Comparative Genomic Analysis of Tigecycline Resistance Development in Clinical Isolates.

Objective: This study investigated the mechanisms underlying the reduced tigecycline sensitivity of strains isolated from infected patients during antimicrobial therapy. The goal is to provide clinical insights into the development of tigecycline resistance in , with a focus on multidrug-resistant strains commonly associated with hospital-acquired infections.

Methods: We conducted dynamic tracking of multidrug-resistant (MDR-AB) infections in three patients to monitor changes in tigecycline sensitivity during antimicrobial therapy.

Emergence of a novel sequence type carbapenem-resistant hypervirulent ST6417 harboring on the lncX3 plasmid.

Unlabelled: Carbapenem-resistant hypervirulent (CR-hvKP) is a significant pathogen causing major public health problems worldwide. This study characterized a novel sequence type 6417 (ST6471) CR-hvKP strain recovered from the blood of a male patient with septicemia. Strain CR2021 is not susceptible to carbapenems, cephalosporin, sulfonamides, quinolones, or levofloxacin and is susceptible to amikacin and tigecycline.