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The abuse of new psychoactive substances and narcotic drugs as drug substitutes poses a serious threat to public health and safety. This study outlines the effective use and negative abuse of drug substitutes and outlines associated criminal behaviors to help readers understand the potential risks of such substances. By summarizing the technical bottlenecks in the analysis and detection of criminal cases, this study highlights their impact on case discrimination, which in turn can limit or even render policy implementation ineffective. Finally, based on database analysis and the current regulatory system, flexible control strategies were proposed to address the constantly emerging "new" substances, providing a reference for relevant control guidelines to be formulated.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310920 | PMC |
http://dx.doi.org/10.3389/fpsyt.2025.1600212 | DOI Listing |
FASEB Bioadv
September 2025
Kobilka Institute of Innovative Drug Discovery, School of Medicine The Chinese University of Hong Kong Shenzhen Guangdong China.
Formyl peptide receptor 1 (FPR1) is a G protein-coupled receptor (GPCR) that mediates chemotaxis and bactericidal activities in phagocytes. The monoclonal antibody 5F1 is generated against full-length FPR1 and used widely for detection of FPR1 expression. This study aimed to characterize 5F1 for its functions.
View Article and Find Full Text PDFFront Pharmacol
August 2025
Department of Pharmacy, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Objective: Digestive tract tumors are the common tumors in China. Platinum-based chemotherapy drugs, especially oxaliplatin, play an important role in the treatment of gastrointestinal tumors. Starting from October 2021, the fifth national centralized volume-based procurement (NCVBP) was implemented in China to reduce the price of oxaliplatin.
View Article and Find Full Text PDFBioorg Chem
September 2025
The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China; Qinghai Provincial Key Laboratory of Tibetan Medicine Research, North
The high prevalence and drug resistance of superficial fungal infections (SFIs) pose a serious global public health challenge, urgently necessitating the development of novel antifungal drugs with unique structures and novel targets. Evodiamine derivatives are promising antifungal drug leads, yet they suffer from suboptimal activity and unclear action mechanisms. In this study, a series of N(14)-phenyl evodiamine derivatives were designed, synthesized and tested for their biological activities.
View Article and Find Full Text PDFEur J Med Chem
September 2025
Shanghai Frontiers Science Center of Drug Target Identification and Delivery, National Key Laboratory of Innovative Immunotherapy, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, China; State Key Laboratory of Innovative Immunotherapy, Central Research Institute,
Overexpression of protein lysine methyltransferase G9a, which catalyzes mono- and di-methylation of histone H3K9 and non-histone proteins, is closely associated with poor prognosis and metastasis of various cancers. Here, we designed and synthesized a series of novel G9a inhibitors bearing 2-tetrahydroisoquinoline substituted quinazoline scaffold. Among them, compound 31 with 2-dioxole fused tetrahydroisoquinoline exhibited the most potent inhibitory effects against G9a with an IC value of 0.
View Article and Find Full Text PDFArch Pharm (Weinheim)
September 2025
Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
Nitazoxanide (NTZ), an FDA-approved drug, served as the framework for synthesizing 22 new broad-spectrum antimicrobial agents from 4-aminosalicylic acid via protection-deprotection, Staudinger reduction, Clauson-Kaas pyrrole synthesis, and nucleophilic substitution. These compounds were evaluated for antibacterial, antimycobacterial, and antitrypanosomal activities. Several compounds, particularly 10, 11, 13, and 22, surpassed the antibacterial activity of NTZ and its active metabolite tizoxanide (TIZ) against all tested pathogens, with MICs ranging from 1.
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