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The next generation of power electronics necessitates materials capable of rapid response at tens of kilohertz frequencies while ensuring minimal core losses. Accelerating the advancement of power electronics hinges on addressing the current shortage of ultra-low core loss soft magnets, thereby enabling sustainable energy utilization and paving the way toward achieving zero carbon footprints. Here we demonstrate an approach that integrates nanostructure engineering with high-frequency domain structure control, significantly enhancing the performance of Fe-enriched amorphous ribbons. Our strategy reduces core loss by 55%, achieving an ultra-low loss of ~ 75 ± 1.3 W/kg at 10 kHz, 1 T. We attribute this improvement to optimized perpendicular magnetic anisotropy, which is induced by positive magnetostriction and compressive stress generated from partial nanocrystallization of α-Fe in a residual amorphous matrix. These configurations lead to the formation of a narrow stripe-shaped magnetic domain (~ 4.8 ± 0.6 μm wide), resulting in minimal excess loss. These findings highlight a pivotal advancement in soft magnet design, facilitating energy-efficient, miniaturized power electronics for modern applications.
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http://dx.doi.org/10.1038/s41467-025-63139-1 | DOI Listing |
Circulation
September 2025
Division of Cardiology, Columbia University Irving Medical Center, New York, NY (S.A.P.).
Background: Limited treatment options exist for infrapopliteal disease in patients with chronic limb-threatening ischemia (CLTI), a condition associated with a high risk of limb loss. Interventional management of diseased infrapopliteal vessels with percutaneous transluminal angioplasty (PTA) is associated with high rates of restenosis and reintervention. In the LIFE-BTK trial, the drug-eluting resorbable scaffold (DRS) demonstrated superior 12-month efficacy compared with PTA in a selected CLTI population with predominantly noncomplex, mildly to moderately calcified lesions.
View Article and Find Full Text PDFTemperature (Austin)
June 2025
Department of Mechanical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Sweating is a vital thermoregulatory mechanism in humans for maintaining thermal balance during exercise and exposure to hot environments. The development of models that predict sweat rate based on body temperature has been ongoing for over half a century. Here, we compared predicted water loss rates (WLR) from these models to actual observations collected during 780 participant-exposures in three independent laboratory-based experiments.
View Article and Find Full Text PDFAdv Mater
September 2025
School of Chemistry and Chemical Engineering, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Mi
Ammonia oxidation reaction (AOR) is critical for efficient ammonia utilization as a hydrogen carrier, yet state-of-the-art Pt-based catalysts suffer significant activity loss due to strong NO species (NO, NO) adsorption. Herein, Pd@Pt mesoporous core-shell nanospheres with interstitial Co in Pt shell (Pd@Pt-Co MCSN) are demonstrated as an excellent AOR electrocatalyst, which achieves a mass activity of 293.6 A g at 0.
View Article and Find Full Text PDFCell Chem Biol
September 2025
iHuman Institute, ShanghaiTech University, Shanghai 201210, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; Department of Integrative Structural and Computational Biology, Scripps Research, La Jolla, CA 92037, USA; Institute of Molecular Biology and Bio
Balanced or biased G protein and arrestin transmembrane signaling by the adenosine 2A receptor (AAR) is related to ligand-induced allosterically triggered variation of structural dynamics in the intracellular half of the transmembrane domain (TMD). F-nuclear magnetic resonance (NMR) of a network of genetically introduced meta-trifluoromethyl-L-phenylalanine (mtfF) probes in the core of the TMD revealed signaling-related structure rearrangements leading from the extracellular orthosteric drug-binding site to the G protein and arrestin contacts on the intracellular surface. The key element in this structural basis of signal transfer is dynamic loss of structural order in the intracellular half of the TMD, as manifested by local polymorphisms and associated rate processes within the molecular architecture determined previously by X-ray crystallography.
View Article and Find Full Text PDFSci Total Environ
September 2025
Department of Orthopedics and Traumatology, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, Sichuan Province, China. Electronic address:
The objective of this research was to use a network toxicology approach to examine the possible toxicity of the cigarette toxicants nicotine and coal tar that cause osteoporosis (OP) as well as its molecular processes. We determined the primary chemical structures and 128 targets of action of tar and nicotine using the Swiss Target Prediction, NP-MRD, and PubChem databases. We discovered that genes including DNAJB1, CCDC8, LINC00888, ATP6V1G1, MPV17L2, PPCS, and TACC1 had a disease prognostic guiding value by LASSO analysis and differential analysis of GEO microarray data.
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