Gas-Phase Assembly of Semiconductor Nanostructures into Functional Field-Effect Transistors.

Conventional semiconductor manufacturing relies on top-down lithography, which faces fundamental limitations in resolution, material versatility, and cost at the nanoscale. While bottom-up colloidal strategies offer alternative pathways, they are constrained by ligand contamination and insufficient precision for integrated circuits. Here a gas-phase synthesis and assembly platform is reported that overcomes these challenges by combining plasma-generated, stabilizer-free semiconductor nanoparticles (NPs) with electric-field-guided 3D nanoprinting.

Genome-wide characterization and adaptive evolution of favorable gibberellin 2-oxidase alleles contributing to wheat agronomic traits.

Introduction: Gibberellins are essential phytohormones that regulate plant growth and development. Gibberellin 2-oxidases (GA2oxs) deactivate bioactive gibberellin isoforms and many GA2ox genes have been validated as key regulators of agronomic traits in model plants and crops. However, there are few studies on GA2ox genes in wheat, one of the most important staple crops.

Wheat domestication gene Q interplays with TaARF12 to antagonistically modulate plant architecture by integrating multiple hormone homeostasis.

Wheat domestication gene Q controls threshability and also pleiotropically affects plant morphogenesis. However, its specific roles in modulating plant architecture and the underlying mechanisms remain unclear. We dissected Q effects on plant architecture using transgenic overexpression and knockout assays.

CALD1-derived circ-0003746 targeting miR-526b promotes EMT-mediated bladder cancer progression.

CALD1 is critical to bladder cancer (BCa) development. Circ-0003746 is a circRNA derived from two exons of CALD1. However, the functional role of circ-0003746 in BCa remains inadequately explored.

Deciphering genetic architecture and regulatory mechanism underlying the accumulation of seed storage proteins in wheat.

Wheat seed storage proteins (SSPs) are an important source of nutrients and also greatly affect human health. SSPs form a polymer complex conferring wheat dough elasticity and extensibility, and their variations in components and abundance determine processing quality. Therefore, deciphering the genetic machinery and regulatory mechanism underlying SSP variation will facilitate wheat quality improvement.

Vertically-Aligned Hybrid Plasmonic Nanoantennas with Tailored Visible-Light Responses.

Plasmonic nanoantennas enable unprecedented control of light-matter interactions at subwavelength scales, yet conventional fabrication methods limit designs to planar geometries with fixed resonant properties. Here, we demonstrate 3D-printed plasmonic nanoantenna arrays featuring record aspect ratios (15:1), miniaturized features (∼40 nm), and high density (1.0 × 10 mm) on silicon wafers.

Transcription factor ZNF207 drives aerobic glycolysis and facilitates malignancy progression in hepatocellular carcinoma.

Zinc-finger protein 207 (ZNF207), a prominent member of the zinc finger protein family, exhibits consistent upregulation in various cancer types, including hepatocellular carcinoma (HCC). Unfortunately, the specific oncogenic mechanism of ZNF207 in HCC remains unknown. Our research involved a comprehensive approach, utilizing bioinformatics analysis alongside cell functional experiments, dual-luciferase reporter gene assays, ChIP and qPCR investigations, as well as in vivo studies involving nude mice models for subcutaneous tumor transplantation and tail vein lung metastasis, to delve into the molecular mechanisms underlying its oncogenic properties.

The role of notch signaling pathway in cancer: mechanistic insights, therapeutic potential, and clinical progress.

This article presents a comprehensive literature review on the role of the Notch signaling pathway in cancer and its molecular mechanisms. The Notch signaling pathway plays an important role in various types of cancer by regulating key biological processes such as epithelial-endothelial transition, angiogenesis, apoptosis and metabolic reprogramming. This article reviews the relevant mechanisms of the Notch signaling pathway in colorectal cancer, ovarian cancer, oral squamous cell carcinoma, gastric cancer and chronic lymphocytic leukemia, highlighting its dual roles in promoting tumor growth, inhibiting tumor progression and potential therapeutic applications in oncology.

Slow and highly confined plasmons observed in atomically thin TaS.

Extreme light confinement down to the atomic scale has been theoretically predicted for ultrathin, Ta-based transition metal dichalcogenides (TMDs). In this work, we report the observation of highly confined plasmons in 2H-TaS monolayers and bilayers via momentum-resolved electron energy loss spectroscopy (q-EELS), with a resolution of 0.0056 Å.

Surface bio-engineering of melt electrowritten tubular scaffolds via plasma immersion ion implantation (PIII).

Melt electrowriting (MEW) enables the fabrication of highly controlled, open-pore tubular constructs for replicating the complex architectures of vascular, renal, and other tissues. However, a key challenge is to functionalize their surfaces so that they not only support but also instruct key biological interactions, particularly in promoting vascularization. Here, we propose plasma immersion ion implantation (PIII) as a biofunctionalization strategy for open-pore tubular constructs fabricated by MEW.

Sb(Ⅴ) has distinct cellular uptake route and cytotoxic mechanism from Sb(Ⅲ): Anion channel 2 and sulfhydryl binding.

Antimony (Sb), a metalloid element with important industrial applications, exists as valence states of Sb(III) and Sb(V). Understanding on the Sb induced cytotoxicity, especially Sb(V), is still limited. In this study, human hepatoma (HepG2) and nephrocyte (HEK293T) cell lines were used to investigate the cytotoxicity, uptake and biotransformation of Sb.

Effects of nitrogen and precipitation on the life history of spring- and autumn-germinated plants of Hypecoum erectum L. (Papaveraceae).

Nitrogen deposition and precipitation are the topics of current global climate change, and also the major environmental factors influencing plant growth. This study utilized the ephemeral plant H. erectum, which is distributed in the Gurbantunggut Desert in northwest China, as the experimental material to analyze the influence of nitrogen deposition and water-nitrogen interaction treatment on the phenology, survival rate, plant traits, biomass accumulation, and seed dormancy of spring- and autumn-germinated plants.

Faraday Lithography.

As Moore's Law continues to push critical dimension (CD) scaling in integrated circuits, conventional photolithography approaches fundamental resolution limits. While alternative strategies such as self-aligned double patterning and directed self-assembly address these challenges, they introduce process complexity and manufacturing variability. Here we develop Faraday lithography (FL), a novel approach that hybridizes nanoscale 3D printing with conventional nanofabrication to overcome these limitations.

Wafer-Scale Nanoprinting of 3D Interconnects beyond Cu.

Cloud operations and services, as well as many other modern computing tasks, require hardware that is run by very densely packed integrated circuits (ICs) and heterogenous ICs. The performance of these ICs is determined by the stability and properties of the interconnects between the semiconductor devices and ICs. Although some ICs with 3D interconnects are commercially available, there has been limited progress on 3D printing utilizing emerging nanomaterials.

The pressure-induced photoconductivity enhancement of black-TiO.

The pressure-induced enhancement of the optoelectronic properties of black-TiO nanocrystals is presented. The underlying mechanisms are elucidated by comparing the behavior with that of white-TiO. The disordered layer in black-TiO contributes to the enhanced photoconductivity, while the crystal structure dominates in relation to photoconductivity variations.

Establishment of a genotyping criteria for Bandavirus dabieense and confirmation of new genotypes.

Bandavirus dabieense (DBV) causes severe fever with thrombocytopenia syndrome, which has a mortality rate of 6.18% of 27%. DBV has been classified into five to six genotypes using phylogenetic analyses.

Bioinstructive 3D-Printed Magnesium-Baghdadite Bioceramic Scaffolds for Bone Tissue Engineering.

Current synthetic bioceramic scaffolds often lack bioinstructive ability for effective bone regeneration. We have selected magnesium-doped baghdadite (Mg-BAG) scaffolds, known for their promising osteoinductive and mechanical properties, as the base material and fabricated them using a liquid crystal display 3D printing technique. Building on this foundation, we have advanced the application of ion-assisted plasma polymerization (IAPP) technology, adapted for 3D structures, to develop homogeneous bioinstructive interfaces on these scaffolds for enhanced osteoinductive properties.

3D-Printed High-Entropy Alloy Nanoarchitectures.

System miniaturization is a key driver in developing nanoelectromechanical systems, sensors, and microchips. To enhance reliability and extend operational lifetimes, high-entropy alloys (HEAs) have emerged as promising materials due to their exceptional mechanical robustness and thermal stability. These advantageous properties are predominantly demonstrated in bulk HEA forms; however, research on small-dimensional HEAs is largely confined to nanoparticles, nanopillars, and thin films, limiting their broader applications in nanodevice systems.

Identification of early prognostic biomarkers in Severe Fever with Thrombocytopenia Syndrome using machine learning algorithms.

Objective: We aimed at identifying acute phase biomarkers in Severe Fever with Thrombocytopenia Syndrome (SFTS), and to establish a model to predict mortality outcomes.

Methods: A retrospective analysis was conducted on multicenter clinical data. Group-based trajectory modeling (GBTM) was utilized to demonstrate the overall trend of laboratory indicators and their correlation with mortality.

Formation of Multiple Naturally Occurring Meroterpenoid Scaffolds by the Norrish-Yang Reaction of a p-Benzoquinone.

The Norrish-Yang reaction, as a typical example, demonstrates the inherent ability of photochemical reaction to facilitate formation of sterically congested C-C bonds, efficiently crafting intricate ring structure in complex organic molecules. Herein we report for the first time a unified synthesis using quinone-based acid-promoted Norrish-Yang photocyclization for the stereoselective construction of multiple avarane-type meroterpenoid natural products.

Suppression of Interferon Response and Antiviral Strategies of Bunyaviruses.

The order Bunyavirales belongs to the class of Ellioviricetes and is classified into fourteen families. Some species of the order Bunyavirales pose potential threats to human health. The continuously increasing research reveals that various viruses within this order achieve immune evasion in the host through suppressing interferon (IFN) response.

Structure-Activity Relationship Studies of Substituted 2-Phenyl-1,2,4-triazine-3,5(2,4)-dione Analogues: Development of Potent eEF2K Degraders against Triple-Negative Breast Cancer.

eEF2K, an atypical alpha-kinase, is responsible for regulating protein synthesis and energy homeostasis. Aberrant eEF2K function has been linked to various human cancers, including triple-negative breast cancer (TNBC). However, limited cellular activity of current eEF2K modulators impedes their clinical application.

A comparative evaluation of bioequivalence of Gan & Lee glargine U300 and Toujeo in Chinese healthy male participants.

Background: To assess the bioequivalence between Gan & Lee (GL) glargine U300 and Toujeo regarding pharmacokinetics (PK), pharmacodynamics (PD), and safety in Chinese healthy male participants.

Methods: A single-center, randomized, double-blind, single-dose, two-preparation, two-sequence, four-cycle repeated crossover design study was performed to compare GL glargine U300 and Toujeo in 40 healthy participants. The primary PK endpoints were the area under the curve of glargine metabolites, M1 concentration from 0 to 24 hours (AUC), and the maximum glargine concentration within 24 hours post-dose (C).

Kunth Extract Is a Novel Natural Drug against .

As a widely distributed plant in Northeast China, Kunth (CMK) is generally considered to have antibacterial properties; however, there is a lack of scientific evidence for this. Therefore, we investigated the chemical composition of CMK extract and its effect against A total of 105 compounds were identified in the alcohol extracts of CMK by UPLC-Q-TOF-MS. Most were flavonoids, with being the most represented.

Serum dithiothreitol-oxidizing capacity (DOC) is a promising biomarker for excluding significant liver fibrosis: a proof-of-concept study.

Background: APRI and FIB-4 scores are used to exclude clinically significant fibrosis (defined as stage ≥ F2) in patients with chronic viral hepatitis. However, the cut-offs for these scores (generated by Youden indices) vary between different patient cohorts. This study aimed to evaluate whether serum dithiothreitol-oxidizing capacity (DOC), i.