Tunable Optical Metamaterial Enables Steganography, Rewriting, and Multilevel Information Storage.

In the realm of secure information storage, optical encryption has emerged as a vital technique, particularly with the miniaturization of encryption devices. However, many existing systems lack the necessary reconfigurability and dynamic functionality. This study presents a novel approach through the development of dynamic optical-to-chemical energy conversion metamaterials, which enable enhanced steganography and multilevel information storage.

Impact of endogenous vasohibin 1 and vasohibin 2 gene expression on ferroptosis in a mouse cerebral infarction model.

The vasohibin 1 (Vash1) and vasohibin 2 (Vash2) genes, known for their role in regulating angiogenesis, are also implicated in various cellular processes, including ferroptosis, a form of programmed cell death. However, the relationship between the endogenous Vash1 and Vash2 gene and ferroptosis in ischemic stroke was unknown. In this study, we investigated the function of the endogenous vasohibin genes in ferroptosis in a transient middle cerebral artery occlusion mice model.

Pathogen purification and genetic characterization of SPF BWEL chicken population.

Specific pathogen free (SPF) chickens are crucial biological resources for fundamental research and industrial development in biomedicine, pharmaceutical sciences, and disease prevention and control. China achieved a significant milestone in 2000 by establishing its first independently developed SPF BWEL chicken population with proprietary intellectual property rights. During SPF chicken population development, rigorous quality control of microorganism, genetics, and environment are crucial for maintaining research-grade standards.

Selective Plasticity of Hippocampal Sub-Regions in the Amnestic Mild Cognitive Impairment After Acupuncture.

Background: Acupuncture has been demonstrated to be effective in reducing cognitive decline in patients with amnestic mild cognitive impairment (aMCI). Hippocampal atrophy has been typically reported as a core neuromechanism in the aMCI. However, whether and how hippocampal subregions plasticity exists in aMCI after acupuncture remains largely unknown.

Serum miR-146a as a diagnostic and predictive biomarker for osteoporosis and bisphosphonate treatment efficacy.

Objective: To evaluate the diagnostic and predictive value of miR-146a for osteoporosis and bisphosphonate treatment outcomes, and to investigate the underlying mechanism by which bisphosphonates exert therapeutic effects via miR-146a regulation.

Methods: A retrospective cohort of 96 patients with osteoporosis and 90 healthy individuals undergoing routine health examinations was analyzed. Serum miR-146a levels were measured to assess their diagnostic utility for osteoporosis.

Micromechanical Finite Element Model Investigation of Cracking Behavior and Construction-Related Deficiencies in Asphalt Mixtures.

This study investigated the fracture behavior of asphalt mixtures under indirect tensile loading by comparing the performance of homogenized and micromechanical finite element (FEMs) models based on the cohesive zone model (CZM). Five asphalt mixture types were tested experimentally, and both models were calibrated and validated using load-displacement curves from indirect tensile tests (IDTs). The micromechanical model, incorporating random aggregate generation and three-phase material definition, exhibited significantly higher predictive accuracy (R = 0.

Biomolecular Condensates as Emerging Biomaterials: Functional Mechanisms and Advances in Computational and Experimental Approaches.

Biomolecular condensates, a ubiquitous class of biomaterials found in living cells, have been shown to be responsible for key physiological processes, such as gene regulation, signal transduction, and stress response. Since their discovery, extensive efforts have been devoted to this field to better understand the underlying mechanisms using both computational and experimental techniques. While great progress has been achieved, the key challenges still exist.

Intelligent Design of Microbial Carbohydrate Factories: Integrated Chassis-Tools-Strategies Frameworks.

Carbohydrates, natural polymers of monosaccharides interconnected via glycosidic bonds, serve as versatile biomolecules with broad applications across food, pharmaceuticals, agriculture, and chemical industries. Traditionally, carbohydrate production has predominantly relied on extraction or chemical synthesis methods; however, with the progression of synthetic biology, microbial production of carbohydrates has emerged as a promising alternative, offering rapid and environmentally sustainable manufacturing processes. This review presents integrated methodologies for engineering carbohydrate-synthesizing microbial factories.

Discovery of Novel Isoindolin-1-one Derivatives as GABA Receptors Positive Allosteric Modulators with Antiepileptic Efficacy.

Epilepsy is one of the most common and life-threatening neurological diseases, and the GABARs are important therapeutic targets for epilepsy. Herein, a series of novel 2,7-disubstituted isoindolin-1-one derivatives were designed and synthesized, and extensive structure-activity relationships led to a number of highly potent PAMs of GABARs with EC values at 10-10 M level and value of 5-15-fold. In particular, exhibited strong in vitro potentiation effects toward both synaptic and extra-synaptic GABARs, and produced highly potent in vivo efficacies in mouse seizure models, including sc-PTZ (ED = 8.

Grifolic acid, a FFAR4 agonist, identified as a dual antagonist of voltage-gated sodium and Ca2.2 channels with potent antinociceptive effects.

Background And Purpose: Chronic pain affects nearly 30% of the global population. Because of significant adverse effects of opioids, alternative therapies are urgently needed. In a drug discovery project, we identified grifolic acid (GA) as a potent Na1.

CRISPR/Cas13a combined with reverse transcription-multienzyme isothermal rapid amplification for hepatitis B virus RNA detection.

Background: Hepatitis B virus (HBV) infection represents a major global public health challenge. The covalently closed circular DNA (cccDNA), which serves as the key reservoir for viral persistence, currently requires invasive liver biopsy for clinical monitoring. Recent studies have identified serum HBV pregenomic RNA (pgRNA) and its splicing variants emerging as potential noninvasive and reliable biomarkers for tracking disease progression and forecasting prognosis in chronic HBV infection.

Design, Synthesis, and Structure-Activity Relationship of Novel Quinazolinone Derivatives.

A series of novel quinazolinone derivatives targeting were designed and synthesized. Their structures were confirmed through comprehensive analyses of H and C NMR and MS data. Biological assays showed that compounds -, -, -, and - exhibit superior insecticidal activity against compared to commercial compounds pyrifluquinazon, imidacloprid, and pymetrozine.

The Effect of Developmental Characteristics of Adolescents' Perceived Social Support on Social-Emotional Competence from a Cumulative Ecological Resources Theory Perspective.

Cumulative Ecological Resources Theory offers an integrative perspective for social-emotional interventions by overcoming the traditional dichotomy between internal and external resources. As a crucial ecological resource, perceived social support is known to be heterogeneous, yet its mechanism of influence on social-emotional competence remains to be clarified. This study investigates the effect of developmental characteristics of adolescents' perceived social support on social-emotional competence.

Shared and distinct brain activation patterns of acupoints HT7, ST36, and KI4: a task-based fMRI study.

Objective: We aimed to investigate the shared and distinct of brain responses to manual acupuncture at HT7, ST36, and KI4.

Methods: Sixteen healthy participants receiving acupuncture at HT7, 19 at ST36, and 16 at KI4. All subjects experienced deqi sensation without severe pain during the acupuncture sessions.

Development and validation of an LDH-focused nomogram for the early prediction of heart failure in patients with acute ST-elevation myocardial infarction after percutaneous coronary intervention.

Background: ST-elevation myocardial infarction (STEMI) patients remain at significant risk of heart failure (HF) despite successful percutaneous coronary intervention (PCI) reperfusion, imposing a considerable public health burden. Lactate dehydrogenase (LDH), a key enzyme in glycolysis, functions as a notable biomarker of cardiac pathology, yet it is frequently often overlooked in clinical practice. This study focused on establishing a nomogram incorporating LDH levels to assess the probability of HF occurring within one year following PCI in individuals who have previously experienced STEMI.

Retraction Notice to: HOXA5-miR-574-5p axis promotes adipogenesis and alleviates insulin resistance.

[This retracts the article DOI: 10.1016/j.omtn.

Advances and challenges in pathomics for liver cancer: From diagnosis to prognostic stratification.

Hepatocellular carcinoma (HCC), a leading cause of cancer mortality, faces diagnostic and therapeutic challenges due to its histopathological complexity and clinical heterogeneity. Pathomics, an emerging discipline that integrates artificial intelligence (AI) with quantitative pathology image analysis, aims to decode disease heterogeneity by extracting high-dimensional features from histopathological specimens. This review highlights how AI-driven pathomics has revolutionized liver cancer management through automated analysis of whole-slide images.

Circ_0084927 promotes progression of intrahepatic cholangiocarcinoma by sponging miR-4725-5p to activate the PDPK1/AKT/mTOR signaling pathway.

Background: Numerous studies have indicated that circular RNAs (circRNA) are involved in the regulation of various malignant tumors, including intrahepatic cholangiocarcinoma (ICC). However, the exact role of circRNA in the progression of ICC and their underlying regulatory mechanisms remain to be further elucidated.

Methods: We investigated the dysregulation of circRNA expression profiles in five pairs of ICC tissues and adjacent normal tissues through high-throughput sequencing, revealing a significant upregulation of circ_0084927.

Optimised nanobody-based quenchbodies for enhanced protein detection.

Quenchbodies, antibodies labelled with fluorophores that increase in intensity upon antigen binding, offer great promise for biosensor development. Nanobody-based quenchbodies are particularly attractive due to their small size, ease of expression, high stability, rapid evolvability, and amenability to protein engineering. However, existing designs for protein detection show limited dynamic range, with fluorescence increases of only 1.

A machine learning-based predictive model for the occurrence of lower extremity deep vein thrombosis after laparoscopic surgery in abdominal surgery.

Background & Aims: Deep vein thrombosis, a common complication after laparoscopic surgery, can negatively affect patients' limb motor function and even seriously threaten their lives. Therefore, it is crucial to accurately identify patients at high risk of lower extremity deep vein thrombosis. Thus, the aim of this study was to develop a model to predict the occurrence of deep vein thrombosis in patients after laparoscopy.

A naturally occurring SNP modulates thermotolerance divergence among grapevines.

With the increasing challenges posed by global warming and climate change, heat stress has become a significant threat to the sustainable production of grapevines. However, the genetic basis of grapevine thermotolerance remains poorly understood. Here, we combine genome-wide association study with transcriptomic profiling to identify TTC4 (thermotolerance on chromosome 4), a gene encoding a WRKY transcription factor, as a key determinant of thermotolerance in grapevine.

Effects of dietary grape seed proanthocyanidin extract supplementation on muscle water-holding capacity of finishing pigs.

Water-holding capacity (WHC) is essential for both pork quality and industrial economics. Preliminary studies have shown that grape seed proanthocyanidin extract (GSPE) helps reduce drip loss in the longissimus thoracis (LT) muscle of finishing pigs. However, the mechanism by which GSPE affects the WHC of pork remains unclear.

Hydrofluorocarbons (HFCs) in Southern China: High-Frequency Observations and Emission Estimates.

Hydrofluorocarbons (HFCs) are potent greenhouse gases whose global abundance continues to rise and subsequently warm the Earth. Southern China is a rapidly developing region that has experienced a sharp increase in its HFC consumption. Here, we present the first high-frequency HFC observations in Southern China from 2022 to 2023, analyzing the atmospheric mole fractions of four HFCs (HFC-134a, HFC-32, HFC-125, and HFC-143a) and using inverse modeling to estimate their emissions in Southern China.

Comprehensive analysis of SQOR involvement in ferroptosis resistance of pancreatic ductal adenocarcinoma in hypoxic environments.

Introduction: Pancreatic ductal adenocarcinoma (PDAC) exhibits higher hypoxia level than most solid tumors, and the presence of intratumoral hypoxia is associated with a poor prognosis. However, the identification of hypoxia levels based on pathological images, and the mechanisms regulating ferroptosis resistance, remain to be elucidated. The objective of this study was to construct a deep learning model to evaluate the hypoxia characteristics of PDAC and to explore the role of Sulfide quinone oxidoreductase (SQOR) in hypoxia-mediated ferroptosis resistance.