Prognostic and immune microenvironment analysis of cuproptosis-related lncRNAs in human pancreatic cancer.

Pancreatic cancer remains one of the most lethal malignancies, with limited treatment options and poor prognosis. Emerging evidence implicates cuproptosis-related long non-coding RNAs (lncRNAs) in tumor progression, though their roles in pancreatic cancer remain unexplored. To identify cuproptosis-linked lncRNAs in pancreatic cancer, RNA-seq data from The Cancer Genome Atlas (TCGA) were evaluated.

Adjuvant icotinib for resected EGFR-mutated stage II-IIIA non-small-cell lung cancer (ICTAN, GASTO1002): a randomized comparison study.

The efficacy, safety and ideal treatment duration of an adjuvant epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for patients with resected EGFR-mutated non-small-cell lung cancer (NSCLC) were not known until 2014, when this study was initiated. In this phase 3 ICTAN trial (GASTO1002, NCT01996098), patients with completely resected, EGFR-mutated, stage II-IIIA NSCLC after adjuvant chemotherapy were assigned in a 1:1:1 ratio to receive icotinib (125 mg, three times daily) for 12 months, to receive icotinib for 6 months, or to undergo observation. The primary endpoint was disease-free survival (DFS).

Strategies to enhance the effects of nanotechnology-mediated photodynamic therapy.

Photodynamic therapy (PDT) is a noninvasive therapeutic approach, particularly effective in tumor treatment. PDT utilizes photosensitizers (PSs) to absorb light at specific wavelengths, converting photon energy into chemical energy and subsequently generating cytotoxic reactive oxygen species (ROS). These ROS trigger cell death through apoptosis, necrosis and autophagy-related pathways.

Secure wireless communication of brain-computer interface and mind control of smart devices enabled by space-time-coding metasurface.

Brain-computer interface (BCI) provides an interconnected pathway between the human brain and external devices and paves a potential route for mind manipulations. However, most existing BCI technologies are based on simple signal transmission and are independent of other interface devices, with limited consideration for the reliability and security of the human brain's information interaction in complicated wireless environments. Here, we propose a deep fusion coding scheme that combines the BCI visual stimulation coding with metasurface space-time coding at the physical layer, enabling reliable and secure information transfers between the human brain and external devices.

Engineering a biocompatible chitosan/MOF aerogel for hyperbilirubinemia treatment in liver failure.

Liver failure, marked by a rapid or progressive decline in liver function, leads to complications such as hyperbilirubinemia and infections, contributing to approximately 2 million global deaths each year. Current hemoperfusion methods for hyperbilirubinemia treatment are limited by their low adsorption selectivity and inadequate biosafety, necessitating better treatments. In this study, a chitosan-based HKUST-1 aerogel (HC) was developed as a highly selective, biosafe, and antibacterial adsorbent.

Metformin-Sensitized Chemotherapy of Docetaxel Nanoemulsions Based on a Sequential Administration.

Chemotherapy has a broad-spectrum anti-tumor effect and is still the core strategy for cancer treatment. However, the side effects caused by its cytotoxicity, the chemoresistance caused by tumor heterogeneity and abnormal microenvironment seriously restrict the efficacy of chemotherapy. Metformin presents the ability to sensitize chemotherapy by interfering with metabolic processes of tumor cells.

Mechanosensitive Ion Channel Piezo Therapy in Digestive Diseases.

In recent years, Piezo channels-a novel class of mechanosensitive cation channels-have attracted considerable attention due to their role in digestive system diseases. In this system, Piezo channel expression and function are closely related to various physiological activities and pathological states, playing a pivotal role in digestive disease development. This paper aims to provide a comprehensive review of the structural characteristics of Piezo channels, their expression patterns in the digestive system, and their mechanisms of action, as well as their potential therapeutic applications in various digestive diseases.

Liver cirrhosis in 2021: Global Burden of Disease study.

Background: Liver cirrhosis is a chronic progressive disease caused by various liver injury mechanisms, characterized by irreversible fibrosis, hepatocyte degeneration and necrosis, and the formation of regenerative nodules, ultimately leading to liver failure and multiple severe complications, significantly increasing the risk of mortality.

Methods: This study analyzes global and China-specific trends in liver cirrhosis incidence, prevalence, mortality, and disability-adjusted life years (DALYs) from 1990 to 2021, focusing on various causes including hepatitis B virus (HBV), hepatitis C virus (HCV), alcoholic liver disease, and non-alcoholic fatty liver disease (NAFLD). Data from the Global Burden of Disease (GBD) database were used to assess changes in liver cirrhosis statistics globally and in China.

Modulatory role of radioprotective 105 in mitigating oxidative stress and ferroptosis via the HO-1/SLC7A11/GPX4 axis in sepsis-mediated renal injury.

Sepsis-associated acute kidney injury (SA-AKI) is a critical condition characterized by high morbidity and mortality rates, particularly in intensive care settings. This study focuses on RP105, a pattern recognition receptor, exploring its role in moderating the mechanisms of oxidative stress and ferroptosis during SA-AKI, offering insights into its potential as a therapeutic target. SA-AKI model was established using RP105 knockout (KO) and wild-type (WT) mice through cecal ligation and puncture (CLP).

A rationally thin composite membrane with differentiated pore structure for industrial-scale alkaline water electrolysis.

Alkaline water electrolysis is one of the most prospective technologies for large-scale production of green hydrogen. Nevertheless, current porous membranes face the problem of weak ion transport or poor gas barrier performance. Here, we demonstrate a facile yet massive two-step casting and phase separation strategy to design a thin, asymmetric pore-structure modulated composite membrane for efficient, safe, and industrial-grade alkaline water electrolysis.

A retrospective study of the effect of papaverine on perioperative efficacy of microvascular decompression in the treatment of hemifacial spasm.

Objective: Retrospective analysis was conducted to evaluate the differences in intraoperative electrophysiological changes and postoperative efficacy of microvascular decompression(MVD) for hemifacial spasm.

Methods: Cases of hemifacial spasm treated by MVD at the Affiliated Hospital of Southwest Medical University over the past three years were retrospectively analyzed. Patients were divided into two groups: the papaverine group, which received papaverine treatment intraoperatively and postoperatively, and the control group, which did not receive papaverine.

Surgical Outcomes With Neoadjuvant Durvalumab Plus Chemotherapy Followed by Adjuvant Durvalumab in Resectable NSCLC.

Introduction: In AEGEAN, perioperative durvalumab plus neoadjuvant chemotherapy, versus neoadjuvant chemotherapy alone, significantly improved event-free survival (p = 0.004) and pathologic complete response (p < 0.001; primary end points; modified intention-to-treat [mITT] population, which excluded patients with known EGFR or ALK aberrations) with a manageable safety profile in patients with resectable (R)-NSCLC.

Precision nanomedicine for pneumonocyte-targeting: Emerging strategies and clinical prospects in refractory pulmonary disease therapy.

Refractory pulmonary diseases, including chronic obstructive pulmonary disease (COPD) and tuberculosis (TB), pose a critical global health challenge due to the limitations of conventional therapies in advanced stages, such as poor drug penetration, systemic side effects, and inability to eradicate pathogens in protected microenvironments. While the lung's complex structure is essential for respiratory function, it also facilitates persistent damage from environmental and infectious agents. Nanomedicine provides a transformative approach by utilizing customizable carriers (e.

PPS Gradient Filter Material with High Efficiency and Excellent Dust Removal Capacity for Industrial Flue Gas Treatment by Integrating Numerical Modeling and Melt-Blown-Lamination Technology.

The filter material is the key to controlling flue gas pollution with bag filter technology. Surface treatment of filter media using the PTFE membrane can improve its filtration performance. Badly, the reprocessing of used filter media has become a major challenge due to the ecological impact and potential human toxicity of PTFE.

Multi-Dimensional Multiplexed Metasurface for Multifunctional Near-Field Modulation by Physics-Driven Intelligent Design.

Metasurface is a revolutionary platform to achieve desired properties by artificially engineering meta-atom's arrangements. However, the explosively expanding design space of advanced metasurfaces with multiple degrees of freedom (MDOF) has made the traditional human-guided design methods increasingly ineffective, limiting the development of the metasurfaces. Intelligent design methods have been presented to tackle these challenges by introducing innovative computational models, but they are predominantly data-driven and faced the issues of data scarcity, poor physical interpretability, and weak generalization capability.

BioMeta: modular reprogrammable metasurface for noninvasive human respiration monitoring.

Human vital-sign sensing using electromagnetic wave has emerged as a promising technology for the noninvasive monitoring of individuals' health status. Here, a modular reprogrammable metasurface system is presented to suppress noise in noninvasive human respiration sensing. The proposed reprogrammable Biological Metasurface () provides three-dimensional dynamic control over wavefront shaping and thus can reduce interference from human limb motions.

Inhibition of PDT-induced PGE2 surge for enhanced photo-immunotherapy.

Nowadays, photodynamic therapy (PDT) offers a non-invasive tumor treatment with high safety profiles and minimal side effects, implying a promising clinical application for patients with malignant tumors. However, the lack of efficacy in metastasis and recurrence still notably limits its application. To solve this problem, one promising strategy is to improve the immune response activated by PDT.

Reductive Adjuvant Nanosystem for Alleviated Atopic Dermatitis Syndromes.

Atopic dermatitis (AD) is a recurrent and chronic inflammatory skin condition characterized by a high lifetime prevalence and significant impairment of patients' quality of life, primarily due to intense itching and discomfort. However, current pharmacological interventions provide only moderate efficacy and are frequently accompanied by adverse side effects. The immune-pathogenesis of AD involves dysregulation of the Th2 immune response and exacerbation of inflammation related to excessive reactive oxygen species (ROS).

[Savolitinib Induced Pathological Complete Response in Non-small Cell Lung Cancer with MET Amplification: A Case Report].

Mesenchymal-epithelial transition factor (MET) gene mutation is a large class of mutations commonly seen in non-small cell lung cancer (NSCLC). MET mutation includes subtypes such as MET exon 14 skipping mutation (METex14m) and MET amplification (METamp). For advanced NSCLC with METex14m, Savolitinib has a high sensitivity as a member of tyrosine kinase inhibitors (TKIs).

Vaccine Specifically for Immunocompromised Individuals against Superbugs.

Immunocompromised populations, including cancer patients, elderly individuals, and those with chronic diseases, are the primary targets of superbugs. Traditional vaccines are less effective due to insufficient or impaired immune cells. Inspired by the "vanguard" effect of neutrophils (NE) during natural infection, this project leverages the ability of NE to initiate the NETosis program to recruit monocytes and DC cells, designing vaccines that can rapidly recruit immune cells and enhance the immune response.

Dynamic transcriptomics unveils parallel transcriptional regulation in artemisinin and phenylpropanoid biosynthesis pathways under cold stress in Artemisia annua.

Cold stress, a major abiotic factor, positively modulates the synthesis of artemisinin in Artemisia annua and influences the biosynthesis of other secondary metabolites. To elucidate the changes in the synthesis of secondary metabolites under low-temperature conditions, we conducted dynamic transcriptomic and metabolite quantification analyses of A. annua leaves.

Anterior capsulotomy and accumbensotomy of obsessive-compulsive disorder with obsessional slowness: a case report.

Unlabelled: Obsessional slowness (OS) is characterized by a syndrome of extreme slowness in doing ordinary, day-to-day activities. Several scholars regarded OS as secondary to obsessive compulsive disorder (OCD). Therefore, it is commonly thought to be the consequence of extensive rituals and has been paid minimal attention in its own right.

Giant second-harmonic generation in monolayer MoS boosted by dual bound states in the continuum.

Dielectric metasurfaces open new avenues in nonlinear optics through their remarkable capability of boosting frequency conversion efficiency of nonlinear optical interactions. Here, a metasurface consisting of a square array of cruciform-shaped silicon building blocks covered by a monolayer MoS is proposed. By designing the metasurface so that it supports optical bound states in the continuum (BICs) at the fundamental frequency and second harmonic, nearly 600× enhancement of the second-harmonic generation (SHG) in the MoS monolayer as compared to that of the same MoS monolayer suspended in air is achieved.