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http://dx.doi.org/10.1007/s00394-025-03794-8 | DOI Listing |
Eur J Nutr
September 2025
College of Life Science, Qingdao University, 308 Ningxia Road, Qingdao, 266071, China.
Discov Oncol
September 2025
Department of Oncology, LongHua Hospital, Shanghai University of Traditional Chinese Medicine, No. 725 Wanping South Road, Xuhui District, Shanghai, 200032, China.
Purpose: Ursolic Acid (UA), a triterpenoid extracted from Hedyotis Diffusa Willd. (HDW), is known for its anti-inflammatory, antioxidant, and antitumor effects. Nevertheless, the mechanisms underlying UA's anti-colorectal cancer (CRC) effects remain insufficiently understood.
View Article and Find Full Text PDFMar Drugs
July 2025
College of Life Sciences, Qingdao University, Qingdao 266071, China.
Colorectal cancer (CRC) remains a predominant cause of global cancer-related mortality, highlighting the pressing demand for innovative therapeutic strategies. Natural polysaccharides have emerged as promising candidates in cancer research due to their multifaceted anticancer mechanisms and tumor-suppressive potential across diverse malignancies. In this study, we enzymatically extracted a polysaccharide, named ERPP, from and comprehensively evaluated its anti-colorectal cancer activity.
View Article and Find Full Text PDFNPJ Sci Food
August 2025
Beijing Laboratory of Food Quality and Safety, College of Food Science and Engineering, Beijing University of Agriculture, Beijing, China.
This study elucidates the anti-colorectal cancer (CRC) mechanism of Rosa rugosa cv. Plena polysaccharide RPP1 against AOM/DSS-induced carcinogenesis. Purified via water extraction and chromatography, RPP1 was characterized as an eight-monosaccharide polymer by HPLC.
View Article and Find Full Text PDFSci Rep
July 2025
Center of Excellence for Mangrove, Universitas Sumatera Utara, Medan, 20155, Indonesia.
Colorectal cancer (CRC) remains a significant global health challenge, with the current therapies often being inadequate. This study investigates the potential of Avicennia alba (A. alba), a mangrove plant, as a source of new anticancer drug candidates.
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