Gas-Phase Assembly of Semiconductor Nanostructures into Functional Field-Effect Transistors.

Conventional semiconductor manufacturing relies on top-down lithography, which faces fundamental limitations in resolution, material versatility, and cost at the nanoscale. While bottom-up colloidal strategies offer alternative pathways, they are constrained by ligand contamination and insufficient precision for integrated circuits. Here a gas-phase synthesis and assembly platform is reported that overcomes these challenges by combining plasma-generated, stabilizer-free semiconductor nanoparticles (NPs) with electric-field-guided 3D nanoprinting.

A Dynamic Multi-Scale Feature Fusion Network for Enhanced SAR Ship Detection.

This study aims to develop an enhanced YOLO algorithm to improve the ship detection performance of synthetic aperture radar (SAR) in complex marine environments. Current SAR ship detection methods face numerous challenges in complex sea conditions, including environmental interference, false detection, and multi-scale changes in detection targets. To address these issues, this study adopts a technical solution that combines multi-level feature fusion with a dynamic detection mechanism.

Doubly Urea-Bridged Face-to-Face Dinuclear Metalloporphyrins for Efficient Electrocatalytic CO Reduction in Aqueous Solutions.

Electrocatalytic CO reduction reaction (CORR) is involved in new energy conversion scheme. Although many electrocatalysts for CORR have been developed, improving the activity and selectivity of molecular catalysts in aqueous solutions remains a challenge. Herein, the synthesis and electrocatalytic CORR features of doubly urea-bridged face-to-face dinuclear metalloporphyrins 1-M (M = Co, Fe) are reported.

Role of CclA Loss in Parametarhizium changbaiense in Enhancing Priming Resistance of Mung Bean Against Damping Off Induced by Rhizoctonia solani.

Rhizoctonia solani is a soil-borne pathogen causing destructive diseases on various economically important crops. Beneficial plant and fungus interactions are well acknowledged to enhance plant resistance to biotic stresses. However, the underlying mechanisms are not fully understood, especially the contribution of fungal epigenetic regulation remains poorly understood.

Single- and two-level osteotomy for the treatment of thoracolumbar kyphosis in ankylosing spondylitis patients with concomitant coronal malalignment.

Purpose: To investigate the influence of apical vertebrae difference (AVD) on surgical decision-making and clinical outcomes of single- and two-level osteotomy in ankylosing spondylitis (AS) thoracolumbar kyphoscoliosis with sagittal and coronal imbalance.

Methods: A total of 27 AS patients with thoracolumbar kyphoscoliosis were enrolled in the study. Patients were divided into single- and two-level osteotomy groups based on the number of osteotomy levels.

Broad neuraminidase antibodies confer protection against seasonal and avian influenza viruses.

Neuraminidase (NA) is a critical target for universal influenza vaccines and therapeutic antibodies, yet its antigenic landscape remains incompletely understood. Here we identify two broadly cross-protective monoclonal antibodies, CAV-F6 and CAV-F34, from influenza-infected individuals. These antibodies inhibit NA enzymatic activity across multiple subtypes and confer protection against seasonal influenza in female mouse models.

[Quality of life and its influencing factors in children and adolescents with type 1 diabetes in Xinjiang].

Objectives: To investigate the current status and influencing factors of quality of life in children and adolescents with type 1 diabetes (T1DM) in Xinjiang.

Methods: A convenience sampling method was used to select 259 children with T1DM and their primary caregivers who attended three tertiary hospitals in Xinjiang from January 2023 to February 2024. The Pediatric Quality of Life Inventory Version 4.

Lipid droplets in plants: turnover and stress responses.

Lipid droplets (LDs) have emerged as dynamic organelles central to plant lipid metabolism, stress adaptation, and energy homeostasis. This review synthesizes recent advances in understanding LD biogenesis and degradation in plants, highlighting conserved and divergent mechanisms relative to other eukaryotes. LD formation originates in the endoplasmic reticulum (ER), where neutral lipids synthesized by diacylglycerol acyltransferases (DGAT) and phospholipid: diacylglycerol acyltransferases (PDAT) accumulate into lens-like structures.

Family Resilience in Adolescent and Young Adult Patients With Hematological Malignancies: A Qualitative Study of Patients and Family Caregivers.

Objective: Family resilience plays a vital role in coping with cancer. However, little research has explored how adolescents and young adults (AYAs) with hematological malignancies and their families adapt to cancer, particularly during this critical developmental stage.

Aims: This study aims to explore how AYAs with hematological malignancies and their families experience the dynamic process of family resilience.

Androgens Are a Key Factor Affecting Immune Related Diseases.

Androgens mainly have suppressing effects on immune function, affecting the different progression of immune diseases in males and females, but their main mechanisms are still unclear. Bibliometric methods are used to analyze relevant literature in the Web of Science Core Collection (WoSCC) database over the past decade, with a focus on key and hot topics. The results show that prostate cancer, triple negative breast cancer, and sex differences in respiratory diseases, etc.

Kiwifruit branch compost reduces the bioavailability of the rare earth elements lanthanum and cerium in agricultural soils.

Rare earth elements are widely used due to their distinctive magnetic, optical and electrical properties. As a consequence, they inevitably enter the environment, potentially posing a threat to human health through the food chain. This experiment sought to investigate the impact of compost made by kiwifruit branches and sheep manure on the lanthanum (La) and cerium (Ce) in soils.

Panoramic photoacoustic computed tomography with learning-based classification enhances breast lesion characterization.

Breast cancer diagnosis is crucial due to the high prevalence and mortality rate associated with the disease. However, mammography involves ionizing radiation and has compromised sensitivity in radiographically dense breasts, ultrasonography lacks specificity and has operator-dependent image quality, and magnetic resonance imaging faces high cost and patient exclusion. Photoacoustic computed tomography (PACT) offers a promising solution by combining light and ultrasound for high-resolution imaging that detects tumour-related vasculature changes.

Unlocking the potential of engineered microbes in immunotoxin-based cancer therapy.

Immunotoxins (ITs), as targeted cancer therapies, confront limitations including off-target effects, immunogenicity, and inadequate tumor penetration, hindering clinical translation. Advances in tumor microenvironment (TME) understanding and genetic engineering have enabled engineered microorganisms such as attenuated , Nissle 1917, and modified eukaryotic platforms (e.g.

Porous Co@NC Materials Obtained by Pyrolyzing Metal-Organic Framework-Supported Multinuclear Metal Clusters for the Oxygen Reduction Reaction.

The design and development of efficient oxygen reduction reaction (ORR) electrocatalysts have become a key challenge for fuel cells and metal-air batteries. As a cutting-edge field in electrocatalysis, single-atom catalysts have been widely used in ORR due to their maximum atomic utilization and tunable coordination environment. In this study, multinuclear metal clusters were selected as precursors to construct metal nanoparticles and single-atomic metal sites doped carbon materials for electrocatalytic ORR.

Long Non-coding RNA DANCR Regulates the Proliferation and Migration of Human Adipose-derived Mesenchymal Stromal Cells in Inflammation Conditions.

Background: Mesenchymal stromal cells (MSCs) and Dexamethasone (Dex) are both effective methods to treat inflammatory diseases. However, the interaction between inflammatory factors, Dex, and MSCs in repair is not fully understood. The purpose of this study is to clarify the effects and mechanisms of glucocorticoids on the tissue repair characteristics of MSCs in an inflammatory environment.

Native Ligand-Inspired peptides for c-MET targeted PET probes development.

Purpose: Native ligand-derived peptides have significantly advanced the development of targeting ligands in radiopharmaceutical discovery and design. Herein, we report the first attempt to develop novel mesenchymal-epithelial transition factor (c-MET) targeted peptide positron emission tomography (PET) probes based on the endogenous biomolecule, hepatocyte growth factor (HGF).

Methods: Three c-MET targeted peptides were designed from the N-terminal and kringle 1 domain (NK1: 32-207 amino acid residues) of HGF.

Abscisic acid enhances DNA damage response through the nuclear shuttling of clathrin light chain 2 in plant cells.

DNA damage arises from various environmental stresses, and ABA is well known for its roles in plant stress resistance. However, its function in plant DNA damage tolerance remains unclear. In this study, we showed that ABA supplementation significantly enhances plant tolerance to DNA-damaging treatments.

Remote ischemia precondition protects against renal IRI through apoptosis associated vesicles carrying MIF protein via modulating DUSP6/JNK signaling axis.

Background: Remote ischemic preconditioning (rIPC) has been reported to protect against kidney ischemia-reperfusion injury (IRI) through the delivery of extracellular vesicles (EVs). Among these, apoptosis-induced compensatory proliferation signaling-related vesicles (ACPSVs) can transmit proliferation signals to surrounding cells. However, the underlying mechanisms remain unclear.

SLC6A6-Mediated Taurine Uptake Sustains Corneal Epithelial Stem/Progenitor Cell Function to Counteract Age-Related Dysfunction.

Purpose: This study aimed to elucidate the role of SLC6A6-mediated taurine transport in maintaining corneal limbal stem/progenitor cell (LSPC) function and its implications for age-associated corneal wound healing.

Methods: Corneal amino acid profiles from C57BL/6J mice were analyzed via liquid chromatography-tandem mass spectrometry (LC-MS/MS). SLC6A6 expression patterns were mapped using single-cell RNA sequencing, quantitative PCR, and immunofluorescence.

Mechanistic Studies of Catalytic O-to-HO Conversion at a Single Cobalt Site.

Understanding oxygen reduction reaction (ORR) mechanisms is of fundamental significance. Although metal hydrosuperoxos and metal hydroperoxos are considered to be key intermediates in ORR, these two species as well as their reaction natures are poorly understood because they are highly active with various reaction pathways. Herein, we report on the mechanistic studies of the ORR with Co porphyrin .

Small-Molecule Probe [Ga]Ga-SMIC-2501 Targeting the V-Domain Immunoglobulin Suppressor of T Cell Activation Protein for Positron Emission Tomography Imaging.

V-domain immunoglobulin suppressor of T cell activation (VISTA) inhibits T-cell effector functions and helps tumor immune evasion, making it an important biomarker and therapeutic target in cancer immunotherapy. To facilitate VISTA-targeted strategy development and enable the accurate detection of tumor VISTA expression, a novel small-molecule probe [Ga]Ga-SMIC-2501 was developed for noninvasive imaging. The radiochemical purity was over 95%, with a radiochemical yield of around 90%.

Decursin, Identified via High-Throughput Chemical Screening, Enhances Plant Disease Resistance via Two Independent Mechanisms.

In order to overcome the damage caused by phytopathogens, plants have evolved a complex defence system to protect themselves, such as the two-tiered innate immunity system. Chemical screening has led to the identification of plant immune-priming compounds, which facilitate the functional dissection of the plant immune system and contribute to chemical control for plant diseases. In this study, we identified decursin, a coumarin natural product, through high-throughput screening for activators of the expression of FLG22-INDUCED RECEPTOR KINASE 1 (FRK1).

DAC-less PAM-4 signal generation using a thin-film lithium niobate dual-drive MZI modulator.

In this study, we demonstrate DAC-less PAM-4 signal generation using a lithium niobate on insulator (LNOI) dual-drive Mach-Zehnder modulator (DD-MZM). The modulator is driven by two independent binary streams, eliminating the need for power-hungry digital-to-analog converters (DACs). The high electro-optical (EO) bandwidth and excellent linearity of the LNOI modulator make it suitable for generating high-speed, equally spaced PAM-4 signals.