridyl)ruthenium(II) chloride (Ru(Hdcbpy)·Cl) as the ligands, are capable of emitting stable cathodic and anodic ECL signals when potassium persulfate (KSO) and triethylamine (TPrA) are present.

Insight into congener substitution effects on the combustion chemistry of tetramethoxysilane and tetramethoxymethane: an experimental and kinetic modeling study.

Methoxysilane precursors are widely used in the flame synthesis of nano-silica, while the unclear combustion reaction mechanism hinders the development of directional synthesis technology. To obtain an in-depth understanding of the methoxysilane combustion chemistry and to explore the differences between Si and its congener C, this work presents a comprehensive study on the congener substitution effects in the combustion kinetics of the flame synthesis precursor tetramethoxysilane (TMOS) and its oxygenated hydrocarbon counterpart tetramethoxymethane (TMOM). The rate constants of H-abstraction reactions, isomerization and β-scission reactions are calculated, and the congener substitution effects between TMOM and TMOS are theoretically revealed.

Organoid-Guided Precision Medicine: From Bench to Bedside.

Organoid technology, as an emerging field within biotechnology, has demonstrated transformative potential in advancing precision medicine. This review systematically outlines the translational trajectory of organoids from bench to bedside, emphasizing their construction methodologies, key regulatory factors, and multifaceted applications in personalized healthcare. By recapitulating physiological architectures and disease phenotypes through three-dimensional culture systems, organoids leverage natural and synthetic scaffolds, stem cell sources, and spatiotemporal cytokine regulation to model tissue-specific microenvironments.

Impact of Microplastics on Ciprofloxacin Adsorption Dynamics and Mechanisms in Soil.

The co-occurrence of microplastics (MPs) and antibiotics as emerging contaminants demonstrates significant ecological perturbations in soil matrices. Of particular scientific interest is the potential for MPs to mediate the environmental fate and transport dynamics of co-existing antibiotics. This study investigated MP-mediated ciprofloxacin (CIP) adsorption in lateritic soils.

Slow intravenous infusion reduces the accelerated blood clearance of PEGylated liposomes by removing anti-PEG antibodies.

Anti-PEG antibodies exist in many individuals and accelerate the clearance of PEGylated liposomes. Herein, we reported that the slow intravenous infusion of PEGylated liposomes significantly reduced their accelerated blood clearance (ABC) phenomenon in rats. This was mainly because the PEGylated liposomes that first entered the bloodstream were sufficient to clear anti-PEG antibodies, thus reducing the clearance of subsequently injected liposomes.