A novel high-pressure low-temperature interface shear apparatus: Mechanical behavior of interface between hydrate-bearing sediment and foundation structure.

Metastable hydrates are widely distributed in shallow deep-sea sediments, posing significant risks to the long-term stability of offshore foundation structures. Unveiling the weakening mechanisms at the hydrate-bearing sediment-structure interface is crucial for establishing a theoretical framework for the safe design of deep-sea structures. A high-pressure (up to 12.

Electrically-Induced Droplet Detachment and Transport on Bionic Honeycomb-Fiber Composite Surfaces.

The complex regulation of droplet dynamics, based on the application of external electric fields and micro/nano functional surfaces, has garnered widespread attention in fields such as enhanced oil-water separation, self-cleaning systems, and novel imaging technologies. In this study, a PLE surface (composite biomimetic hydrophobic surface with micron-level honeycomb texture and nanoscale villi) was fabricated. Using a high-speed microscopy system, the detachment and movement of droplets on the biomimetic surface under a direct current electric field were experimentally investigated.

Single-Cell Isolation Chip Integrated with Multicolor Barcode Array for High-Throughput Single-Cell Exosome Profiling in Tissue Samples.

Exosomes, functional biomarkers involved in cancer progression, have gained widespread attention for promoting tumor formation, growth, and metastasis. Current bulk exosome detections in bodily fluids enable cancer functional analysis, but average secretion levels from cell populations, losing parent cell information and ignoring exosome heterogeneity from diverse cell subgroups, necessitating an effective platform for analyzing single-cell exosome functional heterogeneity. Here, a high-throughput platform is presented, capable of efficient single-cell isolation and multi-color exosome phenotype analysis, as well as quantifying trace exosomes secreted by single cells.

Suppression of coffee rings by controllable nanoparticle enrichment through superhydrophobicity-enabled dynamic evaporation.

Coffee rings formed by evaporation of analyte-containing droplets are widely observed in micropatterning, bio-arrays, and trace detection. The coffee-ring effect caused by contact line pinning significantly affects the detection uniformity and sensitivity. Here, we propose a simple and operable method to effectively suppress coffee rings through controllable nanoparticles aggregation by superhydrophobicity-enabled dynamic evaporation.

RNA extraction-free reduced graphene oxide-based RT-LAMP fluorescence assay for highly sensitive SARS-CoV-2 detection.

Infectious diseases have always been a seriously endanger for human life and health. A rapid, accurate and ultra-sensitive virus nucleic acid detection is still a challenge to deal with infectious diseases. Here, a RNA extraction-free reduced graphene oxide-based reverse transcription-loop-mediated isothermal amplification (EF-G-RT-LAMP) fluorescence assay was developed to achieve high-throughput, rapid and ultra-sensitive SARS-CoV-2 RNA detection.

What Makes a Hospital Excellent? A Qualitative Study on the Organization and Management of Five Leading Public Hospitals in China.

Purpose: To summarize the organizational and management experiences and explore the organizational theoretical model of five leading public hospitals in China.

Patients And Methods: Purposive sampling was used to select five leading hospitals in different regions of China under the National Health Commission and Provincial Health Commission as study hospitals for the study. From August 2021 to March 2022, 8 leaders and 39 managers from these hospitals were surveyed using semi-structured interviews.

Laser-Induced Graphene Superhydrophobic Surface Transition from Pinning to Rolling for Multiple Applications.

The fabrication and applications of superhydrophobic surfaces (contact angle >150°, sliding angle <10°) have attracted worldwide interest with respect to materials and devices. In this work, the laser-induced graphene (LIG) superhydrophobic surface transition from pinning to rolling via an extremely simple solvent treatment of LIG in air is reported. By adding a certain solvent (e.

Controllable Nanoparticle Aggregation through a Superhydrophobic Laser-Induced Graphene Dynamic System for Surface-Enhanced Raman Scattering Detection.

Surface-enhanced Raman scattering (SERS) is widely used for low-concentration molecular detection; however, challenges related to detection uniformity and repeatability are bottlenecks for practical application, especially as regards ultrasensitive detection. Here, through the coupling of bionics and fluid mechanics, a lotus-leaf effect and rose-petal effect (LLE-RPE)-integrated superhydrophobic chip is facilely developed using laser-induced graphene (LIG) fabricated on a polyimide film. Dense and uniform aggregation of gold nanoparticles (AuNPs) in droplets is realized through a constant contact angle (CCA) evaporation mode in the dynamic enrichment process, facilitating reliable ultrasensitive detection.

Mechanical Stress Induces a Transient Suppression of Cytokine Secretion in Astrocytes Assessed at the Single-Cell Level with a High-Throughput Microfluidic Chip.

Brain cells are constantly subjected to mechanical signals. Astrocytes are the most abundant glial cells of the central nervous system (CNS), which display immunoreactivity and have been suggested as an emerging disease focus in the recent years. However, how mechanical signals regulate astrocyte immunoreactivity, and the cytokine release in particular, remains to be fully characterized.

Continuous Movement Mechanism of Oil Droplets Adhered on Surfaces with Different Wettability in the Flow Field.

In this aticle, the continuous movement patterns and characteristic parameters of oil droplets on surfaces with different wettability immersed in a laminar flow field were observed, and the change rules of the geometric parameters of oil droplets under different experimental conditions were obtained. Then, the factors influencing the continuous moving behaviors of the oil droplets were analyzed, and the continuous movement velocity of the oil droplets under different experimental conditions was demonstrated. On this basis, the change law of the continuous movement velocity of oil droplets with the flow velocity was discussed.

Migration and Adherence of Oil Droplets on Surfaces with Different Wettability in a Laminar Flow Field.

In this article, the rising trajectories of oil droplets near the substrates of small channels in the laminar flow field were observed using a high-speed camera. Chemical modifications were made on the surfaces of the brass sheets to change the surface properties, and the controllable regulation of the superoleophilic-superoleophobic wettability gradient was achieved. The adhesion behaviors of the oil droplets on surfaces with different wettabilities at different flow velocities were observed as well.