The ribonucleoprotein hnRNP K promotes hepatic steatosis by suppressing the nuclear hormone receptor PPARα.

Ectopic triglyceride accumulation resulting from impaired fatty acid β-oxidation (FAO) plays a crucial role in metabolic dysfunction-associated steatotic liver disease. The PPARα activation can promote FAO, thus reducing hepatic lipid levels. HnRNP K is known to act as an enhancer or repressor to regulate gene transcription, yet the relevance of hnRNP K to lipid metabolism remains elusive.

The mechanism of parvalbumin interneurons regulating glutamatergic neurons involvement in stress induced anxiety in the basolateral amygdala of male mice.

Modern life's fast-paced and the unexpected conditions contribute to escalating stress levels, often leading to anxiety disorders and posing significant challenges to physical and mental health. In judicial practice, the parties often suffer from anxiety disorder under the great stress. However, the precise mechanisms underlying stress-induced anxiety disorders remain incompletely understood.

Accuracy-based equivalence evaluation using reference data for the clinical application of patient-based quality control models.

Background: Patient-based real-time quality control (PBRTQC) is an effective quality control (QC) strategy using patient test results to monitor analytical performance. Most studies have proposed different PBRTQC models and tested their performance by developers themselves. However, there remains a need for validating the accuracy-based equivalence of the models/software before clinical application and for periodic review, which is also the requirement of testing and calibration laboratories competence accreditation criteria.

lnc15qD3 expression in the NAc shell regulates the reconsolidation of opioid reward memories.

Following memory retrieval, permanent drug memories become unstable and easily disrupted, followed by reconsolidation; this pattern holds promise for treating substance use disorder (SUD). Recent research has demonstrated that epigenetic modifications, including long noncoding RNA (lncRNA) regulation, participate in learning and memory. However, the role of lncRNAs in drug-memory reconsolidation remains unclear.

The invasion of fall armyworm and green pest control: an analysis of farmers' willingness to adopt genetically modified insect-resistant maize in Southwest China.

The invasion of fall armyworm poses a serious threat to global food security, necessitating the urgent promotion of environmentally friendly pest control technologies. As a key strategy in green pest control, the effectiveness of genetically modified (GM) insect-resistant crops largely depends on the extent of farmer acceptance. Based on survey data from 426 GM maize pilot farmers in Yunnan Province, this study employs an ordered Logit model to analyze the key factors influencing farmers' adoption intentions from a behavioral decision-making perspective.

Oleanolic acid enhanced the anticancer effect of fluorouracil by regulating Ca2+ levels in hepatocellular carcinoma cells.

Oleanolic acid (OA) is recognized for its anticancer properties, which are similar to those of conventional chemotherapeutic agents used in clinical practice. However, its role in modulating the sensitivity of cancer cells to fluorouracil (5FU) has not yet been documented. This study aimed to examine the effects of OA and 5FU co-administration on hepatocellular carcinoma (HCC) and uncover the mechanisms involved.

Tetracycline removal from aqueous media and hospital wastewater using a magnetic composite of mango lignocellulosic kernel biochar/MnFeO/Cu@Zn-BDC MOF.

This study explored the use of mango lignocellulosic kernel biochar (MKB) modified with MnFeO magnetic nanoparticles and a Cu@Zn-BDC metal-organic framework (MOF) (MKB/MnFeO/Cu@Zn-BDC MOF) for tetracycline (TC) removal from aqueous solutions and hospital wastewater. The modified biochar exhibited strong magnetic properties (19.803 emu/g) and a specific surface area of 30.

Correction: Yu et al. The Role of circTmeff-1 in Morphine Addiction Memory of Mice. 2023, , 1985.

In the original publication [...

LncRNA-Snhg3 regulates mouse hepatic glycogenesis under normal chow diet.

Long noncoding RNAs (lncRNAs) are strongly associated with glucose homeostasis, but their roles remain largely unknown. In this study, the potential role of lncRNA-Snhg3 in glucose metabolism was evaluated both in vitro and in vivo. Here, we found a positive relationship between Snhg3 and hepatic glycogenesis.

Next-Generation Patient-Based Real-Time Quality Control Models.

Patient-based real-time QC (PBRTQC) uses patient-derived data to assess assay performance. PBRTQC algorithms have advanced in parallel with developments in computer science and the increased availability of more powerful computers. The uptake of Artificial Intelligence in PBRTQC has been rapid, with many stated advantages over conventional approaches.

Synergy of higher education resources and digital infrastructure construction in China: Regional differences, dynamic evolution and trend forecasting.

The deep integration of higher education with digital technology represents an inevitable trend, and evaluating the interplay between higher education resources (HER) and digital infrastructure construction (DIC) holds significant value for advancing the development of digital higher education and mitigating regional disparities in China. This study establishes two comprehensive evaluation frameworks for HER and DIC. Panel data from 31 provinces, spanning the period from 2011 to 2020, are utilized for analysis.

Enhanced patient-based real-time quality control using the graph-based anomaly detection.

Objectives: Patient-based real-time quality control (PBRTQC) is an alternative tool for laboratories that has gained increasing attention. Despite the progress made by using various algorithms, the problems of data volume imbalance between in-control and out-of-control results, as well as the issue of variation remain challenges. We propose a novel integrated framework using anomaly detection and graph neural network, combining clinical variables and statistical algorithms, to improve the error detection performance of patient-based quality control.

Roles of lncLingo2 and its derived miR-876-5p in the acquisition of opioid reinforcement.

Recent studies found that non-coding RNAs (ncRNAs) played crucial roles in drug addiction through epigenetic regulation of gene expression and underlying drug-induced neuroadaptations. In this study, we characterized lncRNA transcriptome profiles in the nucleus accumbens (NAc) of mice exhibiting morphine-conditioned place preference (CPP) and explored the prospective roles of novel differentially expressed lncRNA, lncLingo2 and its derived miR-876-5p in the acquisition of opioids-associated behaviours. We found that the lncLingo2 was downregulated within the NAc core (NAcC) but not in the NAc shell (NAcS).

Dopaminergic dominance in the ventral medial hypothalamus: A pivotal regulator for methamphetamine-induced pathological aggression.

Methamphetamine (METH) abuse is associated with a spectrum of behavioral consequences, among which heightened aggression presents a significant challenge. However, the causal role of METH's impact in aggression and its target circuit mechanisms remains largely unknown. We established an acute METH exposure-aggression mouse model to investigate the role of ventral tegmental area (VTA) dopaminergic neurons and ventral medial hypothalamus VMH glutamatergic neuron.

Elevated of NDUFA4L2 expression in colon adenocarcinoma is correlated with an unfavorable prognosis and increased immune cell infiltration.

Background: Colon adenocarcinoma (COAD) is a prevalent malignancy worldwide, yet, its underlying pathogenesis and genetic characteristics are still unclear. Previous studies have suggested that NADH dehydrogenase 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2) may affect tumor progression across various cancers. However, this effect on COAD has rarely been reported.

The Role of circTmeff-1 in Morphine Addiction Memory of Mice.

In addition to the essential pharmacological effects of opioids, situational cues associated with drug addiction memory are key triggers for drug seeking. CircRNAs, an emerging hotspot regulator in crown genetics, play an important role in central nervous system-related diseases. However, the internal mediating mechanism of circRNAs in the field of drug reward and addiction memory remains unknown.

Roles of nucleus accumbens shell small-conductance calcium-activated potassium channels in the conditioned fear freezing.

Background: Posttraumatic stress disorder (PTSD), a psychiatric disorder caused by stressful events, is characterized by long-lasting fear memory. The nucleus accumbens shell (NAcS) is a key brain region that regulates fear-associated behavior. Small-conductance calcium-activated potassium channels (SK channels) play a key role in regulating the excitability of NAcS medium spiny neurons (MSNs) but their mechanisms of action in fear freezing are unclear.

Spatial spillover effect of Green Finance and Clean Energy on China's Provincial Green Economic Development.

Green finance is a new financing mode that pays attention to environmental benefits. Achieving a balance between the economy and the environment requires clean energy. For formulating policies to achieve sustainable development goals, it is very important to explore whether integrating green finance and clean energy is conducive to promoting green economic development (GED).

High-performance diode-end-pumped Nd:YLF laser operating at 1314 nm.

A stable, efficient, and powerful 1314 nm Nd:YLF laser inband-pumped by a wavelength-locked narrowband 880 nm laser diode is demonstrated. The influence of mode-to-pump ratio on the performance of the diode-end-pumped Nd:YLF laser has been systematically investigated by taking into account the thermal effect and the energy transfer upconversion effect. For the optimum mode-to-pump ratio of 0.

New Poplar-Derived Biocomposites via Single-Step Thermoforming Assisted by Phosphoric Acid Pretreatment.

One-step thermoforming represents an effective approach to preparing glue-free biocomposites. This study aimed to produce glue-free biocomposites with high-temperature resistance and mechanical properties using phosphoric acid pretreatments combined with thermoforming. Due to the hot-moulding process, the cell wall was destroyed, which allowed the fibres to adhere closely together.

Influence of digital finance and green technology innovation on China's carbon emission efficiency: Empirical analysis based on spatial metrology.

The carbon emission efficiency can be employed to estimate the reduction of carbon emissions and sustainable economic development. Carbon emission efficiency is believed to be affected significantly by green technology innovation. In terms of promoting green technology innovation, digital finance enhances the contribution of traditional finance due to its information-based nature.

CircTmeff-1 in the nucleus accumbens regulates the reconsolidation of cocaine-associated memory.

Reconsolidation of drug memories is the process of restoring unstable memories after unconditioned (UCS; e.g., drugs) or conditioned stimulus (CS; e.