Mechanistic Study of MiR-30c-5p Regulation of SIRT Expression in Polycystic Ovary Syndrome.

Abnormal development of granulosa cells is widely recognized as a critical factor contributing to polycystic ovary syndrome (PCOS). However, the precise etiology and underlying mechanisms of this disorder remain largely elusive. Accumulating evidence suggests that dysregulation of microRNAs (miRNAs) plays a pivotal role in the pathogenesis of PCOS.

Deep Learning-Enhanced Opportunistic Osteoporosis Screening in 100 kV Low-Voltage Chest CT: A Novel Way Toward Bone Mineral Density Measurement and Radiation Dose Reduction.

Rationale And Objectives: To explore the feasibility and accuracy of a deep learning (DL) method for fully automated vertebral body (VB) segmentation, region of interest (ROI) extraction, and bone mineral density (BMD) calculation using 100kV low-voltage chest CT performed for lung cancer screening across various scanners from different manufacturers and hospitals.

Materials And Methods: This study included 1167 patients who underwent 100 kV low-voltage chest and 120 kV lumbar CT from October 2022 to August 2024. Patients were divided into a training set (495 patients), a validation set (169 patients), and three test sets (245, 128, and 130 patients).

Clinical Diagnostic Value of 5 T MRI for Knee Injuries: A Comparison Study With 1.5 or 3 T.

Background: Preliminary studies have shown the potential of 5 T MRI in cardiac, neurovascular, and abdominal imaging. However, the clinical diagnostic value of 5 T for assessing knee injuries remains unclear.

Purpose: To compare the image quality, anatomic visibility, and diagnostic performance of 1.

Investigating mitophagy mechanisms in bronchopulmonary dysplasia through bioinformatics.

Background: Bronchopulmonary dysplasia (BPD) is a prevalent respiratory disease in premature infants and is accompanied by impaired lung function, increased infection risk, and other long-term complications. This study aimed to elucidate the molecular mechanisms of BPD, especially mitophagy.

Methods: Bioinformatics analyses were performed to identify differentially expressed genes (DEGs) in BPD.

Characteristics of ecosystem multifunctionality and influencing factors of different grassland types in temperate desert of Longzhong Loess Plateau.

Introduction: Ecosystem multifunctionality (EMF) refers to the integrated capacity of an ecosystems to provide a variety of services and functions. It plays a crucial role in maintaining ecological balance and achieving sustainable grassland development. Grassland type is a classification unit based on dominant species within the grassland ecosystem.

Stabilizing Zn Metal Anode via an Innovative Cu-MOF/Carbon Cloth Ion-Buffering Layer.

The performance of aqueous zinc-ion batteries is frequently hindered by anode-related issues such as uncontrolled dendrite formation and side reactions. Metal-organic frameworks (MOFs), characterized by their highly ordered porous structures, remarkably large specific surface areas, and tunable active sites, offer a promising solution by regulating Zn flux and promoting uniform Zn deposition. In this study, a Cu-MOF was synthesized in situ on carbon cloth (CM-C) and functioned as an ion-buffering layer within the battery.

Gut Fungal Community Modulates Fat Deposition in Ningxiang Pigs: Species-Specific Regulation via the Glucose-SCFAs Metabolic Axis.

Despite limited understanding of gut fungal roles in fat deposition among indigenous pig breeds, a comparative study between high-fat-accumulating Ningxiang (NX) pigs and lean-type Duroc × Landrace × Yorkshire (DLY) pigs reveals a fungal-driven regulatory mechanism. NX pigs exhibited significantly higher fat percentage, elevated serum glucose, and markedly reduced total colonic short-chain fatty acids (SCFAs) compared to DLY pigs (all < 0.001), with butyrate showing the most pronounced decrease.

Screening criteria for high-quality Glycyrrhiza uralensis Fisch. seeds from the Ordos Plateau.

In the standardized production of the herb Glycyrrhiza uralensis Fisch., high-quality seeds and seedlings serve as the basis of production and are the main precondition that ensures the quality of herbs produced from these sources. Using traditional seed quality testing methods such as the halving method, soaking method, hundred grain weight method, red ink dyeing method, electrical conductivity method, and high-temperature drying method, quality grading standards for G.

Total-area world-record efficiency of 27.03% for 350.0 cm commercial-sized single-junction silicon solar cells.

Performance improvement is the cornerstone to facilitate the healthy and sustainable development of photovoltaic industry. Meanwhile, the aesthetics of solar panels becomes growingly concerned with the continuously improved requirements from customers. Accordingly, developing the modules having both a higher power conversion efficiency (PCE) and better aesthetic appearance is increasingly important.

Feasibility of 100 kV Low-voltage Bone Mineral Density Measurement with Quantitative CT: Phantom and Clinical Research.

To investigate the feasibility and accuracy of 100 kV low-voltage quantitative CT (QCT) for bone mineral density (BMD) measurement using the European Spine Phantom and patients. The accuracy and precision of the BMD measurements were assessed using relative measurement error (RME%), coefficient of variation (CV%), root mean square standard deviation (RMS-SD), and root mean square CV (RMS-%CV). Linear regression and Bland‒Altman analyses were used to assess the agreement between 100 and 120 kV QCT-based BMD measurements.

Integration of polyethylenimine functionalized carbon nanotubes nanocarriers for efficient DNA delivery.

Optically active nanocarrier has shown great application prospects in cancer photothermal and gene therapy. However, monotherapy has many side effects and limited therapeutic effect, and the combination therapy with high anti-cancer efficiency has become the current research trend. We reported a facile chemical grafting strategy to construct a combination of photothermal and gene therapy nanocarrier system through amide reaction.

CT delta-radiomics predicts the risks of blood transfusion and massive bleeding during spinal tumor surgery.

Background: Intraoperative bleeding is a serious complication of spinal tumor surgery. Preoperative identification of patients at high risk of intraoperative blood transfusion (IBT) and intraoperative massive bleeding (IMB) before spinal tumor resection surgery is difficult but critical for surgical planning and blood management. This study aims to develop and validate delta radiomics prediction models for IBT and IMB in spinal tumor surgery.

Defective KTiO Nanorod Supports Enable Stable High-Current-Density Acidic Water Electrolysis via Confinement-Engineered IrO.

This study tackles the dual challenges of sluggish oxygen evolution reaction (OER) kinetics and excessive iridium loading in proton exchange membrane water electrolysis (PEMWE) via rational catalyst design. Through a rapid synthesis strategy, it is anchored ultrafine IrO nanoparticles (<3 nm) on KTiO (KTO), achieving exceptional acidic OER activity with ultra-low Ir content (10.89 wt.

Diagnostic value of dual-energy CT virtual monochromatic imaging for supraspinatus tendon injuries: a comparison with standard CT and MRI.

Objectives: This study aimed to compare the diagnostic value of dual-energy computed tomography (DECT) virtual monochromatic imaging with that of standard computed tomography (SCT) in evaluating supraspinatus tendon injuries.

Materials And Methods: This retrospective study involved patients who underwent a single-source DECT system, 3.0-T MRI, and shoulder arthroscopy within 14 days.

Single-Atom Supported Catalysts and Beyond.

Tuning electronic configurations of active components in supported metal catalysts can be achieved via strong metal-support interaction (SMSI) between loaded metal species and support, which has a profound effect on catalytic efficiency. Distinct from conventional supports, single-atom catalysts, due to their rich unsaturated coordination metal sites and versatile electronic states, are employed as supports to load active metal species, which can manipulate the SMSI and thereby regulate catalytic performance. Although single-atom supported catalysts have demonstrated remarkable advance in catalytic capabilities, this field is still in its infancy with a large room for improvement.

Current status and influencing factors of the second victim experience and support of operating room nurses.

Background: As the second victim, nurses may suffer severe physical and mental damage. How to reduce the trauma level of operating room nurses after adverse events, enhance career resilience, and stabilize the nursing team has become an urgent concern for operating room nursing managers.

Objective: To investigate the experience of operating room nurses as the Second Victim of adverse events, and analyze the risk factors affecting the psychological status of operating room nurses as the Second Victim.

Airway-applied mRNA vaccine needs tailored sequence design and high standard purification that removes devastating dsRNA contaminant.

The development of mucosal mRNA vaccines is promising but extremely challenging. Major efforts have been focused on optimizing delivery systems, but it is still unknown whether the intrinsic quality of mRNA components significantly impacts the potency of airway-inoculated mRNA vaccines. Here, we systematically demonstrate that mucosal mRNA vaccine requires higher standards of purification and a tailor-designed sequence to fulfill its potency compared to its parenteral-route-inoculated counterpart.

Identification of Therapeutic Targets for Hyperuricemia: Systematic Genome-Wide Mendelian Randomization and Colocalization Analysis.

: At present, there are still limitations and challenges in the treatment of hyperuricemia (HUA). Mendelian randomization (MR) has been widely used to identify new therapeutic targets. Therefore, we conducted a systematic druggable genome-wide MR to explore potential therapeutic targets and drugs for HUA.

Gradient Protein Thin-Film-Based Bragg's Mirror.

Conventional structural color sensors with an even thickness can hardly detect tiny structural changes caused by analytes at extremely low concentrations. Herein, we construct a gradient protein thin-film-based Bragg's mirror, which reveals a highly effective signaling translation from the 3D gradient surface to 2D interference patterns and thus realizes an extremely high sub 0.5 Å of spatial resolution by using a simple CCD camera, exhibiting 1000-fold improvement than the color recognition.

Enhancing Zn Metal Anode Stability via TiCT MXene/PEI Composite Coating.

Aqueous Zn-ion batteries (AZIBs) are considered a promising candidate for large-scale energy storage application owing to their high capacity, good safety, low cost, and environmental friendliness. However, the presence of active water leads to issues such as corrosion, dendrite growth and hydrogen evolution reaction on Zn metal anodes, severely limiting the cycle lifetime and reversibility of AZIBs. To address these challenges, this study introduces a simple drop-casting method to deposit a composite protective coating of 2D titanium carbide (TiCT) MXene and polyethyleneimine (PEI) on the surface of Zn foil, i.

Efficient and Stable Carbon-Based Hole-Transport-Layer-Free CsPbIBr Solar Cells by Adding Trace Amounts of Yttrium Acetate into the Photoactive Layer.

CsPbIBr solar cells are a kind of important inorganic perovskite photovoltaic (PV) device that can serve as the top cells in a tandem configuration or semitransparent PV devices with balanced structural stability and light absorption. However, the issues relating to their power conversion efficiency (PCE) and long-term stability are still severely impeded by uncoordinated Pb and migratable I. To effectively passivate the uncoordinated Pb and meanwhile anchor the migratable I, herein, we propose a simple strategy by adding yttrium acetate (Y(Ac)) in the photoactive layer.

Treatment with inactivated Metschnikowia bicuspidata protects against the later infection in Chinese mitten crab Eriocheir sinensis.

In recent years, infection by the fungus Metschnikowia bicuspidata has caused significant mortality in Chinese mitten crab Eriocheir sinensis and substantial economic losses, leaving effective control measures still unavailable. The protective effect of immune priming against the secondary bacterial infection reported in crabs provides a promising idea for the development of disease prevention strategies against M. bicuspidate invasion.

Hydrofluorocarbons (HFCs) in Southern China: High-Frequency Observations and Emission Estimates.

Hydrofluorocarbons (HFCs) are potent greenhouse gases whose global abundance continues to rise and subsequently warm the Earth. Southern China is a rapidly developing region that has experienced a sharp increase in its HFC consumption. Here, we present the first high-frequency HFC observations in Southern China from 2022 to 2023, analyzing the atmospheric mole fractions of four HFCs (HFC-134a, HFC-32, HFC-125, and HFC-143a) and using inverse modeling to estimate their emissions in Southern China.

Consciousness Disorders and Swallowing Difficulties.

With the advancement of medicine, the survival rate of patients with brain injuries has significantly increased. Among these patients, some remain in a chronic state of altered consciousness and experience difficulties in swallowing. Swallowing difficulties can lead to clinical issues such as aspiration and malnutrition.