Schisandrol A-loaded mesenchymal stem cell exosomes modulate FTO/miR-21/WNT5A axis to promote skin healing.

Background: Schisandrol A (SA), the primary active component of Schisandra chinensis, exhibits antioxidant properties, safeguarding cells from oxidative damage. However, its effect on wound healing remains elusive, and its low water solubility restricts its utilization efficiency.

Objective: This study aimed to explore the impact of SA on HaCaT cell proliferation and migration through in vitro experiments, thereby providing deeper insights into its role in skin wound healing.

The application of organoids in colorectal diseases.

Intestinal organoids are a three-dimensional cell culture model derived from colon or pluripotent stem cells. Intestinal organoids constructed strongly mimic the colon epithelium in cell composition, tissue architecture, and specific functions, replicating the colon epithelium in an culture environment. As an emerging biomedical technology, organoid technology has unique advantages over traditional two-dimensional culture in preserving parental gene expression and mutation, cell function, and biological characteristics.