Gender differences in face pareidolia: The effect of cognitive style and judgment criteria.

Face pareidolia refers to perceiving facial features on inanimate objects. Previous studies have identified gender differences in pareidolia, but the factors behind these differences remain unclear. This study examined potential influences, including task requirement, low-frequency information encoding ability, and cognitive style.

Development and validation of mortality risk prediction model for sepsis secondary to pneumonia at intensive care unit admission: a retrospective case-cohort study.

Background: To establish a noninvasive mortality risk prediction model for sepsis secondary to pneumonia (SSP) and validate the model in the prediction of mortality risk in SSP patients at hospital admission.

Methods: A retrospective cohort of SSP patients were recruited from January 2017 to December 2020 at the Henan Provincial People's Hospital. Clinical data were collected at admission.

Fluorinated C20-epi-Deoxysalinomycin Derivatives: Synthesis and Evaluation of Anticancer Activities.

Salinomycin exhibits potent cytotoxic activity against various cancer types. Leveraging the advantages of fluorination in drug development, we efficiently synthesized 17 fluorinated C20-epi-deoxysalinomycin derivatives through a streamlined 4-5 step synthetic route. Key transformations, including room-temperature azidation, copper-catalyzed click reactions, and amide condensation, were performed under mild conditions with satisfactory yields.

Burden of non-CO poisoning in 204 countries and territories, 1990-2021: results from the global burden of disease study 2021.

Background: Non-carbon monoxide (non-CO) poisoning remains a significant global public health issue, contributing to considerable morbidity and mortality. However, there is a lack of comprehensive analysis regarding the global burden and trends of non-CO poisoning.

Methods: Data from the Global Burden of Disease (GBD) 2021 study were used to assess the global, regional, and national prevalence, mortality, and disability-adjusted life years (DALYs) associated with non-CO poisoning from 1990 to 2021.

Epicardial adipose tissue volume is associated with impaired left ventricular strain in patients with metabolic syndrome: the mediating role of myocardial energetic efficiency.

Background: Epicardial adipose tissue volume (EATV) has been linked to cardiac dysfunction in metabolic syndrome (MetS), but the underlying mechanisms remain unclear. The aim of this study was to investigate whether myocardial energetic efficiency partially explains the relationship between EATV and impaired left ventricular (LV) myocardial strain in MetS patients using cardiac magnetic resonance (CMR).

Methods: A total of 225 patients with MetS and 68 age - and sex - matched controls underwent CMR.

Clinical Observational Study on HBV Reactivation After Direct-Acting Antiviral Therapy in HCV/HBV Coinfected Patients in Guizhou, China.

The objective of this study is to analyse the prevalence and clinical characteristics of HCV/HBV coinfection in Guizhou, and evaluate the rate of HBV reactivation during and after anti-HCV treatment in a real-world study. This retrospective study included 1652 patients with hepatitis C virus (HCV) infection who received direct-acting antiviral (DAA) therapy at the Guiyang Public Health Clinical Center between January 2018 and December 2022 Baseline, on-treatment and posttreatment data were collected, including HCV RNA, HCV genotypes, liver function, hepatitis B virus (HBV) markers (HBsAg, HBcAb) and HBV DNA levels. The HCV/HBV coinfection rate was analysed, and the risk of HBV reactivation and disease progression following DAA therapy was assessed.

Identification of DNA Replication Stress-Related Genes as Prognostic Biomarkers for Bladder Cancer.

Introduction: Bladder cancer (BLCA) is a highly aggressive malignancy with poor prognosis. DNA replication stress-related genes (DRSGs) hold prognostic significance in multiple cancers, and their expression patterns in BLCA may reveal novel biomarkers and therapeutic targets.

Methods: This study was designed using a public database and the Cancer Genome Atlas (TCGA).

The adverse effects of metabolic disorder on left ventricular myocardial mechano-energetic efficiency and dysfunction in ischemic cardiomyopathy: insight from a cardiac MRI study.

Purpose: Metabolic risk factors (MetF) have emerged as the leading drivers of ischemic cardiomyopathy (ICM) worldwide. However, in patients who have already experienced myocardial ischemia/infarction, whether and in what pattern the MetF act on the heart needs to be further elucidated. This study aims to determine the adverse effects of MetF on left ventricular (LV) indexed myocardial mechano-energetic efficiency (MEEi) and dysfunction in patients with ICM, and further clarify which MetF classification is more clinically significant.

Excellent mechanical properties and corrosion resistance of Al-Ce-Zr alloys.

In this study, the effect of Zr elements on Al-10Ce alloys were investigated in terms of the microstructure, mechanical properties at room and high temperatures, and corrosion resistance. Meanwhile, the finite element simulations on tensile fracture was adopted to explain the fracture process of Al-Ce alloys. Results showed that as Zr content increased from 0.

Synergistic effects of crystal habit and confining pressure on the compressive mechanical behavior of crystalline rock: a grain-based modeling analysis.

This study investigates the synergistic effects of crystal habit and confining pressure on the compressive mechanical behavior of crystalline rocks using a grain-based model implemented in the Universal Distinct Element Code. Synthetic granite samples with euhedral, subhedral, and anhedral microstructures were simulated by adjusting grain boundary irregularity, quantified by fractal dimension (D), which increased from euhedral to anhedral. Deformation and failure were depicted using a compression-hardening contact model and a cohesion-weakening-friction-strengthening material model.

Construction of colon-specific Pickering emulsions with rhein-chitosan conjugated nanoparticles as emulsifier and its application in murine ulcerative colitis.

Rhein demonstrates therapeutic advantages in ulcerative colitis treatment through multi-target synergy and multi-pathways, yet its clinical application is limited by poor oral bioavailability due to low solubility and poor medication compliance caused by gastrointestinal irritation. The study constructed a composite oral colon-specific delivery system based on rhein-loaded Pickering emulsions (Rhein@Rh-CS/TPP PEs), in which rhein-chitosan conjugated nanoparticles (Rh-CS/TPP NPs) serving as emulsifier, aiming to enhance rhein' bioavailability, improve its anti-ulcerative colitis efficacy, and reduce side effects. Briefly, rhein was covalently modified onto chitosan to increase hydrophobicity of chitosan, then the synthesized Rh-CS/TPP NPs were served as solid particle emulsifier.

Characterization of Global Research Trends and Prospects on Prone Positioning in Respiratory Failure: Bibliometric Analysis.

Background: Prone positioning has emerged as a crucial intervention in managing acute respiratory failure, especially in acute respiratory distress syndrome and patients with COVID-19. Given the increasing interest in this field, it is important to characterize global research trends and key contributors to identify future research directions.

Objective: This study aimed to analyze global research trends, collaboration networks, and research hotspots related to prone positioning in respiratory failure through a comprehensive bibliometric analysis.

Long Non-coding RNA DANCR Regulates the Proliferation and Migration of Human Adipose-derived Mesenchymal Stromal Cells in Inflammation Conditions.

Background: Mesenchymal stromal cells (MSCs) and Dexamethasone (Dex) are both effective methods to treat inflammatory diseases. However, the interaction between inflammatory factors, Dex, and MSCs in repair is not fully understood. The purpose of this study is to clarify the effects and mechanisms of glucocorticoids on the tissue repair characteristics of MSCs in an inflammatory environment.

Mult-omics analysis reveals the lipid-lowering effects of sea buckthorn and milk thistle solid beverage in hyperlipidemic rats.

Background: Hyperlipidemia is a common metabolic disorder and a risk factor for cardiovascular disease. The traditional medicine herb, Hippophae rhamnoides L., known as sea buckthorn, has anti-obesity and lipid-lowering effects, while Silybum marianum (L.

Comparison of right ventricular function and clinical outcomes in type 2 diabetes patients with and without obstructive coronary artery disease: insights from a CMR study.

Background: Obstructive coronary artery disease (OCAD) marks a high-risk group within patients with type 2 diabetes mellitus (T2DM), underscoring the need for tailored prevention and management strategies. However, limited data exist on right ventricular (RV) function and clinical outcomes in T2DM patients with versus without OCAD. This study aimed to investigate the differences in RV function and clinical outcomes between these two groups.

The mC methyltransferase NSUN2 promotes progression of acute myeloid leukemia by regulating serine metabolism.

Acute myeloid leukemia (AML) is one of the most prevalent heterogeneous hematologic malignancies with a complicated etiology. RNA post-transcriptional modifications have been linked to the incidence and progression of AML, while the detailed mechanism remains to be elucidated. In this study, we find that NOP2/Sun domain family member 2 (NSUN2), a methyltransferase of 5-methylcytosine (mC) RNA methylation, is upregulated in AML and predicts a poor prognosis for patients with AML.

MicroRNA-593-3p Inhibits Growth and Metastasis of Human Breast Cancer Cells by Regulating TIMM17A Expression.

Breast cancer poses significant therapeutic challenges, necessitating the identification of novel molecular targets for effective treatment. This study explores the tumor-suppressive role of miR-593-3p and its regulatory interaction with TIMM17A in breast cancer. Expression analysis revealed a marked downregulation of miR-593-3p in breast cancer cell lines compared to normal mammary epithelial cells.

Alternative splicing categorizes organ development by stage and reveals unique human splicing variants linked to neuromuscular disorders.

Alternative splicing (AS) diversifies protein expression and contributes to species-specific differences in organ development. Here, we focused on stage-specific splicing variants and their correlation with disease in humans compared to mice during brain and heart development. Temporal transcriptomic analysis revealed that splicing factors (SFs) can accurately classify organ developmental stages, and 5 SFs were identified specifically upregulated in humans during organogenesis.

The association between the triglyceride-glucose index and vulnerable plaques in patients with type 2 diabetes mellitus: insights from coronary computed tomography angiography.

Background: The triglyceride‒glucose index (TyG index) has been verified to be a useful predictor of insulin resistance (IR), and is associated with the occurrence of acute coronary syndrome (ACS). However, the effect of the TyG index on vulnerable plaques (VP), which were identified when at least two high-risk features are present within the same lesion, in type 2 diabetes mellitus (T2DM) patients is not fully understood. This study aimed to explore the association between the TyG index and the presence of VP.

Left-atrioventricular interaction and left-atrial deformation in patients with type 2 diabetes mellitus with or without chronic aortic regurgitation: a 3.0-T cardiac magnetic resonance feature-tracking study.

Background: The prevalence of type 2 diabetes mellitus (T2DM) and chronic aortic regurgitation (AR) increases with age and may also increase cardiac morbidity and mortality; however, their comprehensive effects based on cardiac strain remain unexplored. This study aimed to use cardiac magnetic resonance (CMR) feature tracking to investigate the additive effects of T2DM and AR on the left heart and left-atrioventricular interaction in patients with T2DM and AR.

Methods: A total of 286 patients with T2DM (203 without AR and 83 with AR) and 105 controls were retrospectively included from January 2015 to October 2022.