A spontaneous nonhuman primate model of inherited retinal degeneration.

Inherited retinal degenerations (IRDs) are important causes of progressive, irreversible blindness. Hereditary macular diseases, in particular, are significant in their effect on the specialized, central cone photoreceptor-rich macula responsible for high resolution vision. Autosomal dominant Best vitelliform macular dystrophy (BVMD), caused by variants in the BEST1 gene, is one of the most common inherited macular dystrophies.

Identification and Functional Characterization of Soybean Microexon in Response to Saline-Alkali Stress.

Salt-alkali stress is one of the most widespread and devastating abiotic stress. Alternative splicing is a response pathway to such stress. However, the role of microexons in response to salt-alkali stress in soybean remains obscure.

Role of METTL14 in cardiomyocyte pyroptosis in mice with heart failure by regulating miR-221-3p RNA methylation.

Heart failure (HF) is a serious and chronic condition. Methyltransferase like 14 (METTL14) is an important component of the m6A methyltransferase complex. This study seeks to explore the mechanism by which METTL14 regulates cardiomyocyte pyroptosis in mice with HF, providing a novel target for HF treatment.

Mathematical modeling of multi-component aerosol droplet evaporation and growth in indoor environments.

Multi-component droplets from daily activities and production processes severely degrade indoor air quality. Their health hazards and removal efficiency depend on size and composition, significantly affected by evaporation and growth. The phase transition process is complex, involving a broad spectrum of droplet sizes with diverse heat and mass transfer characteristics.

Overexpression of Enhances Resistance against to Soybean Pod Borer () in Soybean.

Soybean [ (L.) Merr.], an essential staple food and oil crop worldwide, boasts abundant vegetable proteins and fats beneficial for both human and animal consumption.

Effective treatment of optic neuropathies by intraocular delivery of MSC-sEVs through augmenting the G-CSF-macrophage pathway.

Optic neuropathies, characterized by injury of retinal ganglion cell (RGC) axons of the optic nerve, cause incurable blindness worldwide. Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) represent a promising "cell-free" therapy for regenerative medicine; however, the therapeutic effect on neural restoration fluctuates, and the underlying mechanism is poorly understood. Here, we illustrated that intraocular administration of MSC-sEVs promoted both RGC survival and axon regeneration in an optic nerve crush mouse model.

Prostacyclin Mitigates Renal Fibrosis by Activating Fibroblast Prostaglandin I 2 Receptor.

Significance Statement: Renal fibrosis is a common pathologic process of progressive CKD. We have provided strong evidence that PGI 2 is an important component in the kidney injury/repairing process by reducing fibrosis and protecting renal function from declining. In our study, administration of a PGI 2 analog or selective PTGIR agonist after the acute injury ameliorated renal fibrosis.

Nonhuman Primate Eyes Display Variable Growth and Aging Rates in Alignment With Human Eyes.

Purpose: To assess age-related biometric changes of the eye in nonhuman primates (NHPs), to and decipher the growth and aging rates and their comparability with humans.

Methods: Ocular anatomic measurements were performed on 341 macaca fascicularis aged 0.5 to 23 years via multimodal approaches including IOLMaster 700.

Overexpression of the aldehyde dehydrogenase from in soybean increases saline-alkali stress tolerance.

Soybean production is severely hampered by saline-alkaline stress caused by saline-alkalization. Plants have aldehydrogenase (ALDH) family members that convert reactive aldehydes to carboxylic acids to remove active aldehyde molecules. However, little is known about the increased saline-alkali tolerance caused by the ALDH function in soybean.

Identification and functional validation of super-enhancers in .

Super-enhancers (SEs) are exceptionally large enhancers and are recognized to play prominent roles in cell identity in mammalian species. We surveyed the genomic regions containing large clusters of accessible chromatin regions (ACRs) marked by deoxyribonuclease (DNase) I hypersensitivity in . We identified a set of 749 putative SEs, which have a minimum length of 1.

Endothelial prostacyclin protects the kidney from ischemia-reperfusion injury.

Prostacyclin, or PGI, is a product of PGI synthase (PGIS), down-stream of cyclooxygenase pathway. PGI has been demonstrated to play an important role in maintaining renal blood flow. Non-steroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclooxygenase are reported to increase the susceptibility of patients to acute kidney injury (AKI).

Transgenic soybean plants expressing Spb18S dsRNA exhibit enhanced resistance to the soybean pod borer Leguminivora glycinivorella (Lepidoptera: Olethreutidae).

The soybean pod borer [SPB; Leguminivora glycinivorella (Mats.) Obraztsov] is a major soybean pest in northeastern Asia. A useful method for addressing this problem is the generation of transgenic plants producing double-stranded RNA (dsRNA) that target essential insect genes.

Expression of the double-stranded RNA of the soybean pod borer Leguminivora glycinivorella (Lepidoptera: Tortricidae) ribosomal protein P0 gene enhances the resistance of transgenic soybean plants.

Background: The soybean pod borer [SPB; Leguminivora glycinivorella (Matsumura) (Lepidoptera: Tortricidae)] is the most important soybean pest in northeastern Asia. Silencing genes using plant-mediated RNA-interference is a promising strategy for controlling SPB infestations. The ribosomal protein P0 is important for protein translation and DNA repair in the SPB.