YOLOv11-GSF: an optimized deep learning model for strawberry ripeness detection in agriculture.

The challenge of efficiently detecting ripe and unripe strawberries in complex environments like greenhouses, marked by dense clusters of strawberries, frequent occlusions, overlaps, and fluctuating lighting conditions, presents significant hurdles for existing detection methodologies. These methods often suffer from low efficiency, high computational expenses, and subpar accuracy in scenarios involving small and densely packed targets. To overcome these limitations, this paper introduces YOLOv11-GSF, a real-time strawberry ripeness detection algorithm based on YOLOv11, which incorporates several innovative features: a Ghost Convolution (GhostConv) convolution method for generating rich feature maps through lightweight linear transformations, thereby reducing computational overhead and enhancing resource utilization; a C3K2-SG module that combines self-moving point convolution (SMPConv) and convolutional gated linear units (CGLU) to better capture the local features of strawberry ripeness; and a F-PIoUv2 loss function inspired by Focaler IoU and PIoUv2, utilizing adaptive penalty factors and interval mapping to expedite model convergence and optimize ripeness classification.

A review on the chemical composition, biological activity, and potential health benefits applications of Longan (Dimocarpus longan Lour.).

Longan (Dimocarpus longan Lour.) is a tropical tree species known for its nutritional, economic, and medicinal benefits. Its fruit consists of pulp, peel, and seed, all rich in bioactive compounds with various health and pharmacological effects.

Broad-spectrum antitumor analysis of the telomerase activity inhibitor TPCH derived from the human constitutively expressed protein LPTS/PinX1.

Background: The human liver-related putative tumor suppressor LPTS/PinX1 is a gene encoding a telomerase inhibitory protein. Overexpression of LPTS/PinX1 protein can inhibit the growth of multiple telomerase-positive cancer cell lines. LPTS/PinX1 has therapeutic potential for cancer.

Anti-PS IgG Immune Complexes Impair Macrophage Phagocytosis in SLE via LOX-Dependent Oxidative Stress.

Purpose: Systemic lupus erythematosus (SLE) is a severe autoimmune disease with systemic complications mediated by immune-complex formation. The elevated level of anti-phosphatidylserine (PS) IgG has been implicated in SLE pathogenesis. In this study, we aimed to explore the effector mechanisms of PS immune-complex during lupus development.

Methyltransferase-like 14 (METTL14)-mediated N6-methyladenosine (m6A) Modification of Forkhead Box Protein 1 (FOXP1) Regulates Trophoblast Inflammation and Function via Transmembrane BAX Inhibitor Motif-Containing 6 (TMBIM6).

Pre-eclampsia (PE) represents a serious pregnancy complication characterized by impaired trophoblast function. Although methyltransferase-like 14 (METTL14) has been implicated in PE pathogenesis and trophoblast dysfunction, its precise molecular mechanisms remain unclear. mRNA expression was detected by quantitative real-time polymerase chain reaction (qRT-PCR).

Delineating unique MASH-endothelial cells in metabolic dysfunction-associated steatotic liver disease using single-cell lensing.

Background: The role of hepatocytes in metabolic dysfunction-associated steatotic liver disease (MASLD) is well-documented. However, the contribution of endothelial cells to MASLD pathology remains poorly understood.

Methods: In this study, we employed a multifaceted approach that integrated high-dimensional weighted gene co-expression network analysis (hdWGCNA), interaction analysis, machine learning, immune cell infiltration assessment, and Mendelian randomization.

Bioconversion of Baijiu Huangshui for single cell protein using Saccharomyces cerevisiae: A study on influence of carbon metabolic pathways.

The study presented a novel approach to treating Huangshui, a typical organic wastewater from Chinese Baijiu industry, utilizing Saccharomyces cerevisiae (S. cerevisiae) to convert the carbon source from Huangshui into its cellular component, ultimately forming single cell protein (SCP). S.

Sweroside ameliorates intestinal mucosal microcirculatory disturbances in ulcerative colitis mice by modulating the VEGF and Hippo signaling pathways.

Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease closely linked to intestinal mucosal microcirculatory dysfunction. Sweroside (SOS), a natural iridoid glycoside derived from plants such as Swertia mussotii, Swertia pseudochinensis, and Lonicera japonica, exhibits anti-inflammatory properties. Yet, its therapeutic potential and mechanisms in UC remain unexplored.

Neuronal intranuclear inclusion disease with subtle imaging findings: a case report and literature review.

Introduction: Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder. Hyperintense signals on diffusion-weighted imaging (DWI) at the corticomedullary junction are key diagnostic features. Early manifestations are often overlooked, leading to misdiagnoses.

Composition Analysis and In Vitro Investigation on Antioxidant, α-Amylase, and Pancreatic Lipase Inhibitory Activities of Major Mushrooms in Qinling Mountains.

Edible mushrooms exhibit a range of pharmacological activities, including anticancer, antimicrobial, antioxidant, anti-obesity, and hepatoprotective effects, thereby holding significant potential for applications in the development of functional foods. This study aimed to evaluate the bioactivities of methanolic extracts from various edible mushrooms (MEMs) found in the Qinling Mountains, China, with the following species used as materials: Suillus granulatus (L.) Roussel (S.

Fluorescence lifetime imaging microscopy approach reveals quantitative signatures for hepatocellular carcinoma diagnosis.

Hepatocellular carcinoma (HCC) remains a critical global health challenge, and current histopathological diagnosis relies heavily on hematoxylin and eosin (H&E) staining-a widely adopted clinical tool for assessing tissue morphology. However, H&E staining alone cannot provide quantitative data for diagnosis of tumor samples. Poorly differentiated or unclear lesions are difficult to distinguish.

Binary combined toxicity of neonicotinoids and co-existing pollutants to non-target invertebrates: A meta-analysis.

Mixture exposures dominate real-world environmental settings, yet the toxic impacts of neonicotinoid insecticides (NEOs), one of the most widely used pesticide classes, when combined with co-occurring pollutants on non-target invertebrates remain poorly synthesized. This extensive global analysis integrated data from 47 studies retrieved via Web of Science, PubMed, and CNKI, covering 1706 toxicity endpoint records standardized by toxicological parameters (e.g.

The effect of musical sensory orientation training in improving consciousness level in patients with disorders of consciousness: a pilot study.

Introduction: Musical sensory orientation training (MSOT) is an innovative technique to improve the state of consciousness and cognitive function. Compared with traditional arousal therapies, MSOT offers a non-invasive, safe, and easily operable alternative with no side effects. This study aimed to conduct a preliminary investigation into the effect of MSOT in improving consciousness levels in patients with DoC (Disorders of Consciousness), as well as the feasibility of its clinical application, thereby providing reference for future large-sample randomized controlled studies.

π-Extended 1,1'-Binaphthyl with Fused Pentagons.

1,1'-Biaryls are a class of axially chiral compounds, while π-extension with nonbenzenoid rings has been less known. Herein, we report a π-extended 1,1'-binaphthyl containing a nor[5]helicene skeleton. The synthesis was performed via an intermolecular SAr-type reaction of 5,11-di(naphthalen-2-yl)tetracene.

Tirelizumab-Induced Immune Encephalitis: A Case Report.

In the contemporary landscape of oncology, immune checkpoint blockade therapy has emerged as a paramount therapeutic modality. However, concomitant with the pervasive deployment of immune checkpoint inhibitors (ICIs), there has been an escalating incidence of adverse drug reactions over the years. Immunological encephalitis, a prevalent form of central nervous system toxicity, poses a significant threat to the lives of affected patients.

[Retracted] Sensitization strategies in lung cancer.

[This retracts the article DOI: 10.3892/ol.2016.

Formal [1 + 2 + 3] Annulation of Anilines and CF‑Containing Ynones via 6π-Electrocyclization.

Six-membered -heterocycles, such as 2-pyridones, are crucial in bioactive compounds and prevalent in natural products and pharmaceuticals, necessitating innovative synthesis approaches. Traditional methods, typically reliant on the transition-metal-catalyzed direct cyclization of alkynes, face limitations in product complexity. This study introduces a [1 + 2 + 3] annulation strategy for synthesizing 2-pyridones, employing anilines and CF-ynones through a base-promoted metal-free catalytic system.

Effects of steaming practices on the cadmium distribution in edible tissues of the swimming crabs () and its health risk assessment.

This study investigated the redistribution of cadmium (Cd) in edible tissues of swimming crabs () during steaming and evaluated associated human health risks. Experimental results demonstrated that Cd was significantly transferred from brown meat to leg muscles, resulting in a nearly tenfold increase in Cd concentration in steamed leg muscles compared to raw tissues. Human health risk assessment results indicate that the target cancer risk (TCR) values for brown meat and cooking liquor range from 1.

TSC2-mutated perivascular epithelioid cell tumor with partial response to mTOR inhibition: a case report and literature review.

Perivascular epithelioid cell tumors (PEComas), rare mesenchymal neoplasms with heterogeneous behavior, are molecularly characterized by TSC2 inactivation driving mammalian target of rapamycin (mTOR) pathway activation. We present a typical case of a 63-year-old female with metastatic high-grade PEComa featuring a TSC2 mutation (68.57% VAF) and elevated tumor mutational burden (19.

Lipid Regulation of Tea Protein Lipid-Lowering Peptides on 3T3-L1 Preadipocytes and High-Fat Mice.

In this study, tea protein lipid-lowering peptides were prepared by enzymatic hydrolysis, and 3T3-L1 preadipocytes and high-fat mice were used to investigate its in vitro and in vivo lipid regulating effect. The results showed that tea protein lipid-lowering peptides could significantly inhibit the adipogenic differentiation of 3T3-L1 preadipocytes and reduce lipid accumulation. At the peptides concentration of 0.

Effects of TEACCH on social functioning in individuals with autism spectrum disorders: a systematic review and meta-analysis.

Objective: To investigate the effects of Treatment and Education of Autistic and Related Communication Handicapped Children (TEACCH) on social functioning in individuals with autism spectrum disorders (ASD).

Methods: Relevant studies on TEACCH intervention in ASD individuals were systematically searched in PubMed, The Cochrane Library, Embase, CNKI, and Wanfang from inception to March 2024. The main outcome measures were social, cognitive performance, fine motor, communication, daily living, imitation, and cognitive verbal skills.

Uncharted territory: retinal vasculitis and cryoglobulinemia in Behçet's disease - a case report.

Behçet's disease (BD) is a systemic inflammatory disorder characterized by recurrent oral and genital ulcers, skin lesions, and ocular involvement, often presenting with retinal vasculitis as a severe complication. Although mixed cryoglobulinemia, typically associated with hepatitis C virus (HCV) infection, is well-documented in other autoimmune diseases, its coexistence with BD is exceedingly rare. This report details the case of a 56-year-old male presenting with BD complicated by HCV-related mixed cryoglobulinemia, manifesting as retinal vasculitis, purpuric skin lesions, and systemic vasculitis.

Bioaccumulation, Ecotoxicity, and Microbial Responses in Tadpoles Following Co-Exposure to Imidacloprid and Microplastics.

Agricultural organic pollutants have been identified as a key factor contributing to amphibian population decline, particularly during early developmental stages when tadpoles are frequently exposed to neonicotinoids (NEOs) and microplastics (MPs). In this study, tadpoles were exposed to imidacloprid (IMI: 0.045, 0.

In-situ formed Ti/TiH from exfoliated few-layered TiCT as hydrogen pump enhances the hydrogen storage properties of MgH.

Magnesium hydride (MgH) is broadly‌ deemed as one of the most prospective solid-state hydrogen storage materials. However, its large-scale application is hindered by several drawbacks, including an excessive dehydrogenation temperature (>300 °C), sluggish kinetic behavior, and inevitable agglomeration and growth during cycling. To address these challenges, two-dimensional few-layered laminated‌ titanium carbide catalyst (FL-TiCT) was synthesized via LiF/HCl etching followed by liquid-phase ultrasonic exfoliation.

An Exploration of the Relationship Between Gut Virome and Cardiovascular Disease: A Comprehensive Review.

This study reviews the correlation between the gut virome and cardiovascular diseases (CVDs) and investigates the potential role of the gut virome in CVD progression. The gut virome, which includes bacteriophages and eukaryotic viruses, interacts with the intestinal microbiota and the host immune system, and affects the overall health of the host. Previous studies have demonstrated that alterations in the gut virome are closely associated with various cardiovascular conditions, including hypertension, atherosclerosis, atrial fibrillation, heart failure, and viral myocarditis.