The deficiency of DIP2C leads to congenital heart defects in patients with 10p15.3 microdeletion syndrome.

Background: Recurrent 10p15.3 microdeletion syndrome is a rare multisystem disorder characterized by abnormal facial features, global developmental delay (DD)/intellectual disability (ID), short stature, hand/foot malformation, and congenital heart defects (CHDs). However, the specific genetic defects that contribute to the cardiac phenotype remain unclear.

Chrysin Attenuates Myocardial Cell Apoptosis in Mice.

Myocardial infarction (MI), induced by ischemia and hypoxia of the coronary arteries, presents as myocardial necrosis. Patients often experience intense, prolonged retrosternal pain that is unrelieved by rest or nitrate therapy and is frequently associated with high blood myocardial enzyme levels. Physical effort may exacerbate this anxiety, increasing the likelihood of life-threatening consequences such as arrhythmias, shock, or cardiac failure.

Advances in Research on Monogenic Hereditary Hypertension.

Hypertension is one of the most significant preventable health risk factors globally. Among its various forms, monogenic hypertension, although rare, warrants attention. As awareness of monogenic hypertension grows within both the public and medical communities, research efforts are intensifying.

Isowighteone attenuates vascular calcification by targeting HSP90AA1-mediated PI3K-Akt pathway and suppressing osteogenic gene expression.

Background: Isowighteone, an isoflavonoid compound derived from L.f. (, Moraceae), has demonstrated significant anti-inflammatory properties in prior studies.

Cardiac Dual-Targeting Nanocatalysts for Heart Failure Therapy by Breaking the ROS-Inflammation Positive Feedback.

Heart failure (HF) is a global public health challenge closely associated with oxidative stress and immune dysregulation. However, current therapeutic strategies for HF generally lack specific targeting to cardiac tissue, and the high perfusion rate of the heart further exacerbates insufficient drug accumulation at lesion sites, thus compromising therapeutic efficacy. Inspired by the barb-hook of Xanthium strumarium, FeO@UiO-66 is functionalized with tannic acid (TA) to obtain a dual-target nanocatalyst, termed FUTA.

Childhood Obesity Raises GDM Risk Through Adult Obesity: Evidence From Lifecourse Mendelian Randomization Study.

Background: The relationship between childhood and adulthood obesity and the risk of gestational diabetes mellitus (GDM) remains unclear. To clarify the independent and joint effects of childhood and adulthood body size on GDM risk, and explore inflammation's role.

Methods: Using female-specific UK Biobank genome-wide association study data, genetic instruments for childhood/adult body size ("thinner," "about average," "plumper") and C-reactive protein (CRP) were identified.

Associations Between Hematologic Parameters and All-Cause Death in Individuals With Cardio-Renal-Metabolic Multimorbidity: A National Cohort Study.

Background: Cardio-renal-metabolic multimorbidity is common and a major cause of death. This study investigates the associations between hematologic parameters and all-cause death, aiming to redefine complete blood count reference intervals for individuals with cardio-renal-metabolic multimorbidity.

Methods: The study cohort consisted of 4482 adults drawn from the National Health and Nutrition Examination Survey conducted between 1999 and 2018.

The evolution of concomitant mitral regurgitation in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement: a prospective multi-center China-DVD2 cohort study.

Background: Severe aortic stenosis (AS) often coexists with mitral regurgitation (MR). This study evaluated the significant evolution of MR in patients undergoing transcatheter aortic valve replacement (TAVR) for AS.

Methods: This multi-center China Degenerative Valve Disease II Cohort (China-DVD2) Study enrolled patients undergoing TAVR for AS from January 2020 to October 2023.

Three-dimensional quantitative evaluation of hypertension-induced aortic fibre remodelling based on multiphoton microscopy: a cross-age perspective.

Hypertension is the primary cause of cardiovascular diseases, and its worldwide prevalence has continued to increase recently. Aortic fibre remodelling is critical in the development of hypertension and is strikingly age-related. However, the underlying microlevel variations remain unknown.

Early pharmacological blockade of the CXCL12-CXCR4 axis attenuates vertebral hypercalcification in a zebrafish model of pseudoxanthoma elasticum.

Pseudoxanthoma elasticum (PXE), caused by pathogenic variants in , is characterized by pathological ectopic calcification with poorly understood mechanisms and no effective therapies. To address this, we developed the first zebrafish model of human PXE by introducing the pathogenic point mutation ( , F2 generation) using the highly efficient zhyA3A-CBE5 cytosine base editor. Three mutant types (Type1-Type3, T1-T3) stratified by calcification severity, exhibited reduced levels of the calcification inhibitors vitamin K1 (VK1) and carboxylated matrix Gla protein (cMGP), which were inversely correlated with the severity of calcification.

Sarcopenia index based on serum creatinine and cystatin C is associated with the risk of stroke in middle-aged and older adults in Chinese: a prospective cohort study from the China health and retirement longitudinal study.

Objective: The sarcopenia index (SI), calculated as the serum creatinine divided by the serum cystatin C, multiplied by 100, is recommended for predicting sarcopenia. However, limited evidence exists regarding its association with incident stroke. The aim of this study was to assess the relationship between SI and the risk of stroke in middle-aged and older adults.

Hypoxanthine Promotes Pulmonary Vascular Remodeling and Adenosine Deaminase Is a Therapeutic Target for Pulmonary Hypertension.

Uric acid metabolism is implicated in the pathogenesis of pulmonary arterial hypertension, wherein the key metabolite hypoxanthine exhibits elevated levels, thereby promoting pulmonary vascular remodeling through facilitation of cell proliferation and migration as well as regulation of adenosine triphosphate binding cassette transport signaling pathway. Consequently, therapeutic interventions targeting hypoxanthine synthesis may hold promise for the management of pulmonary arterial hypertension.

Exploring the impact of high rosuvastatin plasma exposure on new-onset diabetes mellitus: insights from machine learning-based prediction.

Background: The association between rosuvastatin (RST) and the risk of new-onset diabetes mellitus (NODM) is controversial. Although the link between RST and NODM is still debated, there is a lack of effective strategies to predict and prevent potential RST-induced NODM in clinical practice. This study aimed to determine the association between plasma exposure to RST and the risk of developing NODM in patients with cardiovascular disease and to establish predictive models for the early detection of RST-induced NODM.

Retinal Photoreceptors and Arterioles Alterations Detected using Adaptive Optics Scanning Laser Ophthalmoscopy in Diabetes and Diabetic Retinopathy.

Methods: Thirty subjects were recruited in the Guangdong Diabetic Retinopathy Multiple-omics Study (GD-RMOS). Adaptive optics scanning laser ophthalmoscopy (AOSLO) was adopted for image acquisition. An AI-based algorithm conducted quantitative analyses of photoreceptor morphology, including cone density, spacing, and regularity.

Single-Cell Dissection of the Biological Function and Molecular Features Underlying the Micropeptide LSMEM1 in Kidney.

Advances in computational biology and large-scale transcriptome analysis have revealed an increasing number of short open reading frames (sORFs) encoding functional peptides. These small proteins or micropeptides can function independently or exert their biological functions by binding to and/or regulating larger regulatory proteins. LSMEM1 (leucine rich single-pass membrane protein 1, also known as C7orf53) has been found to be significantly upregulated in chronic kidney disease (CKD).

Dynamic Changes of Distinct Compartmental LV Remodeling Following Septal Myectomy in Hypertrophic Obstructive Cardiomyopathy.

Background: In hypertrophic obstructive cardiomyopathy, left ventricular mass index (LVMi) regresses following septal myectomy, but the specific dynamics, mechanisms (involving cellular and extracellular compartments), and related factors remain unclear.

Methods: This prospective study included hypertrophic obstructive cardiomyopathy patients who underwent septal myectomy. Cardiac magnetic resonance imaging was performed preoperatively and at 6, 12, and 24 months postoperatively.

Sex differences in venous thromboembolism outcomes: findings from the GARFIELD-VTE registry.

Background: The association of sex with clinical outcome risk in venous thromboembolism (VTE) is unclear.

Objective: To investigate sex differences in clinical outcomes and anticoagulation effectiveness in VTE in the GARFIELD-VTE registry.

Methods: Outcomes included all-cause mortality, VTE recurrence, major and any bleeding, myocardial infarction (MI)/acute coronary syndrome (ACS), and stroke/transient ischaemic attack (TIA) over 3 years of follow-up.

Retrospective study comparing three approaches for keloids: surgery + radiotherapy, surgery + pharmacological injection, and surgery alone.

Objective: To investigate the differential efficacy of various treatment modalities adjunct to surgical excision of keloids and to analyze prognostic factors influencing outcomes.

Methodology: A retrospective observational study approach was employed. Clinical data from 121 patients with keloids who met the inclusion criteria were collected for analysis of clinical characteristics and evaluation of treatment efficacy.

The importance of measuring the endometrial cavity length in deciding the ideal place for embryo transfer: a retrospective cohort study.

Background: The relationship between clinical pregnancy rates and embryo transfer positioning remains a matter of considerable debate, with persistent inconsistencies reported across existing studies. A notable limitation of existing studies is their failure to systematically account for anatomical variations in the endometrial cavity dimensions. The purpose of the present study was to determine the ideal location for embryo transfer according to different endometrial cavity lengths.

Incident arrhythmias in relation to ventilatory parameters and pulmonary disease: evidence from two prospective cohort studies.

Background: Emerging epidemiological evidence implicates pulmonary dysfunction in cardiovascular pathogenesis, yet its arrhythmogenic potential remains poorly defined.

Objectives: We aimed to assess the link between ventilatory parameters, pulmonary disease phenotypes and risk of incident arrhythmias across diverse populations.

Methods: We analyzed data from 17,684 adults in two prospective cohort studies-the Atherosclerosis Risk in Communities (ARIC; n = 12,929) and Cardiovascular Health Study (CHS; n = 4,755).

Balloon-Assisted Traction Removal of a Fractured Catheter in the Distal Tibial Artery.

Objective: A patient with fractured catheter in the distal tibial artery was successfully retrieved using balloon-assisted traction.

Key Steps: 1) Detect the fracture and dislodgement of the catheter; 2) under fluoroscopy, identify the route of dislodgement; 3) confirming the catheter had dislodged into the right lower limb, perform arterial angiography via puncture of a contralateral artery; 4) advance a guidewire through the fractured catheter, traversing its midsection to the distal end; 5) pass 1.5-mm Maverick balloon over the catheter and inflate it to 16 atm; and 6) secure and carefully retrieve the catheter.

The role of the mitochondrial dynamic distribution in oocyte development arrest induced by F-53B.

Chlorinated polyfluoroalkyl ether sulfonates (F-53B), an alternative to perfluorooctane sulfonate (PFOS), has gained attention for reproductive toxicity, but data on its specific effects on oocyte remain limited. We conducted in vitro maturation (IVM) experiments on ICR mouse oocytes exposed to F-53B at its medium inhibition of maturation concentration (IM). PFOS and 0.