Publications by authors named "Xiaojing Mu"

Ultrasonic non-destructive testing is indispensable for assessing the compressive strength of concrete and is widely utilized in concrete structure health monitoring. However, traditional ultrasonic transducers typically have a large size, narrow bandwidth, and low sensitivity, and often rely on complex circuitry, facing numerous challenges. These limitations hinder their widespread application in real-world engineering practice.

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Background: The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) are peripheral serum markers commonly utilized as cost-effective indicators of inflammation. However, their efficacy as predictors of clinical disease activity in inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), remains uncertain. To address this ambiguity, we conducted a meta-analysis to evaluate the clinical significance of NLR, PLR, and LMR in patients with IBD.

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Gastric cancer (GC) is one of the most common malignancies globally, with notable morbidity and mortality rates. Despite advances in surgical techniques and adjuvant therapies, recurrence and metastasis remain major challenges, highlighting the need for novel biomarkers and therapeutic targets. Long non-coding RNAs (lncRNAs) have emerged as key regulators in various types of cancer, including GC, which can influence tumor progression through diverse mechanisms.

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Early equipment fault diagnosis can identify potential risks, significantly reduce maintenance costs, and minimize property damage. However, vibration, strain, and force sensors operating at low frequencies with narrow bandwidths are insufficiently sensitive to fault information, making early fault prediction challenging. Here, we introduce a high-performance, cost-effective, and tiny-sized micro-electromechanical system (MEMS) acoustic emission sensor.

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Background: Ubiquitin-specific peptidase 20 (USP20) acts as oncogene or tumor suppressor gene in different types of cancer. But there are only a few reports about the effect of USP20 on colorectal cancer (CRC). This study aims to further explore the novel molecular mechanisms of USP20 in intraperitoneal metastasis of CRC.

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Surface-enhanced spectroscopy technology based on metamaterials has flourished in recent years, and the use of artificially designed subwavelength structures can effectively regulate light waves and electromagnetic fields, making it a valuable platform for sensing applications. With the continuous improvement of theory, several effective universal modes of metamaterials have gradually formed, including localized surface plasmon resonance (LSPR), Mie resonance, bound states in the continuum (BIC), and Fano resonance. This review begins by summarizing these core resonance mechanisms, followed by a comprehensive overview of six main surface-enhanced spectroscopy techniques across the electromagnetic spectrum: surface-enhanced fluorescence (SEF), surface-enhanced Raman scattering (SERS), surface-enhanced infrared absorption (SEIRA), terahertz (THz) sensing, refractive index (RI) sensing, and chiral sensing.

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The human voice stands out for its rich information transmission capabilities. However, voice communication is susceptible to interference from noisy environments and obstacles. Here, we propose a wearable wireless flexible skin-attached acoustic sensor (SAAS) capable of capturing the vibrations of vocal organs and skin movements, thereby enabling voice recognition and human-machine interaction (HMI) in harsh acoustic environments.

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Sound signals not only serve as the primary communication medium but also find application in fields such as medical diagnosis and fault detection. With public healthcare resources increasingly under pressure, and challenges faced by disabled individuals on a daily basis, solutions that facilitate low-cost private healthcare hold considerable promise. Acoustic methods have been widely studied because of their lower technical complexity compared to other medical solutions, as well as the high safety threshold of the human body to acoustic energy.

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Article Synopsis
  • Ultrasonic biochemical detection is crucial for identifying biomarkers and monitoring drugs, but current methods are expensive and unreliable, making them unsuitable for low-cost rapid testing.
  • This study introduces a new detection mechanism using Rayleigh scattering from nanoparticles, which alters sound pressure and enhances measurement reliability by modifying antibodies on a separate substrate.
  • Results show that using a CMUT chip, the detection of CA19-9 cancer antigen is successful across various concentrations, while minimizing interference from other markers, proving the effectiveness of this approach.
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Article Synopsis
  • - This study creates a model to predict metastasis and survival in colorectal cancer by focusing on specific macrophage types, especially EEF1G+ macrophages found in liver metastases.
  • - Researchers utilized scRNA-seq data and established an 8-gene risk model (EMGS) that classifies patients into high-risk and low-risk groups, with high-risk patients experiencing poorer survival rates and aggressive tumor pathways.
  • - The findings reveal that the high-risk group has an immunosuppressive environment and suggests potential drug targets for better treatment outcomes, indicating a need for personalized strategies in managing colorectal cancer patients with liver metastases.
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Human biomechanical energy, with features of fluctuating amplitudes and low frequency, has been considered as a potential sustainable power source for wearable healthcare monitoring devices. Developing an effective energy harvester to ensure robust energy harvesting efficiency remains highly desired. Herein, we propose a wearable pendulum-rotor-separated triboelectric-electromagnetic hybrid generator (PTEHG).

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With the rapid development of the Industrial Internet of Things in rotating machinery, the amount of data sampled by mechanical vibration wireless sensor networks (MvWSNs) has increased significantly, straining bandwidth capacity. Concurrently, the safety requirements for rotating machinery have escalated, necessitating enhanced real-time data processing capabilities. Conventional methods, reliant on experiential approaches, have proven inefficient in meeting these evolving challenges.

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With the rapid development of mobile communication technology, the POI (piezoelectric on insulator) structure has gained recognition in the field of RF filtering. However, transverse modes remain in the passband of corresponding surface acoustic wave (SAW) devices, which impedes their application in crowded spectra. This article introduces a groove configuration to suppress transverse modes for POI SAW resonators employing a 50°YX-LiTaO/SiO/Si multilayered structure.

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Ultrasonic flowmeter is one of the most widely used devices in flow measurement. Traditional bulk piezoelectric ceramic transducers restrict their application to small pipe diameters. In this paper, we propose an ultrasonic gas flowmeter based on a PZT piezoelectric micromachined ultrasonic transducer (PMUT) array.

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Staphylococcus aureus inhabits diverse habitats including food waste and wastewater treatment plants. Cases of S. aureus-induced infection are commonly reported worldwide.

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Article Synopsis
  • Triboelectric nanogenerators (TENGs) are promising for capturing environmental energy for applications like self-powered sensors, wearables, and corrosion protection, but their low output power limits their development.
  • The review emphasizes selecting and optimizing triboelectric materials to improve the surface charge density, which is crucial for TENG performance.
  • Various methods to enhance charge density are discussed, along with challenges and future research opportunities in the field.
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Activated sludge (AS) plays a vital role in removing organic pollutants and nutrients from wastewater. However, the risks posed by horizontal gene transfer (HGT) between bacteria in AS are still unclear. Here, a total of 478 high-quality non-redundant metagenome-assembled genomes (MAGs) were obtained.

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One of the fundamental hurdles in infrared spectroscopy is the failure of molecular identification when their infrared vibrational fingerprints overlap. Refractive index (RI) is another intrinsic property of molecules associated with electronic polarizability, but with limited contribution to molecular identification in mixed environments currently. Here, we investigate the coupling mode of localized surface plasmon and surface phonon polaritons for vibrational de-overlapping.

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Vibrio parahaemolyticus is a common pathogen, and has emerged with multiple antimicrobial resistance (AMR). However, few studies have conducted large-scale investigations of AMR and virulence trends of V. parahaemolyticus worldwide.

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Left-sided and right-sided colon cancer (LSCC and RSCC) display different biological and clinical characteristics. However, the differences in their tumorigenesis and tumor microenvironment remain unclear. In this study, we profiled the proteomic landscapes of LSCC and RSCC with data-independent acquisition mass spectrometry (DIA-MS) using fresh tumor and adjacent normal tissues from 24 patients.

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Surface-enhanced infrared absorption (SEIRA) has proven its ability to improve the detection performance of traditional infrared spectroscopy at unprecedented levels. However, the resonant frequency of the metamaterial absorber (MA) lacks tunability once the structure is fabricated, which poses a challenge for broadband fingerprint retrieval of molecules. Here, we propose a pixelated and electric tunable hybrid graphene MA with a broadband response for molecular fingerprint retrieval.

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Two new acridinium esters with a 2-(succinimidyloxycarbonyl)ethyl side arm, namely, 9-(2,6-dibromophenoxycarbonyl)-10-methyl-2-(2-(succinimidyloxycarbonyl)ethyl)acridinium trifluoromethanesulfonate and 9-(4-(2-(succinimidyloxycarbonyl)ethyl)phenoxycarbonyl)-2,7-dimethoxy-10-methylacridinium triflate, have been produced and characterized. The chemiluminescent properties and hydrolytic stabilities of the new acridinium esters have been investigated.

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Tailoring light-matter interactions via plasmonic nanoantennas (PNAs) has emerged as a breakthrough technology for spectroscopic applications. The detuning between molecular vibrations and plasmonic resonances, as a fundamental and inevitable optical phenomenon in light-matter interactions, reduces the interaction efficiency, resulting in a weak molecule sensing signal at the strong detuning state. Here, it is demonstrated that the low interaction efficiency from detuning can be tackled by overcoupled PNAs (OC-PNAs) with a high ratio of the radiative to intrinsic loss rates, which can be used for ultrasensitive spectroscopy at strong plasmonic-molecular detuning.

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Sensors based on triboelectric nanogenerators (TENGs) have gained worldwide interest owing to their advantages of low cost and self-powering. However, the detection of most triboelectric vibration sensors (TVS) is restricted to low frequency, whereas high-frequency vibration signals are successfully measured in recent studies; their sensitivity still requires improvement. Hence, a highly sensitive vibration sensor based on TENG (HSVS-TENG) with ultrawide frequency response is presented.

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