Construction of colon-specific Pickering emulsions with rhein-chitosan conjugated nanoparticles as emulsifier and its application in murine ulcerative colitis.

Rhein demonstrates therapeutic advantages in ulcerative colitis treatment through multi-target synergy and multi-pathways, yet its clinical application is limited by poor oral bioavailability due to low solubility and poor medication compliance caused by gastrointestinal irritation. The study constructed a composite oral colon-specific delivery system based on rhein-loaded Pickering emulsions (Rhein@Rh-CS/TPP PEs), in which rhein-chitosan conjugated nanoparticles (Rh-CS/TPP NPs) serving as emulsifier, aiming to enhance rhein' bioavailability, improve its anti-ulcerative colitis efficacy, and reduce side effects. Briefly, rhein was covalently modified onto chitosan to increase hydrophobicity of chitosan, then the synthesized Rh-CS/TPP NPs were served as solid particle emulsifier.

Synthetic Multidimensional Aharonov-Bohm Cages in Fock State Lattices.

Fock-state lattices, composed of photon number states with infinite Hilbert space, have emerged as a promising platform for simulating high-dimensional physics due to their potential to extend into arbitrarily high dimensions. Here, we demonstrate the construction of multidimensional Fock-state lattices using superconducting quantum circuits. By controlling artificial gauge fields within their internal structures, we investigate flux-induced extreme localization dynamics, such as Aharonov-Bohm caging, extending from 2D to 3D.

Deterministic quantum state and gate teleportation between distant superconducting chips.

Quantum teleportation is of both fundamental interest and great practical importance in quantum information science. To date, quantum teleportation has been implemented in various physical systems, among which superconducting qubits are of particular practical significance as they emerge as a leading system to realize large-scale quantum computation. Nevertheless, scaling up the number of superconducting qubits on a single chip becomes increasing challenging because of some emergent technical difficulties.

[Immobilization of Heavy Metals by Phosphorus-solubilizing Bacteria and Inhibition of Cd and Pb Uptake by Wheat].

Phosphorus-solubilizing microorganisms convert insoluble phosphorus in the soil into phosphorus that can be absorbed by plants. Soluble phosphate combines with heavy metals to form precipitation, reducing the content of available heavy metals, thereby reducing the absorption of heavy metals by crops, which plays an important role in the remediation of heavy metal-contaminated soil. The effects of the immobilization of Cd and Pb and the release of PO by the phosphorus-solubilizing bacterium sp.

8-oxoguanine DNA glycosylase-1 may serve as biomarker of mechanical asphyxia.

Aim: To identify mtDNA and OGG1 as potential biomarker candidates for mechanical asphyxia.

Method: The human tissues are divided into experimental group (hanging and strangulation) and control groups (hemorrhagic shock, brain injury group, and poisoning group). Detected the expression of OGG1 and integrity of mtDNA in cardiac tissue of each group.

Design and development of a soluble PDA-Emodin-PVP-MN patch and its anti-obesity effect in rats.

Emodin has been proven to have weight-reducing and lipid-lowering effects. In order to make emodin play a better anti-obesity role, we designed and developed an emodin loaded dissolving microneedle patch, in which emodin existed in the form of emodin-polyvinylpyrrolidone co-precipitate (Emodin-PVP). Meanwhile, polydopamine (PDA) was added to the microneedle patch (PDA-Emodin-PVP-MN) for photothermal-enhanced chemotherapy of obesity.

Deciphering dynamic interactions between spermatozoa and the ovarian microenvironment through integrated multi-omics approaches in viviparous Sebastes schlegelii.

The ovarian microenvironment plays a crucial role in ensuring the reproductive success of viviparous teleosts. However, the molecular mechanism underlying the interaction between spermatozoa and the ovarian microenvironment has remained elusive. This study aimed to contribute to a better understanding of this process in black rockfish (Sebastes schlegelii) using integrated multi-omics approaches.

Cholesterol-lowering effects of rhubarb free anthraquinones and their mechanism of action.

Rhubarb free anthraquinones (RhA) have significant lipid-regulating activity. However, whether RhA monomers have a role in lipid-regulating and their mechanism of action remains unclear. Based on the cholesterol accumulated HepG2 cell model, the cholesterol-regulating effect of RhA monomers and their combinations was investigated.

Demonstrating Path-Independent Anyonic Braiding on a Modular Superconducting Quantum Processor.

Anyons, exotic quasiparticles in two-dimensional space exhibiting nontrivial exchange statistics, play a crucial role in universal topological quantum computing. One notable proposal to manifest the fractional statistics of anyons is the toric code model; however, scaling up its size through quantum simulation poses a serious challenge because of its highly entangled ground state. In this Letter, we demonstrate that a modular superconducting quantum processor enables hardware-pragmatic implementation of the toric code model.

An analysis of differences in Carbapenem-resistant Enterobacterales in different regions: a multicenter cross-sectional study.

Objective: This study aimed to explore the characteristics of carbapenem-resistant Enterobacterales (CRE) patients in the intensive care unit (ICU) in different regions of Henan Province to provide evidence for the targeted prevention and treatment of CRE.

Methods: This was a cross-sectional study. CRE screening was conducted in the ICUs of 78 hospitals in Henan Province, China, on March 10, 2021.

Pressure-induced phase transition of LuTiOand LuCeTiOpyrochlores.

This study utilizes both experimental and computational approaches to investigate the performance of LuTiO(LTO) and LuCeTiO(LCTO) pyrochlores under high pressure. The structural changes of LTO and LCTO pyrochlores were characterized usingsynchrotron x-ray diffraction (SXRD) andRaman spectroscopy at pressures up to 44.6 GPa.

Stool-softening effect and action mechanism of free anthraquinones extracted from Rheum palmatum L. on water deficit-induced constipation in rats.

Ethnopharmacological Relevance: In traditional Chinese herbal medicine, rhubarb is said to remove accumulation with purgation, clearing heat, and discharging fire. Modern pharmacology has shown that rhubarb extract has a purgative effect when given to experimental animals in an appropriate dose. However, the active components and their mechanism of action are still not clearly defined.

Longitudinal-Torsional Ultrasonic Grinding of GCr15: Development of Longitudinal-Torsional Ultrasonic System and Prediction of Surface Topography.

The common material of bearing rings is GCr15 bearing steel which is a typical difficult-to-machine material. As an important working surface of the bearing, the inner surface of the raceway plays a vital role in the performance of the bearing. As an important means to solve the high-performance manufacturing of difficult-to-machine materials, longitudinal-torsional ultrasonic processing is widely used in various types of processing.

Efficacy and safety of colistin sulfate in the treatment of infections caused by carbapenem-resistant organisms: a multicenter retrospective cohort study.

Background: Polymyxins have become an important treatment option for carbapenem-resistant organisms (CRO) infections. However, there is a rare of clinical studies on colistin sulfate. This study sought to investigate the rate of clinical improvement and adverse reactions of colistin sulfate in the treatment of severe infections caused by CRO in critically ill patients and assess the factors associated with 28-day all-cause mortality.

Rapid and Sensitive Detection of in Based on Multienzyme Isothermal Rapid Amplification.

Infectious diseases caused by lead to massive death of fish, compose a serious threat to the global aquaculture industry, and constitute a risk to humans who deal with raw fish. In order to realize the early diagnosis of , and control the outbreak and spread of disease, it is of great significance to establish fast, sensitive, and convenient detection methods for . In the present study, two methods of real-time MIRA (multienzyme isothermal rapid amplification, MIRA) and MIRA-LFD (combining MIRA with lateral flow dipsticks (LFD)) for the gene of were established, which could complete amplification at a constant temperature of 42 °C within 20 min.

Fluorescence lifetime tracking and imaging of single moving particles assisted by a low-photon-count analysis algorithm.

Fluorescence lifetime imaging microscopy (FLIM) has been widely used in the field of biological research because of its high specificity, sensitivity, and quantitative ability in the sensing cellular microenvironment. The most commonly used FLIM technology is based on time-correlated single photon counting (TCSPC). Although the TCSPC method has the highest temporal resolution, the data acquisition time is usually long, and the imaging speed is slow.

A novel mitochondria-related gene signature in esophageal carcinoma: prognostic, immune, and therapeutic features.

Esophageal carcinoma (ESCA) is a common and lethal malignant tumor worldwide. The mitochondrial biomarkers were useful in finding significant prognostic gene modules associated with ESCA owing to the role of mitochondria in tumorigenesis and progression. In the present work, we obtained the transcriptome expression profiles and corresponding clinical information of ESCA from The Cancer Genome Atlas (TCGA) database.

[Effect of continuous renal replacement therapy on plasma concentration, clinical efficacy and safety of colistin sulfate].

Objective: To investigate the effects of continuous renal replacement therapy (CRRT) on plasma concentration, clinical efficacy and safety of colistin sulfate.

Methods: Clinical data of patients received with colistin sulfate were retrospectively analyzed from our group's previous clinical registration study, which was a prospective, multicenter observation study on the efficacy and pharmacokinetic characteristics of colistin sulfate in patients with severe infection in intensive care unit (ICU). According to whether patients received blood purification treatment, they were divided into CRRT group and non-CRRT group.