Development of a multi-feature predictive model for risk stratification in stage IB-IIA non-small cell lung cancer: a multicenter analysis.

Objective: This study aimed to develop a comprehensive risk stratification model for stage IB-IIA non-small cell lung cancer (NSCLC) by integrating clinicopathological data with pre-treatment CT imaging.

Methods: This retrospective study included three independent cohorts of patients with stage IB-IIA NSCLC for model development and validation (Training: n = 370; Internal validation: n = 120; External validation: n = 70). Disease-free survival (DFS) was the primary endpoint.

Atomic dynamics of gas-dependent oxide reducibility.

Understanding oxide reduction is critical for advancing metal production, catalysis and energy technologies. Although carbon monoxide (CO) and hydrogen (H) are widely used reductants, the mechanisms by which they work are often presumed to be similar, both involving lattice oxygen removal. However, because of growing interest in replacing CO with H to lower CO emissions, distinguishing gas-specific reduction pathways is critical.

Stabilizing Highly Active Metastable Bi (101) Facet via Covalent Organic Frameworks to Break Activity-Stability Trade-off in CO-to-HCOOH Electrocatalysis.

Electrochemical CO reduction reaction (eCORR) offers a sustainable route to convert greenhouse gases into value-added chemicals. Bismuth (Bi) has emerged as a promising electrocatalyst for CO-to-HCOOH conversion due to its low cost, nontoxicity, and favorable adsorption properties for the key *OCHO intermediate. However, its relatively contracted 5d and expanded 6p orbitals lead to inevitable thermodynamically driven structural reconstruction during eCORR, resulting in a persistent trade-off between activity and stability.

Preoperative pectoralis muscle index predicts distant metastasis-free survival in non-small cell lung cancer patients: a retrospective study.

Background: Thoracic muscles contribute to respiration, is a crucial indicator for assessing functional recovery following lung resection. However, there is a lack of research on the long-term prognostic value of pectoralis muscle.

Methods: Consecutive patients who underwent curative-intent resection for stage I to IIIA NSCLC between 2013 and 2018 at a cancer center were retrospectively identified.

Sub-angstrom strain in high-entropy intermetallic boosts the oxygen reduction reaction in fuel cell cathodes.

The strain effect of high-entropy intermetallic (HEI) catalysts on oxygen reduction reaction (ORR) performance remains largely unexplored, primarily due to the significant challenges associated with characterizing and calculating the intricate local coordination environments. Here, we design a nitrogen (N)-doped L1-ordered PtCoNiFeCu intermetallic catalyst supported on Ketjenblack carbon (N-HEI/KB), and reveal the origin of the sub-angstrom strain in N-HEI and its impact on ORR performance by combining atomic-scale characterization and theoretical calculations. The synergistic interplay of the sub-angstrom strain, the pinning effect of metal-N bonds, and the high-entropy effect contribute to the competitive stability of N-HEI/KB catalysts, providing high current density of 1388 mA cm at 0.

Defect-Driven Redox Interplay on Anatase TiO: Surface-Structure Dependent Activation for CO Hydrogenation Catalysis.

Titanium dioxide (TiO) is one of the most extensively studied oxides as an active catalyst or catalyst support, particularly in energy and environmental applications, but the atomistic mechanisms governing its dynamic response to reactive environments and their correlation to reactivity remain largely elusive. Using in situ environmental transmission electron microscopy (ETEM), synchrotron X-ray diffraction (XRD), ambient-pressure X-ray photoelectron spectroscopy (AP-XPS), temperature-programmed reduction (TPR), reactivity measurements, and theoretical modeling, we reveal the dynamic interplay between oxygen loss and replenishment of anatase TiO under varying reactive conditions. Under H exposure, anatase TiO undergoes surface reduction via lattice oxygen loss, forming TiO.

Mechanism of soil microbial community degradation under long-term tomato monoculture in greenhouse.

Tomato ( L.), an economically significant crop, is frequently cultivated in greenhouses under continuous monoculture systems. Motivated by intensive agricultural practices and economic incentives, continuous cropping has become prevalent in China, yet it often results in soil degradation, including nutrient imbalances and microbial community shifts.

Immunophenotype-guided interpretable radiomics model for predicting neoadjuvant anti-PD-1 response in stage III-IV d-MMR/MSI-H colorectal cancer.

Background: Neoadjuvant immunotherapy significantly improves the pathological complete response (pCR) rate in colorectal cancer (CRC). However, the lack of reliable tools to accurately identify responders remains a key barrier to its widespread clinical adoption. This study aimed to develop an interpretable radiomics model guided by immunophenotypes to predict response to preoperative immunotherapy in CRC, with the goal of enabling more precise and personalized treatment strategies.

An interpretable CT-based machine learning model for predicting recurrence risk in stage II colorectal cancer.

Objectives: This study aimed to develop an interpretable 3-year disease-free survival risk prediction tool to stratify patients with stage II colorectal cancer (CRC) by integrating CT images and clinicopathological factors.

Methods: A total of 769 patients with pathologically confirmed stage II CRC and disease-free survival (DFS) follow-up information were recruited from three medical centers and divided into training (n = 442), test (n = 190), and validation cohorts (n = 137). CT-based tumor radiomics features were extracted, selected, and used to calculate a Radscore.

Effects of primary tumor location in the basal segment or superior segment (S6) on patient survival in lung cancer: a meta-analysis.

Background: Among the key factors influencing the prognosis of lung cancer, the primary tumor site has garnered significant attention in recent years, as it may affect the surgical difficulty and the risk of lymph node metastasis, thereby impacting overall prognosis. Numerous retrospective studies have produced conflicting conclusions, highlighting the necessity for a meta-analysis to consolidate these findings and ascertain the effects of primary tumor location in the basal versus superior segment of the lower lobe(S6) on survival outcomes.

Methods: We conducted a comprehensive literature search up to January 2025 and identified six relevant retrospective studies.

Fully exposed Pt cluster catalysts enable cascade oxidation of polyol to dicarboxylic acid.

The polyol oxidation to dicarboxylic acid, a crucial value-accretive reaction, is still challenging due to the paradoxical relationship between efficient activation of C-H bond and rapid desorption of carboxylic acid. Herein, we break this contradiction by constructing fully exposed Pt cluster supported on hydroxyapatite (Pt/HAP) to promote two primary hydroxyl groups of polyol oxidation to dicarboxylic acid. Such fully exposed Pt cluster with an average Pt-Pt coordination number of ∼3.

Redox-Induced Microstructure and Phase Dynamics in Nickel: Insights from In Situ Synchrotron X-ray Diffraction.

Using in situ synchrotron X-ray diffraction, we interrogate the microstructural and phase evolution of polycrystalline nickel (Ni) during redox cycling in O, H, and HO environments. Oxidation in O promotes strong (111) texturing in both the NiO overlayer and the underlying Ni substrate. However, this crystallographic alignment is lost following reduction in H and subsequent reoxidation, demonstrating irreversible microstructural changes.

The role of histone methyltransferases in therapeutic resistance of NSCLC.

Conventional treatments, including chemotherapy, immunotherapy, targeted therapy and radiotherapy, are effective clinical strategies for non-small cell lung cancer (NSCLC) patients, which can significantly improve life quality and prolong survival time. However, the application of drugs in NSCLC patients inevitably leads to therapeutic resistance. In recent years, many studies have shown that histone methyltransferases (HMTs), including both protein arginine methyltransferases (PRMTs) and lysine methyltransferases (KMTs), play pivotal roles in tumor initiation, progression, and treatment resistance.

Plasma-Engineered Sub-10 nm Surface Fluorination Enables Ultraselective Hollow Fiber Membranes.

While polymeric hollow fiber membranes (HFMs) offer scalable solutions for gas separations, their performance is fundamentally limited by the permeance-selectivity tradeoff and imprecise microporosity regulation. Herein, we propose a surface fluorination strategy using carbon tetrafluoride (CF) plasma to engineer a sub-10 nm fluorinated and crosslinked layer on polydimethylsiloxane (PDMS)-coated Matrimid HFMs. Through precise modulation of plasma parameters, we achieved controlled substitution of PDMS methyl groups/methyl hydrogen atoms with fluorine species (up to 27.

Clinical Practice Consensus Statement 2025: Management of Hyperuricemia and Gout in Adolescents.

Background: In response to the increasing global prevalence of gout, there is a concerning shift towards a younger demographic, with China at the forefront of this trend. Hyperuricemia, a central factor in the pathogenesis of gout, is becoming increasingly common among adolescents, particularly males, and is associated with various health risks, including joint pain, CKD, metabolic disorders, and premature death. Despite the seriousness of this issue, there is a lack of specific guidelines addressing adolescent and hyperuricemia gout management.

Integrative multi-omics characterization of 12 syngeneic mouse models.

Mouse syngeneic models serve as indispensable tools for elucidating tumor-immune interactions and assessing immunotherapy efficacy. In this study, we first conducted a comprehensive evaluation of six label-free protein quantification pipelines across 12 mouse syngeneic models, revealing that data-independent acquisition (DIA) significantly outperforms data-dependent acquisition (DDA) in terms of data coverage, reproducibility, and inter-model discrimination. We next performed an integrative multi-omics analysis to uncover molecular mechanisms associated with treatment response.

MR imaging of breast cancer: Interpretable radiomics analysis to assess treatment response and survival prognosis after neoadjuvant therapy.

The early prediction of pathological complete response (pCR) status after neoadjuvant chemotherapy (NAC) determines individualized treatment and prognosis in breast cancer patients. The study aimed to develop a biologically interpretable MRI-based radiomics model for predicting pCR. A total of 843 eligible breast cancer patients were retrospectively recruited from three medical centers and further divided into training, internal, and external validation cohorts.

[Advances in the Treatment of Multiple Primary Lung Cancer].

In recent years, the incidence of multiple primary lung cancer (MPLC) has been increasing, and it cannot be ignored in clinical practice. The treatment of MPLC is still controversial, but surgical treatment is recognized as the most important treatment. However, current studies have shown that the treatment of MPLC needs to develop multimodal treatment according to different patients.

In-Situ Atomic-Scale Revelation of Amorphous Metallic Iron Formation during Hydrogen-Driven Reduction of Iron Oxides.

The transition to hydrogen as a green reductant in metal production is critical for decarbonizing the metallurgical industry, yet atomic-scale mechanisms governing reduction pathways and phase evolution remain unresolved. Using in situ environmental transmission electron microscopy, we identify a hidden pathway that reveals dynamic formation of amorphous metallic iron (Fe) during the hydrogen-driven reduction of ferrous oxides of FeO and FeO. Real-time imaging uncovers three coexisting transformation routes: (i) FeO → FeO, (ii) FeO → amorphous Fe, and (iii) FeO → amorphous Fe.

Role of Immune Cells in Mediating the Effect of Hypothyroidism on Idiopathic Pulmonary Fibrosis.

Introduction: Idiopathic pulmonary fibrosis (IPF) leads to irreversible scarring of lung tissue, resulting in deteriorating respiratory function, particularly in older adults. We aimed to explore the causative link between hypothyroidism and IPF, particularly focusing on immune cell phenotypes as mediating factors.

Methods: A two-sample Mendelian randomization (MR) approach was utilized to investigate the influence of hypothyroidism on IPF and the role of 731 distinct immune cell phenotypes as mediators.

Value of F-FDG PET metabolic parameters combined with the dynamic monitoring of molecular residual disease (MRD) in predicting the prognosis of non-small-cell lung cancer after surgery.

Objective: To study the ability of the combination of F-FDG positron-emission tomography/computed tomography (PET/CT) metabolic parameters and the dynamic monitoring of molecular residual disease (MRD) in predicting the prognosis of non-small-cell lung cancer (NSCLC) after surgery.

Methods: The clinical data and disease-free survival (DFS) data of 157 NSCLC patients who underwent F-FDG PET/CT at 2 weeks before surgery and were regularly monitored for MRD after surgery were retrospectively analyzed. The correlation between PET metabolic parameters and the dynamic monitoring of MRD and the values of the two in predicting prognosis of NSCLC were analyzed.

Multiomic integration reveals subtype-specific predictors of neoadjuvant treatment response in breast cancer.

Neoadjuvant therapy has been widely used in breast cancer, but treatment response varies among individuals. We conducted multiomic profiling on tumor samples from 149 Chinese patients with breast cancer across ERHER2, ERHER2, and ERHER2 subtypes, categorizing outcomes as pathologic complete response (pCR;  = 81) or residual disease (RD;  = 68). We identified distinct molecular features linked to pCR in each subtype: elevated cell proliferation in patients with ERHER2 pCR, higher methylation in patients with ERHER2 RD, increased methylation in patients with ERHER2 RD, and hypermethylation in patients with ERHER2 RD.

Development and validation of an MRI radiomics-based interpretable machine learning model for predicting the progression-free survival in locally advanced nasopharyngeal carcinoma.

Background: Locally advanced nasopharyngeal carcinoma (LANPC) is a common malignant tumor of the nasopharynx, characterized by poor prognosis and a high susceptibility to recurrence and metastasis after surgery. The aim of this study was to establish and validate a radiomics model based on clinicopathological data and magnetic resonance imaging (MRI) information to predict progression-free survival (PFS) in LANPC patients, and to reveal the internal prediction process of the model through SHapley Additive exPlanation (SHAP) and image visualization techniques.

Methods: A total of 1,098 patients with pathologically and clinically diagnosed LANPC were recruited from three hospitals {training, n=700 [70% from hospitals I (Guangxi Medical University Cancer Hospital) and II (Wuzhou Red Cross Hospital)]; internal validation, n=300 (remaining 30%); and external validation, n=98 [hospital III (The Second Affiliated Hospital of Guangxi Medical University)]}.

[Role of antibiotic eluting absorbable calcium sulfate in phaseⅠrevision treatment of periprosthetic knee infection].

Objective: To explore the role of antibiotic-eluting absorbable calcium sulfate in treating periprosthetic infection after one-stage revision of knee arthroplasty.

Methods: A retrospective analysis was performed on 36 patients(36 knees)who underwent phaseⅠrevision for periprosthesis infection after total knee arthroplasty from January 2018 to March 2022. All patients were underwent knee cavity puncture before operation and had positive results of aseptic body fluid culture, 21 patients received revision combined with antibiotic loaded calcium sulfate at stageⅠ(calcium sulfate group) during operation, and 15 patients underwent renovation at stageⅠ(revision group).

Nanodrug Modulates Premetastatic Niche and Suppresses Metastatic Lung Adenocarcinoma via Programmed Cell Death Ligand 1 Blockade and STING Pathway Activation.

Metastasis is a major cause of mortality in patients with lung adenocarcinoma (LUAD), with the premetastatic niche (PMN) playing a crucial role in LUAD metastasis. However, the mechanisms underlying PMN formation in LUAD remain poorly understood, hindering therapeutic advancements. Herein, we developed a PMN-targeted nanodrug by coating programmed cell death protein 1 (PD-1)-high expressed T cell membranes on the surface of STING activator 2'3'-cGAMP-loaded PLGA@MnO nanoparticles (PSMP) for suppressing metastatic LUAD.