Dynamic data balancing strategy-based Xception-dual-channel LSTM model for laparoscopic cholecystectomy phase recognition.

Purpose: To enhance the temporal feature learning capability of the laparoscopic cholecystectomy phase recognition model and address the class imbalance issue in the training data, this paper proposes an Xception-dual-channel LSTM fusion model based on a dynamic data balancing strategy.

Methods: The model dynamically adjusts the undersampling rate for each surgical phase, extracting short video clips from the original data as training samples to balance the data distribution and mitigate biased learning. The Xception model, utilizing depthwise separable convolutions, extracts fundamental visual features frame by frame, which are then passed to a dual-channel LSTM network.

Electroacupuncture therapy improves cognitive dysfunction after ischemic stroke in Sprague-Dawley rats by adjusting the lncRNA-MEG3/miR-4640-3p axis.

Background: Ischemic stroke (IS) is a common disease that can cause cognitive dysfunction. Electroacupuncture (EA) is an effective way to alleviate cognitive dysfunction, but its molecular regulatory mechanism is still unclear. Long noncoding RNA-MEG3 (MEG3) is an important factor in the incidence and progression of IS.

[Research progress on the diagnosis of ectodermal dysplasia and early oral prosthodontic treatment].

Ectodermal dysplasia is a group of hereditary diseases characterized by developmental defects of ectodermal structures. Its oral manifestations mainly center on congenital missing teeth, abnormal tooth morphology, and maxillofacial bone developmental disorders, which seriously affect the masticatory function, maxillofacial development, and mental health of affected children. In this article, the multidimensional diagnostic strategy system for children with ectodermal dysplasia and the related progress of early oral prosthodontic treatment methods were systematically reviewed to provide references for clinicians in the diagnosis and treatment of children with ectodermal dysplasia.

Application of a SODOSM-based MCDM method for evaluating comprehensive fruit quality: A case study of pineapple.

This study constructs an evaluation index system and model by integrating objective evaluation methods such as the entropy weight method and TOPSIS with subjective evaluation methods like Delphi and AHP. By analyzed the scatter plots of the comprehensive quality evaluation values of commodity quality before and after weighting, it was found that the quality evaluation values before and after weighting are highly correlated, with correlation coefficients of 0.908 respectively.

Prognostic value of gut microbiota and low-density lipoprotein cholesterol subfractions in patients with ST-segment elevation myocardial infarction.

Objective: Gut dysbiosis and the distribution of low-density lipoprotein cholesterol (LDL-C) subfractions have been implicated in cardiovascular risk among patients with ST-segment elevation myocardial infarction (STEMI). However, the prognostic significance of LDL-C subfractions in relation to gut microbiota composition remains largely unexplored. This study aimed to assess differences in gut microbiota profiles and LDL-C subfraction distribution between patients with STEMI with and without major adverse cardiovascular events (MACEs) and to elucidate their potential interplay.

Phosphorus-Driven Stem-Biased Allocation: NPK Synergy Optimizes Growth and Physiology in T. C. Chen Seedlings.

Valued for furniture, crafts, and medicine, T. C. Chen confronts critically depleted wild populations and slow cultivation growth, necessitating precision nutrient formulation to overcome physiological constraints.

Preparation and Applications of Silver Nanowire-Polyurethane Flexible Sensor.

To expand the application of silver nanowires (AgNWs) in the field of flexible sensors, this study developed a stretchable flexible sensor based on thermoplastic polyurethane (TPU). Initially, the TPU nanofiber membrane was prepared by electrospinning. Subsequently, high-aspect-ratio AgNWs were synthesized via a one-step polyol reduction method.

Two-Year Results of Percutaneous Endocardial Septal Radiofrequency Ablation for Hypertrophic Obstructive Cardiomyopathy.

Background: Hypertrophic obstructive cardiomyopathy (HOCM) is a hereditary myocardial disease. Percutaneous endocardial septal radiofrequency ablation (PESA) is an innovative approach for treating HOCM. Consequently, we present the outcomes of the PESA for HOCM.

Increased expression of OX40 on peripheral CD4/CD8 memory T lymphocytes in the pathogenesis of type 1 diabetes.

Aims: Autoreactive memory T cells are considered to be a primary contributor to chronic islet inflammation in individuals with type 1 diabetes (T1D). OX40-expressing T cells not only facilitate and sustain the presence of CD4 memory T cells but also promote the generation of CD8 memory T cells. We aimed to investigate the role of OX40CD4/CD8 memory T lymphocytes in the pathogenesis of T1D.

Manipulating polarization dynamics of temporal solitons in a 20-GHz micro fiber Fabry-Pérot laser.

In this work, we report on manipulating the polarization characteristics of temporal solitons in a microfiber Fabry-Pérot (FP) laser with a fundamental repetition rate of 20 GHz at 1.5 μm. By controlling the temperature of the microfiber oscillator, the state of temporal solitons can be switched from vector to scalar (linearly polarized) state.

Prognostic value of FIB-4 and NFS for cardiovascular events in patients with and without NAFLD.

Background: The association between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) is well studied. Liver fibrosis is the main histopathologic manifestations of NAFLD. However, whether concomitant NAFLD influence the association of non-invasive liver fibrosis scores with CVD remains unclear.

Plasma ddPCR for etiological diagnosis of focal bacterial infections.

Background: Plasma droplet digital polymerase chain reaction (ddPCR) has been used for pathogen detection and has shown good diagnostic value, but no studies have yet demonstrated its application in focal infections. Herein a pilot study using plasma ddPCR to diagnose focal infection is discussed.

Methods: Eight patients with a diagnosed focal infection who underwent plasma ddPCR for bacterial detection between 2021 and 2022 in Sir Run Run Shaw hospital were enrolled in this retrospective single-center pilot study.

Structural and Transcriptional Plasticity of OBP3 Confers Insecticide Adaptation in .

This study reveals a dual defense role of odorant-binding protein OBP3 in , combing direct insecticide sequestration and stress-responsive transcriptional regulation. We found stage-specific OBP3 enrichment in larval chemosensory tissues (head/integument), with 2.51 to 16.

Multiply doses of FDC of rosuvastatin and ezetimibe versus rosuvastatin monotherapy in Chinese patients with hypercholesterolemia (ROSE-CH): multicenter, randomized-controlled trial.

Objective: Rosuvastatin plus ezetimibe improves the lipid-lowering effect through different mechanisms of action. This study intended to compare the efficacy and safety of the fixed-dose combination (FDC) of rosuvastatin/ezetimibe vs. rosuvastatin alone in hypercholesterolemia patients.

Association between genomic features and toxic metal(loid) accumulation in left-sided and right-sided colorectal cancer.

Background: Colorectal cancer (CRC) is a high heterogenous disease of genetic variations, which was influenced by tumor anatomic location and toxic metal(loid) accumulation. Current study aims to investigate genomic heterogeneity of CRC influenced by toxic metal(loid) accumulation based on tumor anatomic location.

Methods: In this study, a total of 94 patients with CRC were recruited including 69 left-sided tumors and 35-right sided tumors.

Unraveling SREBF1's role in elevating colorectal cancer prognosis through proliferation and migration inhibition.

Sterol Regulatory Element-Binding Protein 1 (SREBF1), a central regulator of lipid metabolism, has unclear pan-cancer roles and clinical implications. This study integrated various databases and functional experiments to systematically investigate the heterogeneous characteristics of SREBF1 across cancers. Pan-cancer analysis revealed significant upregulation of SREBF1 in multiple cancer types, including colorectal cancer (CRC).

Casein Kinase 2α Ablation Confers Protection Against Metabolic Dysfunction-Associated Steatotic Liver Disease: Role of FUN14 Domain Containing 1-Dependent Regulation of Mitophagy and Ferroptosis.

Mitochondrial dyshomeostasis provokes the onset of metabolic dysfunction-associated steatotic liver disease (MASLD) although its precise involvement in particular mitophagy in MASLD remains elusive. This work evaluated the role of casein kinase 2α (CK2α) and FUNDC1 in high-fat diet (HFD)-evoked MASLD. WT and CK2α deletion (CK2α ) mice were subjected to low fat or HFD for 20 weeks.

Disrupting tumor homeostasis with an autoamplificatory nanoinducer to augment pyroptosis for efficient immunotherapy.

Abnormal tumor homeostasis is crucial in maintaining tumor cell survival and growth. Thus, developing effective antitumor strategies that can simultaneously disrupt multiple intracellular homeostatic mechanisms may be more effective and less laborious. Herein, an autoamplificatory nanoinducer (CLRN) composed of photosensitizer Ce6, glucose metabolism inhibitor lonidamine and methyltransferase inhibitor RG108 is designed and constructed to enhance pyroptosis and upregulate immunosurveillance by disrupting intracellular redox and metabolic homeostasis.

Spherical Polar Pattern Matching for Star Identification.

To endow a star sensor with strong robustness, low algorithm complexity, and a small database, this paper proposes an all-sky star identification algorithm based on spherical polar pattern matching. The proposed algorithm consists of three main steps. First, the guide star is rotated to be a polar star, and the polar and azimuth angles of neighboring stars are used as polar pattern elements of the guide star.

Effects of Monochromatic and Composite Light Withering on Black Tea Aroma.

In this study, the effects of different monochromatic (red, blue, and yellow light) and composite (red-blue and red-yellow) LED light withering on the aroma of black tea was investigated. The results showed that among monochromatic LED treatments, red light withering achieved the highest sensory evaluation score for aroma. However, yellow light withering enhanced soluble sugar content and reduced tea polyphenol levels.

Treatment of delirium in intensive care patients with sepsis using daily intravenous infusions with omega-3 fatty acids.

Background: The development of delirium is closely linked to inflammatory processes. Omega-3 fatty acids can modulate the immune response and may contribute to reducing the incidence of sepsis-associated delirium (SAD).

Aims: To investigate the effects of omega-3 fatty acids on delirium in patients with sepsis.

Association between trajectory of triglyceride-glucose index and all-cause mortality in critically ill patients with atrial fibrillation: a retrospective cohort study.

Introduction: Previous evidence showed that triglyceride-glucose (TyG) index is strongly associated with poor prognosis in atrial fibrillation (AF) in the general population. In critically ill patients, physiological stress may cause rapid fluctuation in the TyG index, making single measurements insufficient for prognosis assessment. Furthermore, the impact of TyG index trajectories on outcomes in critically ill patients with atrial fibrillation has not yet been well elucidated.

Identification and validation of CKAP2 as a novel biomarker in the development and progression of rheumatoid arthritis.

Background: Rheumatoid arthritis (RA) is a common chronic joint disease. However, many patients exhibit inadequate responses to treatment due to disease heterogeneity. Identifying novel biomarkers for RA is crucial for advancing molecular diagnosis and identifying potential therapeutic targets.

Serum exosomal microRNA profiling reveals a down-regulation of hsa-miR-124-3p in patients with severe acne.

Background: Acne is a chronic inflammatory skin disease affecting pilosebaceous unit. However, its specific mechanism remain incompletely understood.

Objectives: This study aims to identify and analyze the differential expression of serum exosomal miRNA in severe acne, revealing new insights into the pathogenesis of acne.