Integrating hydrological and economic assessments of soil infiltration enhancement for urban flood resilience.

Urban flooding, exacerbated by climate change and the expansion of impervious surfaces, poses growing risks to sustainable urban development. Enhancing soil infiltration through green infrastructure is a promising nature-based solution, yet its hydrological effectiveness and economic viability under diverse rainfall scenarios remain insufficiently quantified. This study develops an interdisciplinary framework integrating column experiments, physically distributed hydrological modeling, and cost-benefit analysis to assess ceramsite-amended soils for urban flood resilience.

The ribonucleoprotein hnRNP K promotes hepatic steatosis by suppressing the nuclear hormone receptor PPARα.

Ectopic triglyceride accumulation resulting from impaired fatty acid β-oxidation (FAO) plays a crucial role in metabolic dysfunction-associated steatotic liver disease. The PPARα activation can promote FAO, thus reducing hepatic lipid levels. HnRNP K is known to act as an enhancer or repressor to regulate gene transcription, yet the relevance of hnRNP K to lipid metabolism remains elusive.

MCTR1 ameliorates LPS-induced lung injury by inhibiting neutrophil reverse transendothelial migration.

Objectives: Dysregulated inflammatory responses during sepsis often result in acute lung injury (ALI). Neutrophils activated at the primary site of injury can re-enter the circulation through reverse transendothelial migration (rTEM), subsequently infiltrating other organs and contributing to systemic inflammation and multi-organ damage. The specialized pro-resolving lipid mediator (SPM) maresin conjugate in tissue regeneration 1 (MCTR1) has been shown to mitigate organ injury in sepsis.

FPGA-based process, voltage, and temperature insensitive picosecond resolution timing generators with offset correction for automatic test equipment.

This paper presents the implementation of a picosecond resolution timing generator (TG) insensitive to process, voltage, and temperature (PVT) variations for automatic test equipment. The TG is implemented in field-programmable gate arrays (FPGAs) using two-stage time interpolation, which utilizes a multi-phase generator, IDELAY3, and carry-chain resources. To enhance the test rate, each channel of the proposed TG consists of four parallel operating edge generators.

Synthesis of ultra-large diameter graphene oxide flakes from natural flake graphite.

Graphene and its derivatives are widely used in various fields due to their unique two-dimensional lamellar structure. This study aims to synthesize ultra-large graphene oxide (GO) sheets from natural flake graphite and investigate the factors influencing their size. Using a two-intercalation method based on the modified Hummers' method, we address the challenge of intercalating large-diameter graphene oxide by employing a secondary intercalation technique.

Thermal transport in CNmonolayer: a machine learning based molecular dynamics study.

The successful synthesis of a novel CNcarbon nitride monolayer offers expansive prospects for applications in the fields of semiconductors, sensors, and gas separation technologies, in which the thermal transport properties of CNare crucial for optimizing the functionality and reliability of these applications. In this work, based on our developed machine learning potential (MLP), molecular dynamics (MD) simulations including homogeneous non-equilibrium, non-equilibrium, and their respective spectral decomposition methods are performed to investigate the effects of phonon transport, temperature, and length on the thermal conductivity of CNmonolayer. Our results reveal that low-frequency and in-plane phonon modes dominate the thermal conductivity.

Promotes M1-polarization and diabetic wound healing using Prussian blue nanozymes.

Long-term inflammation and impaired angiogenesis are the main reasons for the difficulty of diabetic wound healing. What to do to effectively promote vascular endothelial cell response and immune cell reprogramming is the key to diabetic skin healing. However, contemporary therapies cannot simultaneously coordinate the promotion of vascular endothelial cells and macrophage polarization, which leads to an increased rate of disability in patients with chronic diabetes.

LncRNA-Snhg3 regulates mouse hepatic glycogenesis under normal chow diet.

Long noncoding RNAs (lncRNAs) are strongly associated with glucose homeostasis, but their roles remain largely unknown. In this study, the potential role of lncRNA-Snhg3 in glucose metabolism was evaluated both in vitro and in vivo. Here, we found a positive relationship between Snhg3 and hepatic glycogenesis.

Synergistic antibacterial effects of closantel and its enantiomers in combination with colistin against multidrug resistant gram-negative bacteria.

Drug combinations and repurposing have recently provided promising alternatives to cope with the increasingly severe issue of antibiotic resistance and depletion of natural drug molecular repertoires that undermine traditional antibacterial strategies. Closantel, an effective adjuvant, reverses antibiotic resistance in gram-negative bacteria. Herein, the combined antibacterial enantioselectivity of closantel is presented through separate enantiomer studies.

Determination of marker residues of quinoxaline-1,4-di-N-oxides and its prototype identification by liquid chromatography tandem mass spectrometry.

Quinoxaline-1,4-di-N-oxides (QdNOs), such as carbadox, olaquindox, mequindox, quinocetone, etc. are a class of antibacterial drugs. Prototype drugs residues can not be detected due to their rapid metabolism in animals.

The antihelminth drug rafoxanide reverses chromosomal-mediated colistin-resistance in .

The emergence and rapid spread of multi-drug-resistant (MDR) bacteria pose a serious threat to global healthcare. Although the synergistic effect of rafoxanide and colistin was reported, little is known regarding the potential mechanism of this synergy, particularly against chromosomal-mediated colistin-resistant . In the present study, we elucidated the synergistic effect of rafoxanide and colistin against chromosomal-mediated colistin-resistant isolates from human (KP-9) and swine (KP-1) infections.

Mass Spectrometric Analysis of Urinary N-Glycosylation Changes in Patients with Parkinson's Disease.

Urine is thought to provide earlier and more sensitive molecular changes for biomarker discovery than blood. Numerous glycoproteins, peptides, and free glycans are present in urine through glomerular filtration of plasma, cell shedding, apoptosis, proteolytic cleavage, and exosome secretion. Urine biomarkers have enormous diagnostic potential, and the use of these biomarkers is a long-standing practice.

Hyaluronic acid modified carbon nanotubes using for photothermal therapy by promoting apoptosis of nasopharyngeal carcinoma cells.

The present work illustrates the role of multi-walled carbon nanotubes in photothermal therapy. Nasopharyngeal carcinoma (NPC) is a malignant tumor of the head and neck with significant ethnic and geographic differences, and conventional treatment options are no longer suitable to improve the prognosis and survival of patients. Photothermal therapy (PTT) has emerged as a new strategy for oncology treatment in recent years and is now used in the treatment of many common cancers.

Effects of Cu ratios on the C-C growth mechanism on copper-nickel bimetallic surfaces.

The adsorption and growth mechanisms of C ( = 1-6) on different Cu-Ni surfaces are calculated by density functional theory (DFT). The results demonstrate that Cu doping affects the growth mechanism of the deposited carbon on the catalyst surface. Firstly, the addition of Cu weakens the interaction between C and the adsorbed surface, which is proved by the results of density of states (DOS) and partial density of states (PDOS).

Recent Advances in Graphitic Carbon Nitride Based Electro-Catalysts for CO Reduction Reactions.

The electrocatalytic carbon dioxide reduction reaction is an effective means of combating the greenhouse effect caused by massive carbon dioxide emissions. Carbon nitride in the graphitic phase (g-CN) has excellent chemical stability and unique structural properties that allow it to be widely used in energy and materials fields. However, due to its relatively low electrical conductivity, to date, little effort has been made to summarize the application of g-CN in the electrocatalytic reduction of CO.

Exploiting RIG-I-like receptor pathway for cancer immunotherapy.

RIG-I-like receptors (RLRs) are intracellular pattern recognition receptors that detect viral or bacterial infection and induce host innate immune responses. The RLRs family comprises retinoic acid-inducible gene 1 (RIG-I), melanoma differentiation-associated gene 5 (MDA5) and laboratory of genetics and physiology 2 (LGP2) that have distinctive features. These receptors not only recognize RNA intermediates from viruses and bacteria, but also interact with endogenous RNA such as the mislocalized mitochondrial RNA, the aberrantly reactivated repetitive or transposable elements in the human genome.

Potential health benefits of lowering gas production and bifidogenic effect of the blends of polydextrose with inulin in a human gut model.

Polydextrose is a nutrient supplement, which is widely applied in the food industry. The use of polydextrose in combination with prebiotics and probiotics has recently increased, whereas the fermentation properties of its blend have not yet been fully revealed. We evaluated the metabolic profile of polydextrose, inulin, and their blends by a batch fermentation of fifteen human fecal inocula.

Bond Properties of Magnesium Phosphate Cement-Based Engineered Cementitious Composite with Ordinary Concrete.

A magnesium phosphate cement-based engineered cementitious composite (MPC-ECC) was developed using polyvinyl alcohol (PVA) fibers and fly ash. In this study, the bond behavior of MPC-ECC with ordinary concrete was evaluated through single and double shear bond strength tests. The effects of the water to solid mass ratio (W/S), the sand to binder mass ratio (S/B), the molar ratio of MgO to KH2PO4 (M/P), the fly ash content (F), the borax dosage (B), the volume fraction of PVA fibers (Vf), and curing age on the bond behavior of MPC-ECC with ordinary concrete were examined.

Hydroxypropylmethyl Cellulose Modified with Carbon Dots Exhibits Light-Responsive and Reversible Optical Switching.

A light-responsive optical switching material is reported, which was obtained by incorporating carbon dots (CDs) into thermochromic hydroxypropylmethyl cellulose (HPMC). The ultrasmall size of CDs guarantees the considerable transparency of CDs/HPMC. Under illumination, CDs/HPMC shows rapid and reversible optical switching between transparent and opaque states due to the remarkable photothermal effect of CDs.