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Stretchable electronics enable seamless integration of wearables with the human body, thereby creating new opportunities in biomedical applications. Miniaturized multilayer stretchable printed circuit boards are key for achieving high functional density circuits with minimal footprint. However, current microfabrication technologies struggle with simultaneously achieving tissue-like softness (<<1 MPa), high resolution and low sheet resistance. This study demonstrates a scalable printing method that enables ultra-soft (<0.4 MPa) stretchable conductors (>300% strain) with high-resolution (<2.5 µm width) and high aspect-ratio tracks (>1) connected by ultra-fine (20 µm) vertical-interconnect-access (VIA) for multi-layered configurations. The method is based on stencil printing into laser-defined bio-masks comprising the abundant biopolymer lignin, thereby achieving printing capabilities beyond conventional methods in a sustainable manner. Based on the unique capabilities, a miniaturized multilayer ultra-soft wireless near-field-communication temperature logger is developed. Laser-defined printing can pave the way for the next generation of ultra-soft miniaturized wearables.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12288821 | PMC |
http://dx.doi.org/10.1002/smll.202501175 | DOI Listing |
The next generation of power electronics necessitates materials capable of rapid response at tens of kilohertz frequencies while ensuring minimal core losses. Accelerating the advancement of power electronics hinges on addressing the current shortage of ultra-low core loss soft magnets, thereby enabling sustainable energy utilization and paving the way toward achieving zero carbon footprints. Here we demonstrate an approach that integrates nanostructure engineering with high-frequency domain structure control, significantly enhancing the performance of Fe-enriched amorphous ribbons.
View Article and Find Full Text PDFMol Cancer
September 2025
Department of Thoracic Surgery, The First Hospital of China Medical University, No. 155 Nanjingbei Street, Heping District, Shenyang, 110001, Liaoning, China.
Iron oxide nanoparticles (IONPs) have transitioned from conventional magnetic resonance imaging (MRI) contrast agents into structurally programmable combined imaging/treatment tools, leveraging their superparamagnetism, catalytic activity, and surface engineering versatility to achieve spatiotemporal control over drug delivery and immune modulation. Advances in nanofabrication now yield size-optimized aggregates with enhanced tumor accumulation through the enhanced permeability and retention (EPR) effect, while clinically approved formulations like ferumoxytol demonstrate intrinsic immunomodulatory functionality, positioning IONPs as pivotal tools for precision oncology. Conversely, cancer immunotherapy remains limited by the immunosuppressive tumor microenvironment (TME), where cellular suppression via M2-polarized macrophages and regulatory T cells (Tregs) synergizes with physical exclusion from dense extracellular matrices and metabolic sabotage through lactate-driven acidosis.
View Article and Find Full Text PDFAdv Intell Syst
August 2025
Inspired by bacteria flagella, miniature robots often use a helical shape to propel themselves in fluids at low Reynolds numbers. The helical microstructures in the robots are often rigid and are made by advanced 3D micro-/nanofabrication techniques. However, it remains challenging to fabricate these 3D helical structures without complicated machinery.
View Article and Find Full Text PDFBiosens Bioelectron
August 2025
College of Electronic Engineering, South China Agricultural University, Guangzhou, 510642, China. Electronic address:
The human finger, with its high concentration of sensory receptors, excels at sensing both surface patterns and subsurface properties within soft tissue. However, replicating this dual capability in artificial systems poses significant challenges. This study presents a smart finger system based on a high-density piezoresistive sensor array, which demonstrates high sensitivity, fast response, and the ability to recognize both surface and subsurface patterns.
View Article and Find Full Text PDFACS Appl Mater Interfaces
August 2025
School of Mechanical and Manufacturing Engineering, The University of New South Wales, Sydney, New South Wales 2052, Australia.
Flexible endoscopes equipped with multimodal sensors offer an innovative minimally invasive approach to perioperative diagnosis and intraoperative ablation monitoring, addressing the limitations of conventional mechanical- and optical-based techniques. Over the years, various miniaturized sensors have been developed, providing essential insights through minimally invasive surgeries (MIS). Among them, tactile sensors hold significant potential to revolutionize the diagnosis of tissue malignancy, serving to detect differences in the mechanical properties between healthy and cancerous tissues.
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